LOCUS       NM_026148               4246 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus LIM and senescent cell antigen-like domains 1 (Lims1),
            transcript variant 1, mRNA.
ACCESSION   NM_026148
VERSION     NM_026148.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4246)
  AUTHORS   He,T., Zhou,B., Sun,G., Yan,Q., Lin,S., Ma,G., Yao,Q., Wu,X.,
            Zhong,Y., Gan,D., Huo,S., Jin,W., Chen,D., Bai,X., Cheng,T., Cao,H.
            and Xiao,G.
  TITLE     The bone-liver interaction modulates immune and hematopoietic
            function through Pinch-Cxcl12-Mbl2 pathway
  JOURNAL   Cell Death Differ 31 (1), 90-105 (2024)
   PUBMED   38062244
  REMARK    GeneRIF: The bone-liver interaction modulates immune and
            hematopoietic function through Pinch-Cxcl12-Mbl2 pathway.
REFERENCE   2  (bases 1 to 4246)
  AUTHORS   Wu,X., Lin,S., Liao,R., Yao,Q., Lin,L., Zou,X. and Xiao,G.
  TITLE     Brief research report: Effects of Pinch deficiency on cartilage
            homeostasis in adult mice
  JOURNAL   Front Cell Dev Biol 11, 1116128 (2023)
   PUBMED   36743414
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4246)
  AUTHORS   Liao,H., Wang,F., Lu,K., Ma,X., Yan,J., Luo,L., Sun,Y. and Liang,X.
  TITLE     Requirement for PINCH in skeletal myoblast differentiation
  JOURNAL   Cell Tissue Res 391 (1), 205-215 (2023)
   PUBMED   36385586
  REMARK    GeneRIF: Requirement for PINCH in skeletal myoblast
            differentiation.
REFERENCE   4  (bases 1 to 4246)
  AUTHORS   Wang,X., Wang,R., Jiang,K., Zhu,M., Guo,L. and Wu,C.
  TITLE     PINCH-1 promotes IGF-1 receptor expression and skin cancer
            progression through inhibition of the GRB10-NEDD4 complex
  JOURNAL   Theranostics 12 (6), 2613-2630 (2022)
   PUBMED   35401828
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4246)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4246)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 4246)
  AUTHORS   Wilson,S.M., Householder,D.B., Coppola,V., Tessarollo,L.,
            Fritzsch,B., Lee,E.C., Goss,D., Carlson,G.A., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice
  JOURNAL   Genomics 74 (2), 228-233 (2001)
   PUBMED   11386759
REFERENCE   8  (bases 1 to 4246)
  AUTHORS   Takahashi,T., Sugishita,Y., Nojiri,T., Shimizu,T., Yao,A.,
            Kinugawa,K., Harada,K. and Nagai,R.
  TITLE     Cloning of hypoxia-inducible factor 1alpha cDNA from chick
            embryonic ventricular myocytes
  JOURNAL   Biochem Biophys Res Commun 281 (4), 1057-1062 (2001)
   PUBMED   11237772
REFERENCE   9  (bases 1 to 4246)
  AUTHORS   Abu-Hayyeh,S., Eddleston,J., Murdoch,J.N., Tham,M., Copp,A.J. and
            Stanier,P.
  TITLE     Linkage mapping of Lims1l, the murine homolog of the human LIM
            domain gene PINCH, to mouse chromosome 10
  JOURNAL   Cytogenet Cell Genet 82 (1-2), 46-48 (1998)
   PUBMED   9763658
REFERENCE   10 (bases 1 to 4246)
  AUTHORS   Rearden,A.
  TITLE     A new LIM protein containing an autoepitope homologous to
            'senescent cell antigen'
  JOURNAL   Biochem Biophys Res Commun 201 (3), 1124-1131 (1994)
   PUBMED   7517666
  REMARK    Erratum:[Biochem Biophys Res Commun 2001 Apr 13;282(4):1074]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY714471.1, AK152679.1 and AC155323.9.
            
            On Dec 21, 2017 this sequence version replaced NM_026148.3.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152679.1, AK151938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BY714471.1         80-131
            53-1215             AK152679.1         1-1163
            1216-4246           AC155323.9         142418-145448
FEATURES             Location/Qualifiers
     source          1..4246
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 29.31 cM"
     gene            1..4246
                     /gene="Lims1"
                     /gene_synonym="2310016J22Rik; 4921524A02Rik;
                     C430041B13Rik; Lims1l; PINCH; PINCH1"
                     /note="LIM and senescent cell antigen-like domains 1"
                     /db_xref="GeneID:110829"
                     /db_xref="MGI:MGI:1195263"
     exon            1..141
                     /gene="Lims1"
                     /gene_synonym="2310016J22Rik; 4921524A02Rik;
                     C430041B13Rik; Lims1l; PINCH; PINCH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1123
                     /gene="Lims1"
                     /gene_synonym="2310016J22Rik; 4921524A02Rik;
                     C430041B13Rik; Lims1l; PINCH; PINCH1"
                     /note="isoform 1 is encoded by transcript variant 1; LIM
                     and senescent cell antigen-like-containing domain protein
                     1; particularly interesting new Cys-His protein 1"
                     /codon_start=1
                     /product="LIM and senescent cell antigen-like-containing
                     domain protein 1 isoform 1"
                     /protein_id="NP_080424.2"
                     /db_xref="CCDS:CCDS23860.1"
                     /db_xref="GeneID:110829"
                     /db_xref="MGI:MGI:1195263"
                     /translation="MLGVAAGMTNSNMANALASATCERCKGGFAPAEKIVNSNGELYH
                     EQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSW
                     HPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLI
                     FKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVN
                     AMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEGDVV
                     SALNKAWCVSCFACSTCNTKLTLKNKFVEFDMKPVCKKCYEKFPLELKKRLKKLSETL
                     GRK"
     exon            142..301
                     /gene="Lims1"
                     /gene_synonym="2310016J22Rik; 4921524A02Rik;
                     C430041B13Rik; Lims1l; PINCH; PINCH1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..368
                     /gene="Lims1"
                     /gene_synonym="2310016J22Rik; 4921524A02Rik;
                     C430041B13Rik; Lims1l; PINCH; PINCH1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..489
                     /gene="Lims1"
                     /gene_synonym="2310016J22Rik; 4921524A02Rik;
                     C430041B13Rik; Lims1l; PINCH; PINCH1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..639
                     /gene="Lims1"
                     /gene_synonym="2310016J22Rik; 4921524A02Rik;
                     C430041B13Rik; Lims1l; PINCH; PINCH1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..790
                     /gene="Lims1"
                     /gene_synonym="2310016J22Rik; 4921524A02Rik;
                     C430041B13Rik; Lims1l; PINCH; PINCH1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..883
                     /gene="Lims1"
                     /gene_synonym="2310016J22Rik; 4921524A02Rik;
                     C430041B13Rik; Lims1l; PINCH; PINCH1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..932
                     /gene="Lims1"
                     /gene_synonym="2310016J22Rik; 4921524A02Rik;
                     C430041B13Rik; Lims1l; PINCH; PINCH1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1008
                     /gene="Lims1"
                     /gene_synonym="2310016J22Rik; 4921524A02Rik;
                     C430041B13Rik; Lims1l; PINCH; PINCH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..4246
                     /gene="Lims1"
                     /gene_synonym="2310016J22Rik; 4921524A02Rik;
                     C430041B13Rik; Lims1l; PINCH; PINCH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4223..4228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lims1"
                     /gene_synonym="2310016J22Rik; 4921524A02Rik;
                     C430041B13Rik; Lims1l; PINCH; PINCH1"
                     /note="hexamer: AATAAA"
     polyA_site      4242
                     /gene="Lims1"
                     /gene_synonym="2310016J22Rik; 4921524A02Rik;
                     C430041B13Rik; Lims1l; PINCH; PINCH1"
                     /note="major polyA site"
ORIGIN      
        1 tgcctgggac cggccctcaa atcgactgct cgccgccgca gcgagggaag agggtgcggc
       61 cgccgcggcg gggactgagg cacagactga cccggcgtgg accgcggaga tgctgggcgt
      121 ggcggccgga atgaccaaca gcaacatggc caatgccttg gccagtgcca cgtgtgagcg
      181 ctgcaaggga ggctttgcgc ctgctgagaa gatcgtgaac agtaatggtg agctgtacca
      241 cgaacagtgc ttcgtatgtg ctcagtgctt ccagcagttc ccagaaggac tcttttatga
      301 gtttgaagga aggaagtact gtgagcatga tttccaaatg ctctttgctc cctgctgcca
      361 ccaatgtggt gaattcatca ttggcagggt tatcaaagcc atgaacaaca gctggcatcc
      421 tgagtgcttc cgatgtgacc tctgccagga agtgctggca gacatagggt ttgtcaagaa
      481 tgctggcaga cacctatgtc gcccatgtca taatcgtgaa aaagccagag gccttggaaa
      541 atacatctgc cagaaatgcc atgccatcat tgatgaacag cctctgatct tcaagaacga
      601 cccttaccat ccagaccact tcaactgtgc caactgcggg aaggagctaa ctgctgatgc
      661 tcgggagctg aaaggggagc tatactgtct gccatgccat gataagatgg gggtccctat
      721 ctgtggcgcc tgcaggaggc ccattgaagg gcgagtagtg aatgccatgg gcaagcaatg
      781 gcatgtggag cattttgttt gtgccaaatg tgaaaaacca tttcttgggc atcgccatta
      841 tgagaggaag ggcttggcct actgtgaaac tcactataat cagctgtttg gtgatgtttg
      901 tttccattgc aaccgtgtca tagaaggtga tgtggtctct gctctcaaca aggcctggtg
      961 tgtgagctgc tttgcctgct ccacctgcaa taccaaactc acactcaaga ataaatttgt
     1021 ggaatttgac atgaagccag tctgtaagaa gtgctacgag aaatttcctt tggagctgaa
     1081 gaaaagactt aagaaactat ctgagacctt aggaaggaaa taacttttgg tgtctttttt
     1141 ctctctcttc taatcaatgt tacttaacct gatctaccct tgcttaaaac tatgtcagag
     1201 cattagaatg gttttcttca tttccctttt ctcatttaaa aacgaaagaa aatgtttatt
     1261 tctatgtaaa acacagatga aatcaggact ttcatttctt tagccatatt agtctgtagg
     1321 cattaaaagt atataaccaa aaacaaaaac aaacaaaaaa aaaaggttaa agggtagttt
     1381 taattaagcc atccaaaata taaatttaac ttcagagtta aacaccctgc tctatggacc
     1441 aaccaaagca cttgctgcca gcctagtact aagttgaatc cttaagagag tatctgagac
     1501 agtgtccaca tgggtcatgt ggagcaagaa cttactccca caagttgttc tctaacctcc
     1561 acagatggcc atggtgcata tgcgccaaca cacagttaat aaacataata gacaaccact
     1621 gttataaaga gtcagctttc acgggactca cataagcttt gcttccctga tcgcataaga
     1681 aaatcatttc ccattcatat actgggaact gtatgggaag ataagtgccc aaacagttcc
     1741 tatgttgtca tgtgcttatc cagttagcat tgtaaaagga acatgcatat tactaagaag
     1801 caaaaacatt tcaggatgac tgatttcttt ttttattaaa tcactaagct tagttttcta
     1861 ttttgttctc cttataaatt tttccttcat aaaattactt aacatacttg taactactaa
     1921 tgcatctttt acatttttaa gcaaaacaaa acaaaaattt gccagttatc tggaaaatat
     1981 tgcatacatt gtgatgttgg ggaaatgaag cattttaaaa ctatattaca cataaaatgc
     2041 atagtattca aatgggacat gaaatgcact ataatgcagc ttcgaatgta tggctttcaa
     2101 aagtgagcgt gagccaggtg tggtggcact aggcttcaat cccagctctc tgcaggcaga
     2161 tctctgtgag tcctaggcca cccagggctg catattaaaa ccttgtttca gaaagaatga
     2221 ctgtatctcg tattatcttt gtgctaatat ctatacttca tacataatct aacttgcctt
     2281 gccttagaaa actgcatcct atatcaggaa ttctagatat ttcttataat atcaaaatga
     2341 gtattttgat tgagattcat aaatttagaa tcattcacca ctgatacata ctttaaaaat
     2401 tcttttctca ggaagccagt gaaagttaat tcctgtcctc ttattagaac tatgctgata
     2461 tactaaaaca ttttaatgaa ggctttttta tttcaaatgt cataactggg ttttgtttac
     2521 tataaagcag taaagcagta taaatgatac ctttagactg aaagagggtg gtaagagtat
     2581 caactctaag gaaaaattgg ggagttctac tttataaaac tgtttatcct gaaatgtctg
     2641 ggccattctg tttgtatgaa ctcaatatgc aagagtatga acatttttta aatttttctg
     2701 ctgctaacat gttaccttct ttttcagttg ccaagatata ttttgcaaat actgctgaat
     2761 ataatgactc acattgtagt ctcagcattt gggaggctga ggcagaaaga ttaccaggag
     2821 ttggagacaa atcctaggtt acagtgtgag atactatccc ccaaaacatc cccacaaaca
     2881 aaaacactag tgtattgttt tgccgtaaag aatatctctg gggcctagga aaacgttcag
     2941 tcagtaatgg actcacacca gccttaggac ctgagtttaa acttggaggg agcagatccc
     3001 tggattttac gaggtagcca aactcagcct aactagtgag ccccagatcc aagggggaaa
     3061 tcctgtattc caaaaagcaa ggtggatgcc tcctgaggaa gggccgccta gactgatccc
     3121 tagcctccac atccacacac acacatgcac acattcagaa atatggatgt gtacacacaa
     3181 aaaggatatc tcaggatgct gttactctgc cattaaaagt ttataatcat gaatttttaa
     3241 aatacttgat tatgcacatt atggaataca tttctgtttc cagataacta acttgtaacc
     3301 aatcatttta tttcctaata tccttttcat attaagagaa ttatatgtga ctaaaaatat
     3361 acatgatttg tgtttgttaa gcattttaaa tttgtctttg cttttgacaa taagaaccaa
     3421 aatttcttcc gtgtgccttt gtcagctaag aatgactagc agtggctacc ttagaagtat
     3481 ttatgaacta ttgtacatgc gtttaggcag atagaacttg tagtctagcg tcttgatgta
     3541 acttacatac ctcactggaa gtatggagca gaaaagcact cattcccgtg ctttccccat
     3601 ccctttcgag gtgtgtggcc ttgcctgact gcctttgctt acgtgacatc gcttaagcca
     3661 gagtccccac tgctgtcttt gctcacttct cttcagacag gaatattcca gtaagtttga
     3721 tctcataatt atgtggtaat tcatctagag atggtgcttt tcactgtggg gtaaatcatt
     3781 agagccctta gtgtggaaga tggaggtcta aatggggcca agacagagac ttcatctact
     3841 tcctattagt tgtggggttt cactggctgc tggcatttgt cagtgaacat ctgtttgaat
     3901 ttctgagaac aatctgaaat aattcattgt gcttatgaaa tttctaagtg ccctttttgt
     3961 ccttatccta atataacatg gaaaatggat acacaaaaaa gattttttgt gtcatgttca
     4021 aagccttatt ataacacttt gcctgaaata ggtcattttg cctcatccat ttgccaaatt
     4081 agccaatttc aagttaggga aactttgatg taggctgaca atatccttgt attttatttt
     4141 agattgtaag cttaatggca agaaattata tcaataattg tgctttttat gtagcaacca
     4201 ttgctgtgta cttttggtgc ttaataaata ttcataatta ttcata
//
