LOCUS       NM_010712               1853 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus LIM homeobox protein 4 (Lhx4), mRNA.
ACCESSION   NM_010712
VERSION     NM_010712.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1853)
  AUTHORS   Renaux,E., Baudouin,C., Marchese,D., Clovis,Y., Lee,S.K.,
            Gofflot,F., Rezsohazy,R. and Clotman,F.
  TITLE     Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of
            spinal V2a interneurons
  JOURNAL   Cell Mol Life Sci 81 (1), 286 (2024)
   PUBMED   38970652
  REMARK    GeneRIF: Lhx4 surpasses its paralog Lhx3 in promoting the
            differentiation of spinal V2a interneurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1853)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   3  (bases 1 to 1853)
  AUTHORS   Morello,F., Borshagovski,D., Survila,M., Tikker,L., Sadik-Ogli,S.,
            Kirjavainen,A., Estartus,N., Knaapi,L., Lahti,L., Toronen,P.,
            Mazutis,L., Delogu,A., Salminen,M., Achim,K. and Partanen,J.
  TITLE     Molecular Fingerprint and Developmental Regulation of the Tegmental
            GABAergic and Glutamatergic Neurons Derived from the Anterior
            Hindbrain
  JOURNAL   Cell Rep 33 (2), 108268 (2020)
   PUBMED   33053343
REFERENCE   4  (bases 1 to 1853)
  AUTHORS   Dong,X., Yang,H., Zhou,X., Xie,X., Yu,D., Guo,L., Xu,M., Zhang,W.,
            Liang,G. and Gan,L.
  TITLE     LIM-Homeodomain Transcription Factor LHX4 Is Required for the
            Differentiation of Retinal Rod Bipolar Cells and OFF-Cone Bipolar
            Subtypes
  JOURNAL   Cell Rep 32 (11), 108144 (2020)
   PUBMED   32937137
  REMARK    GeneRIF: LIM-Homeodomain Transcription Factor LHX4 Is Required for
            the Differentiation of Retinal Rod Bipolar Cells and OFF-Cone
            Bipolar Subtypes.
REFERENCE   5  (bases 1 to 1853)
  AUTHORS   Lo Giudice,Q., Leleu,M., La Manno,G. and Fabre,P.J.
  TITLE     Single-cell transcriptional logic of cell-fate specification and
            axon guidance in early-born retinal neurons
  JOURNAL   Development 146 (17) (2019)
   PUBMED   31399471
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1853)
  AUTHORS   Uelmen,P.J., Oka,K., Sullivan,M., Chang,C.C., Chang,T.Y. and
            Chan,L.
  TITLE     Tissue-specific expression and cholesterol regulation of
            acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice.
            Molecular cloning of mouse ACAT cDNA, chromosomal localization, and
            regulation of ACAT in vivo and in vitro
  JOURNAL   J Biol Chem 270 (44), 26192-26201 (1995)
   PUBMED   7592824
REFERENCE   7  (bases 1 to 1853)
  AUTHORS   Li,H., Witte,D.P., Branford,W.W., Aronow,B.J., Weinstein,M.,
            Kaur,S., Wert,S., Singh,G., Schreiner,C.M., Whitsett,J.A. et al.
  TITLE     Gsh-4 encodes a LIM-type homeodomain, is expressed in the
            developing central nervous system and is required for early
            postnatal survival
  JOURNAL   EMBO J 13 (12), 2876-2885 (1994)
   PUBMED   7913017
REFERENCE   8  (bases 1 to 1853)
  AUTHORS   Rowe,L.B., Nadeau,J.H., Turner,R., Frankel,W.N., Letts,V.A.,
            Eppig,J.T., Ko,M.S., Thurston,S.J. and Birkenmeier,E.H.
  TITLE     Maps from two interspecific backcross DNA panels available as a
            community genetic mapping resource
  JOURNAL   Mamm Genome 5 (5), 253-274 (1994)
   PUBMED   8075499
  REMARK    Erratum:[Mamm Genome 1994 Jul;5(7):463]
REFERENCE   9  (bases 1 to 1853)
  AUTHORS   Kern,M.J., Argao,E.A., Birkenmeier,E.H., Rowe,L.B. and Potter,S.S.
  TITLE     Genomic organization and chromosome localization of the murine
            homeobox gene Pmx
  JOURNAL   Genomics 19 (2), 334-340 (1994)
   PUBMED   7910581
REFERENCE   10 (bases 1 to 1853)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049834.1 and AC117598.7.
            
            On Jun 19, 2008 this sequence version replaced NM_010712.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049834.1, AF135415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1279              BC049834.1         1-1279
            1280-1853           AC117598.7         151512-152085       c
FEATURES             Location/Qualifiers
     source          1..1853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 67.47 cM"
     gene            1..1853
                     /gene="Lhx4"
                     /gene_synonym="A330062J17Rik; Gsh-4; Gsh4"
                     /note="LIM homeobox protein 4"
                     /db_xref="GeneID:16872"
                     /db_xref="MGI:MGI:101776"
     exon            1..226
                     /gene="Lhx4"
                     /gene_synonym="A330062J17Rik; Gsh-4; Gsh4"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1323
                     /gene="Lhx4"
                     /gene_synonym="A330062J17Rik; Gsh-4; Gsh4"
                     /note="LIM homeo box protein 4"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx4"
                     /protein_id="NP_034842.2"
                     /db_xref="CCDS:CCDS48399.1"
                     /db_xref="GeneID:16872"
                     /db_xref="MGI:MGI:101776"
                     /translation="MMQSAAVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILK
                     VLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVV
                     RKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRP
                     RTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKD
                     AGRHRWGQFYKSVKRSRGGSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGN
                     VGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTV
                     DSNLGIIAHAGQGVSQTLRAMAGGPTSDLSTGSSVGYPDFPTSPASWLDEMDHPPF"
     exon            227..398
                     /gene="Lhx4"
                     /gene_synonym="A330062J17Rik; Gsh-4; Gsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            399..601
                     /gene="Lhx4"
                     /gene_synonym="A330062J17Rik; Gsh-4; Gsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            602..756
                     /gene="Lhx4"
                     /gene_synonym="A330062J17Rik; Gsh-4; Gsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            757..928
                     /gene="Lhx4"
                     /gene_synonym="A330062J17Rik; Gsh-4; Gsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1853
                     /gene="Lhx4"
                     /gene_synonym="A330062J17Rik; Gsh-4; Gsh4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctcccgg agacgcggag ggctcggttt cctctgtgac ttcagcggcc tggttggttt
       61 tattattatt attttcaaat ttccgaatcc agccagaggg agagagcgag agatctcggt
      121 agactgcgac ttgctgcctc tggctccaag atgatgcaga gcgcggctgt ccccgcggag
      181 ggggctgtca aggggctccc ggagatgctc ggtgtgccga tgcaacagat tccccagtgt
      241 gctggctgca accaacatat cctggataag ttcatcctga aggtcctgga cagacactgg
      301 cacagctcct gcctcaagtg cgcagactgc cagatgcagc tggctgacag atgcttctcc
      361 agggccggca gtgtctactg caaggaagat ttcttcaaac gctttggcac aaaatgcaca
      421 gcctgccagc agggcatccc cccgacccag gtggtccgca aggctcagga ctttgtctac
      481 cacctgcact gctttgcctg catcatctgc aaccggcagc tggccacggg ggacgagttc
      541 taccttatgg aggatggccg gctagtgtgc aaagaagact atgagacagc caagcaaaac
      601 gatgactcgg aggctggggc taagcgacct cggaccacca tcacagcaaa gcagctggag
      661 acactaaaga acgcatacaa gaactcccca aagcctgccc ggcatgtgag agagcagctc
      721 tcctccgaga caggcctgga catgagagta gtacaggttt ggtttcagaa cagaagagcc
      781 aaggagaaaa ggctaaagaa ggacgcgggg cgccatcgct ggggccagtt ctacaagagt
      841 gtcaagagga gccggggagg cagcaagcag gagaaggaga gctcagcaga ggactgtggg
      901 gttagtgaca gtgagctgag cttccgagaa gatcaaatac tctcagagct tggccacacc
      961 aataggattt atggcaacgt gggggacgtt acaggcggac agttaatgaa tgggagtttc
     1021 tccatggatg ggacaggaca atcctatcag gacttgaggg atgggagccc ttatggaatc
     1081 ccccagtctc cgtcctccat atcgtccctc ccatcccatg ctcctttgct caatgggctg
     1141 gattacaccg tggacagtaa tctgggcatc attgcgcatg cagggcaggg agtcagccag
     1201 acactgagag ccatggctgg gggacccacc tctgacctct cgacaggaag cagtgtaggc
     1261 taccctgatt ttccaactag cccagcctct tggctcgatg agatggacca tcctcctttt
     1321 tagactttcc tcgtcaccct ccttgtcctc ctggtatgag agaatgtctt caaggatcaa
     1381 aagtacgcca atgtgaattt ccattatttt caatggaagt cctccgccga ttcccaggag
     1441 gcggagacca cactaggata ctgctttctt gggaagagac aggagagcag cctcatctct
     1501 accacagcac aggggtggac agcctagaac tctaaggatg ctggcttgtt ggctccctcc
     1561 cctcccgccc tgcttagagg ctttggctgc tcagtgcttg gacagcacaa ggtgactgtg
     1621 acaggccacc ttggcctttg gggactctgc tccagctggt gcatctcaca cttggtctcc
     1681 caaatcatcc ctctcaccag aaccaggatt cccgtggggg aggcaccatg gtgccccccc
     1741 cccccagaat aataaaatag tttctggacc accttgatta cacactaatt ttcaaaataa
     1801 agtcagttct aaaggctagt aaaatactga tgcccacagt ttgatattaa aaa
//
