LOCUS       NM_010710               2295 bp    mRNA    linear   ROD 26-MAR-2023
DEFINITION  Mus musculus LIM homeobox protein 2 (Lhx2), transcript variant 1,
            mRNA.
ACCESSION   NM_010710 XM_904190
VERSION     NM_010710.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2295)
  AUTHORS   Singh N, Singh D, Bhide A, Sharma R, Bhowmick S, Patel V and Modi
            D.
  TITLE     LHX2 in germ cells control tubular organization in the developing
            mouse testis
  JOURNAL   Exp Cell Res 425 (1), 113511 (2023)
   PUBMED   36796745
  REMARK    GeneRIF: LHX2 in germ cells control tubular organization in the
            developing mouse testis.
REFERENCE   2  (bases 1 to 2295)
  AUTHORS   Cohen-Gulkar M, David A, Messika-Gold N, Eshel M, Ovadia S, Zuk-Bar
            N, Idelson M, Cohen-Tayar Y, Reubinoff B, Ziv T, Shamay M, Elkon R
            and Ashery-Padan R.
  TITLE     The LHX2-OTX2 transcriptional regulatory module controls retinal
            pigmented epithelium differentiation and underlies genetic risk for
            age-related macular degeneration
  JOURNAL   PLoS Biol 21 (1), e3001924 (2023)
   PUBMED   36649236
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2295)
  AUTHORS   Chen GD, Fatima I, Xu Q, Rozhkova E, Fessing MY, Mardaryev AN,
            Sharov AA, Xu GL and Botchkarev VA.
  TITLE     DNA dioxygenases Tet2/3 regulate gene promoter accessibility and
            chromatin topology in lineage-specific loci to control epithelial
            differentiation
  JOURNAL   Sci Adv 9 (2), eabo7605 (2023)
   PUBMED   36630508
REFERENCE   4  (bases 1 to 2295)
  AUTHORS   Govek KW, Chen S, Sgourdou P, Yao Y, Woodhouse S, Chen T, Fuccillo
            MV, Epstein DJ and Camara PG.
  TITLE     Developmental trajectories of thalamic progenitors revealed by
            single-cell transcriptome profiling and Shh perturbation
  JOURNAL   Cell Rep 41 (10), 111768 (2022)
   PUBMED   36476860
REFERENCE   5  (bases 1 to 2295)
  AUTHORS   Li X, Gordon PJ, Gaynes JA, Fuller AW, Ringuette R, Santiago CP,
            Wallace V, Blackshaw S, Li P and Levine EM.
  TITLE     Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog
            signaling during early retinal neurogenesis
  JOURNAL   Elife 11, e78342 (2022)
   PUBMED   36459481
  REMARK    GeneRIF: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog
            signaling during early retinal neurogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2295)
  AUTHORS   Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ and Zoghbi
            HY.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   7  (bases 1 to 2295)
  AUTHORS   Matsumoto K, Tanaka T, Furuyama T, Kashihara Y, Ishii N, Tohyama M,
            Kitanaka J, Takemura M, Mori T and Wanaka A.
  TITLE     Differential expression of LIM-homeodomain genes in the embryonic
            murine brain
  JOURNAL   Neurosci Lett 211 (3), 147-150 (1996)
   PUBMED   8817562
REFERENCE   8  (bases 1 to 2295)
  AUTHORS   Pfaff SL, Mendelsohn M, Stewart CL, Edlund T and Jessell TM.
  TITLE     Requirement for LIM homeobox gene Isl1 in motor neuron generation
            reveals a motor neuron-dependent step in interneuron
            differentiation
  JOURNAL   Cell 84 (2), 309-320 (1996)
   PUBMED   8565076
REFERENCE   9  (bases 1 to 2295)
  AUTHORS   Roberson MS, Schoderbek WE, Tremml G and Maurer RA.
  TITLE     Activation of the glycoprotein hormone alpha-subunit promoter by a
            LIM-homeodomain transcription factor
  JOURNAL   Mol Cell Biol 14 (5), 2985-2993 (1994)
   PUBMED   7513049
REFERENCE   10 (bases 1 to 2295)
  AUTHORS   Xu Y, Baldassare M, Fisher P, Rathbun G, Oltz EM, Yancopoulos GD,
            Jessell TM and Alt FW.
  TITLE     LH-2: a LIM/homeodomain gene expressed in developing lymphocytes
            and neural cells
  JOURNAL   Proc Natl Acad Sci U S A 90 (1), 227-231 (1993)
   PUBMED   7678338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053572.1 and BX813320.2.
            
            [WARNING] On May 2, 2023 this sequence was replaced by NM_010710.5.
            
            On Mar 15, 2014 this sequence version replaced NM_010710.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053572.1, BC055741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2286              AK053572.1         2-2287
            2287-2295           BX813320.2         2530-2538
FEATURES             Location/Qualifiers
     source          1..2295
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..2295
                     /gene="Lhx2"
                     /gene_synonym="ap; apterous; Lh-2; LH2A; Lim2"
                     /note="LIM homeobox protein 2"
                     /db_xref="GeneID:16870"
                     /db_xref="MGI:MGI:96785"
     exon            1..586
                     /gene="Lhx2"
                     /gene_synonym="ap; apterous; Lh-2; LH2A; Lim2"
                     /inference="alignment:Splign:2.1.0"
     CDS             467..1687
                     /gene="Lhx2"
                     /gene_synonym="ap; apterous; Lh-2; LH2A; Lim2"
                     /note="isoform a is encoded by transcript variant 1;
                     LIM/homeobox protein Lhx2; homeobox protein LH-2; LIM
                     homeo box protein 2"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx2 isoform a"
                     /protein_id="NP_034840.1"
                     /db_xref="CCDS:CCDS16008.1"
                     /db_xref="GeneID:16870"
                     /db_xref="MGI:MGI:96785"
                     /translation="MLFHSLSGPEVHGVIDEMDRRAKSEAPAISSAIDRGDTETTMPS
                     ISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYC
                     KEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKD
                     SLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGSAGANPLGLPYYNGVG
                     TVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHH
                     QLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVD
                     KTSDATLQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGH
                     EPHSPSQTTLTNLF"
     exon            587..789
                     /gene="Lhx2"
                     /gene_synonym="ap; apterous; Lh-2; LH2A; Lim2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1193
                     /gene="Lhx2"
                     /gene_synonym="ap; apterous; Lh-2; LH2A; Lim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1399
                     /gene="Lhx2"
                     /gene_synonym="ap; apterous; Lh-2; LH2A; Lim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..2295
                     /gene="Lhx2"
                     /gene_synonym="ap; apterous; Lh-2; LH2A; Lim2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accccggggg gaagagacgt gcaggcatct gggccgccgc gggcacctag ctgttcctgg
       61 gtgaaccccg actgcagcca ccgccgcctg gggcagagtt tgcgcccctg atttgcgccc
      121 tgggcgccag aacccagcta gcgatgcctg cggcgtgaaa gcgcccacag cgggcgccga
      181 cctctgccct ggtctcccgc ccccacctca ccccctgccc ttgtgaccct ggcttcggcg
      241 ccgccgtcca ggcgccccgc gatgtagctg cccccacgcc tcggcgggag gcgtcctggc
      301 ccgcaggcgc ccgcggcccg gagcccagcc tgggggcgca gccgagctcg ggcggggccg
      361 gggccgcggt ggcgatgcac tgggccggtt aacgccggga gcgccaggca gctgaggcgg
      421 ggggcaagcc cttcctcggg gcagccgcat ccccggtccc gccgcgatgc tgttccacag
      481 tctgtcgggc cccgaggtgc acggggtcat cgacgagatg gaccgcaggg ccaagagcga
      541 ggctccggcc atcagctccg ccatcgaccg cggcgacacg gagacgacca tgccgtccat
      601 cagcagtgac cgggcagcgt tgtgtgctgg ctgtgggggc aagatctctg accgctacta
      661 cctgctggca gtagacaagc aatggcacat gcgctgcctc aagtgctgtg aatgcaagct
      721 caacctggag tcggaactca cctgcttcag caaggatggc agcatctact gcaaagaaga
      781 ctactacagg cggttctctg tgcagcgctg cgcccgctgc cacctgggca tctcggcctc
      841 agagatggtg atgcgcgctc gggacttggt ttatcacctc aactgcttca catgcacaac
      901 gtgtaacaag atgctgacga ccggcgacca tttcggcatg aaggacagcc tggtctattg
      961 ccgcttgcac ttcgaggctc tgctgcaggg cgaataccca gcacacttta accatgccga
     1021 cgtggcagcg gcggcagccg cagccgcagc agctaagagt gcaggattgg gctcagccgg
     1081 ggctaatccg ctgggtcttc cctactacaa cggcgtgggc actgtgcaaa aggggaggcc
     1141 gagaaagcgc aagagtccag gacccggggc agatctggca gcttacaacg ccgcgcttag
     1201 ctgtaacgag aacgatgctg aacacctgga tcgtgaccag ccctacccca gcagccaaaa
     1261 gacaaagcgc atgcgcacct ccttcaagca ccaccagctt cggacaatga agtcttactt
     1321 tgccattaac cacaatcccg atgccaagga cttgaagcag cttgcgcaaa agaccggcct
     1381 caccaagaga gtcctccagg tctggtttca gaatgcccgg gccaagttca ggcgcaacct
     1441 tttacggcag gaaaacacgg gcgtggacaa gacgtcagat gccacgctgc agacagggac
     1501 gccgtcaggg cccgcctcgg agctgtccaa cgcctcgctc agcccctcca gcacgcctac
     1561 aaccctcaca gacttgacta gccccaccct gccgactgtg acgtcagtct taacttctgt
     1621 gcctggcaac ctggagggcc acgagcccca cagcccttca caaacgactc ttaccaacct
     1681 tttctaatga ctcgccaccc ccttctcccc gagcccccac gatttcttta aaaaagaaat
     1741 tatctttagt tgaattccaa gtgtatttta aaaatagagg tttgagcaac taactaacca
     1801 cgttttagga tctcgcctgg aaacagaggg aaaaaagaat tgtgcgtcgg gctaacgcag
     1861 cggtgtgtgc tgaggaatta cttgggagat atatctgcaa cacaacattt gtgtccctgt
     1921 acagttttgt ggactgagcg aggaaaacaa caaataattt aagttggctg agagcttccg
     1981 tattttcaaa gactgccacg tgccttagga atactgtttt atcttcatac tttggatgaa
     2041 ttgttcgttt tttttcctct ccctcttttt ctctctgtat atttatgacc agagcaaaat
     2101 gtaaaaaagg aaaaaacaaa aaatgtttgt tactttgaat agtcctaaaa agaaaaagga
     2161 aaaaaaaata aggaaaaaaa aatcaaatcc cctccaacgg tcgctttctt gttttagaat
     2221 tttaaggtgg aagtctgttc ggatatcaga atttgtaaaa cctaaccagt aataaaatca
     2281 cttatcgaaa agact
//
