LOCUS       NM_023684               1987 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus Lck interacting transmembrane adaptor 1 (Lime1), mRNA.
ACCESSION   NM_023684
VERSION     NM_023684.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1987)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1987)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1987)
  AUTHORS   Lindquist,S., Karitkina,D., Langnaese,K., Posevitz-Fejfar,A.,
            Schraven,B., Xavier,R., Seed,B. and Lindquist,J.A.
  TITLE     Phosphoprotein associated with glycosphingolipid-enriched
            microdomains differentially modulates SRC kinase activity in brain
            maturation
  JOURNAL   PLoS One 6 (9), e23978 (2011)
   PUBMED   21915273
REFERENCE   4  (bases 1 to 1987)
  AUTHORS   Gregoire,C., Simova,S., Wang,Y., Sansoni,A., Richelme,S.,
            Schmidt-Giese,A., Simeoni,L., Angelisova,P., Reinhold,D.,
            Schraven,B., Horejsi,V., Malissen,B. and Malissen,M.
  TITLE     Deletion of the LIME adaptor protein minimally affects T and B cell
            development and function
  JOURNAL   Eur J Immunol 37 (11), 3259-3269 (2007)
   PUBMED   17918199
REFERENCE   5  (bases 1 to 1987)
  AUTHORS   Ahn,E., Lee,H. and Yun,Y.
  TITLE     LIME acts as a transmembrane adapter mediating BCR-dependent B-cell
            activation
  JOURNAL   Blood 107 (4), 1521-1527 (2006)
   PUBMED   16249387
  REMARK    GeneRIF: LIME is an essential transmembrane adaptor linking B-cell
            receptor ligation to the downstream signaling events that lead to
            B-cell activation.
REFERENCE   6  (bases 1 to 1987)
  AUTHORS   Pritsker,M., Doniger,T.T., Kramer,L.C., Westcot,S.E. and
            Lemischka,I.R.
  TITLE     Diversification of stem cell molecular repertoire by alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14290-14295 (2005)
   PUBMED   16183747
REFERENCE   7  (bases 1 to 1987)
  AUTHORS   Brdickova,N., Brdicka,T., Angelisova,P., Horvath,O., Spicka,J.,
            Hilgert,I., Paces,J., Simeoni,L., Kliche,S., Merten,C., Schraven,B.
            and Horejsi,V.
  TITLE     LIME: a new membrane Raft-associated adaptor protein involved in
            CD4 and CD8 coreceptor signaling
  JOURNAL   J Exp Med 198 (10), 1453-1462 (2003)
   PUBMED   14610046
REFERENCE   8  (bases 1 to 1987)
  AUTHORS   Hur,E.M., Son,M., Lee,O.H., Choi,Y.B., Park,C., Lee,H. and Yun,Y.
  TITLE     LIME, a novel transmembrane adaptor protein, associates with p56lck
            and mediates T cell activation
  JOURNAL   J Exp Med 198 (10), 1463-1473 (2003)
   PUBMED   14610044
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF115339.1 and DT916951.1.
            
            On Sep 14, 2006 this sequence version replaced NM_023684.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF115339.1, SRR1660817.35210.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-521               AF115339.1         1-521
            522-1032            DT916951.1         76-586
            1033-1987           AF115339.1         1033-1987
FEATURES             Location/Qualifiers
     source          1..1987
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.63 cM"
     gene            1..1987
                     /gene="Lime1"
                     /gene_synonym="2810038K19Rik; LIME"
                     /note="Lck interacting transmembrane adaptor 1"
                     /db_xref="GeneID:72699"
                     /db_xref="MGI:MGI:1919949"
     exon            1..1080
                     /gene="Lime1"
                     /gene_synonym="2810038K19Rik; LIME"
                     /inference="alignment:Splign:2.1.0"
     CDS             983..1792
                     /gene="Lime1"
                     /gene_synonym="2810038K19Rik; LIME"
                     /note="lck-interacting molecule"
                     /codon_start=1
                     /product="lck-interacting transmembrane adapter 1"
                     /protein_id="NP_076173.1"
                     /db_xref="CCDS:CCDS17211.1"
                     /db_xref="GeneID:72699"
                     /db_xref="MGI:MGI:1919949"
                     /translation="MRPPVPSAPLALWVLGCFSLLLWLWALCTACHRKRAQRQQTGLQ
                     DSLVPVEMPLLRQTHLCSLSKSDTRLHELHRGPRSSIAPRPASMDLLHPRWLEMSRGS
                     TRSQVPNSAFPPRQLPRAPPAAPATAPSTSSEATYSNVGLAAIPRASLAASPVVWAGT
                     QLTISCARLGPGAEYACIQKHKGTEQGCQELQQKAKVIPATQMDVLYSRVCKPKRRDP
                     RPVTDQLNLQDGRTSLPLGSDVEYEAINLRGQDMKQGPLENVYESIKEMGL"
     exon            1081..1138
                     /gene="Lime1"
                     /gene_synonym="2810038K19Rik; LIME"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1226
                     /gene="Lime1"
                     /gene_synonym="2810038K19Rik; LIME"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1588
                     /gene="Lime1"
                     /gene_synonym="2810038K19Rik; LIME"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1959
                     /gene="Lime1"
                     /gene_synonym="2810038K19Rik; LIME"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1940..1945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lime1"
                     /gene_synonym="2810038K19Rik; LIME"
                     /note="hexamer: ATTAAA"
     polyA_site      1959
                     /gene="Lime1"
                     /gene_synonym="2810038K19Rik; LIME"
                     /note="major polyA site"
ORIGIN      
        1 gaggagagca gagactgtgg gagcaactgc gcaagagctg tgtggctgct gggaggtgct
       61 ctgagaaaca caggaagtga ggtgaggcgt caccagcagc ccacaaagat cttcctggct
      121 gtcctagaca gggccaagca gcaaatcccc ggtggcctcg gtaagtgctc cctcaccctt
      181 tatcctgggc cagcccccaa gcctctccat gctctggggt ctgggagggt tagtccctgc
      241 ctggttaggc cattgataac ttggctgtag ccaggttagt cagcttgggc ccactcagtg
      301 aaagaagcct acactccaag cctgaacaga caggccctca cctcagaagg ctgttgttca
      361 ccccaatttt acttaccttt aacgtctggg tgagacccta atcagctctg caaagggtaa
      421 ctccagggaa gccccagagc cccgggaagt gtggagtagg gtgggagtac gtggccctca
      481 tagcagctcc tcctgttcat tgacacacac ctcccccacc caccctttct gtagtgagta
      541 gtctaggaag attgcctgac acaggggtca ctctgtgggc attggtggcc ggaggtgaga
      601 cctgtggtct gtggctcaga gtcagagtga agtcagagat tccccaggtg atgggcttga
      661 gctccagtta tacacccttg ttcagttgag gtcatagcta ccctggccat gctcctctat
      721 ctccatctcc attcctgata actaacaggg ataggcagag cacttcttac caggaaccct
      781 agctagagag ggaaaggtgg gtccccctag agcacggcaa aaatgcaagg cttgggggtt
      841 tccggtgtgc tgagtcaacc agggagaagg aacccactag tgggcaagat ctgcaagtag
      901 gctgcagctg tacactgctc tcgcagccag cccccagtgc tcatctcttc tgtccccagg
      961 gctctcttcc ctgtttcaca ggatgaggcc accagtgcct tcagccccac tagctctctg
     1021 ggtcctgggc tgcttctccc tgctcctttg gctatgggca ctgtgcacag cctgccacag
     1081 gaagagagct cagaggcagc aaactgggct gcaggacagt ttggtaccag tggaaatgcc
     1141 actgctgaga cagacccacc tctgctccct cagcaagtct gacaccagac tgcatgagct
     1201 gcaccgaggc ccacgctcca gcatagcccc acggcctgct agcatggatc ttctgcatcc
     1261 acgctggcta gagatgtcca ggggcagcac caggtctcag gtacccaact ctgccttccc
     1321 accacggcag ctgcccaggg cccctcctgc tgctcctgca actgcacctt ctactagctc
     1381 tgaggccact tattccaatg tggggctggc tgcaattccc agggccagcc tggctgctag
     1441 ccctgtggtg tgggctggaa cacagctgac cattagttgt gccaggcttg gtcctggggc
     1501 cgaatatgcc tgcatccaga agcacaaagg gacagagcaa ggctgccaag aattgcagca
     1561 gaaggctaag gtgatcccag ctactcagat ggacgtccta tactctaggg tttgcaagcc
     1621 taaaagaaga gacccaagac ccgtcacaga ccagctgaac ctgcaggatg ggagaacaag
     1681 tctgccgctt gggagtgatg tggagtacga ggccatcaat ctcaggggcc aggatatgaa
     1741 gcaagggccc ttagaaaatg tgtatgaaag catcaaggag atgggcctgt gagcagctca
     1801 ggccttacat cctgtcttta acatgagtta ggaagagtac caaggcttct gcttcaggat
     1861 ggtttgattg cagatccttc tgtgtccttc cacctccaca gctggcagca cagctatcag
     1921 ggccagtcct tgaggcctaa ttaaacctct gttcaataaa aaaaaaaaaa aaaaaaaaaa
     1981 aaaaaaa
//
