LOCUS       NM_010717               3337 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus LIM domain kinase 1 (Limk1), transcript variant 1,
            mRNA.
ACCESSION   NM_010717 XM_359385
VERSION     NM_010717.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3337)
  AUTHORS   Nik Akhtar,S. and Lu,Q.
  TITLE     RhoA-LIMK Signaling Axis Reveals Rostral-Caudal Plane and Spatial
            Dysregulation in the Brain of Alzheimer's Disease Mouse Models
  JOURNAL   J Alzheimers Dis 95 (4), 1643-1656 (2023)
   PUBMED   37718806
  REMARK    GeneRIF: RhoA-LIMK Signaling Axis Reveals Rostral-Caudal Plane and
            Spatial Dysregulation in the Brain of Alzheimer's Disease Mouse
            Models.
REFERENCE   2  (bases 1 to 3337)
  AUTHORS   Yamada,S., Mizukoshi,T., Tokunaga,A. and Sakakibara,S.I.
  TITLE     Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal
            development
  JOURNAL   PLoS Genet 18 (10), e1010438 (2022)
   PUBMED   36301793
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3337)
  AUTHORS   Zhou,Z., He,G., Zhang,X., Lv,X., Zhang,X., Liu,A., Xia,S., Xie,H.,
            Dang,R., Han,L., Qi,J., Meng,Y., Yu,S., Xie,W. and Jia,Z.
  TITLE     NGPF2 triggers synaptic scaling up through
            ALK-LIMK-cofilin-mediated mechanisms
  JOURNAL   Cell Rep 36 (7), 109515 (2021)
   PUBMED   34407403
  REMARK    GeneRIF: NGPF2 triggers synaptic scaling up through
            ALK-LIMK-cofilin-mediated mechanisms.
REFERENCE   4  (bases 1 to 3337)
  AUTHORS   Zhang,H., Ben Zablah,Y., Liu,A., Lee,D., Zhang,H., Meng,Y.,
            Zhou,C., Liu,X., Wang,Y. and Jia,Z.
  TITLE     Overexpression of LIMK1 in hippocampal excitatory neurons improves
            synaptic plasticity and social recognition memory in APP/PS1 mice
  JOURNAL   Mol Brain 14 (1), 121 (2021)
   PUBMED   34315506
  REMARK    GeneRIF: Overexpression of LIMK1 in hippocampal excitatory neurons
            improves synaptic plasticity and social recognition memory in
            APP/PS1 mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3337)
  AUTHORS   Chen,P., Jing,H., Xiong,M., Zhang,Q., Lin,D., Ren,D., Wang,S.,
            Yin,D., Chen,Y., Zhou,T., Li,B., Fei,E. and Pan,B.X.
  TITLE     Spine impairment in mice high-expressing neuregulin 1 due to LIMK1
            activation
  JOURNAL   Cell Death Dis 12 (4), 403 (2021)
   PUBMED   33854034
  REMARK    GeneRIF: Spine impairment in mice high-expressing neuregulin 1 due
            to LIMK1 activation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3337)
  AUTHORS   Bernard,O., Burkitt,V., Webb,G.C., Bottema,C.D., Nicholl,J.,
            Sutherland,G.R. and Matthew,P.
  TITLE     Structure and chromosomal localization of the genomic locus
            encoding the Kiz1 LIM-kinase gene
  JOURNAL   Genomics 35 (3), 593-596 (1996)
   PUBMED   8812497
REFERENCE   7  (bases 1 to 3337)
  AUTHORS   Mao,X., Jones,T.A., Williamson,J., Gutowski,N.J., Proschel,C.,
            Noble,M. and Sheer,D.
  TITLE     Assignment of the human and mouse LIM-kinase genes (LIMK1; Limk1)
            to chromosome bands 7q11.23 and 5G1, respectively, by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 74 (3), 190-191 (1996)
   PUBMED   8941371
REFERENCE   8  (bases 1 to 3337)
  AUTHORS   Proschel,C., Blouin,M.J., Gutowski,N.J., Ludwig,R. and Noble,M.
  TITLE     Limk1 is predominantly expressed in neural tissues and
            phosphorylates serine, threonine and tyrosine residues in vitro
  JOURNAL   Oncogene 11 (7), 1271-1281 (1995)
   PUBMED   7478547
REFERENCE   9  (bases 1 to 3337)
  AUTHORS   Cheng,A.K. and Robertson,E.J.
  TITLE     The murine LIM-kinase gene (limk) encodes a novel serine threonine
            kinase expressed predominantly in trophoblast giant cells and the
            developing nervous system
  JOURNAL   Mech Dev 52 (2-3), 187-197 (1995)
   PUBMED   8541208
REFERENCE   10 (bases 1 to 3337)
  AUTHORS   Bernard,O., Ganiatsas,S., Kannourakis,G. and Dringen,R.
  TITLE     Kiz-1, a protein with LIM zinc finger and kinase domains, is
            expressed mainly in neurons
  JOURNAL   Cell Growth Differ 5 (11), 1159-1171 (1994)
   PUBMED   7848918
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ066818.1, AK141813.1,
            CV563459.1, BQ828670.1 and BX527775.1.
            
            On Apr 8, 2015 this sequence version replaced NM_010717.2.
            
            Summary: This gene encodes a member of the LIM kinase family of
            proteins. This protein is a serine/threonine kinase that regulates
            actin polymerization via phosphorylation and inactivation of the
            actin binding factor cofilin. This protein also stimulates axon
            growth and may play a role in brain development. Homozygous
            knockout mice for this gene exhibit reduced bone mass, abnormal
            neuronal morphology and altered synaptic function. Multiple
            pseudogenes of this gene have been identified. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Apr
            2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CJ066818.1         3-18
            17-708              AK141813.1         2-693
            709-709             CV563459.1         453-453
            710-993             AK141813.1         695-978
            994-994             CV563459.1         738-738
            995-1691            AK141813.1         980-1676
            1692-1692           BQ828670.1         44-44
            1693-3163           AK141813.1         1678-3148
            3164-3337           BX527775.1         45-218
FEATURES             Location/Qualifiers
     source          1..3337
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 74.73 cM"
     gene            1..3337
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /note="LIM domain kinase 1"
                     /db_xref="GeneID:16885"
                     /db_xref="MGI:MGI:104572"
     exon            1..250
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2139
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     LIM-domain containing, protein kinase"
                     /codon_start=1
                     /product="LIM domain kinase 1 isoform 1"
                     /protein_id="NP_034847.1"
                     /db_xref="CCDS:CCDS19724.1"
                     /db_xref="GeneID:16885"
                     /db_xref="MGI:MGI:104572"
                     /translation="MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNAD
                     WHADCFRCCECSVSLSHQYYEKDGQLFCKKDYWARYGESCHGCSEHITKGLVMVAGEL
                     KYHPECFICLACGNFIGDGDTYTLVEHSKLYCGQCYYQTVVTPVIEQILPDSPGSHLP
                     HTVTLVSIPASAHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIH
                     VGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDSLGHGPVSDPSPLSSP
                     VHTPSGQAASSARQKPVLRSCSIDTSPGTSSLASPASQRKDLGRSESLRVVCRPHRIF
                     RPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLE
                     HPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKNMDSQYPWSQRVSFAKDIASGMAY
                     LHSMNIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKNQSEDLRSLKKPDRKKRYT
                     VVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGF
                     LDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEQWLETLRMHLSGHLPLGPQLEQL
                     ERGFWETYRRGESSLPAHPEVPD"
     exon            251..347
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            348..486
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..596
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..803
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..909
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1076
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1260
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1347
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1479
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1539
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1605
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1762
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1818
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1976
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..3323
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3286..3291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /note="hexamer: AATAAA"
     polyA_site      3310
                     /gene="Limk1"
                     /gene_synonym="KIZ-1; Limk; LIMK-1"
                     /note="major polyA site"
ORIGIN      
        1 ggagccggtg tccctcaagc ctggtgtggg agtgcagcgg gacagcatcg ccgaacccgg
       61 agcggagcgc tcggctccgg ccccgcgctc cccgcctccc gccttctcgg gccggcggcg
      121 ggcgagctcg cgggcccggc cccagctctc cggtgccccg ccggttgccg gcggtccccg
      181 ccccccgccg agtgcatgag gttgacgcta ctttgttgca cctggaggga agaacgtatg
      241 ggagaggaag gaagcgagtt gcctgtgtgt gcgagctgtg gccagaggat ctatgacggc
      301 cagtacctcc aggccctgaa tgctgactgg catgcagact gcttcaggtg ctgcgagtgt
      361 agcgtctccc tttcacacca gtactacgag aaggatggac agctcttctg caagaaggac
      421 tactgggccc gctatggcga gtcttgccac gggtgctccg agcacatcac caaagggctg
      481 gtcatggtgg ctggggagct gaagtaccac cctgagtgtt tcatctgcct cgcctgtgga
      541 aacttcattg gcgatgggga cacctacaca ctggtggagc actccaagct gtactgtggc
      601 cagtgctact accagaccgt ggtaactcca gtcatcgaac agatcctacc tgactcaccc
      661 ggctcccacc tgccccacac agtcaccctc gtgtctatcc cagcctctgc ccatggcaaa
      721 cgaggcctgt ctgtctccat cgacccccct cacggcccac caggatgtgg cacggagcat
      781 tcgcacactg tccgagtcca aggagtggac ccaggctgca tgagcccaga tgtgaagaat
      841 tccatccacg ttggagaccg gatcttggaa atcaatggca cgcccatccg gaatgtgccg
      901 ctggacgaga tcgacttgct gatccaggag accagccgcc tgctccagct gaccctcgag
      961 cacgaccccc atgactcact gggccatggg cccgtgtcgg atcccagccc cctgagctcc
     1021 ccggtgcaca ctcccagcgg acaggcagcc agctctgccc ggcagaaacc tgtcttgagg
     1081 agctgcagta ttgacacgtc cccgggtacc agctcactag cctctccagc ctcccagcgc
     1141 aaggacctgg gtcgctccga atccctccga gtggtctgcc gaccacaccg aatcttccgg
     1201 ccatctgatc tcatccatgg ggaagtgctg ggcaagggct gttttggcca ggccatcaag
     1261 gtgacacacc gagaaacagg cgaggtgatg gtgatgaagg aacttatccg gtttgatgag
     1321 gagacccaga ggacattcct caaggaggta aaggtcatgc gctgcctgga gcaccctaac
     1381 gtgctcaagt tcatcggagt gctctacaag gacaagcggc taaacttcat cacagagtac
     1441 atcaagggcg gcaccctgcg gggcatcatc aagaacatgg acagccagta cccgtggagt
     1501 cagagggtca gctttgccaa ggacattgca tcagggatgg cctacctcca ttcgatgaac
     1561 atcatccacc gagacctcaa ctcccacaac tgtctggtcc gtgagaatag gaacgtggtg
     1621 gtggccgact ttgggctggc tcgactcatg atcgatgaaa agaatcagtc tgaagactta
     1681 cgcagcctta agaagccgga ccgcaagaag cggtacacag tggtgggcaa cccctactgg
     1741 atggcgccag agatgatcaa tggtcgtagt tatgatgaaa aggtggacgt gttttccttt
     1801 ggaattgtcc tctgtgagat tatcgggcgt gtgaatgcag accctgacta tctgccccgc
     1861 actatggact ttggcctcaa tgtaaggggt ttcctggacc gctactgtcc accaaactgt
     1921 cccccaagtt tcttccccat cactgtgcgc tgctgtgacc tggatcctga aaagagaccc
     1981 tcttttgtaa agctggaaca atggctagaa acacttcgca tgcacttgtc tggtcacctg
     2041 ccactgggcc cacaactgga acaactggag cggggcttct gggagaccta ccggcggggc
     2101 gagagctcac tgcctgccca ccccgaggtc cctgactgag ctcagcgggc cccaccatct
     2161 gcatccctac ctttggagac gataccctca ccagatttct cagcaggggt ggcctaggcc
     2221 tggagccctc agccagggcc gtggtgccca cacccatccc ccagacccag gccctgacct
     2281 gccttttccc ctcatgcagg gtgcccccca gcctctctct gcctctggcc cccaagtcac
     2341 caggctgcac acacacgtgg tcggtcacat tgccctgcct tacctcccag gggccaaccc
     2401 ctcactggtc ttgcatgagc tagagggttg ggaagctggg ctcattccac gcattgcctg
     2461 cagccatctg cacactgcac ctgctggcag ctcctcccca gcaaggctgg gctagaaggc
     2521 agctttagaa gtgagcccct ctaatgccaa gggagcggct ctgtgcccag gaacccaagg
     2581 ggaggctagg atccccttgg ggaaatccag gtagcatcag gtattgacag ggatctgaat
     2641 cccaaagcag agagagaggt ccaaccccgt gtggccaggc agtggcccct cactcttgct
     2701 tagtgtccat ctcatttctt gatcaaagcc actttagtga gaaataggta ccagtcctca
     2761 ggacgagcca ggatccctca ggggagaggg cagacgatgc ctgggatcca gctgacagga
     2821 gggtccagcc cgcactacag aggctgggca gagggaagga ggcagccacc caccagcacc
     2881 ccagccctcc agggtcatct cagcacccag gcctctcccc atggctgggg cagccccgcc
     2941 ccctccctgg gtgcatctgc cctctgagtt ctttctgtgt gatctatttt ttaagaagag
     3001 tttgtattat tttttcataa cggctgcagc agcagctgct gggggtttag ggggatggtt
     3061 ttgttttgtt gttttgtttt ggtttaggtg ggtgggggtg ggagggccat gtcttcactc
     3121 cgcttcagtt gaccatctag ggcatattaa actgtgaagc tttcccagtg cactttgaat
     3181 atggaagaga atttgagcag acccccgcgg gaccaagact gaaagaggca aggtctcctt
     3241 gcctcggccc agtgatcatg acaggaatga acccaaactc agaacaataa aatcaattct
     3301 gtgctcccca cgcggggctt gcaaaaaaaa aaaaaaa
//
