LOCUS       NM_145833               3480 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus lin-28 homolog A (Lin28a), mRNA.
ACCESSION   NM_145833 NM_031383
VERSION     NM_145833.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3480)
  AUTHORS   Zhou,S., Guo,L., Cui,X., Zhang,X., Yang,Y., Zhang,M. and Zhang,P.
  TITLE     Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin
            damage repair after burn injury
  JOURNAL   Cell Signal 120, 111217 (2024)
   PUBMED   38729326
  REMARK    GeneRIF: Inhibition of Let-7b-5p maturation by LIN28A promotes
            thermal skin damage repair after burn injury.
REFERENCE   2  (bases 1 to 3480)
  AUTHORS   Xu,M., Pang,M., Wang,C., An,N., Chen,R., Bai,Y., He,J., Wang,C. and
            Qi,Y.
  TITLE     MiR-92a-3p Knockdown Attenuates Transforming Growth
            Factor-beta1-induced Tubulointerstitial Fibrosis by Targeting
            LIN28A-mediated EMT Pathway
  JOURNAL   J Physiol Investig 67 (4), 198-206 (2024)
   PUBMED   39148295
  REMARK    GeneRIF: MiR-92a-3p Knockdown Attenuates Transforming Growth
            Factor-beta1-induced Tubulointerstitial Fibrosis by Targeting
            LIN28A-mediated EMT Pathway.
REFERENCE   3  (bases 1 to 3480)
  AUTHORS   Tan,T., Gao,B., Yu,H., Pan,H., Sun,Z., Lei,A., Zhang,L., Lu,H.,
            Wu,H., Daley,G.Q., Feng,Y. and Zhang,J.
  TITLE     Dynamic nucleolar phase separation influenced by non-canonical
            function of LIN28A instructs pluripotent stem cell fate decisions
  JOURNAL   Nat Commun 15 (1), 1256 (2024)
   PUBMED   38341436
  REMARK    GeneRIF: Dynamic nucleolar phase separation influenced by
            non-canonical function of LIN28A instructs pluripotent stem cell
            fate decisions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3480)
  AUTHORS   Chen,L.L., Li,Y.Q., Kang,Z.H., Zhang,X., Gu,S.Y., Wang,N. and
            Shen,X.Y.
  TITLE     Blocking the interaction between circTNRC18 and LIN28A promotes
            trophoblast epithelial-mesenchymal transformation and alleviates
            preeclampsia
  JOURNAL   Mol Cell Endocrinol 579, 112073 (2024)
   PUBMED   37774938
  REMARK    GeneRIF: Blocking the interaction between circTNRC18 and LIN28A
            promotes trophoblast epithelial-mesenchymal transformation and
            alleviates preeclampsia.
REFERENCE   5  (bases 1 to 3480)
  AUTHORS   Wang,P., Liu,X., Yao,Z., Chen,Y., Luo,L., Liang,K., Tan,J.E.,
            Chua,M.J., Chua,Y.B., Ma,S., Zhang,L., Ma,W., Liu,S., Cao,W.,
            Guo,L., Guang,L., Wang,Y., Zhao,H., Ai,N., Li,Y., Li,C., Wang,R.R.,
            Teh,B.T., Jiang,L., Yu,K. and Shyh-Chang,N.
  TITLE     Lin28a maintains a subset of adult muscle stem cells in an
            embryonic-like state
  JOURNAL   Cell Res 33 (9), 712-726 (2023)
   PUBMED   37188880
  REMARK    GeneRIF: Lin28a maintains a subset of adult muscle stem cells in an
            embryonic-like state.
REFERENCE   6  (bases 1 to 3480)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   7  (bases 1 to 3480)
  AUTHORS   Sempere,L.F., Freemantle,S., Pitha-Rowe,I., Moss,E., Dmitrovsky,E.
            and Ambros,V.
  TITLE     Expression profiling of mammalian microRNAs uncovers a subset of
            brain-expressed microRNAs with possible roles in murine and human
            neuronal differentiation
  JOURNAL   Genome Biol 5 (3), R13 (2004)
   PUBMED   15003116
REFERENCE   8  (bases 1 to 3480)
  AUTHORS   Yang,D.H. and Moss,E.G.
  TITLE     Temporally regulated expression of Lin-28 in diverse tissues of the
            developing mouse
  JOURNAL   Gene Expr Patterns 3 (6), 719-726 (2003)
   PUBMED   14643679
  REMARK    GeneRIF: Temporally regulated expression of Lin-28 in the mouse
            embryo.
REFERENCE   9  (bases 1 to 3480)
  AUTHORS   Moss,E.G. and Tang,L.
  TITLE     Conservation of the heterochronic regulator Lin-28, its
            developmental expression and microRNA complementary sites
  JOURNAL   Dev Biol 258 (2), 432-442 (2003)
   PUBMED   12798299
  REMARK    GeneRIF: microRNA regulation is a conserved feature of the Lin-28
            gene in diverse animals.
            Erratum:[Dev Biol. 2003 Oct 15;262(2):361]
REFERENCE   10 (bases 1 to 3480)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF521097.1.
            
            On Aug 16, 2003 this sequence version replaced NM_031383.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF521097.1, BC068304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..3480
                     /gene="Lin28a"
                     /gene_synonym="Gm10299; Lin-28; lin-28A; Lin28; Tex17"
                     /note="lin-28 homolog A"
                     /db_xref="GeneID:83557"
                     /db_xref="MGI:MGI:1890546"
     exon            1..106
                     /gene="Lin28a"
                     /gene_synonym="Gm10299; Lin-28; lin-28A; Lin28; Tex17"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..705
                     /gene="Lin28a"
                     /gene_synonym="Gm10299; Lin-28; lin-28A; Lin28; Tex17"
                     /note="RNA-binding protein LIN-28; testis-expressed
                     protein 17; testis expressed gene 17"
                     /codon_start=1
                     /product="protein lin-28 homolog A"
                     /protein_id="NP_665832.1"
                     /db_xref="CCDS:CCDS18761.1"
                     /db_xref="GeneID:83557"
                     /db_xref="MGI:MGI:1890546"
                     /translation="MGSVSNQQFAGGCAKAAEKAPEEAPPDAARAADEPQLLHGAGIC
                     KWFNVRMGFGFLSMTARAGVALDPPVDVFVHQSKLHMEGFRSLKEGEAVEFTFKKSAK
                     GLESIRVTGPGGVFCIGSERRPKGKNMQKRRSKGDRCYNCGGLDHHAKECKLPPQPKK
                     CHFCQSINHMVASCPLKAQQGPSSQGKPAYFREEEEEIHSPALLPEAQN"
     exon            107..303
                     /gene="Lin28a"
                     /gene_synonym="Gm10299; Lin-28; lin-28A; Lin28; Tex17"
                     /inference="alignment:Splign:2.1.0"
     exon            304..488
                     /gene="Lin28a"
                     /gene_synonym="Gm10299; Lin-28; lin-28A; Lin28; Tex17"
                     /inference="alignment:Splign:2.1.0"
     exon            489..3480
                     /gene="Lin28a"
                     /gene_synonym="Gm10299; Lin-28; lin-28A; Lin28; Tex17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3446..3451
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lin28a"
                     /gene_synonym="Gm10299; Lin-28; lin-28A; Lin28; Tex17"
                     /note="hexamer: AATAAA"
     polyA_site      3468
                     /gene="Lin28a"
                     /gene_synonym="Gm10299; Lin-28; lin-28A; Lin28; Tex17"
                     /note="major polyA site"
ORIGIN      
        1 cctttgcctc cggacttctc tggggccagc agccgcccga cctggggccc ggggccacgg
       61 gctcagcaga cgaccatggg ctcggtgtcc aaccagcagt ttgcaggtgg ctgcgccaag
      121 gcagcggaga aggcgccaga ggaggcgccg cctgacgcgg cccgagcggc agacgagccg
      181 cagctgctgc acggggccgg catctgtaag tggttcaacg tgcgcatggg gttcggcttc
      241 ctgtctatga ccgcccgcgc tggggtcgcg ctcgaccccc cggtggacgt ctttgtgcac
      301 cagagcaagc tgcacatgga agggttccga agcctcaagg agggtgaggc ggtggagttc
      361 acctttaaga agtctgccaa gggtctggaa tccatccgtg tcactggccc tggtggtgtg
      421 ttctgtattg ggagtgagcg gcggccaaaa gggaagaaca tgcagaagcg aagatccaaa
      481 ggagacaggt gctacaactg cggtgggcta gaccatcatg ccaaggaatg caagctgcca
      541 ccccagccca agaagtgcca cttttgccaa agcatcaacc atatggtggc ctcgtgtcca
      601 ctgaaggccc agcagggccc cagttctcag ggaaagcctg cctacttccg ggaggaagag
      661 gaagagatcc acagccctgc cctgctccca gaagcccaga attgaggccc aggagtcagg
      721 gttattcttt ggctaatggg gagtttaagg aaagaggcat caatctgcag agtggagaaa
      781 gtgggggtaa gggtgggttg cgtgggtagc ttgcactgcc gtgtctcagg ccggggttcc
      841 cagtgtcacc ctgtctttcc ttggagggaa ggaaaggatg agacaaagga actcctacca
      901 cactctatct gaaagcaagt gaaggctttt gtggggagga accaccctag aacccgaggc
      961 tttgccaagt ggctgggcta gggaagttct tttgtagaag gctgtgtgat atttcccttg
     1021 ccagacggga agcgaaacaa gtgtcaaacc aagattactg aacctacccc tccagctact
     1081 atgttctggg gaagggactc ccaggagcag ggcgaggtta ttttcacacc gtgcttattc
     1141 ataaccctgt cctttggtgc tgtgctggga atggtctcta gcaacgggtt gtgatgacag
     1201 gcaaagaggg tggttgggga gacaactgct gacctgctgc ccacacctca ctcccagccc
     1261 tttctgggcc aatgggattt taatttattt gctcccttag gtaactgcac cttgggtccc
     1321 actttctcca ggatgccaac tgcactatct acgtgcgaat gacgtatctt gtgcgttttt
     1381 ttttttttta atttttaaaa ttttttttca tcttcttaat ataaataatg ggtttgtatt
     1441 tttgtatatt ttaatcttaa ggccctcatt cctgcactgt gttctcaggt acatgagcaa
     1501 tctcagggat aataagtccg tagcagctcc aggtctgctc agcaggaata ctttgttttg
     1561 ttttgttttg atcaccatgg agaccaacca tttggagtgc acagcctgtt gaactacctc
     1621 atttttgccg attacagctg gcttttctgc catagcgtcc ttgaaaaatg tgtctcacgg
     1681 gtttcgattg agctgcccca agacttgatc tggatttggc aaaacatagg acatcactct
     1741 aaacaggaaa gggtggtaca gagacattaa aaggctgggc caggtgaaag gcacaagagg
     1801 aactttccat accagatcca tccttttgcc agattagtgg aagcctgcca tgcacagcag
     1861 ggtgtgagag agagagtgtg tatgtatgtg tgtgtggatt ttttttaatg caaatttatg
     1921 aagacgaggt gggttttgtt tatttgattg ctttttgtgc tggggatgga atcttgggct
     1981 tcatttgtgc taggaagtac actgccactg agttatccca gtaagaatgc aacttaagac
     2041 cagtaccctt attcccacac tgtgctgtcc aggcatggga acatgaggca gggactcaac
     2101 tccttagcct ttcacaatct tggctttctg agagactcat gagtatgggc ctcagtggca
     2161 agtgtcctgc cctgctgtag cgtgatggtt gatagctaaa ggaaagaggg ggtggggagt
     2221 ttcgtttaca tgctttgaga tcgccacaaa cctacctcac tgtgttgaaa cgggacaaat
     2281 gcaatagaac acattgggtg gtgtgtgtgt gtgtctgatc ttggtttctt gtctccctct
     2341 ccccccaaat gctgccctca cccctagtta attgtattcg tctggccttt gtaggacttt
     2401 tactgtctct gagttggtga ttgctaggtg gcctagttgt gtaaatataa atgtgttggt
     2461 cttcatgttc ttttggggtt ttattgttta caaaactttt gttgtattga gagaaaaata
     2521 gccaaagcat ctttgacaga aagctctgca ccagacaaca ccatctgaaa cttaaatgtg
     2581 cggtcctctt ctcaaagtga acctctggga ccatggctta tccttacctg ttcctcctgt
     2641 gtctcccatt ctggaccaca gtgaccttca gacagcccct cttctccctc gtaagaaaac
     2701 ttaggctcat ttacttcttt gagcatctct gtaactcttg aaggacccat gtgaaaattc
     2761 tgaagaagcc aggaacctca ttctttcctt gtccctaact cagtgaagag ttttggttgg
     2821 tggttttgag acagggcctc actctgtagc tggagataga gagcctcggg ttcctggctc
     2881 tcctcctgcc ttctgcacag agtcccctgt gcagggattg caggtgccgc ttctccctgg
     2941 caagaccatt tatttcatgg tgtgattcgc ctttggatgg atcaaaccaa tgtaatctgt
     3001 cacccttagg tcgagagaag caattgtggg gccttccatg tagaaagttg gaatctggac
     3061 accagaaaag ggactatgaa tgtacagtga gtcactcagg aacttaatgc cggtgcaaga
     3121 aacttatgtc aaagaggcca caagattgtt actaggagac ggacgaatgt atctccatgt
     3181 ttactgctag aaaccaaagc tttgtgagaa atcttgaatt tatggggagg gtgggaaagg
     3241 gtgtacttgt ctgtcctttc cccatctctt tcctgaactg caggagacta aggcccccca
     3301 ccccccgggg cttggatgac ccccacccct gcctggggtg ttttatttcc tagttgattt
     3361 ttactgtacc cgggcccttg tattcctatc gtataatcat cctgtgacac atgctgactt
     3421 ttccttccct tctcttccct gggaaaataa agacttattg gtactccaga gttggtactg
//
