LOCUS       NM_001031772            5420 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus lin-28 homolog B (Lin28b), mRNA.
ACCESSION   NM_001031772 XM_354572 XM_900108
VERSION     NM_001031772.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5420)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5420)
  AUTHORS   Li,Y., Mendoza-Castrejon,J., Patel,R.M., Casey,E.B., Denby,E.,
            Bryder,D. and Magee,J.A.
  TITLE     LIN28B promotes differentiation of fully transformed AML cells but
            is dispensable for fetal leukemia suppression
  JOURNAL   Leukemia 38 (3), 648-651 (2024)
   PUBMED   38321106
REFERENCE   3  (bases 1 to 5420)
  AUTHORS   Subramanian,M., Mills,W.T. 4th, Paranjpe,M.D., Onuchukwu,U.S.,
            Inamdar,M., Maytin,A.R., Li,X., Pomerantz,J.L. and Meffert,M.K.
  TITLE     Growth-suppressor microRNAs mediate synaptic overgrowth and
            behavioral deficits in Fragile X mental retardation protein
            deficiency
  JOURNAL   iScience 27 (1), 108676 (2023)
   PUBMED   38235335
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5420)
  AUTHORS   Shu,Z., Fan,M., Tu,B., Tang,Z., Wang,H., Li,H., Li,H., Yuan,M.,
            Bai,J., Huo,S., Wang,L., Zhu,W.G., Wang,W., Liu,X., Shu,S. and
            Zhao,Y.
  TITLE     The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk
            between cancer associated fibroblasts and tumor epithelium
  JOURNAL   Nat Commun 14 (1), 6885 (2023)
   PUBMED   37898598
  REMARK    GeneRIF: The Lin28b/Wnt5a axis drives pancreas cancer through
            crosstalk between cancer associated fibroblasts and tumor
            epithelium.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5420)
  AUTHORS   Xiao,S., Zhang,W., Li,J. and Manley,N.R.
  TITLE     Lin28 regulates thymic growth and involution and correlates with
            MHCII expression in thymic epithelial cells
  JOURNAL   Front Immunol 14, 1261081 (2023)
   PUBMED   37868985
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5420)
  AUTHORS   Rao,S., Lee,S.Y., Gutierrez,A., Perrigoue,J., Thapa,R.J., Tu,Z.,
            Jeffers,J.R., Rhodes,M., Anderson,S., Oravecz,T., Hunger,S.P.,
            Timakhov,R.A., Zhang,R., Balachandran,S., Zambetti,G.P.,
            Testa,J.R., Look,A.T. and Wiest,D.L.
  TITLE     Inactivation of ribosomal protein L22 promotes transformation by
            induction of the stemness factor, Lin28B
  JOURNAL   Blood 120 (18), 3764-3773 (2012)
   PUBMED   22976955
  REMARK    GeneRIF: Rpl22 inactivation promotes neoplastic transformation by
            inducing expression of Lin28B
REFERENCE   7  (bases 1 to 5420)
  AUTHORS   Beachy,S.H., Onozawa,M., Chung,Y.J., Slape,C., Bilke,S.,
            Francis,P., Pineda,M., Walker,R.L., Meltzer,P. and Aplan,P.D.
  TITLE     Enforced expression of Lin28b leads to impaired T-cell development,
            release of inflammatory cytokines, and peripheral T-cell lymphoma
  JOURNAL   Blood 120 (5), 1048-1059 (2012)
   PUBMED   22723554
  REMARK    GeneRIF: Enforced expression of Lin28b leads to impaired T-cell
            development, release of inflammatory cytokines, and peripheral
            T-cell lymphoma.
REFERENCE   8  (bases 1 to 5420)
  AUTHORS   Yuan,J., Nguyen,C.K., Liu,X., Kanellopoulou,C. and Muljo,S.A.
  TITLE     Lin28b reprograms adult bone marrow hematopoietic progenitors to
            mediate fetal-like lymphopoiesis
  JOURNAL   Science 335 (6073), 1195-1200 (2012)
   PUBMED   22345399
  REMARK    GeneRIF: study reports Lin28b is expressed in fetal liver and
            thymus, but not adult bone marrow or thymus; ectopic expression of
            Lin28 reprograms hematopoietic progenitor cells from adult bone
            marrow, endowing them with ability to mediate fetal-like
            lymphopoiesis
REFERENCE   9  (bases 1 to 5420)
  AUTHORS   Zhu,H., Shyh-Chang,N., Segre,A.V., Shinoda,G., Shah,S.P.,
            Einhorn,W.S., Takeuchi,A., Engreitz,J.M., Hagan,J.P., Kharas,M.G.,
            Urbach,A., Thornton,J.E., Triboulet,R., Gregory,R.I., Altshuler,D.
            and Daley,G.Q.
  CONSRTM   DIAGRAM Consortium; MAGIC Investigators
  TITLE     The Lin28/let-7 axis regulates glucose metabolism
  JOURNAL   Cell 147 (1), 81-94 (2011)
   PUBMED   21962509
  REMARK    GeneRIF: When overexpressed in mice, both Lin28a and LIN28B
            promotes resistance to high-fat-diet induced diabetes; conversely,
            muscle-specific loss of Lin28a or overexpression of let-7 results
            in insulin resistance and impaired glucose tolerance.
REFERENCE   10 (bases 1 to 5420)
  AUTHORS   Matsubara,S., Takahashi,T. and Kimura,A.P.
  TITLE     Epigenetic patterns at the mouse prolyl oligopeptidase gene locus
            suggest the CpG island in the gene body to be a novel regulator for
            gene expression
  JOURNAL   Gene 465 (1-2), 17-29 (2010)
   PUBMED   20600704
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ127225.1 and BC089037.1.
            
            On Apr 22, 2010 this sequence version replaced NM_001031772.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089037.1, CV884017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2743              DQ127225.1         1-2743
            2744-5389           DQ127225.1         2745-5390
            5390-5420           BC089037.1         5381-5411
FEATURES             Location/Qualifiers
     source          1..5420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.5 cM"
     gene            1..5420
                     /gene="Lin28b"
                     /gene_synonym="2810403D23Rik; D030047M17Rik; Lin-28.2"
                     /note="lin-28 homolog B"
                     /db_xref="GeneID:380669"
                     /db_xref="MGI:MGI:3584032"
     exon            1..151
                     /gene="Lin28b"
                     /gene_synonym="2810403D23Rik; D030047M17Rik; Lin-28.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..957
                     /gene="Lin28b"
                     /gene_synonym="2810403D23Rik; D030047M17Rik; Lin-28.2"
                     /note="lin-28B"
                     /codon_start=1
                     /product="protein lin-28 homolog B"
                     /protein_id="NP_001026942.1"
                     /db_xref="CCDS:CCDS35895.1"
                     /db_xref="GeneID:380669"
                     /db_xref="MGI:MGI:3584032"
                     /translation="MAEGGASKGEEPEKLPGLAEDEPQVLHGTGHCKWFNVRMGFGFI
                     SMISREGNPLDIPVDVFVHQSKLFMEGFRSLKEGEPVEFTFKKSPKGLESIRVTGPGG
                     SPCLGSERRPKGKTLQKRKPKGDRWRRQDLLMDQMWTVREEESRMIPRCYNCGGLDHH
                     AKECSLPPQPKKCHYCQSIMHMVANCPHKLAAQLPASSQGRQEAESQPCSSAAPREVG
                     GGHGCTVLFPQEVKSEMAEHSDRSPQEVSSTKAFAAIGEQNKKGPLIQKRKKT"
     exon            152..333
                     /gene="Lin28b"
                     /gene_synonym="2810403D23Rik; D030047M17Rik; Lin-28.2"
                     /inference="alignment:Splign:2.1.0"
     exon            334..518
                     /gene="Lin28b"
                     /gene_synonym="2810403D23Rik; D030047M17Rik; Lin-28.2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..590
                     /gene="Lin28b"
                     /gene_synonym="2810403D23Rik; D030047M17Rik; Lin-28.2"
                     /inference="alignment:Splign:2.1.0"
     exon            591..5403
                     /gene="Lin28b"
                     /gene_synonym="2810403D23Rik; D030047M17Rik; Lin-28.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5365..5370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lin28b"
                     /gene_synonym="2810403D23Rik; D030047M17Rik; Lin-28.2"
                     /note="hexamer: AATAAA"
     polyA_site      5391
                     /gene="Lin28b"
                     /gene_synonym="2810403D23Rik; D030047M17Rik; Lin-28.2"
                     /note="major polyA site"
ORIGIN      
        1 aagaaggaaa gcacattaga ccatgcgaac taaatttgtg atcgcacaaa atcaagatgt
       61 tagactgatg ctgaagatca ctccggtcca aagggaaagt tttcatctct ggagtttgaa
      121 gctgagggcc ggtggggcaa catggccgaa ggcggggcaa gcaaaggtga agagccagaa
      181 aaactgcccg ggctggcaga ggacgaaccc caggttctgc atggcactgg ccactgtaaa
      241 tggttcaacg tgcgcatggg attcggattc atctccatga taagtcgaga gggaaatccc
      301 ttggatattc cagtggatgt atttgtacac caaagcaaac tattcatgga aggatttaga
      361 agcttgaaag aaggagagcc agtggaattt acatttaaaa aatcccccaa aggccttgag
      421 tcaatacggg taacaggccc aggtgggagc ccctgcttag gaagtgaaag aagacctaaa
      481 gggaagaccc tgcaaaagag aaagccaaag ggagataggt ggagacggca ggatttactg
      541 atggatcaga tgtggactgt gcgagaagaa gagtccagga tgattccaag atgctacaac
      601 tgtggtggtc tcgaccatca tgctaaagaa tgcagtctac ctcctcagcc aaagaagtgc
      661 cattactgtc agagcatcat gcacatggtg gccaactgcc cacacaagct tgccgctcag
      721 ctgcccgcca gttctcaggg aagacaggag gcagaatccc agccatgcag ctctgcggca
      781 ccaagagaag tgggaggggg gcatggctgc acagtactgt ttcctcagga ggtgaagtca
      841 gaaatggcag agcactcaga caggtcaccc caagaagttt cttccacgaa agcgtttgca
      901 gcaataggag agcaaaacaa aaaggggcct ttgattcaga aacggaaaaa gacttagtac
      961 ttgtcagtgt tcccttcacc cgggcgggaa gtctacctca tgcaagcaca ggggaatagt
     1021 ggtccacaga gagcagccgg ccgggatgtt aactactgct gaggaactgg gaagttctta
     1081 attagacaaa tcactcttaa gcaaactaca tttaagcagg gtgtcatgtt ttatagaatt
     1141 gagatactac atatagtatg tgcataagtg agaggggaga cttgaatctg tatgtatgtg
     1201 tgaggatttc acataagagt acaggcacac acacacatat atatatacac ttttatatat
     1261 ctgtggttgt ctttgtgtgt gtgtgtgtgt gtatgtgtgt gtgtgtgtgt gtgtatgtag
     1321 ataaaagcac atactcttcc tcagataatt gggcatctct aagcattgaa aatccatgtg
     1381 aagcatttga gatggtttca tagttaaccc ttggaatttt ttctaaatac tacttctttt
     1441 atattatgta aaaaatgacc acgtgactgt tacctttcat gtgaaccaaa gcatacttca
     1501 gatctcagag ctgccagtca aatggtacta aaggcttttg ggatacttgg tgcctcccaa
     1561 gtctgtattc ataactctat cttgatgctg atagagtgtt ttgctgttgc tgttatctgt
     1621 cttctcctgt ttgaaggtag taacttaact ctagatgcct ccgactgcca taagctttta
     1681 atccttggat acgtagctcc agaaaagaca atgaatgtga acttcctgtg ctgatatttc
     1741 agtgtctttt attctgtttg attgtaaatt acatggctat taagaaaaat gaaggggagg
     1801 gtaatgtata tagtaacatg gtccttttca gtggtatttt gatgctaggt cttttacaag
     1861 ggttctgagg tttttaaggg atggtggcaa cagaagcctc ctttgactaa gtagcttttg
     1921 aaccatcact tagatcagga aggtctctta cttactactg aagccttaga gaaaatttta
     1981 attatttggg tatatttttg gtagctgttt ttatttcccc tggagagtcc tcagacctgt
     2041 ttataaaaca aacaaaagca gcatagaaat aaaatagtgg ggcttagaat gaaaattaag
     2101 ttgcccaata gatacagccc atgattgata ctaaaaagaa tagtgtttga tggccagcag
     2161 agtgaatgag tggagcagag ttaccaaagt gcccactgtt ctgtggctag aaatacttta
     2221 tatgataata ttgatgccat ggcaggttcc ttgagtatag aagcggaagt atggtgtgtg
     2281 atagattcag gatgagcact cagatcaagt tataggatct tctcagatgg attctcagtt
     2341 tgctaagatt ggctaggaac tgattgtagt attgggctgt tttccatcat gttttgtttt
     2401 cttttgtttt ttgaatggag ttagcctggt tctaaatgtc atgagcaaac ttttgaaaca
     2461 tcttcaagaa ggtaccaagg gattgcagtg cataattttg gctgtaacta tatgggcctg
     2521 ttggtataag ctcagataat caaacaagaa agcatcgtga ctcatgagac acattctacg
     2581 gaggagtcgc ttcctcctgt gtgtcttgtc atgggagttg ggtggtgcta aggtttcatc
     2641 aagccactag aagaagaaag tgtctccgac tagcttacca gtcttttcca gagtagcttg
     2701 aattgcttga cagtatttat gagagttcct atagtgtttt accgaagtgt cagtgtgctg
     2761 taatacagag cttacctttg acgatattga atgtgatgta gccatagaga agtgctgcct
     2821 tgccttacgt gaggatttca agcttattta aattatgtag acaaatcaaa ggtcatccaa
     2881 gtataatgag caaggtaaca gttgtacaag caaaatatga taggtcactc tgaacgctca
     2941 aaccaaagtt ccttgactat caaaatagga aataatggac ttgaaaactg gacattctgt
     3001 ttacatttaa aatttaagag ctgaggtcat tttaacaaat gaaagtagaa aattcagaaa
     3061 cacttgaata tagaccttat gggtgcagtc aacttctttt cagcatctaa ccagaccgac
     3121 ttactaaaag cacataccaa acctatctta tggttaaaag tttatttttt atatgaaaat
     3181 agtgtcacta ttacatgctc aggacaaaga actttgctca gggaacatac catataatgt
     3241 ttttattgtt tttttttgtt ttgttttgtt ttgttttgtt tttttacaga ctaatgtata
     3301 atcctgcttt ctcagagcaa gccaaataaa ttaagtcttt atgtacgtac atatacttgt
     3361 tagtaactac ctctgagttt gacattgatc ataattctga atatcagata ttggtcctcc
     3421 ctttttaaat ttcatgtcaa agtcttgtaa agcggaattc cactacctgc agatgtgaac
     3481 tcactgatat gagcacttgc tcattcacac aagtgaaaat tctgtttaca gcacatggct
     3541 acctcccagc taccacagag cacaccttga tgctgctgca gcctgcaggt tgctgataat
     3601 tctctggtac agacgctttt aatctgtagc acagataggc atttgcaact gcatgtttct
     3661 gaaaaacgcc tgtttttctc atagatttct catgttaagt agcaaaatct ccaagcattt
     3721 ccttagagtt atcatgtatt aaatgtaagg aagtatggac actctaattt atcctaggcc
     3781 aaacagaaca cagaaacaat cttgaaaata gctctgttac ctagaggtga ggggcagcag
     3841 agataacaaa aggaaacttg gtgtttgtat tttgctgaca agtgttataa aagattccta
     3901 ccgcttcact tgtatctcta cagtactgaa ggcaaagcat actgcagcat tccaagcctc
     3961 aggcacacaa ctaactagca ccagcttgcc atgggggaac ttaaagtgca gtgttgcctt
     4021 gagccagagg ggaacggggt ctgtggagca ccactttgca ggggttcctc atagtgcggt
     4081 gtggtttgag ccatcttttg acctccccct tacagcaaca caaatgtaac tcctaaaaaa
     4141 cgattcacta ccagccttta gcctgcgaac tattcgttct ctacacagca ggacacagtg
     4201 gacacatttt tatacttgca tttctaatct ttggatgtat ttttacaaat gaaagactta
     4261 ggaagatttt tatctgctta tcacctggaa attttagtgt gcaatctaaa gaaaaagata
     4321 aagacatcac attattagca tcagtccacc tcccaaatat aggatgtttt attgccaatt
     4381 atttttgtat tctggctgag ctttattttg caccagggca ggcctaactt gccgctggtt
     4441 gtatgtagtt tgtgaataga agcccataag tgttaataga ccttgtaaca ttcgctgtaa
     4501 gatgaattat acaggatgtg gggaatctca gtaagtctta aagttaattt aaagtaattt
     4561 atctgttttc tctaagaaat gtttatcata aaatatatat gtaacttccc attttggtat
     4621 aaaatctagg gaagtgtgtg caagtggagt tgtgctgact ttgaatttct agatgtctta
     4681 atgagattta tttgttttag aaaaagaaca acttgttgaa agcacccagt tctgtcttac
     4741 atactgtcaa cagcctcttc aagttgtgcc tgtgtgatct gtgacctcct gttcctttaa
     4801 agtgagacag tgacctatga ctcattgttg accttatact tggaacagaa ctacggcatt
     4861 tacggtggag tcctgtacga cgagaaagtg tcaggatatg caacgcacct gtggcttacc
     4921 ccttgacggc ccagcttgga aatgatggca ccgactacct cttcaatcac ttgtggctat
     4981 caaccacagg cacttagcac caggctggct ttaattagtg tgtgttgttt ttgtggtggt
     5041 aacaactcta tccatatgaa gaccaaagtg aaccctggtt tctatatgtc tttaatgcag
     5101 tgttgtatct agtatttgga aattatctca ttcagtgttt agattacctc actccatttt
     5161 gattcatgtt gtttacaagt gaacattttt ttaaagatac acttgaaatt gcgttagaaa
     5221 gaacaaagga ggagttgcta ttagactggc acagtgcatt ccacagactt ggtggactgc
     5281 tctctgcaga catgggccta ggactgtctt tgtaccgaat gtcttactct gttggctatt
     5341 gatgtttaaa atttcatgat agaaaataaa agacacaatg ttggtgttta agatgggttt
     5401 ggaaaaaaaa aaaaaaaaaa
//
