LOCUS       NM_008147               1425 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus leukocyte immunoglobulin-like receptor, subfamily B,
            member 4B (Lilrb4b), transcript variant 1, mRNA.
ACCESSION   NM_008147
VERSION     NM_008147.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1425)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1425)
  AUTHORS   Miyamoto,S., Chiba,T., Itoi,S., Su,M.T. and Takai,T.
  TITLE     LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal
            Adhesion Sites on Mast Cells
  JOURNAL   Tohoku J Exp Med 259 (4), 273-284 (2023)
   PUBMED   36642505
  REMARK    GeneRIF: LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at
            Focal Adhesion Sites on Mast Cells.
REFERENCE   3  (bases 1 to 1425)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1425)
  AUTHORS   Sferruzzi-Perri,A.N., Macpherson,A.M., Roberts,C.T. and
            Robertson,S.A.
  TITLE     Csf2 null mutation alters placental gene expression and trophoblast
            glycogen cell and giant cell abundance in mice
  JOURNAL   Biol Reprod 81 (1), 207-221 (2009)
   PUBMED   19228596
REFERENCE   5  (bases 1 to 1425)
  AUTHORS   Lee,K.H., Ono,M., Inui,M., Yuasa,T. and Takai,T.
  TITLE     Stimulatory function of gp49A, a murine Ig-like receptor, in rat
            basophilic leukemia cells
  JOURNAL   J Immunol 165 (9), 4970-4977 (2000)
   PUBMED   11046024
REFERENCE   6  (bases 1 to 1425)
  AUTHORS   Rojo,S., Stebbins,C.C., Peterson,M.E., Dombrowicz,D., Wagtmann,N.
            and Long,E.O.
  TITLE     Natural killer cells and mast cells from gp49B null mutant mice are
            functional
  JOURNAL   Mol Cell Biol 20 (19), 7178-7182 (2000)
   PUBMED   10982834
REFERENCE   7  (bases 1 to 1425)
  AUTHORS   McCormick,M.J., Castells,M.C., Austen,K.F. and Katz,H.R.
  TITLE     The gp49A gene has extensive sequence conservation with the gp49B
            gene and provides gp49A protein, a unique member of a large family
            of activating and inhibitory receptors of the immunoglobulin
            superfamily
  JOURNAL   Immunogenetics 50 (5-6), 286-294 (1999)
   PUBMED   10630292
REFERENCE   8  (bases 1 to 1425)
  AUTHORS   Kuroiwa,A., Yamashita,Y., Inui,M., Yuasa,T., Ono,M., Nagabukuro,A.,
            Matsuda,Y. and Takai,T.
  TITLE     Association of tyrosine phosphatases SHP-1 and SHP-2, inositol
            5-phosphatase SHIP with gp49B1, and chromosomal assignment of the
            gene
  JOURNAL   J Biol Chem 273 (2), 1070-1074 (1998)
   PUBMED   9422771
REFERENCE   9  (bases 1 to 1425)
  AUTHORS   Castells,M.C., Wu,X., Arm,J.P., Austen,K.F. and Katz,H.R.
  TITLE     Cloning of the gp49B gene of the immunoglobulin superfamily and
            demonstration that one of its two products is an early-expressed
            mast cell surface protein originally described as gp49
  JOURNAL   J Biol Chem 269 (11), 8393-8401 (1994)
   PUBMED   8132564
REFERENCE   10 (bases 1 to 1425)
  AUTHORS   Arm,J.P., Gurish,M.F., Reynolds,D.S., Scott,H.C., Gartner,C.S.,
            Austen,K.F. and Katz,H.R.
  TITLE     Molecular cloning of gp49, a cell-surface antigen that is
            preferentially expressed by mouse mast cell progenitors and is a
            new member of the immunoglobulin superfamily
  JOURNAL   J Biol Chem 266 (24), 15966-15973 (1991)
   PUBMED   1714901
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153530.9.
            
            On Mar 31, 2023 this sequence version replaced NM_008147.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M65027.1, SRR12282455.35851661.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC153530.9         166501-166593
            94-129              AC153530.9         166746-166781
            130-414             AC153530.9         166980-167264
            415-717             AC153530.9         167407-167709
            718-753             AC153530.9         168709-168744
            754-870             AC153530.9         169602-169718
            871-923             AC153530.9         170357-170409
            924-991             AC153530.9         171553-171620
            992-1425            AC153530.9         171728-172161
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 25.5 cM"
     gene            1..1425
                     /gene="Lilrb4b"
                     /gene_synonym="gp49; Gp49a; Lilr4b"
                     /note="leukocyte immunoglobulin-like receptor, subfamily
                     B, member 4B"
                     /db_xref="GeneID:14727"
                     /db_xref="MGI:MGI:102702"
     exon            1..93
                     /gene="Lilrb4b"
                     /gene_synonym="gp49; Gp49a; Lilr4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..971
                     /gene="Lilrb4b"
                     /gene_synonym="gp49; Gp49a; Lilr4b"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; mast cell surface glycoprotein Gp49A;
                     glycoprotein 49 A"
                     /codon_start=1
                     /product="leukocyte immunoglobulin-like receptor subfamily
                     B member 4B isoform 1 precursor"
                     /protein_id="NP_032173.1"
                     /db_xref="CCDS:CCDS23831.1"
                     /db_xref="GeneID:14727"
                     /db_xref="MGI:MGI:102702"
                     /translation="MIAMLTVLLYLALILEPRTAVQAGHLPKPIIWAEPGSVIAAYTS
                     VIIWCWGSWEAQYYYLDKEKSVNPWDTEVPLENRNKTKFKIRFMTASYAGIYNCYYKS
                     AAGFSEHSDAMELVMTGAYENPSLSVYPSSNVTSGVSISFKCSSSTLFGRFILIQEGK
                     HGLSWTLDSQHQANQPTHATFVLDAVAPNHNGTFRCYGFFRNEPQVWSKPSNSLDLMI
                     SETKEQSCTPTEDGLETYQKILIGVLVSFLLLFFLLLFLILIGYQCRHKNKANASVKN
                     TQSEDNAELNSWNPQNEDPPRELCTPR"
     exon            94..129
                     /gene="Lilrb4b"
                     /gene_synonym="gp49; Gp49a; Lilr4b"
                     /inference="alignment:Splign:2.1.0"
     exon            130..414
                     /gene="Lilrb4b"
                     /gene_synonym="gp49; Gp49a; Lilr4b"
                     /inference="alignment:Splign:2.1.0"
     exon            415..717
                     /gene="Lilrb4b"
                     /gene_synonym="gp49; Gp49a; Lilr4b"
                     /inference="alignment:Splign:2.1.0"
     exon            718..753
                     /gene="Lilrb4b"
                     /gene_synonym="gp49; Gp49a; Lilr4b"
                     /inference="alignment:Splign:2.1.0"
     exon            754..870
                     /gene="Lilrb4b"
                     /gene_synonym="gp49; Gp49a; Lilr4b"
                     /inference="alignment:Splign:2.1.0"
     exon            871..923
                     /gene="Lilrb4b"
                     /gene_synonym="gp49; Gp49a; Lilr4b"
                     /inference="alignment:Splign:2.1.0"
     exon            924..991
                     /gene="Lilrb4b"
                     /gene_synonym="gp49; Gp49a; Lilr4b"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1425
                     /gene="Lilrb4b"
                     /gene_synonym="gp49; Gp49a; Lilr4b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1302..1307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lilrb4b"
                     /gene_synonym="gp49; Gp49a; Lilr4b"
                     /note="hexamer: AACAAG"
     polyA_site      1326
                     /gene="Lilrb4b"
                     /gene_synonym="gp49; Gp49a; Lilr4b"
                     /note="major polyA site"
     regulatory      1403..1408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lilrb4b"
                     /gene_synonym="gp49; Gp49a; Lilr4b"
                     /note="hexamer: AATAAA"
     polyA_site      1425
                     /gene="Lilrb4b"
                     /gene_synonym="gp49; Gp49a; Lilr4b"
                     /note="major polyA site"
ORIGIN      
        1 ggacagacat ttgtcagact ggcccaagag aacagctacg aacattgcct ggactcacca
       61 tgatcgccat gctcacagtg ctgctatacc ttgctcttat tctggaaccc aggactgcag
      121 tacaggcagg acacctccca aaacccatca tctgggctga gccaggctct gtgatcgctg
      181 cgtatacatc tgtgattatc tggtgttggg gttcctggga ggcccagtat tattatctgg
      241 ataaagagaa aagtgtaaat ccttgggaca ctgaagtccc tctggaaaac aggaataaga
      301 ccaagttcaa aattcgattt atgacagcct catatgcagg catatataac tgttactata
      361 agagtgctgc tggcttctca gagcacagtg atgccatgga gctggtgatg acaggagcat
      421 atgaaaatcc cagcctgtca gtctatccca gctctaatgt gacctctgga gtttccatat
      481 cctttaagtg cagctcatcc acactatttg gcagattcat tctgatacag gaaggaaagc
      541 atggcctctc gtggaccctg gactcacagc atcaggccaa tcagccaacc catgctactt
      601 ttgttctgga tgctgttgct cccaaccaca atggaacatt cagatgctat ggcttcttta
      661 gaaatgaacc acaggtgtgg tcaaaaccaa gtaactccct agacctcatg atctcagaaa
      721 ccaaggaaca gtcctgtaca cccactgaag atggactgga aacataccag aagattttga
      781 ttggagtcct ggtgtcattc ctcctgcttt tcttcctcct gctttttctc atcctcatcg
      841 gataccagtg tcgtcacaaa aataaggcta atgcttctgt gaagaacaca caatctgagg
      901 acaatgcaga gctgaacagt tggaacccac aaaatgaaga cccccccagg gaattgtgta
      961 cgcccaggta aaatcctcca ggcttcggaa ggacactgca tgcaaagaga cccaggatgt
     1021 aacctatgcc cagttgtgca tcaggacaca ggaacagaac aacagctgaa accagcaagc
     1081 agccaacaca gaaagaagac ccagacccca cattccatga atgaaaacta gggattttct
     1141 ggtatttgat cccagtggac tctatttaat taattcaggc catcatgaat acctcatgtg
     1201 ttatcagaag cttctcagaa ttttgggagt atactttatt ctttgttcag agataacaaa
     1261 tgtccttaca ttttgtaaat aaagccaaat cctcctcaat aaacaagtca tctaatgaga
     1321 aacaaatgaa atgagatatt gcgaattgaa tgactgtaac tagggcacac taatcaatga
     1381 aaattgaatt tttaaaacca agaataaatg tataagcaaa gaaaa
//
