LOCUS       NP_665832                209 aa            linear   ROD 15-OCT-2024
DEFINITION  protein lin-28 homolog A [Mus musculus].
ACCESSION   NP_665832 NP_113560
VERSION     NP_665832.1
DBSOURCE    REFSEQ: accession NM_145833.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 209)
  AUTHORS   Zhou,S., Guo,L., Cui,X., Zhang,X., Yang,Y., Zhang,M. and Zhang,P.
  TITLE     Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin
            damage repair after burn injury
  JOURNAL   Cell Signal 120, 111217 (2024)
   PUBMED   38729326
  REMARK    GeneRIF: Inhibition of Let-7b-5p maturation by LIN28A promotes
            thermal skin damage repair after burn injury.
REFERENCE   2  (residues 1 to 209)
  AUTHORS   Xu,M., Pang,M., Wang,C., An,N., Chen,R., Bai,Y., He,J., Wang,C. and
            Qi,Y.
  TITLE     MiR-92a-3p Knockdown Attenuates Transforming Growth
            Factor-beta1-induced Tubulointerstitial Fibrosis by Targeting
            LIN28A-mediated EMT Pathway
  JOURNAL   J Physiol Investig 67 (4), 198-206 (2024)
   PUBMED   39148295
  REMARK    GeneRIF: MiR-92a-3p Knockdown Attenuates Transforming Growth
            Factor-beta1-induced Tubulointerstitial Fibrosis by Targeting
            LIN28A-mediated EMT Pathway.
REFERENCE   3  (residues 1 to 209)
  AUTHORS   Tan,T., Gao,B., Yu,H., Pan,H., Sun,Z., Lei,A., Zhang,L., Lu,H.,
            Wu,H., Daley,G.Q., Feng,Y. and Zhang,J.
  TITLE     Dynamic nucleolar phase separation influenced by non-canonical
            function of LIN28A instructs pluripotent stem cell fate decisions
  JOURNAL   Nat Commun 15 (1), 1256 (2024)
   PUBMED   38341436
  REMARK    GeneRIF: Dynamic nucleolar phase separation influenced by
            non-canonical function of LIN28A instructs pluripotent stem cell
            fate decisions.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 209)
  AUTHORS   Chen,L.L., Li,Y.Q., Kang,Z.H., Zhang,X., Gu,S.Y., Wang,N. and
            Shen,X.Y.
  TITLE     Blocking the interaction between circTNRC18 and LIN28A promotes
            trophoblast epithelial-mesenchymal transformation and alleviates
            preeclampsia
  JOURNAL   Mol Cell Endocrinol 579, 112073 (2024)
   PUBMED   37774938
  REMARK    GeneRIF: Blocking the interaction between circTNRC18 and LIN28A
            promotes trophoblast epithelial-mesenchymal transformation and
            alleviates preeclampsia.
REFERENCE   5  (residues 1 to 209)
  AUTHORS   Wang,P., Liu,X., Yao,Z., Chen,Y., Luo,L., Liang,K., Tan,J.E.,
            Chua,M.J., Chua,Y.B., Ma,S., Zhang,L., Ma,W., Liu,S., Cao,W.,
            Guo,L., Guang,L., Wang,Y., Zhao,H., Ai,N., Li,Y., Li,C., Wang,R.R.,
            Teh,B.T., Jiang,L., Yu,K. and Shyh-Chang,N.
  TITLE     Lin28a maintains a subset of adult muscle stem cells in an
            embryonic-like state
  JOURNAL   Cell Res 33 (9), 712-726 (2023)
   PUBMED   37188880
  REMARK    GeneRIF: Lin28a maintains a subset of adult muscle stem cells in an
            embryonic-like state.
REFERENCE   6  (residues 1 to 209)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   7  (residues 1 to 209)
  AUTHORS   Sempere,L.F., Freemantle,S., Pitha-Rowe,I., Moss,E., Dmitrovsky,E.
            and Ambros,V.
  TITLE     Expression profiling of mammalian microRNAs uncovers a subset of
            brain-expressed microRNAs with possible roles in murine and human
            neuronal differentiation
  JOURNAL   Genome Biol 5 (3), R13 (2004)
   PUBMED   15003116
REFERENCE   8  (residues 1 to 209)
  AUTHORS   Yang,D.H. and Moss,E.G.
  TITLE     Temporally regulated expression of Lin-28 in diverse tissues of the
            developing mouse
  JOURNAL   Gene Expr Patterns 3 (6), 719-726 (2003)
   PUBMED   14643679
  REMARK    GeneRIF: Temporally regulated expression of Lin-28 in the mouse
            embryo.
REFERENCE   9  (residues 1 to 209)
  AUTHORS   Moss,E.G. and Tang,L.
  TITLE     Conservation of the heterochronic regulator Lin-28, its
            developmental expression and microRNA complementary sites
  JOURNAL   Dev Biol 258 (2), 432-442 (2003)
   PUBMED   12798299
  REMARK    GeneRIF: microRNA regulation is a conserved feature of the Lin-28
            gene in diverse animals.
            Erratum:[Dev Biol. 2003 Oct 15;262(2):361]
REFERENCE   10 (residues 1 to 209)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF521097.1.
            
            On Aug 16, 2003 this sequence version replaced NP_113560.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF521097.1, BC068304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..209
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     Protein         1..209
                     /product="protein lin-28 homolog A"
                     /note="RNA-binding protein LIN-28; testis-expressed
                     protein 17; testis expressed gene 17"
                     /calculated_mol_wt=22589
     Region          1..31
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K3Y3.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylglycine.
                     /evidence=ECO:0000250|UniProtKB:Q9H9Z2; propagated from
                     UniProtKB/Swiss-Prot (Q8K3Y3.1)"
     Site            3
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H9Z2; propagated from
                     UniProtKB/Swiss-Prot (Q8K3Y3.1)"
     Region          42..111
                     /region_name="CSP_CDS"
                     /note="Cold-Shock Protein (CSP) contains an S1-like
                     cold-shock domain (CSD) that is found in eukaryotes,
                     prokaryotes, and archaea. CSP's include the major
                     cold-shock proteins CspA and CspB in bacteria and the
                     eukaryotic gene regulatory factor Y-box protein; cd04458"
                     /db_xref="CDD:239905"
     Site            order(46,55,73,102)
                     /site_type="DNA binding"
                     /note="DNA-binding site [nucleotide binding]"
                     /db_xref="CDD:239905"
     Site            order(52..58,72..75)
                     /site_type="active"
                     /note="RNA-binding motif [active]"
                     /db_xref="CDD:239905"
     Region          113..136
                     /region_name="Flexible linker"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K3Y3.1)"
     Region          <120..>183
                     /region_name="AIR1"
                     /note="Arginine methyltransferase-interacting protein,
                     contains RING Zn-finger [Posttranslational modification,
                     protein turnover, chaperones / Intracellular trafficking
                     and secretion]; COG5082"
                     /db_xref="CDD:227414"
     Site            120
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H9Z2; propagated from
                     UniProtKB/Swiss-Prot (Q8K3Y3.1)"
     Region          177..209
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K3Y3.1)"
     Site            200
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H9Z2; propagated from
                     UniProtKB/Swiss-Prot (Q8K3Y3.1)"
     CDS             1..209
                     /gene="Lin28a"
                     /gene_synonym="Gm10299; Lin-28; lin-28A; Lin28; Tex17"
                     /coded_by="NM_145833.1:76..705"
                     /db_xref="CCDS:CCDS18761.1"
                     /db_xref="GeneID:83557"
                     /db_xref="MGI:MGI:1890546"
ORIGIN      
        1 mgsvsnqqfa ggcakaaeka peeappdaar aadepqllhg agickwfnvr mgfgflsmta
       61 ragvaldppv dvfvhqsklh megfrslkeg eaveftfkks akglesirvt gpggvfcigs
      121 errpkgknmq krrskgdrcy ncggldhhak ecklppqpkk chfcqsinhm vascplkaqq
      181 gpssqgkpay freeeeeihs pallpeaqn
//
