LOCUS       NM_144862               1716 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus LIM and senescent cell antigen like domains 2 (Lims2),
            transcript variant 1, mRNA.
ACCESSION   NM_144862
VERSION     NM_144862.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1716)
  AUTHORS   He,T., Zhou,B., Sun,G., Yan,Q., Lin,S., Ma,G., Yao,Q., Wu,X.,
            Zhong,Y., Gan,D., Huo,S., Jin,W., Chen,D., Bai,X., Cheng,T., Cao,H.
            and Xiao,G.
  TITLE     The bone-liver interaction modulates immune and hematopoietic
            function through Pinch-Cxcl12-Mbl2 pathway
  JOURNAL   Cell Death Differ 31 (1), 90-105 (2024)
   PUBMED   38062244
REFERENCE   2  (bases 1 to 1716)
  AUTHORS   Capriati,M., Hao,C., D'Cruz,S.C., Monfort,C., Chevrier,C.,
            Warembourg,C. and Smagulova,F.
  TITLE     Genome-wide analysis of sex-specific differences in the
            mother-child PELAGIE cohort exposed to organophosphate metabolites
  JOURNAL   Sci Rep 13 (1), 8003 (2023)
   PUBMED   37198424
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1716)
  AUTHORS   Wu,X., Lin,S., Liao,R., Yao,Q., Lin,L., Zou,X. and Xiao,G.
  TITLE     Brief research report: Effects of Pinch deficiency on cartilage
            homeostasis in adult mice
  JOURNAL   Front Cell Dev Biol 11, 1116128 (2023)
   PUBMED   36743414
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1716)
  AUTHORS   Liao,H., Wang,F., Lu,K., Ma,X., Yan,J., Luo,L., Sun,Y. and Liang,X.
  TITLE     Requirement for PINCH in skeletal myoblast differentiation
  JOURNAL   Cell Tissue Res 391 (1), 205-215 (2023)
   PUBMED   36385586
  REMARK    GeneRIF: Requirement for PINCH in skeletal myoblast
            differentiation.
REFERENCE   5  (bases 1 to 1716)
  AUTHORS   Lei,Y., Fu,X., Li,P., Lin,S., Yan,Q., Lai,Y., Liu,X., Wang,Y.,
            Bai,X., Liu,C., Chen,D., Zou,X., Cao,X., Cao,H. and Xiao,G.
  TITLE     LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass
            in mice
  JOURNAL   Bone Res 8, 37 (2020)
   PUBMED   33083097
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1716)
  AUTHORS   Liang,X., Sun,Y., Ye,M., Scimia,M.C., Cheng,H., Martin,J., Wang,G.,
            Rearden,A., Wu,C., Peterson,K.L., Powell,H.C., Evans,S.M. and
            Chen,J.
  TITLE     Targeted ablation of PINCH1 and PINCH2 from murine myocardium
            results in dilated cardiomyopathy and early postnatal lethality
  JOURNAL   Circulation 120 (7), 568-576 (2009)
   PUBMED   19652092
  REMARK    GeneRIF: Absence of either PINCH1 or PINCH2 in myocardium leads to
            exacerbated cardiac injury and deterioration in cardiac function
            after myocardial infarction.
REFERENCE   7  (bases 1 to 1716)
  AUTHORS   Pereira,J.A., Benninger,Y., Baumann,R., Goncalves,A.F., Ozcelik,M.,
            Thurnherr,T., Tricaud,N., Meijer,D., Fassler,R., Suter,U. and
            Relvas,J.B.
  TITLE     Integrin-linked kinase is required for radial sorting of axons and
            Schwann cell remyelination in the peripheral nervous system
  JOURNAL   J Cell Biol 185 (1), 147-161 (2009)
   PUBMED   19349584
REFERENCE   8  (bases 1 to 1716)
  AUTHORS   Aguado,T., Palazuelos,J., Monory,K., Stella,N., Cravatt,B.,
            Lutz,B., Marsicano,G., Kokaia,Z., Guzman,M. and Galve-Roperh,I.
  TITLE     The endocannabinoid system promotes astroglial differentiation by
            acting on neural progenitor cells
  JOURNAL   J Neurosci 26 (5), 1551-1561 (2006)
   PUBMED   16452678
REFERENCE   9  (bases 1 to 1716)
  AUTHORS   Stanchi,F., Bordoy,R., Kudlacek,O., Braun,A., Pfeifer,A., Moser,M.
            and Fassler,R.
  TITLE     Consequences of loss of PINCH2 expression in mice
  JOURNAL   J Cell Sci 118 (Pt 24), 5899-5910 (2005)
   PUBMED   16317048
  REMARK    GeneRIF: LIM1 domain only of either PINCH1 or PINCH2 can prevent
            ILK degradation despite their failure to localize to focal
            adhesions.
            Erratum:[J Cell Sci. 2006 Jan 1;119(Pt 1):196]
REFERENCE   10 (bases 1 to 1716)
  AUTHORS   Braun,A., Bordoy,R., Stanchi,F., Moser,M., Kostka,G. G, Ehler,E.,
            Brandau,O. and Fassler,R.
  TITLE     PINCH2 is a new five LIM domain protein, homologous to PINCHand
            localized to focal adhesions
  JOURNAL   Exp Cell Res 284 (2), 239-250 (2003)
   PUBMED   12651156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131761.4.
            
            On Jul 20, 2018 this sequence version replaced NM_144862.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010816.1, SRR7974084.13287.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC131761.4         36284-36354         c
            72-231              AC131761.4         25935-26094         c
            232-298             AC131761.4         23629-23695         c
            299-419             AC131761.4         23278-23398         c
            420-569             AC131761.4         13249-13398         c
            570-720             AC131761.4         12426-12576         c
            721-813             AC131761.4         11484-11576         c
            814-862             AC131761.4         10833-10881         c
            863-938             AC131761.4         10521-10596         c
            939-1716            AC131761.4         9214-9991           c
FEATURES             Location/Qualifiers
     source          1..1716
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 17.89 cM"
     gene            1..1716
                     /gene="Lims2"
                     /gene_synonym="PINCH2"
                     /note="LIM and senescent cell antigen like domains 2"
                     /db_xref="GeneID:225341"
                     /db_xref="MGI:MGI:2385067"
     exon            1..71
                     /gene="Lims2"
                     /gene_synonym="PINCH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1086
                     /gene="Lims2"
                     /gene_synonym="PINCH2"
                     /note="isoform 1 is encoded by transcript variant 1; LIM
                     and senescent cell antigen-like-containing domain protein
                     2; particularly interesting new Cys-His protein 2"
                     /codon_start=1
                     /product="LIM and senescent cell antigen-like-containing
                     domain protein 2 isoform 1"
                     /protein_id="NP_659111.1"
                     /db_xref="CCDS:CCDS29113.1"
                     /db_xref="GeneID:225341"
                     /db_xref="MGI:MGI:2385067"
                     /translation="MTGSNMSECLADAMCQRCQARFAPTERIVNSNGELYHEHCFVCA
                     QCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGFCGEFVIGRVIKAMNANWHPGCFRC
                     ELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKFICQRCHLAIDEQPLMFKNDPYH
                     PDHFSCSNCGKELTSDARELKGELYCLPCHDKMGIPICGACRRPIEGRVVNALGKQWH
                     VEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDVVSALSKAW
                     CVNCFSCSTCNMKLTLKNKFVEFDMKPVCKRCYERFPLELKKRLKKLSDLSSRKAQPK
                     SVDVNSL"
     exon            72..231
                     /gene="Lims2"
                     /gene_synonym="PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            232..298
                     /gene="Lims2"
                     /gene_synonym="PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            299..419
                     /gene="Lims2"
                     /gene_synonym="PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            420..569
                     /gene="Lims2"
                     /gene_synonym="PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            570..720
                     /gene="Lims2"
                     /gene_synonym="PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..813
                     /gene="Lims2"
                     /gene_synonym="PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            814..862
                     /gene="Lims2"
                     /gene_synonym="PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            863..938
                     /gene="Lims2"
                     /gene_synonym="PINCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1716
                     /gene="Lims2"
                     /gene_synonym="PINCH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1696..1701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lims2"
                     /gene_synonym="PINCH2"
                     /note="hexamer: AATGAA"
     polyA_site      1715
                     /gene="Lims2"
                     /gene_synonym="PINCH2"
                     /note="major polyA site"
ORIGIN      
        1 gagtcctctg tcaggaacac agcgagtgga ctgctgaccg gtgctaggcg cgcggccacc
       61 atgacgggaa gcaacatgtc tgagtgtttg gccgatgcca tgtgccagcg ctgccaggcc
      121 cggtttgccc ccacagagcg catcgtcaac agcaatgggg aactctacca tgagcactgc
      181 tttgtgtgtg cacagtgctt ccggccattt cccgagggac tcttctacga gtttgagggc
      241 cggaagtact gtgaacatga cttccaaatg ctatttgctc catgctgcgg attctgtggt
      301 gaatttgtca ttggccgcgt gatcaaggcc atgaacgcca actggcatcc tggctgcttc
      361 cgctgtgaat tgtgtgatgt ggagctggct gacctgggct ttgtgaagaa cgcaggcagg
      421 cacctctgcc ggccttgcca caaccgtgag aaggccaagg gcttgggcaa attcatctgc
      481 cagcggtgcc acctcgccat cgacgaacag cccctcatgt tcaagaatga tccctaccac
      541 ccggaccact tcagctgctc caactgtggg aaggagctga cctccgatgc ccgagagctg
      601 aagggtgagc tctactgcct gccttgtcac gacaagatgg gcatccccat ctgtggggct
      661 tgccgccggc ccattgaggg ccgcgtggtc aatgcgctgg gcaaacagtg gcatgtggag
      721 cactttgtct gcgccaagtg tgagaagcca ttcctggggc accggcacta tgagaagaag
      781 ggcctagcat actgtgagac ccactacaac cagctctttg gggatgtctg ctacaactgc
      841 agtcatgtga tcgagggtga cgtggtgtca gccctcagca aagcctggtg tgtgaactgc
      901 ttttcctgtt ccacctgcaa catgaagctc actctaaaga acaagtttgt ggagttcgat
      961 atgaagcccg tgtgtaagag gtgctatgaa aggttccccc tggagctgaa gaagaggttg
     1021 aagaagctgt ccgacctgag ctcccgcaag gcccagccca agtctgtgga cgtcaactca
     1081 ctctaaaggt cctcggccgc ctggcctgcc tgcagtacct tagcactcat ccccctgccc
     1141 caggtcctgc tagccacctc ccacttctgc tccagcccag cccgttcctc cggtatgcca
     1201 tcctttctgc ttccagtcca cctcgggcta tgtagccctt tcctctgtgc tgaggcctga
     1261 cccacctcac aggcatttcc tcccgggccc acaacctcca gggacaggaa caaactggag
     1321 caggattatt tgtcacttgc ttgacccgca gatcccaacc cgatgcctct cctctccact
     1381 ctcccaggag agtttcagcc ctcgtgtgac ccttgggctt ggctgagaag ctgtcccaac
     1441 cccagggcca gcaccacgca gatagaggct tcatggaagc acccttctca gttattcgag
     1501 cacagtaggt ccttgtgctt acactgtgtc agcaaaccca cctctggggt gaagcagccc
     1561 gagagcccta ctgccttcac tactcaggag acctcataga aagtgtctca gctgcccacc
     1621 aagtgtgggg gtcccacttc ccaggggcac attgccctgg ccatcgaaga cccacaagtg
     1681 gtcacatact tacacaatga aggctcattc acatac
//
