LOCUS       NM_001358593            9876 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus LIF receptor alpha (Lifr), transcript variant 3, mRNA.
ACCESSION   NM_001358593 XM_006519967
VERSION     NM_001358593.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9876)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 9876)
  AUTHORS   Yang,X., Wang,J., Chang,C.Y., Zhou,F., Liu,J., Xu,H., Ibrahim,M.,
            Gomez,M., Guo,G.L., Liu,H., Zong,W.X., Wondisford,F.E., Su,X.,
            White,E., Feng,Z. and Hu,W.
  TITLE     Leukemia inhibitory factor suppresses hepatic de novo lipogenesis
            and induces cachexia in mice
  JOURNAL   Nat Commun 15 (1), 627 (2024)
   PUBMED   38245529
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9876)
  AUTHORS   Liu,T., Wang,Q., Zhou,L., Zhang,P., Mi,L., Qiu,X., Chen,Z.,
            Kuang,H., Li,S. and Lin,J.D.
  TITLE     Intrahepatic paracrine signaling by cardiotrophin-like cytokine
            factor 1 ameliorates diet-induced NASH in mice
  JOURNAL   Hepatology 78 (5), 1478-1491 (2023)
   PUBMED   35950514
  REMARK    GeneRIF: Intrahepatic paracrine signaling by cardiotrophin-like
            cytokine factor 1 ameliorates diet-induced NASH in mice.
REFERENCE   4  (bases 1 to 9876)
  AUTHORS   Li,R., Wang,T., Marquardt,R.M., Lydon,J.P., Wu,S.P. and DeMayo,F.J.
  TITLE     TRIM28 modulates nuclear receptor signaling to regulate uterine
            function
  JOURNAL   Nat Commun 14 (1), 4605 (2023)
   PUBMED   37528140
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9876)
  AUTHORS   Na,E., Allen,E., Baird,L.A., Odom,C.V., Korkmaz,F.T., Shenoy,A.T.,
            Matschulat,A.M., Jones,M.R., Kotton,D.N., Mizgerd,J.P., Varelas,X.,
            Traber,K.E. and Quinton,L.J.
  TITLE     Epithelial LIF signaling limits apoptosis and lung injury during
            bacterial pneumonia
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 322 (4), L550-L563 (2022)
   PUBMED   35137631
REFERENCE   6  (bases 1 to 9876)
  AUTHORS   Li,M., Sendtner,M. and Smith,A.
  TITLE     Essential function of LIF receptor in motor neurons
  JOURNAL   Nature 378 (6558), 724-727 (1995)
   PUBMED   7501019
REFERENCE   7  (bases 1 to 9876)
  AUTHORS   Tomida,M.
  TITLE     Analysis of recombinant soluble mouse D-factor/LIF receptor
  JOURNAL   J Biochem 117 (6), 1228-1231 (1995)
   PUBMED   7490264
REFERENCE   8  (bases 1 to 9876)
  AUTHORS   Harvey,M.B., Leco,K.J., Arcellana-Panlilio,M.Y., Zhang,X.,
            Edwards,D.R. and Schultz,G.A.
  TITLE     Proteinase expression in early mouse embryos is regulated by
            leukaemia inhibitory factor and epidermal growth factor
  JOURNAL   Development 121 (4), 1005-1014 (1995)
   PUBMED   7743917
REFERENCE   9  (bases 1 to 9876)
  AUTHORS   Gearing,D.P., Comeau,M.R., Friend,D.J., Gimpel,S.D., Thut,C.J.,
            McGourty,J., Brasher,K.K., King,J.A., Gillis,S., Mosley,B. et al.
  TITLE     The IL-6 signal transducer, gp130: an oncostatin M receptor and
            affinity converter for the LIF receptor
  JOURNAL   Science 255 (5050), 1434-1437 (1992)
   PUBMED   1542794
REFERENCE   10 (bases 1 to 9876)
  AUTHORS   Gearing,D.P., Thut,C.J., VandeBos,T., Gimpel,S.D., Delaney,P.B.,
            King,J., Price,V., Cosman,D. and Beckmann,M.P.
  TITLE     Leukemia inhibitory factor receptor is structurally related to the
            IL-6 signal transducer, gp130
  JOURNAL   EMBO J 10 (10), 2839-2848 (1991)
   PUBMED   1915266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104553.7 and AC158747.3.
            
            On Dec 2, 2017 this sequence version replaced XM_006519967.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 3 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155524.1, SRR7652917.881284.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AC104553.7         102175-102429
            256-416             AC104553.7         126990-127150
            417-528             AC104553.7         129759-129870
            529-659             AC104553.7         131994-132124
            660-823             AC104553.7         137132-137295
            824-998             AC104553.7         139486-139660
            999-1253            AC104553.7         141615-141869
            1254-1383           AC104553.7         145459-145588
            1384-1553           AC104553.7         145994-146163
            1554-1699           AC104553.7         148163-148308
            1700-1862           AC104553.7         150035-150197
            1863-1933           AC104553.7         150507-150577
            1934-2147           AC104553.7         151402-151615
            2148-2327           AC104553.7         154456-154635
            2328-2429           AC158747.3         145259-145360       c
            2430-2597           AC158747.3         144344-144511       c
            2598-2759           AC158747.3         143050-143211       c
            2760-2853           AC158747.3         141909-142002       c
            2854-2932           AC158747.3         139884-139962       c
            2933-9876           AC158747.3         132588-139531       c
FEATURES             Location/Qualifiers
     source          1..9876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 3.46 cM"
     gene            1..9876
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /note="LIF receptor alpha"
                     /db_xref="GeneID:16880"
                     /db_xref="MGI:MGI:96788"
     exon            1..255
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            256..416
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..3556
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; leukemia inhibitory factor receptor alpha
                     chain; LIF-R; D-factor/LIF receptor; soluble
                     differentiation-stimulating factor receptor"
                     /codon_start=1
                     /product="leukemia inhibitory factor receptor isoform 1
                     precursor"
                     /protein_id="NP_001345522.1"
                     /db_xref="CCDS:CCDS27369.1"
                     /db_xref="GeneID:16880"
                     /db_xref="MGI:MGI:96788"
                     /translation="MAAYSWWRQPSWMVDNKRSRMTPNLPWLLSALTLLHLTMHANGL
                     KRGVQDLKCTTNNMRVWDCTWPAPLGVSPGTVKDICIKDRFHSCHPLETTNVKIPALS
                     PGDHEVTINYLNGFQSKFTLNEKDVSLIPETPEILDLSADFFTSSLLLKWNDRGSALP
                     HPSNATWEIKVLQNPRTEPVALVLLNTMLSGKDTVQHWNWTSDLPLQCATHSVSIRWH
                     IDSPHFSGYKEWSDWSPLKNISWIRNTETNVFPQDKVVLAGSNMTICCMSPTKVLSGQ
                     IGNTLRPLIHLYGQTVAIHILNIPVSENSGTNIIFITDDDVYGTVVFAGYPPDVPQKL
                     SCETHDLKEIICSWNPGRITGLVGPRNTEYTLFESISGKSAVFHRIEGLTNETYRLGV
                     QMHPGQEIHNFTLTGRNPLGQAQSAVVINVTERVAPHDPTSLKVKDINSTVVTFSWYL
                     PGNFTKINLLCQIEICKANSKKEVRNATIRGAEDSTYHVAVDKLNPYTAYTFRVRCSS
                     KTFWKWSRWSDEKRHLTTEATPSKGPDTWREWSSDGKNLIVYWKPLPINEANGKILSY
                     NVSCSLNEETQSVLEIFDPQHRAEIQLSKNDYIISVVARNSAGSSPPSKIASMEIPND
                     DITVEQAVGLGNRIFLTWRHDPNMTCDYVIKWCNSSRSEPCLLDWRKVPSNSTETVIE
                     SDQFQPGVRYNFYLYGCTNQGYQLLRSIIGYVEELAPIVAPNFTVEDTSADSILVKWD
                     DIPVEELRGFLRGYLFYFQKGERDTPKTRSLEPHHSDIKLKNITDISQKTLRIADLQG
                     KTSYHLVLRAYTHGGLGPEKSMFVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRK
                     REWIKETFYPDIPNPENCKALQFQKSVCEGSNALKTLEMNPCTPNNVEVLESRSIVPK
                     IEDTEIISPVAERPGERSEVDPENHVVVSYCPPIIEEEITNPAADEVGGASQVVYIDV
                     QSMYQPQAKAEEEQDVDPVVVAGYKPQMRLPISPAVEDTAAEDEEGKTAGYRPQANVN
                     TWNLVSPDSPRSTDSNNEVVSFGSPCSINSRQFLIPPKDEDSPKSNGGGWSFTNFFQN
                     KPND"
     exon            417..528
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            529..659
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            660..823
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            824..998
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1253
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1383
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1553
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1699
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1862
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1933
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2147
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2327
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2429
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2597
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2759
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..2853
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            2854..2932
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     exon            2933..9876
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9847..9852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /note="hexamer: AATAAA"
     polyA_site      9871
                     /gene="Lifr"
                     /gene_synonym="A230075M04Rik; LIF"
                     /note="major polyA site"
ORIGIN      
        1 gcgccggagc gtctcggcag tggccgcggc cgttatcgtc gcctggcgct gcggtggctc
       61 gcggggttgg gagaaggcag cggcggccgg tcgtcggtgg ccgctagagc cggcctgcaa
      121 ggggacaggg gcgccaggac ggcggctgct accaccggac tgctccttca ggactgcagt
      181 cctgtgctgc agggtccggg ctgccccggg gcggcggccg actgggatgg caagatagcg
      241 gcgcgggagc ggctgggctg actgaacagc aaggacaatg gcagcttact catggtggag
      301 acagccatcg tggatggtag acaataaaag atcgaggatg actccaaacc tgccatggct
      361 cctgtcagct ctgaccctcc tgcatctgac gatgcatgca aacggtctga agagaggggt
      421 acaagacttg aaatgcacaa ccaacaacat gcgagtgtgg gactgcacgt ggccagctcc
      481 cctcggggtc agccctggaa ctgttaaaga tatttgcatt aaagacaggt tccattcttg
      541 tcacccatta gagacaacaa acgttaaaat tccagctctt tcacctggtg atcacgaagt
      601 cacaataaat tatctaaatg gctttcagag taaattcacg ttgaatgaaa aagatgtctc
      661 tttaattcca gagactcccg agatcctgga tttgtctgct gacttcttca cctcctcctt
      721 actactgaag tggaacgaca gagggtctgc tctgcctcac ccctccaatg ccacctggga
      781 gattaaggtt ctacagaatc caaggacgga accagtagca ctcgtgttac tcaacacaat
      841 gctgagtggt aaagataccg ttcagcactg gaactggacc tcagacctgc ccttgcaatg
      901 tgccactcac tcggtgagca ttcgatggca cattgactcg cctcatttct ccggttacaa
      961 agagtggagt gactggagcc cgctgaagaa catctcctgg attcgtaata cagagactaa
     1021 tgtttttcct caagacaaag tggtgctcgc aggctcaaac atgacaattt gttgtatgag
     1081 tccaacgaaa gtgctttcag gacagatcgg caataccctt cgtcctctca tccatctgta
     1141 cgggcaaacc gttgcgatcc atatcctgaa catccccgtt tctgaaaaca gtggcacaaa
     1201 catcattttc atcacagacg acgatgtgta cggaacggtg gtctttgcag gctatcctcc
     1261 cgatgttcct cagaagctga gctgtgagac acatgactta aaagagatta tatgtagctg
     1321 gaatccagga aggataactg gactggtggg cccacgaaat acagaataca ccctgtttga
     1381 aagcatttca ggaaaatcgg cagtatttca caggattgaa ggacttacaa acgagaccta
     1441 ccggttaggc gtgcaaatgc atcccggcca agaaatccat aacttcaccc tgactggtcg
     1501 caatccactg gggcaggcac agtcagcagt ggtcatcaat gtgactgaga gagttgctcc
     1561 tcatgatccg acttcgttga aagtgaagga catcaattca acagttgtta cattttcttg
     1621 gtatttacca ggaaatttta caaagattaa tcttttatgt caaattgaaa tttgtaaagc
     1681 taattccaag aaagaagtga ggaatgccac aatcagagga gccgaggatt caacttacca
     1741 tgttgctgta gacaaattaa atccatacac tgcatacact ttccgggttc gttgttcttc
     1801 caagactttc tggaagtgga gcaggtggag tgatgagaag cgacatctaa ccacagaagc
     1861 cactccttca aagggaccag acacttggag agagtggagt tctgatggaa aaaatctaat
     1921 cgtctactgg aagcctttac ctattaatga agctaatgga aaaatacttt cctacaatgt
     1981 ttcgtgttca ttgaacgagg agacacagtc agttttggag atcttcgatc ctcaacacag
     2041 agcagagata cagcttagta aaaatgacta catcatcagt gtggtggcaa gaaattctgc
     2101 tggctcatca ccaccttcga aaatagctag tatggaaatc ccaaatgacg acatcacagt
     2161 agagcaagcg gtggggctag gaaacaggat cttcctcacc tggcgtcacg accccaacat
     2221 gacttgtgac tacgtaatta aatggtgcaa ctcatctcgg tctgagccct gcctcctgga
     2281 ctggagaaag gttccttcaa acagcacgga gactgtcata gagtctgatc agtttcagcc
     2341 aggagtaaga tacaactttt acctctatgg gtgcactaac cagggatacc aactgttacg
     2401 ttccataatt ggatacgtag aagaactggc tcccattgtc gcgccaaatt tcaccgtgga
     2461 agatacgtcg gcagactcga tattagtgaa atgggacgac atccccgtgg aagagctccg
     2521 aggcttccta agagggtatt tattttactt tcagaaagga gagagagata cgcccaagac
     2581 gaggagcttg gagccacatc attctgacat caagctaaag aacatcactg acatatccca
     2641 gaagacactg aggattgctg accttcaggg taaaaccagt taccatctgg tcctgcgagc
     2701 ctatacacat ggtggtctgg gcccagagaa gagcatgttt gtggtgacca aggaaaactc
     2761 tgtgggattg attattgcca tcctcatccc agtggctgtg gctgtcattg ttggcgtggt
     2821 aacgagcatc ctttgctatc ggaagcgaga atggattaag gaaacattct acccagatat
     2881 tcccaatcca gaaaactgta aggcgctaca gtttcagaag agcgtctgcg agggaagcaa
     2941 tgctcttaag acattggaaa tgaacccctg taccccgaac aacgttgaag tcctggaatc
     3001 tcggtcgata gtccctaaaa tagaagatac agaaataatt tccccagttg ctgagcgtcc
     3061 tggggaaaga tctgaggtgg accctgagaa ccatgtggtc gtgtcttact gcccacccat
     3121 catcgaggag gaaataacga accccgcggc cgatgaagtg ggaggggctt cccaggtcgt
     3181 gtacatcgat gtgcagtcca tgtatcagcc gcaagccaaa gcagaggaag agcaggacgt
     3241 ggatcctgtg gtggtggcag gctataagcc acagatgcgc cttcccatca gccccgctgt
     3301 ggaagacaca gcagcagaag atgaagaggg taagaccgcc ggttacagac ctcaggccaa
     3361 tgtaaacact tggaatttgg tctctccaga ttccccgagg tccacagaca gcaacaacga
     3421 agttgtctct tttggaagtc cgtgctccat caattccagg caattcttga ttcctcctaa
     3481 agacgaagac tctcctaaat ctaatggagg agggtggtcc tttacaaact tcttccagaa
     3541 caaaccaaat gactaaccag gtcacccttt gtcacttcag tctgccatct cagtaagtcc
     3601 tccctgccgc tgtcctggca gcagctgggg catttctgga gggaccctgc aaatgttgat
     3661 agccagggac cttcactctg ggcaagtgac actagaagtg ttaatgtgct tttaatgtat
     3721 cctaaaagcc agagtgcagt gactcagccc tcagccgcgg aaactcaaga gttgaagctg
     3781 tttttgattg agccaaagaa ccctcccaaa ggacctcaag actaaccaac tctgtgtagt
     3841 acatacatgc taaccagatc tcacaaccgt tttctgttgt taatggcttt ctcagcgttg
     3901 tatggtatgg gattgctagt ggatttacag gcaagggaga aaaccttccc aagtcaaaca
     3961 gcgttaattt gcctgacatt tactgcggtc tagaggagaa ccaagcacag atcttaaagc
     4021 cgtggtgatg tctctgtcca cagcatttac aaaagcaaat ctagtttttc atgtagcagc
     4081 agctatctgg cgttctgttt gataaagcgt gctgatttct gtgcctactg tataatggtt
     4141 atcaaacagt tgtctcaggg gtacaaactt ggaaaaagca agtgcgacgc tgaccagtcc
     4201 gaaatggcat cacaccgtcc tgctttctcg gggtgtgaaa acctttcccc tatcatgtag
     4261 cttgcacgac agcttccatt agtatagttg actgccctaa tgttggaaat ctctcgaact
     4321 atgcccaaat tttctctatt tgctttgtgt tatgttatag ggtctgcttc gtaagagcga
     4381 atttatcatt atttacaggt agataattgt aatgagttac tacgtaagat gactactaag
     4441 aaatagctag tggtgtgtgc tgactgcata gctgtgatta gactcagctc tccctgagag
     4501 gataggccat taagcctaac caatagctgg ctgatgatcg ctgaggcttc tcaggagctt
     4561 tccctgctgc tcatgagtct cggcttctcc cccctcaggc agttgggggt ccagagtctc
     4621 agaccttgcc ttcaaatcca taaacttaaa cataaaggga gataacttcc ctttggagca
     4681 gttagtggtt aaactgtaat agaggtcaga aaacttacgg aagtggtagg tcgtggcctg
     4741 tgatggttcc gtcagcagtg aagtggcaga tcctgagcac agcaccctca atacaccctg
     4801 gtctctcatc agcaacgtgt acagggaatg ggattcttag aaaagctgta aaaacctaaa
     4861 atgtatgtca tgtgtttgct ctgcctttgg gtgcatgaca gtttgaaaca ccccaggagt
     4921 agacgacctt tatttgtgtc atctgaagtc ccccaaatct tacagataat ggcttgttct
     4981 tttagttcag attttatctt ttatttttat tttatttttt attttttatt tcttttctga
     5041 cagggtctca ctatgcagcc ctggctttcc tggaactcac tatgtagata aggccagcct
     5101 cagactcaga gatccacctg tttctgtctc ccaacctgga actcactatg tagataaggc
     5161 cggcctcaga ctcagagatc cacctgtttc tgtctcccaa gtgttggtgt gcgtgtcacc
     5221 atgcctggct tcttatttta tcttctaaag aatcatgtga gaaaaaaaat acaggatgac
     5281 aagggacaaa gtcatgatcc tgtttttaac cctaggattc aactacattt tggagctcca
     5341 tgatatagtt agtagctctt agaaattttc agtactgaaa aatattccaa gccagagcca
     5401 acaccaaaga gtttctgtct tccttgtgcc ctctggctcc atcctctacc cagccactct
     5461 aagccctgct gcctcctccc cccacaccac gcccctcccc ttctcccacc ccctcccccc
     5521 ctccccactc cctgaaacat cttactactg ctatgccctg cttggcctct gccttgttcc
     5581 ccagtgaagc ttctcagttt cttattccca tctaattggg atcagagttt gcgaaggtta
     5641 cagctcatca ttccgcacta cgttaatctg ggaacacggg acggtcagga gaaatggact
     5701 cattctgtcc aaaggatgtc cttttggcgt gggtgtccag aatgttggga gtttagagtg
     5761 ctgctcaccc caccctgcct ctcaagtcca ttctcaagga ccactgactg aggtatgcag
     5821 aagcggggca gccctggatt attgtaggag aatgtgacgt aggactaagg ccaaggcagc
     5881 tttttttttt tttttttttt ttccccattg aagtgaatgc agctgcctcc ctgggcagtg
     5941 ttgttacctc tgtgggtgtg tatataggag tagcctaaac aggaagagga caagggagaa
     6001 gcagaccacc actgccatgc ccttaatacc tgtctcatgg tttgggactt tggcaagtgt
     6061 gcactgcggc atcagtgcaa gggtcgttcg tgccttcagt gcaagttggc ctcgtagtgg
     6121 atatactctg acgtcggggg tcactgtgag agaagagcct acaggtgttc ccagctcgaa
     6181 gtggatatac tctgacatca ggggtcactg tgagagaaga gcctacaggt gttcccagct
     6241 cgaagtggat atactctgac gtcaggggtc actgtgagag aaaagcctac aggtgttccc
     6301 agctcttagg aaaaggagag aaactattcc ttcctaagaa gagcccagtc attggccagg
     6361 caactccaga tatctcgacc agaattaggt tcctgtctgt ctgttgaaca gagccacatg
     6421 cacacccttt tgtaagccag tttcattcag atttccctgg tgagacatgg agattgaggg
     6481 tatcataata cttatgagtg gccattttca ataacatcta attaaagaga acattcttaa
     6541 atacttaata ggctttttga gttttacact ccatgaatta gtgcacatgt accttcggaa
     6601 tcttcctgtt ggttgaacct gtggtgtccc ggccttgaga cggcagctct gcatatctgg
     6661 aacgctgggt tgtgtttctg agctgggtga tagaggtgct tttgttcctg cagctggcaa
     6721 cagaagccgc cattcatcgg gaagctcgag ggaggagctg tcagcctcgg tttgcacatt
     6781 agtcttgctt tcgtggttca ggggaactgg aaggattgca ttccgaacac ccagcactgt
     6841 cgcactcaga catgacagta ggaaatcaca gtcttagaag ttcttgcaaa ctgaactctt
     6901 gttagaaagc tctcctgtca cagtaatcct gactgtattt gcatccgtcc cagccctttc
     6961 agtgctcagt atacctaatt tagtgaaagg cttaagaatg cttcctcccg atagaaattt
     7021 gaagtcaatg tcatggtatt ttgcaattca agtacccctt catatgtcaa tatgcagaaa
     7081 gtattatctc aaagtctctt actgcttagg cacttactca gatagaattt gttgtgtttg
     7141 cactaaggta atttctactg tttcctgttt gaaactgggt tgaaatgagc aaaatggcct
     7201 tttaaaggat cccgaaagta caatacttgg catctcaagt gaagtgtggg ggaagggcca
     7261 tcagctgcta atgccaggca cacagtgaga gttctgtgtc tgtattgatg gggtcccttt
     7321 ctagagtgtg acagattccg tggaactgtc ttgaaggatg ggagagatta agatgtgact
     7381 cgcatagata aaaaagaatt gactgaaaga tttggataca ttgtggaaac agccccacag
     7441 tgtgagggaa actgtgaaga ctcatcaggc ctttcactag atgcgccctg tcagcaccct
     7501 attcactgca gagttgtttg cttttgtgtc atgagctatt agcttggaga cccatctgta
     7561 ccaatctggc ttgcgttatg tcaagcagca tgcatgagcg agcttagctg atcactagaa
     7621 gaactcattg tcttggtaag atataccaag gcatttcctt gaattgattt gatactttct
     7681 tgtgaaaaaa agtttcatgc tgtcatacct gtcttacctc agtgtccagg acaaaaaaat
     7741 ttacagaggg ggtgggggtg gggccaagca aaaactgtta atcttttaga cataacccta
     7801 gaatatcctt caaagtgatt tcgcttgaat cgtggattct gcccagtgct attcaccctg
     7861 tttaaacctc ttagtttact agggttgttg gatttttgct ccctttatct taataattac
     7921 atgaccatat tcatgctgat tataatacag aggacttatt tctaaatgga ggcataaatg
     7981 attgtgagca acatttagct gagcactacc aagttttgtt ttgttttgtt ttgtttttcc
     8041 tcttgttaga gtttctgggg ttgtcctctg gcctagaata gccacatgct tctaattatg
     8101 atacgagatt gtgactggat caggctgtcc ttaaccagag tagtacttct tctcctgtat
     8161 tatgaatggc agtttttgtc caaggtgtaa atagaatttg cttaagttaa attctaactg
     8221 tggcatactt ttattataaa taaaccatat ccgattgcac attaaacaag tgtgcaattt
     8281 ttggttgctg gaaccgaata ctttaaaaat gaaaaaaaca tgctgaggat aaaagacagg
     8341 aacattaatg ttagttgatt catatgggcc ttcaagatcg cctttgtata gacaatcaac
     8401 atgaaaagaa atcccgctgt aataggcatt ttgctgtact tatgcctaga atatttggta
     8461 catctaaatt ggctgccttc ctaattttat tctgatttct tacatgcgct tttatttgta
     8521 attattccat ctcaaatggg tagtttcaac tttccgaact agctccaaca tccagtagca
     8581 tatctttaga gatcaaaata tctttaggta gtaatcccat cgtccttaag tcctgagcag
     8641 ctgagccctt tggcaggtgg tcctagaaca aaaggctgaa gggaggtttg cggggcgatg
     8701 ctctcctttg atgcaaacac tttcactgtc ttttccgatt agctcaatta taaacaccca
     8761 gctccttccg cttacgtttc cttctgatgt agtctttgac aaagtatgaa cagcatggtg
     8821 aaggaatgtt gaggaatgaa ccctgtccag ctccttgtga tggggtagat gttaggggat
     8881 accacaggac acagctgcta aaagacattc tctttagagt tgctttaaaa aggttgttct
     8941 ggatagagag atacgctgag tcccagatga taccaactta caggcatgtc caaaggtaaa
     9001 gtaagccatc tgaaaattct cattggtcct aggaaaattt tttaaaattt attttaccag
     9061 atctttcact agcagacagg ccatcagcca tcttccctgt aacactaaga aattaccact
     9121 ttttttcctt tcaaatttgc attacagtgc attactgttt acaagacaca catactgtga
     9181 acagatctaa gtcttcgtct tttgtaaggt ttgtagaatg aatgttgttt taaaagatgg
     9241 tgtcatgtta aatatctcta ggtctctgta aatgctagct cctgtttact aacttttgtt
     9301 tggtcaggtg tgtgtccatg tagctgaaag aagatagaaa ttgctgtttg cataactttc
     9361 ccctgttttg tttcttgcaa aattatcact acagacttgt gttaaatcaa aggatcggtt
     9421 atgatgtgca atacctaaaa tcatgttcag tcctataagg aatcttttca atgctcacac
     9481 acaggacata aaggagattg atgtgtgtgt gtctgcgatt cactccgact caaaagattc
     9541 tgagttgagt atagaataaa acagtactca cggagattga cagcggagac attcccagct
     9601 ttgtgaaatg ttatgtcgct gttaaaacgg gaaatttgaa ccctttatag cataatttca
     9661 gaatttagcg tccatatctt ttgagagaca tgattatcac aagaacatag atgatgtaaa
     9721 tagcctaaga cactgcaaat ataaaactac tatcgcttgg ctgttaatta tataaagatg
     9781 ttaccaatgt ctgtttttaa aacatgcatg tatttaacaa ttttatcata gtattgtcat
     9841 ggaaaaaata aatatatttt cttacatctt acccta
//
