LOCUS       NM_001410061            1902 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus LIM homeobox protein 8 (Lhx8), transcript variant 3,
            mRNA.
ACCESSION   NM_001410061 XM_036162912
VERSION     NM_001410061.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1902)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   2  (bases 1 to 1902)
  AUTHORS   Biswas,S., Chan,C.S., Rubenstein,J.L.R. and Gan,L.
  TITLE     The transcription regulator Lmo3 is required for the development of
            medial ganglionic eminence derived neurons in the external globus
            pallidus
  JOURNAL   Dev Biol 503, 10-24 (2023)
   PUBMED   37532091
REFERENCE   3  (bases 1 to 1902)
  AUTHORS   Ahmed,N.Y., Knowles,R., Liu,L., Yan,Y., Li,X., Schumann,U.,
            Wang,Y., Sontani,Y., Reynolds,N., Natoli,R., Wen,J., Del Pino,I.,
            Mi,D. and Dehorter,N.
  TITLE     Developmental deficits of MGE-derived interneurons in the Cntnap2
            knockout mouse model of autism spectrum disorder
  JOURNAL   Front Cell Dev Biol 11, 1112062 (2023)
   PUBMED   36819097
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1902)
  AUTHORS   Asgarian,Z., Oliveira,M.G., Stryjewska,A., Maragkos,I., Rubin,A.N.,
            Magno,L., Pachnis,V., Ghorbani,M., Hiebert,S.W., Denaxa,M. and
            Kessaris,N.
  TITLE     MTG8 interacts with LHX6 to specify cortical interneuron subtype
            identity
  JOURNAL   Nat Commun 13 (1), 5217 (2022)
   PUBMED   36064547
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1902)
  AUTHORS   Zhao,L., Song,W. and Chen,Y.G.
  TITLE     Mesenchymal-epithelial interaction regulates gastrointestinal tract
            development in mouse embryos
  JOURNAL   Cell Rep 40 (2), 111053 (2022)
   PUBMED   35830795
REFERENCE   6  (bases 1 to 1902)
  AUTHORS   Grigoriou,M., Tucker,A.S., Sharpe,P.T. and Pachnis,V.
  TITLE     Expression and regulation of Lhx6 and Lhx7, a novel subfamily of
            LIM homeodomain encoding genes, suggests a role in mammalian head
            development
  JOURNAL   Development 125 (11), 2063-2074 (1998)
   PUBMED   9570771
REFERENCE   7  (bases 1 to 1902)
  AUTHORS   Kitanaka,J., Takemura,M., Matsumoto,K., Mori,T. and Wanaka,A.
  TITLE     Structure and chromosomal localization of a murine LIM/homeobox
            gene, Lhx8
  JOURNAL   Genomics 49 (2), 307-309 (1998)
   PUBMED   9598319
REFERENCE   8  (bases 1 to 1902)
  AUTHORS   Wanaka,A., Matsumoto,K., Kashihara,Y., Furuyama,T., Tanaka,T.,
            Mori,T., Tanno,Y., Yokoya,S., Kitanaka,J., Takemura,M. and
            Tohyama,M.
  TITLE     LIM-homeodomain gene family in neural development
  JOURNAL   Dev Neurosci 19 (1), 97-100 (1997)
   PUBMED   9078439
REFERENCE   9  (bases 1 to 1902)
  AUTHORS   Matsumoto,K., Tanaka,T., Furuyama,T., Kashihara,Y., Ishii,N.,
            Tohyama,M., Kitanaka,J., Takemura,M., Mori,T. and Wanaka,A.
  TITLE     Differential expression of LIM-homeodomain genes in the embryonic
            murine brain
  JOURNAL   Neurosci Lett 211 (3), 147-150 (1996)
   PUBMED   8817562
REFERENCE   10 (bases 1 to 1902)
  AUTHORS   Matsumoto,K., Tanaka,T., Furuyama,T., Kashihara,Y., Mori,T.,
            Ishii,N., Kitanaka,J., Takemura,M., Tohyama,M. and Wanaka,A.
  TITLE     L3, a novel murine LIM-homeodomain transcription factor expressed
            in the ventral telencephalon and the mesenchyme surrounding the
            oral cavity
  JOURNAL   Neurosci Lett 204 (1-2), 113-116 (1996)
   PUBMED   8929991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119163.23.
            
            On Jul 27, 2022 this sequence version replaced XM_036162912.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662774.4213780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               AC119163.23        5601-5900
            301-462             AC119163.23        6089-6250
            463-584             AC119163.23        9592-9713
            585-805             AC119163.23        11794-12014
            806-909             AC119163.23        12525-12628
            910-1005            AC119163.23        17417-17512
            1006-1189           AC119163.23        22532-22715
            1190-1902           AC119163.23        27250-27962
FEATURES             Location/Qualifiers
     source          1..1902
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 79.12 cM"
     gene            1..1902
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /note="LIM homeobox protein 8"
                     /db_xref="GeneID:16875"
                     /db_xref="MGI:MGI:1096343"
     exon            1..300
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1236
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /note="isoform 2 is encoded by transcript variant 3;
                     LIM/homeobox protein Lhx8; LIM homeobox protein 7;
                     LIM/homeobox protein Lhx7; LIM homeo box protein 8"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx8 isoform 2"
                     /protein_id="NP_001396990.1"
                     /db_xref="GeneID:16875"
                     /db_xref="MGI:MGI:1096343"
                     /translation="MSEECGRPAALAAGRTRKGAGEEGLVNPEGAGDEDSCSSSAPLS
                     PSSSPQSMASGSVCPPGKCVCSSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRH
                     TSCYIKDKDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQ
                     LSTGEEFALVEEKVLCRVHFDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRA
                     RTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSP
                     NHSSSAPVTAVPSSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHQQLLDSSPCYP
                     IQ"
     exon            301..462
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            463..584
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            585..805
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            806..909
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1005
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1189
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1902
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1877..1882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /note="hexamer: ATTAAA"
     polyA_site      1902
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcctcg agtcgcccgc tggcggcggc ggcccaggga ggctgcgcgc tggccggcca
       61 gctgcgcccg ggctcaggtg ccggcgctcg cacgcgccgc cctcgtgcgc gcccttcaag
      121 agcgcggtgg ggcccgggct gcggggcgcc gcgtgctcgc cgcgggctcc tgaccgctgt
      181 ctccctccct gccttcccgc tctcgcggcg cagtgccccg ggctcatgtc ggaggagtgc
      241 gggcggcctg cagccctggc ggccgggagg acccgcaaag gcgctgggga agaaggactg
      301 gtgaatcccg agggagccgg ggacgaggac tcctgctcct cctcggcccc gctttccccg
      361 tcgtcctcgc cccagtccat ggcctcgggc tccgtgtgcc cgccaggcaa gtgtgtgtgc
      421 agcagctgcg gcctggagat tgtggacaaa tacctcctca aggtgaatga cttatgctgg
      481 catgtccgct gtctctcctg cagtgtctgc agaacgtccc tgggaaggca cacgagctgc
      541 tacattaagg ataaagacat tttctgtaaa ctcgattact tcagacggta tgggacccgc
      601 tgttcccgct gtggcaggca catccactcg actgactggg tccgcagggc caagggcaac
      661 gtgtatcacc tggcctgctt tgcctgcttt tcttgcaaga ggcagctgtc cacgggagag
      721 gagttcgcct tggtggagga gaaggtcctc tgtagagtgc actttgactg catgctggac
      781 aatctgaaga gagaagtgga gaacggtaat gggattagtg tggaaggagc ccttctcaca
      841 gagcaagacg tcaatcatcc aaagccagcc aaaagagctc ggaccagctt cacagccgat
      901 cagctccagg ttatgcaagc acagttcgct caggacaaca acccagatgc acagaccctc
      961 cagaaactgg cagaaaggac aggcttaagc agacgtgtca tacaggtgtg gtttcagaac
     1021 tgcagggccc gccataagaa acacgtcagt cccaaccatt cttcctcagc ccccgtcaca
     1081 gctgtcccct cctccaggct gtccccaccc atgttggaag aaatggctta ttctgcctac
     1141 gtaccccagg atgggacgat gctgactgcg ctgcactcat acatggatgc tcaccaacaa
     1201 ctcctggact ccagcccttg ttaccccatc caatgaccca gctgccaata agtcatacct
     1261 aattccttct ttcagggata gaaatgattg aggttataaa cttgtcattt attatgtata
     1321 aaataccatt gagaagatat taatgttaat tttttattta acactcaaag catttcgaac
     1381 atcctctcgc tgcccaggta tgtatctaga gttggcctgc aagacacttt tattgattct
     1441 tcattttggt ttttttttgt aaaacttatg tttacaaaga agaaaacaag tcaaaacatt
     1501 tttttttgta ttgtctggag atagttggct cgagtgtgtg tctattaact tatttgtcac
     1561 caaaagagca ctttgcctga aaggcaggac tgatcgtgtg caaaacgttt acaatccttt
     1621 gtgaaactgt agtttatcat tagtttgtac ctgtaagtta ttgttataaa tattatctgt
     1681 attttttgtc atatacaact ttataccttg aagcttgtat ctgtgaattt gcaactgaaa
     1741 tttattttgc cagtgttttc gggacaagct gaaggcacgt ccgttgtagc atgccgcgca
     1801 cacccacggg gtgcctgcac ttggagttct agctgtaaat aacactctag tttacaaagc
     1861 ctaccatcct aagttcatta aacactttgc atccttgtga aa
//
