LOCUS       NM_008501               3996 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus leukemia inhibitory factor (Lif), transcript variant
            1, mRNA.
ACCESSION   NM_008501
VERSION     NM_008501.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3996)
  AUTHORS   Zhang,Y., Cong,Y., Du,J., Guo,D., Huang,J., Pan,J., Liang,Y.,
            Zhang,J., Ye,Z., Liu,Y. and Zhou,Y.
  TITLE     Lif-deficiency promote systemic Iron metabolism disorders and
            increases the susceptibility of osteoblasts to ferroptosis
  JOURNAL   Bone 189, 117266 (2024)
   PUBMED   39341481
  REMARK    GeneRIF: Lif-deficiency promote systemic Iron metabolism disorders
            and increases the susceptibility of osteoblasts to ferroptosis.
REFERENCE   2  (bases 1 to 3996)
  AUTHORS   Ou,Y., Fan,L., Wang,X., Xia,H., Cheng,M., Huang,J., Liang,Y.,
            Wang,Y. and Zhou,Y.
  TITLE     Leukemia inhibitory factor protects against experimental
            periodontitis through immuno-modulations of both macrophages and
            periodontal ligament fibroblasts
  JOURNAL   J Periodontol 95 (11), 1073-1085 (2024)
   PUBMED   38488753
REFERENCE   3  (bases 1 to 3996)
  AUTHORS   Alesutan,I., Razazian,M., Luong,T.T.D., Estepa,M., Pitigala,L.,
            Henze,L.A., Obereigner,J., Mitter,G., Zickler,D., Schuchardt,M.,
            Deisl,C., Makridakis,M., Gollmann-Tepekoylu,C., Pasch,A., Cejka,D.,
            Suessner,S., Antlanger,M., Bielesz,B., Muller,M., Vlahou,A.,
            Holfeld,J., Eckardt,K.U. and Voelkl,J.
  TITLE     Augmentative effects of leukemia inhibitory factor reveal a
            critical role for TYK2 signaling in vascular calcification
  JOURNAL   Kidney Int 106 (4), 611-624 (2024)
   PUBMED   39084258
  REMARK    GeneRIF: Augmentative effects of leukemia inhibitory factor reveal
            a critical role for TYK2 signaling in vascular calcification.
REFERENCE   4  (bases 1 to 3996)
  AUTHORS   Gogoi,M., Clark,P.A., Ferreira,A.C.F., Rodriguez Rodriguez,N.,
            Heycock,M., Ko,M., Murphy,J.E., Chen,V., Luan,S.L., Jolin,H.E. and
            McKenzie,A.N.J.
  TITLE     ILC2-derived LIF licences progress from tissue to systemic immunity
  JOURNAL   Nature 632 (8026), 885-892 (2024)
   PUBMED   39112698
  REMARK    GeneRIF: ILC2-derived LIF licences progress from tissue to systemic
            immunity.
REFERENCE   5  (bases 1 to 3996)
  AUTHORS   Sakurai,J., Oka,S., Higuchi,Y., Ohsawa,S. and Fujimori,T.
  TITLE     Effects of blastocyst elongation and implantation chamber formation
            on the alignment of the embryonic axis and uterine axis in mice
  JOURNAL   Front Cell Dev Biol 12, 1421222 (2024)
   PUBMED   38946796
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3996)
  AUTHORS   Stewart,C.L., Kaspar,P., Brunet,L.J., Bhatt,H., Gadi,I., Kontgen,F.
            and Abbondanzo,S.J.
  TITLE     Blastocyst implantation depends on maternal expression of leukaemia
            inhibitory factor
  JOURNAL   Nature 359 (6390), 76-79 (1992)
   PUBMED   1522892
REFERENCE   7  (bases 1 to 3996)
  AUTHORS   Karls,U., Muller,U., Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and
            Harbers,K.
  TITLE     Structure, expression, and chromosome location of the gene for the
            beta subunit of brain-specific Ca2+/calmodulin-dependent protein
            kinase II identified by transgene integration in an embryonic
            lethal mouse mutant
  JOURNAL   Mol Cell Biol 12 (8), 3644-3652 (1992)
   PUBMED   1321343
REFERENCE   8  (bases 1 to 3996)
  AUTHORS   Sakata,T., Iwagami,S., Tsuruta,Y., Yamaguchi,M., Michishita,M.,
            Nagata,K., Takai,Y., Ogata,M., Teraoka,H. and Fujiwara,H.
  TITLE     Constitutive expression of leukemia inhibitory factor (LIF) mRNA
            and production of LIF by a cloned murine thymic stromal cell line
  JOURNAL   Thymus 19 (2), 89-95 (1992)
   PUBMED   1561703
REFERENCE   9  (bases 1 to 3996)
  AUTHORS   Bottorff,D. and Stone,J.C.
  TITLE     The murine leukemia inhibition factor gene (Lif) is located on
            proximal chromosome 11, not chromosome 13
  JOURNAL   Mamm Genome 3 (12), 681-684 (1992)
   PUBMED   1477476
REFERENCE   10 (bases 1 to 3996)
  AUTHORS   Gough,N.M.
  TITLE     Molecular genetics of leukemia inhibitory factor (LIF) and its
            receptor
  JOURNAL   Growth Factors 7 (3), 175-179 (1992)
   PUBMED   1457125
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731658.20.
            
            On Sep 29, 2022 this sequence version replaced NM_008501.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK155959.1, X12810.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849377, SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AL731658.20        15277-15378
            103-223             AL731658.20        24187-24307
            224-405             AL731658.20        25874-26055
            406-3996            AL731658.20        26614-30204
FEATURES             Location/Qualifiers
     source          1..3996
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.94 cM"
     gene            1..3996
                     /gene="Lif"
                     /note="leukemia inhibitory factor"
                     /db_xref="GeneID:16878"
                     /db_xref="MGI:MGI:96787"
     exon            1..102
                     /gene="Lif"
                     /inference="alignment:Splign:2.1.0"
     exon            103..223
                     /gene="Lif"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..816
                     /gene="Lif"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; d factor; differentiation-stimulating factor;
                     myeloid leukaemia inhibitory factor"
                     /codon_start=1
                     /product="leukemia inhibitory factor isoform a precursor"
                     /protein_id="NP_032527.1"
                     /db_xref="CCDS:CCDS24383.1"
                     /db_xref="GeneID:16878"
                     /db_xref="MGI:MGI:96787"
                     /translation="MKVLAAGIVPLLLLVLHWKHGAGSPLPITPVNATCAIRHPCHGN
                     LMNQIKNQLAQLNGSANALFISYYTAQGEPFPNNVEKLCAPNMTDFPSFHGNGTEKTK
                     LVELYRMVAYLSASLTNITRDQKVLNPTAVSLQVKLNATIDVMRGLLSNVLCRLCNKY
                     RVGHVDVPPVPDHSDKEAFQRKKLGCQLLGTYKQVISVVVQAF"
     exon            224..405
                     /gene="Lif"
                     /inference="alignment:Splign:2.1.0"
     exon            406..3996
                     /gene="Lif"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3974..3979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lif"
                     /note="hexamer: AATAAA"
     polyA_site      3996
                     /gene="Lif"
                     /note="major polyA site"
ORIGIN      
        1 agaggagcct caggaggaga gggaagcaga ggggcccaac aacgatggtg tcaccctgaa
       61 gactggacaa ctgtgcagac tgtggagggc tgcgagacca cggctccagt atataaatca
      121 ggcaaattcc ccatttgagc atgaacttct gaaaacggcc tgcatctaag gtctcctcca
      181 aggccctctg gagtccagcc cataatgaag gtcttggccg cagggattgt gcccttactg
      241 ctgctggttc tgcactggaa acacggggca gggagccctc ttcccatcac ccctgtaaat
      301 gccacctgtg ccatacgcca cccatgccac ggcaacctca tgaaccagat caagaatcaa
      361 ctggcacagc tcaatggcag cgccaatgct ctcttcattt cctattacac agctcaaggg
      421 gagccgtttc ccaacaacgt ggaaaagcta tgtgcgccta acatgacaga cttcccatct
      481 ttccatggca acgggacaga gaagaccaag ttggtggagc tgtatcggat ggtcgcatac
      541 ctgagcgcct ccctgaccaa tatcacccgg gaccagaagg tcctgaaccc cactgccgtg
      601 agcctccagg tcaagctcaa tgctactata gacgtcatga ggggcctcct cagcaatgtg
      661 ctttgccgtc tgtgcaacaa gtaccgtgtg ggccacgtgg atgtgccacc tgtccccgac
      721 cactctgaca aagaagcctt ccaaaggaaa aagttgggtt gccagcttct ggggacatac
      781 aagcaagtca taagtgtggt ggtccaggcc ttctagagag gaggtcttga atgtaccatg
      841 gactgaggga cctcaggagc aggatccgga ggtggggagg gggctcaaaa tgtgctgggg
      901 tttgggacat tgttaaatgc aaaacggggc tgctggcaga ccccagggat ttccaggtac
      961 tcactgcact ctgggctggg ccatgatgga atctggcaaa gttgaaactt ccataggcag
     1021 agcttctata cagcccagca ccagctagaa atggcaatga gggtgttggt ctgagagatt
     1081 tctgtctcac tcactcactc actcactctc actcactcac tcactcactc actcagcccc
     1141 ttgcttgctg ggtgtatgaa caagctgcac aagttgtcta cagcagacag caaagggctg
     1201 ggaagtgtcc tagaccccta cagagtcacc atcatctggt cctttgctgt ctctcagaga
     1261 aactttggaa ggcttggttg ggatgtgaga gagctaaggg gactgggatc cagaaggaat
     1321 ccttttattt tattttattt tattttattt tattttattt tataagtttt gtgggtggaa
     1381 gggtaccctg gggtggaatg atggaatgtg tcttctcttg agttggatga gagagttcag
     1441 gcttagagac tgtcagatgg aagagtctag gtcaccagtg ttcaggctcc cacagaagca
     1501 cagcggccag cttccagttg tcaaagcctg acgaactcgg ttagcttcta tgcagttccc
     1561 cccacagcct ggcgtggttg gggtctgcca gctggaccta gaggtgaggt gtgtgcaggc
     1621 aggaagaggc aggctgcaaa ggcaggttcc cagagtcctc ccggggaagg acctctaact
     1681 gtctaggagt cagggaagga gcaaggcagc cagccattgc tgaggcagta gccgactgca
     1741 gctctcatct gcttctcaac ccctgagaac aggtgatctt gagcagacag acaggtagca
     1801 taaagtagaa tgtcgggtct gaggccccgg aggtcgcaaa ggtacttgaa ggggaccaga
     1861 gggctgtctt gggtccctgg agcatggaga agcagaactt gaggtcaggg tctcagggaa
     1921 gatgaggccc agagtgctgt gtttgatcca gcacagctgt ctatttatta ctatgtccta
     1981 tttatattaa cttattggtg ctttaaatgg caaagttaat tccccgaaat ggtatgaggc
     2041 tccttccatg ggagctgggg ccgagactct ccacctagtg gggcctggtc tggaggcaca
     2101 tgattgttac aggtgcagct catgggtcaa atcagagagc tggctagctc ctctgtctcc
     2161 cactgtgact cacttttagg gtgtcagggt cccccagaaa aagctgggcc agtttgtctc
     2221 tctgcttctg tctctgtctc tccgagtctg tctctgtctg tctctgtgtc tctgtctctt
     2281 tgtctctctc tgtctctgtc tctctctctc tctccccgcc cccccccctt ctccctctgg
     2341 tctccaaggg ggtggaacag tttcttgttg ttttgtccca ctgagctctc tggcaccccc
     2401 tagattcctg ctatgcggtg caccattcat aatgaagtga atggctctgg aaccttgggc
     2461 aaaactgatt ccttcctcaa atcgtagctg aggagtgctg aaacatcctg acccggcacc
     2521 cagcgtgctt tcgaccagca tggaagctcc tcgggtggcc cgaacaccca cagagggtga
     2581 atacaggagg ttggagcagt gcaggccctg aactgggcct gaacagctgc ccagtgcgcc
     2641 agagaagggg agatcaaggc ccgagacgcc tgggacacag accaggaagc tgtggtcctt
     2701 gcttcatcgc tgccttccca ctcccgccca tgtctgggct cccaggcagg gaatccgatc
     2761 tgatctctcc tttgtgctga ggccaggcaa gcagaggaac gccctcgatc tgggagcagg
     2821 gtagggagga aggcagccaa gctggggcag tggctgacta cagagctagc tgcctgcctc
     2881 tcaggctctg aacagggcgg tccttagcag ttcagcagtg ggattctgct tcacgcggtt
     2941 ttgcaccttt ctctgtcact ctctaagcac tttacctgga cggcaggtgg acaggccctg
     3001 gagctctggc ttaggaaagg cctggaacca tagatgcagc aaggagacta tggtgggggc
     3061 cacgcgtgtc agcgacaaag ttactccacc gtactcctgt tgctgcgtca ggctcatctc
     3121 aggactggct gcccttctcc aagctgagag tcaatttgtc taaaagccaa gatgatgcca
     3181 cagcctgggg cctgttgggc tttgtcatca cttcacattt gtatggactt ggactctctg
     3241 ggctccgccc acctggcagc tttgaaggct cagggaccaa tggactctct ccgtgcacgc
     3301 ccccgtcccc ccaacgcaac cacctacctg cgtcttactc catcagttgc ccagcatccc
     3361 agaaccattg agcctttggg gaaaacagac tttaggggca ggtagttgct cacctgacat
     3421 ctttcacctg gaagcattga cttccaccga gcatagtagg tagtgtgtct ggaccagaga
     3481 aaaagggatg gggcattttg cagtttatcc agagagaagc aaaggggcct ttatttatta
     3541 tttaaaactt caaacctgaa agcactgaga gtttactggt ctgcccccct ccccccactc
     3601 ttgtctattt ctgtgtcctt gatcccgact caagcaaccc agctctgctt tgcctgctct
     3661 ctggagcaga catggtatgt gggccaggac cccggagtct tgcatggtag cggcttcaga
     3721 agggaaatga tatggctgtc tgcattcgga tgactcccca gtcccagccc agcctctcct
     3781 ttgcactgct gctctccctc tttcctttcc tttggaaggg acttggcctt gggtgacaaa
     3841 ttcctctttg atgaatgtac cctgtgggaa tgtttcatac tgacagatta tttttattta
     3901 ttcaatgtca tatttaaaat atttattttt tatactgaag gagtgtcttt tttttttaaa
     3961 gaaaaaatga aataataaag aactcattct tgttga
//
