LOCUS       NM_013860               4806 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus LIM domains containing 1 (Limd1), transcript variant
            1, mRNA.
ACCESSION   NM_013860
VERSION     NM_013860.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4806)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4806)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4806)
  AUTHORS   Wang,Y., Zhang,C., Yang,W., Shao,S., Xu,X., Sun,Y., Li,P., Liang,L.
            and Wu,C.
  TITLE     LIMD1 phase separation contributes to cellular mechanics and
            durotaxis by regulating focal adhesion dynamics in response to
            force
  JOURNAL   Dev Cell 56 (9), 1313-1325 (2021)
   PUBMED   33891898
  REMARK    GeneRIF: LIMD1 phase separation contributes to cellular mechanics
            and durotaxis by regulating focal adhesion dynamics in response to
            force.
REFERENCE   4  (bases 1 to 4806)
  AUTHORS   Phua,Y.L., Chen,K.H., Hemker,S.L., Marrone,A.K., Bodnar,A.J.,
            Liu,X., Clugston,A., Kostka,D., Butterworth,M.B. and Ho,J.
  TITLE     Loss of miR-17~92 results in dysregulation of Cftr in nephron
            progenitors
  JOURNAL   Am J Physiol Renal Physiol 316 (5), F993-F1005 (2019)
   PUBMED   30838872
REFERENCE   5  (bases 1 to 4806)
  AUTHORS   Iwata,J., Suzuki,A., Yokota,T., Ho,T.V., Pelikan,R., Urata,M.,
            Sanchez-Lara,P.A. and Chai,Y.
  TITLE     TGFbeta regulates epithelial-mesenchymal interactions through WNT
            signaling activity to control muscle development in the soft palate
  JOURNAL   Development 141 (4), 909-917 (2014)
   PUBMED   24496627
REFERENCE   6  (bases 1 to 4806)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4806)
  AUTHORS   Aubert,J., Dunstan,H., Chambers,I. and Smith,A.
  TITLE     Functional gene screening in embryonic stem cells implicates Wnt
            antagonism in neural differentiation
  JOURNAL   Nat Biotechnol 20 (12), 1240-1245 (2002)
   PUBMED   12447396
REFERENCE   8  (bases 1 to 4806)
  AUTHORS   Kiss,H., Darai,E., Kiss,C., Kost-Alimova,M., Klein,G.,
            Dumanski,J.P. and Imreh,S.
  TITLE     Comparative human/murine sequence analysis of the common eliminated
            region 1 from human 3p21.3
  JOURNAL   Mamm Genome 13 (11), 646-655 (2002)
   PUBMED   12461651
REFERENCE   9  (bases 1 to 4806)
  AUTHORS   Kiss,H., Kedra,D., Kiss,C., Kost-Alimova,M., Yang,Y., Klein,G.,
            Imreh,S. and Dumanski,J.P.
  TITLE     The LZTFL1 gene is a part of a transcriptional map covering 250 kb
            within the common eliminated region 1 (C3CER1) in 3p21.3
  JOURNAL   Genomics 73 (1), 10-19 (2001)
   PUBMED   11352561
REFERENCE   10 (bases 1 to 4806)
  AUTHORS   Kiss,H., Kedra,D., Yang,Y., Kost-Alimova,M., Kiss,C., O'Brien,K.P.,
            Fransson,I., Klein,G., Imreh,S. and Dumanski,J.P.
  TITLE     A novel gene containing LIM domains (LIMD1) is located within the
            common eliminated region 1 (C3CER1) in 3p21.3
  JOURNAL   Hum Genet 105 (6), 552-559 (1999)
   PUBMED   10647888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125254.9 and AC132852.12.
            
            On Aug 9, 2022 this sequence version replaced NM_013860.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ132409.1, AK047198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1874              AC125254.9         124361-126234
            1875-1976           AC125254.9         145744-145845
            1977-2044           AC125254.9         156121-156188
            2045-2107           AC125254.9         156829-156891
            2108-2238           AC132852.12        163844-163974       c
            2239-2290           AC132852.12        163335-163386       c
            2291-2359           AC132852.12        162585-162653       c
            2360-4806           AC132852.12        159197-161643       c
FEATURES             Location/Qualifiers
     source          1..4806
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 74.0 cM"
     gene            1..4806
                     /gene="Limd1"
                     /gene_synonym="D9Ertd192e"
                     /note="LIM domains containing 1"
                     /db_xref="GeneID:29806"
                     /db_xref="MGI:MGI:1352502"
     exon            1..1874
                     /gene="Limd1"
                     /gene_synonym="D9Ertd192e"
                     /inference="alignment:Splign:2.1.0"
     CDS             491..2497
                     /gene="Limd1"
                     /gene_synonym="D9Ertd192e"
                     /note="isoform 1 is encoded by transcript variant 1; LIM
                     domain-containing protein 1"
                     /codon_start=1
                     /product="LIM domain-containing protein 1 isoform 1"
                     /protein_id="NP_038888.2"
                     /db_xref="CCDS:CCDS23660.1"
                     /db_xref="GeneID:29806"
                     /db_xref="MGI:MGI:1352502"
                     /translation="MDKYDDLGLEASKFIEDLNMYEASKDGLFRVDKGAGNNPEFEET
                     RRVFATKMAKIHLQQQQQQQLLQEEALPRAGRSPVNGGNRQGASGKLAADGAAKPPLA
                     VPTVAPGLATTTAAAQPSYPSQEQRIRPSAHGARPGSQNCGSREGPVSSQRPALHGLS
                     PSCEDPSCLTHGDYYDNFSLASPQWGDKPEGCPSVSLGVGSGWPGCPGNDSTLPKSCG
                     DHHPYQPQLSTVCSGRSFESGISGQDGGIGGHSSEKPTGLWSTASSQRVNLGFSSMGL
                     ENGTSAQPKGTTVSAPMVPSSASQGACPKRDSGLGYEASGRVFKPLVDTQPWLQDGPK
                     SYLSVSAPLSSTAGKDSTQPGMTTGLDPKFGCVESGTSPKPSPTSNVHPVMSTPSELS
                     CKESSPSWSTDSSLEPVLPGSPTPSRVRLPCQTLAPGPELGPSTAELKLEALTQRLER
                     EMDAHPKADYFGSCVKCSKGVFGAGQACQAMGDLYHDACFTCAACSRKLRGKAFYFVN
                     GKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVP
                     FTVDSENKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCED
                     CGLELNDEDGHRCYPLEDHLFCHSCHVKRLEKGPSPAPLHQHHF"
     exon            1875..1976
                     /gene="Limd1"
                     /gene_synonym="D9Ertd192e"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2044
                     /gene="Limd1"
                     /gene_synonym="D9Ertd192e"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2107
                     /gene="Limd1"
                     /gene_synonym="D9Ertd192e"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2238
                     /gene="Limd1"
                     /gene_synonym="D9Ertd192e"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2290
                     /gene="Limd1"
                     /gene_synonym="D9Ertd192e"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2359
                     /gene="Limd1"
                     /gene_synonym="D9Ertd192e"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..4806
                     /gene="Limd1"
                     /gene_synonym="D9Ertd192e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4779..4784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Limd1"
                     /gene_synonym="D9Ertd192e"
                     /note="hexamer: AATAAA"
     regulatory      4783..4788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Limd1"
                     /gene_synonym="D9Ertd192e"
                     /note="hexamer: AAGAAA"
     polyA_site      4803
                     /gene="Limd1"
                     /gene_synonym="D9Ertd192e"
     polyA_site      4806
                     /gene="Limd1"
                     /gene_synonym="D9Ertd192e"
                     /note="major polyA site"
ORIGIN      
        1 acttccgcgt cccgccgccg gccgccgcca tcggacaatg ggccgcgcgc cgcggctgca
       61 gtgagctctg ctggatccgg ccaccggccc caggccaggg gctgcccggt gtgtttgcaa
      121 gttcgattgt tcgacgtgga tgtgagttta ctttttttct gtggacgttc tctgtcttct
      181 ttcgcctgtt ttgggttttg tgacttggag aagagaactt ttctaagcag gccgggcacg
      241 gctgaaggct gctctgcccc cacgtggacg ctccccgggg gaaaagaagt ctgaaagtaa
      301 acttagcccc gctggcctga aggcctcaac tctggctgga ctgtgagttt tggagtcatg
      361 accttcttgc tgggcaggtg ggaatcttta tctgccttag gctggacctg aaacctcggc
      421 cagcacccaa atctccccca ccacattcac accttgaacc agggctaggc cccggacact
      481 gatctacaac atggataaat acgatgatct gggccttgag gccagtaagt tcatcgagga
      541 cctgaacatg tatgaggcct ccaaggatgg gctcttccgg gtggacaagg gtgctggcaa
      601 caacccagaa tttgaggaaa ctcgaagggt gttcgcgacc aagatggcca aaatccacct
      661 ccagcagcag caacagcagc agctcctaca ggaggaggcc ctacctaggg caggcagaag
      721 cccggtcaac ggtgggaacc gtcagggtgc gagcggcaag ctggctgcag atggggccgc
      781 taagcctcct ctggctgtgc caacagtggc acctggatta gctactacca ctgcggccgc
      841 gcagccctcg tacccatctc aggagcagag gatcaggcca tctgcccatg gtgcaaggcc
      901 tggcagtcag aactgtggtt ccagggaggg gcctgtgagt tcccagagac ctgctttaca
      961 cggcctgagt ccctcctgtg aagacccttc ctgcctcact cacggagact attatgacaa
     1021 tttctctttg gcaagcccac agtggggtga taaacctgaa gggtgcccca gcgtgagtct
     1081 gggtgtagga agtggatggc ctggttgccc agggaatgac tccacattgc ccaaatcctg
     1141 tggagaccat cacccttacc agccacagct ctccacagtg tgctctggca ggtcttttga
     1201 aagtggcatc agtggccagg acggtggcat tggtggccat agcagcgaga agccaacagg
     1261 cctttggtcc actgcctcct ctcagcgagt gaacctcggt ttttcttcca tgggcttgga
     1321 gaatgggacc tccgctcaac ccaagggcac aactgtttca gcaccgatgg tccctagcag
     1381 cgccagccaa ggagcttgtc cgaaaagaga ttcaggtctg ggatatgagg cttcaggcag
     1441 ggtcttcaaa ccccttgtgg acactcagcc ttggctgcag gatgggccca agtcttacct
     1501 ctcagtttct gctccattat cctcgacagc tggcaaggac agtacccagc caggtatgac
     1561 caccgggctg gatcctaagt ttggatgcgt ggagtctggc actagtccca agcccagccc
     1621 caccagtaac gtccatccgg taatgtccac tccatctgag ttatcttgta aagagagttc
     1681 tcccagctgg tccactgaca gtagtctgga acctgtgctc ccagggagtc ccaccccctc
     1741 cagggtgaga ttgccctgcc agaccctcgc accgggccct gagcttggac cctccactgc
     1801 ggaattgaag ttggaagccc tcacccagcg tctggagcga gagatggatg ctcaccccaa
     1861 agcggactac ttcggttcct gtgtgaaatg cagcaaaggg gtgtttggag ctggccaggc
     1921 ctgtcaggcc atgggagatc tctaccacga tgcgtgcttc acctgtgcag cctgcagcag
     1981 gaagttaaga ggaaaggcct tctattttgt caatggcaaa gtattctgtg aggaagactt
     2041 tttgtattct ggctttcagc agtctgcgga caggtgtttt ctttgtggac acctgatcat
     2101 ggacatgatc ctacaggccc tagggaagtc ctatcacccc ggctgtttcc gctgcgtcat
     2161 ctgtaatgaa tgtctggatg gggttccttt caccgtggac tctgagaaca agatctactg
     2221 tgtccgagac tatcacaagg tgctggcccc caagtgtgca gcctgtggcc ttcccatcct
     2281 tccgccagag ggttcagacg agaccatcag agttgtgtcc atggacaggg actaccacgt
     2341 agagtgctac cactgtgagg actgtggtct ggagctcaat gacgaggacg gtcaccgctg
     2401 ctatccactg gaggaccacc tgttctgtca ctcctgccat gtcaagagac tggagaaagg
     2461 accctcacct gcacccctcc accagcacca cttctagcaa ggagacacag tggagatacg
     2521 gggccagcct gctgggggaa atgtctgtgt agcacttctg agctccccca cagctggggc
     2581 acaggaagag gaggggcagg aggtcaagtt cctgtgtgtg tgagtgtgtg tgcgcgtgtg
     2641 aagagggtat cttccttcta accgcagcag tgtgcactcc ccatccagtc catgtgtttt
     2701 caaagtgctt ttctctattg ccacactctc gctgaatcac tcaggaagat gctccagctt
     2761 gcacgtggcc cctgacacaa gatggggctt ttgtgactgg acacatccta gtccctggaa
     2821 agcaggtttt caggttgtgt tgagcacatt ccacagtgtc cctaaagaga aaccttgata
     2881 gaggtgagca gcacttcctc tgggcgagca cctgcacccg gataaccctc acacagccca
     2941 tggtgtgact taacagttca gtccacttca gagctttagc tcttctgaga atacttcaaa
     3001 cacttgactg cattgcagct agaaagaggc tctgcatatg ctttgtacat tggagtttgc
     3061 ttggtgaagg agagccaagc ttggacatct gggaggctgg gtctccctgc tgtgcctctg
     3121 cctttcctcc tgcacctaag acagtggggt tggggcagag gcttgccctg tcctatgcag
     3181 ccagctcaga gagaactggt gcaggcgcca ggcttctcgt ccatgcttgg tgctgtgttt
     3241 tcattgcttc ctccagtctg tgacattgga gttgcttcct caaggtgagt ctgaggcttc
     3301 ctcatatccc tgtcaccttg ttcaactcat ttgaacatga ccgttgggaa tcccagtcca
     3361 tatcctggga gagagctact tctaaaagga aagttttgtg tgtgagatct cagagctagc
     3421 accagaggga gtgcccgagc ttgtttcagc ggacttgtat ctctctggtc ctcttctcag
     3481 cacagacatt tgcttggttt gaggaaacta atataaggta cactgctttt gtctgttttt
     3541 ttaaacgtca ttctttctct ctaccttttc ccacacacaa aacatacctc acagatagtt
     3601 ttcaccaaat cacagatcaa agaggaattc atccatccta ttggagactg ttggtgtatc
     3661 agcagtggcc gttttccaac tcttgaacta cagctaagca gtacagtcgc aacacaaggt
     3721 cttctgagac tagctgcaac tgaagtcatg agttcactct ggcctcatgt gcctctgcat
     3781 gctggctccc gaggttgcca ggctaagatg gagaccacat gctgtcaata ttaagaccac
     3841 ttctgaggtg gatatgtgga catacccgtc ctcccaacat ttgagagcct gaagtttgtg
     3901 aagaaggagt ttaaggctgt cctcaactac atgaggtcat gatctcactc aaaaaaaaaa
     3961 aaaaaaaaac ttaaaagaga aagaaaaaaa ccccacccag cattgaagaa cataattaac
     4021 tttgcctatc acttcccgag gccagaggtc agtgtctcct tggaagttca aatgggtaaa
     4081 actggaaaaa caaaaatgaa atgggtttcc atctgctgtc ttatcttcag ggagtgtccc
     4141 gtgacttgtg gcaggaaggc tgcagtgtct tacttcagca gtcaggctgg gtacccagca
     4201 gctggcttgg gtggtgaagc aaggccggta gagctcctgc cacatgtgaa tgtggactct
     4261 tgactaggcc tcagctagac ctggtagcta ctgcaatcct gctgacctcc attgcctatg
     4321 agaagttcag aactagcact gtggatcagg agcatctttt tcatttttat caggttcctt
     4381 ctgttgggat cctttggcca gatgttactc gtttcctgtt ctagacagag gcccccttaa
     4441 aaaaaaaaaa gctatgaatg tatggggtca ccgagataga ccctgagacc agcgctgttt
     4501 tctctctttg gtttcccggg ctggctttgg caagggtggc agggaaagga gaaaacacaa
     4561 tgtctttgcc ttcctggagg ctctggtaga gtctaatttt gtgtcaagat gattgatgaa
     4621 gattgcagtg gaattagtgt ctgaggtaga tgggatttgt ttgcaaattg aataatttaa
     4681 aactctgtga ttaattttta aatgaaatta aatgaaattc ctgattgaag tgattcagat
     4741 ctgtttgcaa atactacatt ttatattatc aaaaaagcaa taaagaaatt tgtagacttc
     4801 ccagaa
//
