LOCUS       NP_001026942             271 aa            linear   ROD 30-APR-2024
DEFINITION  protein lin-28 homolog B [Mus musculus].
ACCESSION   NP_001026942 XP_354572 XP_905201
VERSION     NP_001026942.1
DBSOURCE    REFSEQ: accession NM_001031772.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 271)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 271)
  AUTHORS   Li,Y., Mendoza-Castrejon,J., Patel,R.M., Casey,E.B., Denby,E.,
            Bryder,D. and Magee,J.A.
  TITLE     LIN28B promotes differentiation of fully transformed AML cells but
            is dispensable for fetal leukemia suppression
  JOURNAL   Leukemia 38 (3), 648-651 (2024)
   PUBMED   38321106
REFERENCE   3  (residues 1 to 271)
  AUTHORS   Subramanian,M., Mills,W.T. 4th, Paranjpe,M.D., Onuchukwu,U.S.,
            Inamdar,M., Maytin,A.R., Li,X., Pomerantz,J.L. and Meffert,M.K.
  TITLE     Growth-suppressor microRNAs mediate synaptic overgrowth and
            behavioral deficits in Fragile X mental retardation protein
            deficiency
  JOURNAL   iScience 27 (1), 108676 (2023)
   PUBMED   38235335
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 271)
  AUTHORS   Shu,Z., Fan,M., Tu,B., Tang,Z., Wang,H., Li,H., Li,H., Yuan,M.,
            Bai,J., Huo,S., Wang,L., Zhu,W.G., Wang,W., Liu,X., Shu,S. and
            Zhao,Y.
  TITLE     The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk
            between cancer associated fibroblasts and tumor epithelium
  JOURNAL   Nat Commun 14 (1), 6885 (2023)
   PUBMED   37898598
  REMARK    GeneRIF: The Lin28b/Wnt5a axis drives pancreas cancer through
            crosstalk between cancer associated fibroblasts and tumor
            epithelium.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 271)
  AUTHORS   Xiao,S., Zhang,W., Li,J. and Manley,N.R.
  TITLE     Lin28 regulates thymic growth and involution and correlates with
            MHCII expression in thymic epithelial cells
  JOURNAL   Front Immunol 14, 1261081 (2023)
   PUBMED   37868985
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 271)
  AUTHORS   Rao,S., Lee,S.Y., Gutierrez,A., Perrigoue,J., Thapa,R.J., Tu,Z.,
            Jeffers,J.R., Rhodes,M., Anderson,S., Oravecz,T., Hunger,S.P.,
            Timakhov,R.A., Zhang,R., Balachandran,S., Zambetti,G.P.,
            Testa,J.R., Look,A.T. and Wiest,D.L.
  TITLE     Inactivation of ribosomal protein L22 promotes transformation by
            induction of the stemness factor, Lin28B
  JOURNAL   Blood 120 (18), 3764-3773 (2012)
   PUBMED   22976955
  REMARK    GeneRIF: Rpl22 inactivation promotes neoplastic transformation by
            inducing expression of Lin28B
REFERENCE   7  (residues 1 to 271)
  AUTHORS   Beachy,S.H., Onozawa,M., Chung,Y.J., Slape,C., Bilke,S.,
            Francis,P., Pineda,M., Walker,R.L., Meltzer,P. and Aplan,P.D.
  TITLE     Enforced expression of Lin28b leads to impaired T-cell development,
            release of inflammatory cytokines, and peripheral T-cell lymphoma
  JOURNAL   Blood 120 (5), 1048-1059 (2012)
   PUBMED   22723554
  REMARK    GeneRIF: Enforced expression of Lin28b leads to impaired T-cell
            development, release of inflammatory cytokines, and peripheral
            T-cell lymphoma.
REFERENCE   8  (residues 1 to 271)
  AUTHORS   Yuan,J., Nguyen,C.K., Liu,X., Kanellopoulou,C. and Muljo,S.A.
  TITLE     Lin28b reprograms adult bone marrow hematopoietic progenitors to
            mediate fetal-like lymphopoiesis
  JOURNAL   Science 335 (6073), 1195-1200 (2012)
   PUBMED   22345399
  REMARK    GeneRIF: study reports Lin28b is expressed in fetal liver and
            thymus, but not adult bone marrow or thymus; ectopic expression of
            Lin28 reprograms hematopoietic progenitor cells from adult bone
            marrow, endowing them with ability to mediate fetal-like
            lymphopoiesis
REFERENCE   9  (residues 1 to 271)
  AUTHORS   Zhu,H., Shyh-Chang,N., Segre,A.V., Shinoda,G., Shah,S.P.,
            Einhorn,W.S., Takeuchi,A., Engreitz,J.M., Hagan,J.P., Kharas,M.G.,
            Urbach,A., Thornton,J.E., Triboulet,R., Gregory,R.I., Altshuler,D.
            and Daley,G.Q.
  CONSRTM   DIAGRAM Consortium; MAGIC Investigators
  TITLE     The Lin28/let-7 axis regulates glucose metabolism
  JOURNAL   Cell 147 (1), 81-94 (2011)
   PUBMED   21962509
  REMARK    GeneRIF: When overexpressed in mice, both Lin28a and LIN28B
            promotes resistance to high-fat-diet induced diabetes; conversely,
            muscle-specific loss of Lin28a or overexpression of let-7 results
            in insulin resistance and impaired glucose tolerance.
REFERENCE   10 (residues 1 to 271)
  AUTHORS   Matsubara,S., Takahashi,T. and Kimura,A.P.
  TITLE     Epigenetic patterns at the mouse prolyl oligopeptidase gene locus
            suggest the CpG island in the gene body to be a novel regulator for
            gene expression
  JOURNAL   Gene 465 (1-2), 17-29 (2010)
   PUBMED   20600704
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ127225.1 and BC089037.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XP_354572.2, XP_905201.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089037.1, CV884017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..271
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 23.5 cM"
     Protein         1..271
                     /product="protein lin-28 homolog B"
                     /note="lin-28B"
                     /calculated_mol_wt=29916
     Region          29..99
                     /region_name="CSP_CDS"
                     /note="Cold-Shock Protein (CSP) contains an S1-like
                     cold-shock domain (CSD) that is found in eukaryotes,
                     prokaryotes, and archaea. CSP's include the major
                     cold-shock proteins CspA and CspB in bacteria and the
                     eukaryotic gene regulatory factor Y-box protein; cd04458"
                     /db_xref="CDD:239905"
     Site            order(34,43,61,90)
                     /site_type="DNA binding"
                     /note="DNA-binding site [nucleotide binding]"
                     /db_xref="CDD:239905"
     Site            order(40..44,52..53,60..63)
                     /site_type="active"
                     /note="RNA-binding motif [active]"
                     /db_xref="CDD:239905"
     Region          <151..187
                     /region_name="PTZ00368"
                     /note="universal minicircle sequence binding protein
                     (UMSBP); Provisional"
                     /db_xref="CDD:173561"
     CDS             1..271
                     /gene="Lin28b"
                     /gene_synonym="2810403D23Rik; D030047M17Rik; Lin-28.2"
                     /coded_by="NM_001031772.2:142..957"
                     /db_xref="CCDS:CCDS35895.1"
                     /db_xref="GeneID:380669"
                     /db_xref="MGI:MGI:3584032"
ORIGIN      
        1 maeggaskge epeklpglae depqvlhgtg hckwfnvrmg fgfismisre gnpldipvdv
       61 fvhqsklfme gfrslkegep veftfkkspk glesirvtgp ggspclgser rpkgktlqkr
      121 kpkgdrwrrq dllmdqmwtv reeesrmipr cyncggldhh akecslppqp kkchycqsim
      181 hmvancphkl aaqlpassqg rqeaesqpcs saaprevggg hgctvlfpqe vksemaehsd
      241 rspqevsstk afaaigeqnk kgpliqkrkk t
//
