LOCUS       NM_001410060            1759 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus LIM homeobox protein 8 (Lhx8), transcript variant 2,
            mRNA.
ACCESSION   NM_001410060
VERSION     NM_001410060.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1759)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   2  (bases 1 to 1759)
  AUTHORS   Biswas,S., Chan,C.S., Rubenstein,J.L.R. and Gan,L.
  TITLE     The transcription regulator Lmo3 is required for the development of
            medial ganglionic eminence derived neurons in the external globus
            pallidus
  JOURNAL   Dev Biol 503, 10-24 (2023)
   PUBMED   37532091
REFERENCE   3  (bases 1 to 1759)
  AUTHORS   Ahmed,N.Y., Knowles,R., Liu,L., Yan,Y., Li,X., Schumann,U.,
            Wang,Y., Sontani,Y., Reynolds,N., Natoli,R., Wen,J., Del Pino,I.,
            Mi,D. and Dehorter,N.
  TITLE     Developmental deficits of MGE-derived interneurons in the Cntnap2
            knockout mouse model of autism spectrum disorder
  JOURNAL   Front Cell Dev Biol 11, 1112062 (2023)
   PUBMED   36819097
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1759)
  AUTHORS   Asgarian,Z., Oliveira,M.G., Stryjewska,A., Maragkos,I., Rubin,A.N.,
            Magno,L., Pachnis,V., Ghorbani,M., Hiebert,S.W., Denaxa,M. and
            Kessaris,N.
  TITLE     MTG8 interacts with LHX6 to specify cortical interneuron subtype
            identity
  JOURNAL   Nat Commun 13 (1), 5217 (2022)
   PUBMED   36064547
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1759)
  AUTHORS   Zhao,L., Song,W. and Chen,Y.G.
  TITLE     Mesenchymal-epithelial interaction regulates gastrointestinal tract
            development in mouse embryos
  JOURNAL   Cell Rep 40 (2), 111053 (2022)
   PUBMED   35830795
REFERENCE   6  (bases 1 to 1759)
  AUTHORS   Grigoriou,M., Tucker,A.S., Sharpe,P.T. and Pachnis,V.
  TITLE     Expression and regulation of Lhx6 and Lhx7, a novel subfamily of
            LIM homeodomain encoding genes, suggests a role in mammalian head
            development
  JOURNAL   Development 125 (11), 2063-2074 (1998)
   PUBMED   9570771
REFERENCE   7  (bases 1 to 1759)
  AUTHORS   Kitanaka,J., Takemura,M., Matsumoto,K., Mori,T. and Wanaka,A.
  TITLE     Structure and chromosomal localization of a murine LIM/homeobox
            gene, Lhx8
  JOURNAL   Genomics 49 (2), 307-309 (1998)
   PUBMED   9598319
REFERENCE   8  (bases 1 to 1759)
  AUTHORS   Wanaka,A., Matsumoto,K., Kashihara,Y., Furuyama,T., Tanaka,T.,
            Mori,T., Tanno,Y., Yokoya,S., Kitanaka,J., Takemura,M. and
            Tohyama,M.
  TITLE     LIM-homeodomain gene family in neural development
  JOURNAL   Dev Neurosci 19 (1), 97-100 (1997)
   PUBMED   9078439
REFERENCE   9  (bases 1 to 1759)
  AUTHORS   Matsumoto,K., Tanaka,T., Furuyama,T., Kashihara,Y., Ishii,N.,
            Tohyama,M., Kitanaka,J., Takemura,M., Mori,T. and Wanaka,A.
  TITLE     Differential expression of LIM-homeodomain genes in the embryonic
            murine brain
  JOURNAL   Neurosci Lett 211 (3), 147-150 (1996)
   PUBMED   8817562
REFERENCE   10 (bases 1 to 1759)
  AUTHORS   Matsumoto,K., Tanaka,T., Furuyama,T., Kashihara,Y., Mori,T.,
            Ishii,N., Kitanaka,J., Takemura,M., Tohyama,M. and Wanaka,A.
  TITLE     L3, a novel murine LIM-homeodomain transcription factor expressed
            in the ventral telencephalon and the mesenchyme surrounding the
            oral cavity
  JOURNAL   Neurosci Lett 204 (1-2), 113-116 (1996)
   PUBMED   8929991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119163.23.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189670.81082.1,
                                           ERR3363658.2612722.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AC119163.23        4165-4234
            71-157              AC119163.23        5814-5900
            158-319             AC119163.23        6089-6250
            320-441             AC119163.23        9592-9713
            442-662             AC119163.23        11794-12014
            663-766             AC119163.23        12525-12628
            767-862             AC119163.23        17417-17512
            863-1046            AC119163.23        22532-22715
            1047-1759           AC119163.23        27250-27962
FEATURES             Location/Qualifiers
     source          1..1759
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 79.12 cM"
     gene            1..1759
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /note="LIM homeobox protein 8"
                     /db_xref="GeneID:16875"
                     /db_xref="MGI:MGI:1096343"
     exon            1..70
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            71..157
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1093
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /note="isoform 2 is encoded by transcript variant 2;
                     LIM/homeobox protein Lhx8; LIM homeobox protein 7;
                     LIM/homeobox protein Lhx7; LIM homeo box protein 8"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx8 isoform 2"
                     /protein_id="NP_001396989.1"
                     /db_xref="GeneID:16875"
                     /db_xref="MGI:MGI:1096343"
                     /translation="MSEECGRPAALAAGRTRKGAGEEGLVNPEGAGDEDSCSSSAPLS
                     PSSSPQSMASGSVCPPGKCVCSSCGLEIVDKYLLKVNDLCWHVRCLSCSVCRTSLGRH
                     TSCYIKDKDIFCKLDYFRRYGTRCSRCGRHIHSTDWVRRAKGNVYHLACFACFSCKRQ
                     LSTGEEFALVEEKVLCRVHFDCMLDNLKREVENGNGISVEGALLTEQDVNHPKPAKRA
                     RTSFTADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKKHVSP
                     NHSSSAPVTAVPSSRLSPPMLEEMAYSAYVPQDGTMLTALHSYMDAHQQLLDSSPCYP
                     IQ"
     exon            158..319
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            320..441
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            442..662
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            663..766
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            767..862
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1046
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1759
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1734..1739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /note="hexamer: ATTAAA"
     polyA_site      1759
                     /gene="Lhx8"
                     /gene_synonym="L3; Lhx7"
                     /note="major polyA site"
ORIGIN      
        1 acttaaccta aggcatggac actctaattt gggagacgaa acctggagcc taagacgctc
       61 acggggcaac tgccccgggc tcatgtcgga ggagtgcggg cggcctgcag ccctggcggc
      121 cgggaggacc cgcaaaggcg ctggggaaga aggactggtg aatcccgagg gagccgggga
      181 cgaggactcc tgctcctcct cggccccgct ttccccgtcg tcctcgcccc agtccatggc
      241 ctcgggctcc gtgtgcccgc caggcaagtg tgtgtgcagc agctgcggcc tggagattgt
      301 ggacaaatac ctcctcaagg tgaatgactt atgctggcat gtccgctgtc tctcctgcag
      361 tgtctgcaga acgtccctgg gaaggcacac gagctgctac attaaggata aagacatttt
      421 ctgtaaactc gattacttca gacggtatgg gacccgctgt tcccgctgtg gcaggcacat
      481 ccactcgact gactgggtcc gcagggccaa gggcaacgtg tatcacctgg cctgctttgc
      541 ctgcttttct tgcaagaggc agctgtccac gggagaggag ttcgccttgg tggaggagaa
      601 ggtcctctgt agagtgcact ttgactgcat gctggacaat ctgaagagag aagtggagaa
      661 cggtaatggg attagtgtgg aaggagccct tctcacagag caagacgtca atcatccaaa
      721 gccagccaaa agagctcgga ccagcttcac agccgatcag ctccaggtta tgcaagcaca
      781 gttcgctcag gacaacaacc cagatgcaca gaccctccag aaactggcag aaaggacagg
      841 cttaagcaga cgtgtcatac aggtgtggtt tcagaactgc agggcccgcc ataagaaaca
      901 cgtcagtccc aaccattctt cctcagcccc cgtcacagct gtcccctcct ccaggctgtc
      961 cccacccatg ttggaagaaa tggcttattc tgcctacgta ccccaggatg ggacgatgct
     1021 gactgcgctg cactcataca tggatgctca ccaacaactc ctggactcca gcccttgtta
     1081 ccccatccaa tgacccagct gccaataagt catacctaat tccttctttc agggatagaa
     1141 atgattgagg ttataaactt gtcatttatt atgtataaaa taccattgag aagatattaa
     1201 tgttaatttt ttatttaaca ctcaaagcat ttcgaacatc ctctcgctgc ccaggtatgt
     1261 atctagagtt ggcctgcaag acacttttat tgattcttca ttttggtttt tttttgtaaa
     1321 acttatgttt acaaagaaga aaacaagtca aaacattttt ttttgtattg tctggagata
     1381 gttggctcga gtgtgtgtct attaacttat ttgtcaccaa aagagcactt tgcctgaaag
     1441 gcaggactga tcgtgtgcaa aacgtttaca atcctttgtg aaactgtagt ttatcattag
     1501 tttgtacctg taagttattg ttataaatat tatctgtatt ttttgtcata tacaacttta
     1561 taccttgaag cttgtatctg tgaatttgca actgaaattt attttgccag tgttttcggg
     1621 acaagctgaa ggcacgtccg ttgtagcatg ccgcgcacac ccacggggtg cctgcacttg
     1681 gagttctagc tgtaaataac actctagttt acaaagccta ccatcctaag ttcattaaac
     1741 actttgcatc cttgtgaaa
//
