LOCUS       NM_013532               1421 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Mus musculus leukocyte immunoglobulin-like receptor, subfamily B,
            member 4A (Lilrb4a), transcript variant 1, mRNA.
ACCESSION   NM_013532
VERSION     NM_013532.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1421)
  AUTHORS   Fu,H., Kong,B., Shuai,W., Zhu,J., Wang,X., Tang,Y., Huang,H. and
            Huang,C.
  TITLE     Leukocyte Ig-like receptor B4 (Lilrb4a) alleviates cardiac
            dysfunction and isoproterenol-induced arrhythmogenic remodeling
            associated with cardiac fibrosis and inflammation
  JOURNAL   Heart Rhythm 21 (10), 1998-2009 (2024)
   PUBMED   38636927
  REMARK    GeneRIF: Leukocyte Ig-like receptor B4 (Lilrb4a) alleviates cardiac
            dysfunction and isoproterenol-induced arrhythmogenic remodeling
            associated with cardiac fibrosis and inflammation.
REFERENCE   2  (bases 1 to 1421)
  AUTHORS   Xiong,J., Ling,J., Yan,J., Duan,Y., Yu,J., Li,W., Yu,W., Gao,J.,
            Xie,D., Liu,Z., Deng,Y. and Liao,Y.
  TITLE     LILRB4 knockdown inhibits aortic dissection development by
            regulating pyroptosis and the JAK2/STAT3 signaling pathway
  JOURNAL   Sci Rep 14 (1), 15564 (2024)
   PUBMED   38971897
  REMARK    GeneRIF: LILRB4 knockdown inhibits aortic dissection development by
            regulating pyroptosis and the JAK2/STAT3 signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1421)
  AUTHORS   Wang,Y., Sun,Y., Deng,S., Liu,J., Yu,J., Chi,H., Han,X., Zhang,Y.,
            Shi,J., Wang,Y., Quan,Y., Li,H. and Xu,J.
  TITLE     Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines
            a class of antibodies to fight solid tumors
  JOURNAL   Cell Rep Med 5 (1), 101374 (2024)
   PUBMED   38232701
  REMARK    GeneRIF: Discovery of galectin-8 as an LILRB4 ligand driving
            M-MDSCs defines a class of antibodies to fight solid tumors.
REFERENCE   4  (bases 1 to 1421)
  AUTHORS   Li,Y., Guo,J., Zhang,H., Li,Z., Ren,Y., Jiang,Y., Liu,X. and Hu,X.
  TITLE     LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6
            pathway during Toxoplasma gondii infection
  JOURNAL   Parasit Vectors 16 (1), 237 (2023)
   PUBMED   37461040
  REMARK    GeneRIF: LILRB4 regulates the function of decidual MDSCs via the
            SHP-2/STAT6 pathway during Toxoplasma gondii infection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1421)
  AUTHORS   Miyamoto,S., Chiba,T., Itoi,S., Su,M.T. and Takai,T.
  TITLE     LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal
            Adhesion Sites on Mast Cells
  JOURNAL   Tohoku J Exp Med 259 (4), 273-284 (2023)
   PUBMED   36642505
  REMARK    GeneRIF: LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at
            Focal Adhesion Sites on Mast Cells.
REFERENCE   6  (bases 1 to 1421)
  AUTHORS   Kuroiwa,A., Yamashita,Y., Inui,M., Yuasa,T., Ono,M., Nagabukuro,A.,
            Matsuda,Y. and Takai,T.
  TITLE     Association of tyrosine phosphatases SHP-1 and SHP-2, inositol
            5-phosphatase SHIP with gp49B1, and chromosomal assignment of the
            gene
  JOURNAL   J Biol Chem 273 (2), 1070-1074 (1998)
   PUBMED   9422771
REFERENCE   7  (bases 1 to 1421)
  AUTHORS   Wang,L.L., Mehta,I.K., LeBlanc,P.A. and Yokoyama,W.M.
  TITLE     Mouse natural killer cells express gp49B1, a structural homologue
            of human killer inhibitory receptors
  JOURNAL   J Immunol 158 (1), 13-17 (1997)
   PUBMED   8977170
REFERENCE   8  (bases 1 to 1421)
  AUTHORS   Rojo,S., Burshtyn,D.N., Long,E.O. and Wagtmann,N.
  TITLE     Type I transmembrane receptor with inhibitory function in mouse
            mast cells and NK cells
  JOURNAL   J Immunol 158 (1), 9-12 (1997)
   PUBMED   8977169
REFERENCE   9  (bases 1 to 1421)
  AUTHORS   Katz,H.R., Vivier,E., Castells,M.C., McCormick,M.J., Chambers,J.M.
            and Austen,K.F.
  TITLE     Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based
            inhibition motifs and suppresses mast cell activation when
            coligated with the high-affinity Fc receptor for IgE
  JOURNAL   Proc Natl Acad Sci U S A 93 (20), 10809-10814 (1996)
   PUBMED   8855262
REFERENCE   10 (bases 1 to 1421)
  AUTHORS   Castells,M.C., Wu,X., Arm,J.P., Austen,K.F. and Katz,H.R.
  TITLE     Cloning of the gp49B gene of the immunoglobulin superfamily and
            demonstration that one of its two products is an early-expressed
            mast cell surface protein originally described as gp49
  JOURNAL   J Biol Chem 269 (11), 8393-8401 (1994)
   PUBMED   8132564
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153530.9.
            
            On Mar 31, 2023 this sequence version replaced NM_013532.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006591.1, SRR5189682.109630.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC153530.9         176814-176891
            79-114              AC153530.9         177037-177072
            115-399             AC153530.9         177274-177558
            400-702             AC153530.9         177701-178003
            703-738             AC153530.9         179010-179045
            739-855             AC153530.9         179902-180018
            856-908             AC153530.9         180633-180685
            909-974             AC153530.9         181834-181899
            975-1421            AC153530.9         182007-182453
FEATURES             Location/Qualifiers
     source          1..1421
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 25.5 cM"
     gene            1..1421
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /note="leukocyte immunoglobulin-like receptor, subfamily
                     B, member 4A"
                     /db_xref="GeneID:14728"
                     /db_xref="MGI:MGI:102701"
     exon            1..78
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1052
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; glycoprotein 49 B; mast cell surface
                     glycoprotein Gp49B; leukocyte immunoglobulin-like
                     receptor, subfamily B, member 4"
                     /codon_start=1
                     /product="leukocyte immunoglobulin-like receptor subfamily
                     B member 4A isoform 1 precursor"
                     /protein_id="NP_038560.1"
                     /db_xref="CCDS:CCDS23832.1"
                     /db_xref="GeneID:14728"
                     /db_xref="MGI:MGI:102701"
                     /translation="MIAMLTVLLYLGLILEPRTAVQAGHLPKPIIWAEPGSVIAAYTS
                     VITWCQGSWEAQYYHLYKEKSVNPWDTQVPLETRNKAKFNIPSMTTSYAGIYKCYYES
                     AAGFSEHSDAMELVMTGAYENPSLSVYPSSNVTSGVSISFSCSSSIVFGRFILIQEGK
                     HGLSWTLDSQHQANQPSYATFVLDAVTPNHNGTFRCYGYFRNEPQVWSKPSNSLDLMI
                     SETKDQSSTPTEDGLETYQKILIGVLVSFLLLFFLLLFLILIGYQYGHKKKANASVKN
                     TQSENNAELNSWNPQNEDPQGIVYAQVKPSRLQKDTACKETQDVTYAQLCIRTQEQNN
                     S"
     exon            79..114
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /inference="alignment:Splign:2.1.0"
     exon            115..399
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /inference="alignment:Splign:2.1.0"
     exon            400..702
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /inference="alignment:Splign:2.1.0"
     exon            703..738
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /inference="alignment:Splign:2.1.0"
     exon            739..855
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /inference="alignment:Splign:2.1.0"
     exon            856..908
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /inference="alignment:Splign:2.1.0"
     exon            909..974
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1421
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1281..1286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /note="hexamer: AATAAA"
     polyA_site      1309
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /note="major polyA site"
     regulatory      1388..1393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /note="hexamer: AATAAA"
     regulatory      1404..1409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /note="hexamer: AAGAAA"
     polyA_site      1409
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
                     /note="major polyA site"
     polyA_site      1421
                     /gene="Lilrb4a"
                     /gene_synonym="CD85K; gp49; Gp49b; HM18; ILT3; Lilrb4;
                     LIR-5"
ORIGIN      
        1 agactggccc aagagaacag ctacgaacat tgcctggact caccatgatc gccatgctca
       61 cagtgctgct ataccttggt cttattctgg aacccaggac tgcagtacag gcaggacacc
      121 tcccaaagcc catcatctgg gctgagccag gctctgtgat cgctgcgtat acatctgtga
      181 ttacctggtg tcagggttcc tgggaggccc agtattatca tctgtataaa gagaaaagtg
      241 taaatccttg ggacactcaa gtccctctgg aaaccaggaa taaggccaag ttcaacattc
      301 caagcatgac aacctcatat gcaggcatat ataagtgtta ctatgagagt gctgctggct
      361 tctcagagca cagtgatgcc atggagctgg tgatgacagg agcatatgaa aatcccagcc
      421 tgtcagtcta tcccagctct aatgtgacct ctggagtttc catatccttt agttgcagct
      481 catccatagt atttggcaga ttcattctga tccaggaagg aaagcatggc ctctcttgga
      541 ccctggactc acagcatcag gccaatcagc catcctatgc tacttttgtt ctggatgctg
      601 ttactcccaa ccacaatgga acattcagat gctatggcta ctttagaaat gaaccacagg
      661 tgtggtcaaa accaagtaac tccctagacc tcatgatctc agaaaccaag gaccagtcct
      721 ctacacccac tgaagatgga ctggaaacat accagaagat tttgattgga gtcctggtgt
      781 cattcctcct gcttttcttc ctcctgcttt ttctcatcct catcggatac cagtatgggc
      841 acaaaaagaa ggctaatgct tctgtgaaga acacacaatc tgagaacaat gcagagctga
      901 acagttggaa cccacaaaat gaagaccccc agggaattgt ctacgcccag gtaaaaccct
      961 ccaggcttca gaaggacact gcatgcaaag agacccagga tgtaacctat gcccagttgt
     1021 gcatcaggac acaggaacag aacaacagct gaaaccagca agcagccaac acagaaagaa
     1081 gacccagacc ccacattcca tgaatgaaaa ctagggattt tctggtattt gatcccagtg
     1141 gactctattt aattaattca ggccatcatg aatacctcat gtgttatcag aagcttctca
     1201 gaattttggg aatatacttt attctttgtt cagagataac aaatgtcatt acattttgta
     1261 aataaagcca aatcctcctc aataaacaat tcatctaatg agaaacaaat gaaatgagat
     1321 attgtgaatt gaaagacaat gtaaccaggg cacactaatc aatgaaactt gaatttttag
     1381 aaccatgaat aaatgtataa gcaaagaaag tgtcttcaaa a
//
