LOCUS       NM_010713               1971 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus LIM homeobox protein 8 (Lhx8), transcript variant 1,
            mRNA.
ACCESSION   NM_010713
VERSION     NM_010713.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1971)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   2  (bases 1 to 1971)
  AUTHORS   Biswas,S., Chan,C.S., Rubenstein,J.L.R. and Gan,L.
  TITLE     The transcription regulator Lmo3 is required for the development of
            medial ganglionic eminence derived neurons in the external globus
            pallidus
  JOURNAL   Dev Biol 503, 10-24 (2023)
   PUBMED   37532091
REFERENCE   3  (bases 1 to 1971)
  AUTHORS   Ahmed,N.Y., Knowles,R., Liu,L., Yan,Y., Li,X., Schumann,U.,
            Wang,Y., Sontani,Y., Reynolds,N., Natoli,R., Wen,J., Del Pino,I.,
            Mi,D. and Dehorter,N.
  TITLE     Developmental deficits of MGE-derived interneurons in the Cntnap2
            knockout mouse model of autism spectrum disorder
  JOURNAL   Front Cell Dev Biol 11, 1112062 (2023)
   PUBMED   36819097
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1971)
  AUTHORS   Asgarian,Z., Oliveira,M.G., Stryjewska,A., Maragkos,I., Rubin,A.N.,
            Magno,L., Pachnis,V., Ghorbani,M., Hiebert,S.W., Denaxa,M. and
            Kessaris,N.
  TITLE     MTG8 interacts with LHX6 to specify cortical interneuron subtype
            identity
  JOURNAL   Nat Commun 13 (1), 5217 (2022)
   PUBMED   36064547
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1971)
  AUTHORS   Zhao,L., Song,W. and Chen,Y.G.
  TITLE     Mesenchymal-epithelial interaction regulates gastrointestinal tract
            development in mouse embryos
  JOURNAL   Cell Rep 40 (2), 111053 (2022)
   PUBMED   35830795
REFERENCE   6  (bases 1 to 1971)
  AUTHORS   Grigoriou,M., Tucker,A.S., Sharpe,P.T. and Pachnis,V.
  TITLE     Expression and regulation of Lhx6 and Lhx7, a novel subfamily of
            LIM homeodomain encoding genes, suggests a role in mammalian head
            development
  JOURNAL   Development 125 (11), 2063-2074 (1998)
   PUBMED   9570771
REFERENCE   7  (bases 1 to 1971)
  AUTHORS   Kitanaka,J., Takemura,M., Matsumoto,K., Mori,T. and Wanaka,A.
  TITLE     Structure and chromosomal localization of a murine LIM/homeobox
            gene, Lhx8
  JOURNAL   Genomics 49 (2), 307-309 (1998)
   PUBMED   9598319
REFERENCE   8  (bases 1 to 1971)
  AUTHORS   Wanaka,A., Matsumoto,K., Kashihara,Y., Furuyama,T., Tanaka,T.,
            Mori,T., Tanno,Y., Yokoya,S., Kitanaka,J., Takemura,M. and
            Tohyama,M.
  TITLE     LIM-homeodomain gene family in neural development
  JOURNAL   Dev Neurosci 19 (1), 97-100 (1997)
   PUBMED   9078439
REFERENCE   9  (bases 1 to 1971)
  AUTHORS   Matsumoto,K., Tanaka,T., Furuyama,T., Kashihara,Y., Ishii,N.,
            Tohyama,M., Kitanaka,J., Takemura,M., Mori,T. and Wanaka,A.
  TITLE     Differential expression of LIM-homeodomain genes in the embryonic
            murine brain
  JOURNAL   Neurosci Lett 211 (3), 147-150 (1996)
   PUBMED   8817562
REFERENCE   10 (bases 1 to 1971)
  AUTHORS   Matsumoto,K., Tanaka,T., Furuyama,T., Kashihara,Y., Mori,T.,
            Ishii,N., Kitanaka,J., Takemura,M., Tohyama,M. and Wanaka,A.
  TITLE     L3, a novel murine LIM-homeodomain transcription factor expressed
            in the ventral telencephalon and the mesenchyme surrounding the
            oral cavity
  JOURNAL   Neurosci Lett 204 (1-2), 113-116 (1996)
   PUBMED   8929991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119163.23.
            
            On Jul 27, 2022 this sequence version replaced NM_010713.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165733.1, D49658.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               AC119163.23        3702-3983
            283-369             AC119163.23        5814-5900
            370-531             AC119163.23        6089-6250
            532-653             AC119163.23        9592-9713
            654-874             AC119163.23        11794-12014
            875-978             AC119163.23        12525-12628
            979-1074            AC119163.23        17417-17512
            1075-1258           AC119163.23        22532-22715
            1259-1971           AC119163.23        27250-27962
FEATURES             Location/Qualifiers
     source          1..1971
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 79.12 cM"
     gene            1..1971
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /note="LIM homeobox protein 8"
                     /db_xref="GeneID:16875"
                     /db_xref="MGI:MGI:1096343"
     exon            1..282
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1305
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     LIM/homeobox protein Lhx8; LIM homeobox protein 7;
                     LIM/homeobox protein Lhx7; LIM homeo box protein 8"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx8 isoform 1"
                     /protein_id="NP_034843.2"
                     /db_xref="CCDS:CCDS17926.1"
                     /db_xref="GeneID:16875"
                     /db_xref="MGI:MGI:1096343"
                     /translation="MYWKSDQMFVCKLEGKEVPELAVPREKCPGLMSEECGRPAALAA
                     GRTRKGAGEEGLVNPEGAGDEDSCSSSAPLSPSSSPQSMASGSVCPPGKCVCSSCGLE
                     IVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRC
                     GRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHFDCMLDNL
                     KREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTL
                     QKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSAPVTAVPSSRLSPPMLEEMAYS
                     AYVPQDGTMLTALHSYMDAHQQLLDSSPCYPIQ"
     exon            283..369
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            370..531
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            532..653
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            654..874
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            875..978
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1074
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1258
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1971
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1946..1951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /note="hexamer: ATTAAA"
     polyA_site      1971
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /note="major polyA site"
ORIGIN      
        1 agtgtggctg agagaggaag aacagtgggt cagagagtgg ttacggtcac tgtggccttt
       61 ttggaacaag acacactggt ggcatcgctg ttctgcctgt tagctttcct tggcctttgg
      121 gggcggagga ggggacactg cggacaccca cagcctctga ccctctggag ctggtatgtg
      181 acgagcagcg cctgcggggc catgtattgg aagagcgatc agatgtttgt gtgtaagctg
      241 gagggaaagg aagtgccgga gctggcggtt ccccgcgaga agtgccccgg gctcatgtcg
      301 gaggagtgcg ggcggcctgc agccctggcg gccgggagga cccgcaaagg cgctggggaa
      361 gaaggactgg tgaatcccga gggagccggg gacgaggact cctgctcctc ctcggccccg
      421 ctttccccgt cgtcctcgcc ccagtccatg gcctcgggct ccgtgtgccc gccaggcaag
      481 tgtgtgtgca gcagctgcgg cctggagatt gtggacaaat acctcctcaa ggtgaatgac
      541 ttatgctggc atgtccgctg tctctcctgc agtgtctgca gaacgtccct gggaaggcac
      601 acgagctgct acattaagga taaagacatt ttctgtaaac tcgattactt cagacggtat
      661 gggacccgct gttcccgctg tggcaggcac atccactcga ctgactgggt ccgcagggcc
      721 aagggcaacg tgtatcacct ggcctgcttt gcctgctttt cttgcaagag gcagctgtcc
      781 acgggagagg agttcgcctt ggtggaggag aaggtcctct gtagagtgca ctttgactgc
      841 atgctggaca atctgaagag agaagtggag aacggtaatg ggattagtgt ggaaggagcc
      901 cttctcacag agcaagacgt caatcatcca aagccagcca aaagagctcg gaccagcttc
      961 acagccgatc agctccaggt tatgcaagca cagttcgctc aggacaacaa cccagatgca
     1021 cagaccctcc agaaactggc agaaaggaca ggcttaagca gacgtgtcat acaggtgtgg
     1081 tttcagaact gcagggcccg ccataagaaa cacgtcagtc ccaaccattc ttcctcagcc
     1141 cccgtcacag ctgtcccctc ctccaggctg tccccaccca tgttggaaga aatggcttat
     1201 tctgcctacg taccccagga tgggacgatg ctgactgcgc tgcactcata catggatgct
     1261 caccaacaac tcctggactc cagcccttgt taccccatcc aatgacccag ctgccaataa
     1321 gtcataccta attccttctt tcagggatag aaatgattga ggttataaac ttgtcattta
     1381 ttatgtataa aataccattg agaagatatt aatgttaatt ttttatttaa cactcaaagc
     1441 atttcgaaca tcctctcgct gcccaggtat gtatctagag ttggcctgca agacactttt
     1501 attgattctt cattttggtt tttttttgta aaacttatgt ttacaaagaa gaaaacaagt
     1561 caaaacattt ttttttgtat tgtctggaga tagttggctc gagtgtgtgt ctattaactt
     1621 atttgtcacc aaaagagcac tttgcctgaa aggcaggact gatcgtgtgc aaaacgttta
     1681 caatcctttg tgaaactgta gtttatcatt agtttgtacc tgtaagttat tgttataaat
     1741 attatctgta ttttttgtca tatacaactt tataccttga agcttgtatc tgtgaatttg
     1801 caactgaaat ttattttgcc agtgttttcg ggacaagctg aaggcacgtc cgttgtagca
     1861 tgccgcgcac acccacgggg tgcctgcact tggagttcta gctgtaaata acactctagt
     1921 ttacaaagcc taccatccta agttcattaa acactttgca tccttgtgaa a
//
