LOCUS       NM_010715               3092 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus ligase I, DNA, ATP-dependent (Lig1), transcript
            variant 2, mRNA.
ACCESSION   NM_010715
VERSION     NM_010715.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3092)
  AUTHORS   Zhou,Z., Yin,H., Suye,S., Ren,Z., Yan,L., Shi,L. and Fu,C.
  TITLE     Fance deficiency inhibits primordial germ cell proliferation
            associated with transcription-replication conflicts accumulate and
            DNA repair defects
  JOURNAL   J Ovarian Res 16 (1), 160 (2023)
   PUBMED   37563658
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3092)
  AUTHORS   Bhandari,S.K., Wiest,N., Sallmyr,A., Du,R., Ferry,L., Defossez,P.A.
            and Tomkinson,A.E.
  TITLE     Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase
            I-deficient cells but abnormal chromatin levels of non-replicative
            histone H1
  JOURNAL   Sci Rep 13 (1), 4363 (2023)
   PUBMED   36928068
  REMARK    GeneRIF: Unchanged PCNA and DNMT1 dynamics during replication in
            DNA ligase I-deficient cells but abnormal chromatin levels of
            non-replicative histone H1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3092)
  AUTHORS   Dickinson,K., Hammond,L., Akpa,M., Chu,L.L., Lalonde,C.T.,
            Goumba,A. and Goodyer,P.
  TITLE     WT1 regulates expression of DNA repair gene Neil3 during
            nephrogenesis
  JOURNAL   Am J Physiol Renal Physiol 324 (3), F245-F255 (2023)
   PUBMED   36546838
REFERENCE   4  (bases 1 to 3092)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3092)
  AUTHORS   Zhou,L., Dai,H., Wu,J., Zhou,M., Yuan,H., Du,J., Yang,L., Wu,X.,
            Xu,H., Hua,Y., Xu,J., Zheng,L. and Shen,B.
  TITLE     Role of FEN1 S187 phosphorylation in counteracting oxygen-induced
            stress and regulating postnatal heart development
  JOURNAL   FASEB J 31 (1), 132-147 (2017)
   PUBMED   27694478
REFERENCE   6  (bases 1 to 3092)
  AUTHORS   Bentley,D., Selfridge,J., Millar,J.K., Samuel,K., Hole,N.,
            Ansell,J.D. and Melton,D.W.
  TITLE     DNA ligase I is required for fetal liver erythropoiesis but is not
            essential for mammalian cell viability
  JOURNAL   Nat Genet 13 (4), 489-491 (1996)
   PUBMED   8696349
REFERENCE   7  (bases 1 to 3092)
  AUTHORS   Perez,M., Rompato,G., Corbi,N., De Gregorio,L., Dragani,T.A. and
            Passananti,C.
  TITLE     Zfp60, a mouse zinc finger gene expressed transiently during in
            vitro muscle differentiation
  JOURNAL   FEBS Lett 387 (2-3), 117-121 (1996)
   PUBMED   8674531
REFERENCE   8  (bases 1 to 3092)
  AUTHORS   Gariboldi,M., Montecucco,A., Columbano,A., Ledda-Columbano,G.M.,
            Savini,E., Manenti,G., Pierotti,M.A. and Dragani,T.A.
  TITLE     Genetic mapping and expression analysis of the murine DNA ligase I
            gene
  JOURNAL   Mol Carcinog 14 (2), 71-74 (1995)
   PUBMED   7576101
REFERENCE   9  (bases 1 to 3092)
  AUTHORS   Jessop,J.K. and Melton,D.W.
  TITLE     Comparison between cDNA clones encoding murine DNA ligase I
  JOURNAL   Gene 160 (2), 307-308 (1995)
   PUBMED   7642116
REFERENCE   10 (bases 1 to 3092)
  AUTHORS   Savini,E., Biamonti,G., Ciarrocchi,G. and Montecucco,A.
  TITLE     Cloning and sequence analysis of a cDNA coding for the murine DNA
            ligase I enzyme
  JOURNAL   Gene 144 (2), 253-257 (1994)
   PUBMED   8039710
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161792.9, AK161793.1 and MG954305.1.
            
            On Dec 5, 2019 this sequence version replaced NM_010715.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028287.1, AK153993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC161792.9         80583-80716
            135-208             AC161792.9         81905-81978
            209-298             AC161792.9         84210-84299
            299-434             AC161792.9         87014-87149
            435-561             AC161792.9         88315-88441
            562-657             AC161792.9         90421-90516
            658-759             AC161792.9         91151-91252
            760-885             AC161792.9         92944-93069
            886-961             AC161792.9         93213-93288
            962-1042            AC161792.9         93896-93976
            1043-1099           AC161792.9         94216-94272
            1100-1272           AC161792.9         97139-97311
            1273-1439           AC161792.9         97985-98151
            1440-1516           AC161792.9         98477-98553
            1517-1608           AC161792.9         100494-100585
            1609-1708           AC161792.9         100797-100896
            1709-1794           AC161792.9         102019-102104
            1795-1910           AC161792.9         102688-102803
            1911-2006           AC161792.9         103141-103236
            2007-2117           AC161792.9         104941-105051
            2118-2189           AC161792.9         105557-105628
            2190-2334           AK161793.1         1348-1492
            2335-2417           MG954305.1         1736-1818
            2418-2470           MG954305.1         3042-3094
            2471-2570           AC161792.9         109329-109428
            2571-2624           AC161792.9         110228-110281
            2625-2768           AC161792.9         110870-111013
            2769-2861           AC161792.9         112766-112858
            2862-3092           AC161792.9         112953-113183
FEATURES             Location/Qualifiers
     source          1..3092
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 7.82 cM"
     gene            1..3092
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /note="ligase I, DNA, ATP-dependent"
                     /db_xref="GeneID:16881"
                     /db_xref="MGI:MGI:101789"
     exon            1..134
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            135..208
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..2942
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /EC_number="6.5.1.1"
                     /note="DNA ligase I; polydeoxyribonucleotide synthase
                     [ATP] 1"
                     /codon_start=1
                     /product="DNA ligase 1"
                     /protein_id="NP_034845.3"
                     /db_xref="GeneID:16881"
                     /db_xref="MGI:MGI:101789"
                     /translation="MQRSIMSFFQPTKEGKAKKPEKETPSSIREKEPPPKVALKERNQ
                     VVPESDSPVKRTGRKVAQVLSCEGEDEDEAPGTPKVQKPVSDSEQSSPPSPDTCPENS
                     PVFNCSSPMDISPSGFPKRRTARKQLPKRTIQDTLEEQNEDKTKTAKKRKKEEETPKE
                     SLAEAEDVKQKEEKEGDQLIVPSEPTKSPESVTLTKTENIPVCKAGVKLKPQEEEQSK
                     PPARGAKTLSSFFTPRKPAVKTEVKQEESGTLRKEETKGTLDPANYNPSKNNYHPIED
                     ACWKHGQKVPFLAVARTFEKIEEVSARLKMVETLSNLLRSVVALSPPDLLPVLYLSLN
                     RLGPPQQGLELGVGDGVLLKAVAQATGRQLESIRAEVAEKGDVGLVAENSRSTQRLML
                     PPPPLTISGVFTKFCDIARLTGSASMAKKMDIIKGLFVACRHSEARYIARSLSGRLRL
                     GLAEQSVLAALAQAVSLTPPGQEFPTAVVDAGKGKTAEARKMWLEEQGMILKQTFCEV
                     PDLDRIIPVLLEHGLERLPEHCKLSPGVPLKPMLAHPTRGVSEVLKRFEEVDFTCEYK
                     YDGQRAQIHVLEGGEVKIFSRNQEDNTGKYPDIISRIPKIKHPSVTSFILDTEAVAWD
                     REKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVRQPLSRRRQLLRE
                     NFVETEGEFVFTTSLDTKDTEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNW
                     LKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLAAYDEESEELQAICKLGTGF
                     SDEELEEHHQSLQALVLPTPRPYVRIDGAVAPDHWLDPSIVWEVKCADLSLSPIYPAA
                     RGLVDKEKGISLRFPRFIRVRKDKQPEQATTSNQVASLYRKQSQIQNQQSSDLDSDVE
                     DY"
     exon            209..298
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            299..434
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            435..561
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            562..657
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            658..759
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            760..885
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            886..961
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1042
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1099
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1272
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1439
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1516
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1608
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1708
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1794
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1910
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2006
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2117
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2189
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2334
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2417
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2570
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2624
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2768
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2861
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..3092
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3069..3074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /note="hexamer: AATAAA"
     polyA_site      3092
                     /gene="Lig1"
                     /gene_synonym="LigI"
                     /note="major polyA site"
ORIGIN      
        1 gtctccgccc cctcccgcca aagtgcgcgc gaaatctgtg tggcgcgaat ttggggattt
       61 cgggtttgcg tctctgagcg agcgagcgag cgagtgagcg agtgtggcgg cgtccggcaa
      121 agtgatttgg agaggtacaa ctgatgagaa aaaaagagca agagaggaaa ggagagactt
      181 ctgctgccaa catgcagaga agtattatgt cattttttca acccacaaaa gaaggtaaag
      241 cgaagaagcc agagaaggag acacccagca gcatcagaga gaaggaaccc cctccaaagg
      301 tggcgctgaa ggagaggaat caagtggtgc ccgagagtga ttctccagtg aagaggacag
      361 gaaggaaggt agcccaggtt ctgagctgtg aaggggagga cgaagatgaa gcccctggca
      421 cccccaaagt ccagaagcct gtgtcagact ctgaacagag ctctcctccc agccctgaca
      481 catgtcctga gaacagtcct gtcttcaact gcagctcccc catggacatc tccccatcag
      541 gattcccaaa gcgtcgaact gcgcggaagc agctccccaa acggacaatt caagacactc
      601 ttgaggagca gaatgaggac aaaaccaaaa cagctaagaa aaggaagaaa gaagaagaga
      661 ccccaaaaga aagcctcgca gaggctgaag acgtaaaaca gaaggaagaa aaggaggggg
      721 accagctcat agtcccctct gagcccacaa agtcccctga gtcagtaacc ctgacaaaga
      781 cagagaacat tccagtgtgt aaggcaggag tgaaactgaa gcctcaggaa gaggaacaga
      841 gcaaacctcc tgctagaggt gccaagacac tgagcagttt cttcacaccc cgaaaaccag
      901 cagtgaaaac tgaagtcaaa caagaagagt caggcactct aaggaaggaa gagaccaagg
      961 gaaccctgga tccagcaaat tataatcctt ccaagaataa ctatcatccc attgaagatg
     1021 cctgctggaa acatggccag aaggtccctt ttctcgccgt ggcccggaca tttgagaaga
     1081 ttgaggaggt ttctgctagg ctcaagatgg tggagacatt gagcaacctg ctgcgctccg
     1141 tggtggccct gtcccctcca gacttgctcc ctgttctcta tctcagcctc aaccgcctcg
     1201 ggccacctca gcagggacta gagctgggtg ttggtgatgg tgtcctcctc aaggccgttg
     1261 cccaggccac aggtcgtcag ctggagtcca tccgggctga ggtagctgag aagggggatg
     1321 tggggctggt ggccgagaac agccgcagca ctcagagact catgctgcct ccacctccac
     1381 ttactatttc tggagtcttc accaaattct gtgacattgc ccggctcact ggcagtgctt
     1441 ccatggccaa gaagatggac attatcaagg gcctttttgt tgcctgccgc cactcagaag
     1501 ccaggtacat tgccaggtcc ctaagcgggc ggctgcgcct tggcctagct gagcagtcgg
     1561 tactggctgc tcttgcccag gctgtgagcc tcacaccccc tggccaagaa tttcccacgg
     1621 cggtggtgga tgctgggaag ggcaagacag cagaggccag aaagatgtgg ttggaagaac
     1681 aaggcatgat cttgaagcag accttctgtg aggttcctga cctggatcga atcatccctg
     1741 tgctgctgga acatggcctg gaacgtctcc cagagcactg caagctgagc ccaggggtcc
     1801 ctcttaaacc aatgctggct catcccactc ggggtgtcag tgaggtccta aaacgctttg
     1861 aggaggtcga cttcacctgt gaatataaat acgatgggca gcgagcacag atacatgttc
     1921 tggaaggtgg agaagtgaag atcttcagca ggaaccagga agacaacaca ggaaagtatc
     1981 ctgacattat cagccgcatc cccaagatta aacacccctc agtcacatct ttcattctgg
     2041 acactgaggc tgtggcctgg gaccgggaaa agaagcagat ccaaccattc caagtactca
     2101 ccacgcgcaa gcgcaaggag gttgatgcat cggagataca ggtgcaagtg tgtctgtatg
     2161 cttttgacct catctacctc aacggagagt ccctggttcg ccagcccctg tctcgacgcc
     2221 ggcagctgct ccgtgagaac ttcgtggaga cagagggtga gtttgtcttc accacctctt
     2281 tggacaccaa ggacaccgag cagattgctg agttcttgga gcagtcagtg aaggactcct
     2341 gtgagggcct gatggtgaag accttggatg ttgatgccac ttatgagatt gccaagaggt
     2401 cacacaactg gctcaagctg aagaaggact accttgacgg tgtgggtgac actctggacc
     2461 ttgtggtgat tggtgcctac ctgggccggg ggaagcgggc tggccggtat ggaggcttcc
     2521 tgttggctgc ctacgatgag gagagtgaag agcttcaggc tatatgcaag ctgggaactg
     2581 gattcagcga tgaggagctg gaggaacacc accagagcct gcaggccctg gtattgccta
     2641 ccccacgccc ctatgtgagg attgatgggg cagtggcccc agaccattgg ctggacccaa
     2701 gcattgtgtg ggaggtgaag tgtgctgatc tttccctgtc ccccatctac cctgctgcac
     2761 ggggcctggt ggacaaagaa aaagggatct ctcttcgttt tcctcggttc attcgtgtcc
     2821 gtaaagacaa gcagccagag caggccacta ccagtaacca ggttgcctct ttgtaccgga
     2881 agcagagtca gattcagaac caacaaagct cagacttgga ctccgacgtt gaagactatt
     2941 aacctcctgc tctcctgggc ctggggtgga ggttgcgaga acatgggcac tgttggattg
     3001 gtggtgttga ttggtgtgtg tggagtcaca ggagtgagat cctggggctg gaatgcttta
     3061 ttttcttcaa taaatgactt cttagatgcc ta
//
