LOCUS       NM_008499               2736 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus LIM homeobox protein 5 (Lhx5), mRNA.
ACCESSION   NM_008499
VERSION     NM_008499.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2736)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2736)
  AUTHORS   Tran,H.N., Nguyen,Q.H. and Jeong,Y.
  TITLE     Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron
            fate and regulates differentiation of the dorsal midbrain into the
            inferior and superior colliculi
  JOURNAL   Front Cell Dev Biol 12, 1336308 (2024)
   PUBMED   38344749
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2736)
  AUTHORS   Cheffer,A., Garcia-Miralles,M., Maier,E., Akol,I., Franz,H.,
            Srinivasan,V.S.V. and Vogel,T.
  TITLE     DOT1L deletion impairs the development of cortical
            parvalbumin-expressing interneurons
  JOURNAL   Cereb Cortex 33 (19), 10272-10285 (2023)
   PUBMED   37566909
REFERENCE   4  (bases 1 to 2736)
  AUTHORS   Takata,N., Miska,J.M., Morgan,M.A., Patel,P., Billingham,L.K.,
            Joshi,N., Schipma,M.J., Dumar,Z.J., Joshi,N.R., Misharin,A.V.,
            Embry,R.B., Fiore,L., Gao,P., Diebold,L.P., McElroy,G.S.,
            Shilatifard,A., Chandel,N.S. and Oliver,G.
  TITLE     Lactate-dependent transcriptional regulation controls mammalian eye
            morphogenesis
  JOURNAL   Nat Commun 14 (1), 4129 (2023)
   PUBMED   37452018
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2736)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2736)
  AUTHORS   Sheng,H.Z., Bertuzzi,S., Chiang,C., Shawlot,W., Taira,M., Dawid,I.
            and Westphal,H.
  TITLE     Expression of murine Lhx5 suggests a role in specifying the
            forebrain
  JOURNAL   Dev Dyn 208 (2), 266-277 (1997)
   PUBMED   9022063
REFERENCE   7  (bases 1 to 2736)
  AUTHORS   Bertuzzi,S., Sheng,H.Z., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Taira,M., Dawid,I.B. and Westphal,H.
  TITLE     Molecular cloning, structure, and chromosomal localization of the
            mouse LIM/homeobox gene Lhx5
  JOURNAL   Genomics 36 (2), 234-239 (1996)
   PUBMED   8812449
REFERENCE   8  (bases 1 to 2736)
  AUTHORS   Matsumoto,K., Tanaka,T., Furuyama,T., Kashihara,Y., Ishii,N.,
            Tohyama,M., Kitanaka,J., Takemura,M., Mori,T. and Wanaka,A.
  TITLE     Differential expression of LIM-homeodomain genes in the embryonic
            murine brain
  JOURNAL   Neurosci Lett 211 (3), 147-150 (1996)
   PUBMED   8817562
REFERENCE   9  (bases 1 to 2736)
  AUTHORS   Pfaff,S.L., Mendelsohn,M., Stewart,C.L., Edlund,T. and Jessell,T.M.
  TITLE     Requirement for LIM homeobox gene Isl1 in motor neuron generation
            reveals a motor neuron-dependent step in interneuron
            differentiation
  JOURNAL   Cell 84 (2), 309-320 (1996)
   PUBMED   8565076
REFERENCE   10 (bases 1 to 2736)
  AUTHORS   Weinstein,D.C., Ruiz i Altaba,A., Chen,W.S., Hoodless,P.,
            Prezioso,V.R., Jessell,T.M. and Darnell,J.E. Jr.
  TITLE     The winged-helix transcription factor HNF-3 beta is required for
            notochord development in the mouse embryo
  JOURNAL   Cell 78 (4), 575-588 (1994)
   PUBMED   8069910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129553.10.
            
            On Oct 24, 2007 this sequence version replaced NM_008499.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033927.1, AK048778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-568               AC129553.10        62625-63192         c
            569-792             AC129553.10        60364-60587         c
            793-1070            AC129553.10        59450-59727         c
            1071-1236           AC129553.10        58605-58770         c
            1237-2736           AC129553.10        53621-55120         c
FEATURES             Location/Qualifiers
     source          1..2736
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.62 cM"
     gene            1..2736
                     /gene="Lhx5"
                     /gene_synonym="Lim2"
                     /note="LIM homeobox protein 5"
                     /db_xref="GeneID:16873"
                     /db_xref="MGI:MGI:107792"
     exon            1..568
                     /gene="Lhx5"
                     /gene_synonym="Lim2"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..1604
                     /gene="Lhx5"
                     /gene_synonym="Lim2"
                     /note="LIM homeo box protein 5"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx5"
                     /protein_id="NP_032525.1"
                     /db_xref="CCDS:CCDS19617.1"
                     /db_xref="GeneID:16873"
                     /db_xref="MGI:MGI:107792"
                     /translation="MMVHCAGCERPILDRFLLNVLDRAWHIKCVQCCECKTNLSEKCF
                     SREGKLYCKNDFFRRFGTKCAGCAQGISPSDLVRKARSKVFHLNCFTCMVCNKQLSTG
                     EELYVIDENKFVCKDDYLSSSSLKEGSLNSVSSCTDRSLSPDLQDPLQDDPKETDNST
                     SSDKETANNENEEQNSGTKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETG
                     LNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLGGRLDESEMLGSTPY
                     TYYGDYQSDYYAPGGNYDFFAHGPPSQAQSPADSSFLAASGPGSTPLGALEPPLAGPH
                     GADNPRFTDMISHPDTPSPEPGLPGALHPMPGEVFSGGPSPPFPMSGTSGYSGPLSHP
                     NPELNEAAVW"
     exon            569..792
                     /gene="Lhx5"
                     /gene_synonym="Lim2"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1070
                     /gene="Lhx5"
                     /gene_synonym="Lim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1236
                     /gene="Lhx5"
                     /gene_synonym="Lim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..2736
                     /gene="Lhx5"
                     /gene_synonym="Lim2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2479..2484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lhx5"
                     /gene_synonym="Lim2"
                     /note="hexamer: AATAAA"
     polyA_site      2506
                     /gene="Lhx5"
                     /gene_synonym="Lim2"
                     /note="major polyA site"
ORIGIN      
        1 aggcggcggc cagacaaaga tgaggatcgg gaccgcttga aagtggggga aagtgccggc
       61 gcctccgcca accgggaaag ccgctcgcca gtgccgaagc cagcagccgc cgaggacacc
      121 tgctcgaagc tggagcgagc gcccggtcgc gacccgtgac atgaggctgt gaccgctgcc
      181 gccctccacg ccactctggg cagtgcagcg ccaggccgga gagcgtcgga ggacttgacc
      241 ccgagaagtc ttggttgatc cgtaacggac tcgcccctac agactcgcct acagactagg
      301 aaggctgaga gccacagcag cggggaccga gagggcctaa gggcccaggg gccccaagga
      361 ggacgaggcg gcccgagccg ccggggcgcg cggctatgat ggtgcactgt gctggctgtg
      421 agcggcccat cctcgaccgc tttctgctga acgtactaga ccgcgcgtgg catatcaaat
      481 gtgttcaatg ctgcgagtgc aaaaccaacc tctcggagaa gtgcttctca cgggaaggca
      541 agctatactg taaaaacgac tttttcaggc gctttggcac aaagtgcgcc ggctgcgcgc
      601 aaggtatctc tccgagcgac ctggtacgga aggcccggag caaagtcttc cacctcaact
      661 gcttcacctg tatggtgtgc aataagcagc tatccaccgg agaggagctc tacgtgatcg
      721 acgagaacaa gtttgtgtgc aaggacgact acttaagctc ctctagcctc aaggaaggaa
      781 gtctcaactc ggtgtcgtcc tgtacggacc gcagtttgtc cccggacctc caggatccgt
      841 tacaggacga ccccaaagag accgacaatt cgacctcatc ggacaaggaa accgctaaca
      901 acgagaatga ggaacagaac tccggcacca aacggcgcgg cccgcgcacc accatcaagg
      961 ccaagcagct ggagacgctc aaggcagcct tcgcagccac gcccaagccc acgcgccaca
     1021 ttcgcgaaca gctggcacag gagacgggcc tcaacatgag ggtcattcag gtgtggtttc
     1081 agaaccgaag gtccaaagaa cgccgcatga aacagctgag cgctctgggc gcgcggagac
     1141 acgccttctt ccggagtccg cggcgcatgc gtcccctggg cggccgcttg gacgagtctg
     1201 agatgttggg gtctacccca tacacttatt acggagacta ccaaagtgac tactacgctc
     1261 cgggaggcaa ttacgatttc ttcgcgcacg gtccgccgtc acaggcgcag tcccctgccg
     1321 actccagctt cctggcagca tcgggacctg gctcgacgcc gctgggcgcg ctggaaccgc
     1381 cgctggccgg gcctcacggc gcggacaacc ccagattcac cgacatgatc tcgcatccgg
     1441 acacgccgag ccccgagccg ggcctgcccg gtgcgctgca ccccatgccg ggagaggtgt
     1501 tcagcggcgg gcccagcccg cccttcccca tgagcggcac cagcggctac agtggacccc
     1561 tgtcgcaccc caaccctgag ctcaacgaag cggccgtatg gtaaggccga ggggctgagt
     1621 tgtccccctg ccaccaagcc cgggacggga cgccgcctgg gtaagcctca agagtcctct
     1681 cgtgggttcg cacccaacca ggccactcgc atcaccaccc ctcagagctt tggcacgcgc
     1741 ctgcgcaatt tctcgggacc aaagtcaata ttctgaaggg tcgagattcc aagcacatct
     1801 tagaagccct ccggatcccc cacccatcat cacctccttg aactaagaga gggggatgag
     1861 gccaaggagc ggagaccatg gcactacccc tccctgcgag ccgaggcatt gtgaaatcct
     1921 atttctcact ttctctttta aaaaaagaaa gaaagaagga aggaaggaag gaaggaaaga
     1981 aagaaagaga ggttgaaagg gggagagaaa gagagagaga gagagagaga gagagagaga
     2041 gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga gcgcgagcga
     2101 gctgaggaaa gctcagccag agaagaaaaa tgaggaggac cgccggtgaa tggtggcttt
     2161 gcaggaagac aaatccacct gcgagttggc gccccctggt ggctcaatgt cagcttgtct
     2221 aggaaggtgc gcggtctggg cctggccttc ctgagcccaa ctccctgctc ctccatactt
     2281 tgagtctgag gggcctggca ggattcgaac cctcccaccc tgctctgacc ctgagccggg
     2341 cgccaagtca ttgagcattt gcccacggat cactctccct gcccgggacc tggaggctgg
     2401 gccatcagga cgaacagtat tatacttttt tggaagtcgg acgcttctag tttccttatt
     2461 ttgtataaag aagaaacaaa taaagtatgt ttttgtgtct actgtttatt tattgtactc
     2521 tagttatctg gggctggaca tttttatatt tttaagagga gggtggggca gagttgggga
     2581 ggggagccag aaagaggttt acaaaaaaaa acaacaacaa caaaataaaa cacacacaaa
     2641 aaaatacaaa aacaaacaaa caaaaaaaaa aacaaaaaaa aatcaacttt tttttaacaa
     2701 aaaagaaaga ttaataaaaa aattcttttt tccctc
//
