LOCUS       NM_008498               4154 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus LIM homeobox protein 1 (Lhx1), mRNA.
ACCESSION   NM_008498
VERSION     NM_008498.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4154)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   2  (bases 1 to 4154)
  AUTHORS   Krishnamurthy,A., Lee,A.S., Bayin,N.S., Stephen,D.N., Nasef,O.,
            Lao,Z. and Joyner,A.L.
  TITLE     Engrailed transcription factors direct excitatory cerebellar neuron
            diversity and survival
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38912572
REFERENCE   3  (bases 1 to 4154)
  AUTHORS   Masuda,A., Nishida,K., Ajima,R., Saga,Y., Bakhtan,M., Klar,A.,
            Hirata,T. and Zhu,Y.
  TITLE     A global gene regulatory program and its region-specific regulator
            partition neurons into commissural and ipsilateral projection types
  JOURNAL   Sci Adv 10 (21), eadk2149 (2024)
   PUBMED   38781326
REFERENCE   4  (bases 1 to 4154)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   5  (bases 1 to 4154)
  AUTHORS   Li,Y., Xiao,D., Chen,H., Zheng,X.F.S. and Xiang,M.
  TITLE     Maf1 controls retinal neuron number by both RNA Pol III- and Pol
            II-dependent mechanisms
  JOURNAL   iScience 26 (12), 108544 (2023)
   PUBMED   38089586
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4154)
  AUTHORS   Shawlot,W. and Behringer,R.R.
  TITLE     Requirement for Lim1 in head-organizer function
  JOURNAL   Nature 374 (6521), 425-430 (1995)
   PUBMED   7700351
REFERENCE   7  (bases 1 to 4154)
  AUTHORS   Richman,D.D. and Bozzette,S.A.
  TITLE     The impact of the syncytium-inducing phenotype of human
            immunodeficiency virus on disease progression
  JOURNAL   J Infect Dis 169 (5), 968-974 (1994)
   PUBMED   7909549
REFERENCE   8  (bases 1 to 4154)
  AUTHORS   Fujii,T., Pichel,J.G., Taira,M., Toyama,R., Dawid,I.B. and
            Westphal,H.
  TITLE     Expression patterns of the murine LIM class homeobox gene lim1 in
            the developing brain and excretory system
  JOURNAL   Dev Dyn 199 (1), 73-83 (1994)
   PUBMED   7909459
REFERENCE   9  (bases 1 to 4154)
  AUTHORS   Barnes,J.D., Crosby,J.L., Jones,C.M., Wright,C.V. and Hogan,B.L.
  TITLE     Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1,
            suggests a role in lateral mesoderm differentiation and
            neurogenesis
  JOURNAL   Dev Biol 161 (1), 168-178 (1994)
   PUBMED   7904966
REFERENCE   10 (bases 1 to 4154)
  AUTHORS   Blatt,C., Aberdam,D., Schwartz,R. and Sachs,L.
  TITLE     DNA rearrangement of a homeobox gene in myeloid leukaemic cells
  JOURNAL   EMBO J 7 (13), 4283-4290 (1988)
   PUBMED   2907477
  REMARK    Erratum:[EMBO J 1989 Apr;8(4):1288]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603708.13.
            
            On Feb 16, 2018 this sequence version replaced NM_008498.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141086.1, Z27410.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1529              AL603708.13        64270-65798         c
            1530-1756           AL603708.13        62326-62552         c
            1757-2034           AL603708.13        61955-62232         c
            2035-2200           AL603708.13        60548-60713         c
            2201-4154           AL603708.13        58239-60192         c
FEATURES             Location/Qualifiers
     source          1..4154
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.31 cM"
     gene            1..4154
                     /gene="Lhx1"
                     /gene_synonym="Lim1"
                     /note="LIM homeobox protein 1"
                     /db_xref="GeneID:16869"
                     /db_xref="MGI:MGI:99783"
     exon            1..1529
                     /gene="Lhx1"
                     /gene_synonym="Lim1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1360..2580
                     /gene="Lhx1"
                     /gene_synonym="Lim1"
                     /note="homeobox protein Lim-1; LIM homeo box protein 1"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx1"
                     /protein_id="NP_032524.1"
                     /db_xref="CCDS:CCDS25187.1"
                     /db_xref="GeneID:16869"
                     /db_xref="MGI:MGI:99783"
                     /translation="MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFS
                     REGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGE
                     ELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESAN
                     VSDKEGGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETG
                     LNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLVDRLEPGELIPNGPF
                     SFYGDYQSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGGLDHPLPGH
                     HPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPFSSLSVNGGASYGN
                     HLSHPPEMNEAAVW"
     exon            1530..1756
                     /gene="Lhx1"
                     /gene_synonym="Lim1"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..2034
                     /gene="Lhx1"
                     /gene_synonym="Lim1"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2200
                     /gene="Lhx1"
                     /gene_synonym="Lim1"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..4154
                     /gene="Lhx1"
                     /gene_synonym="Lim1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4134..4139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lhx1"
                     /gene_synonym="Lim1"
                     /note="hexamer: AATAGA"
     polyA_site      4153
                     /gene="Lhx1"
                     /gene_synonym="Lim1"
                     /note="major polyA site"
ORIGIN      
        1 aacagccagg agcagtgacc gagccgctgg agctggggag agacgcgcgg aagactgggc
       61 caggagacta gggaccgagg gacgcgcgcc tggggagagc caacaaggaa cccgcgggcc
      121 ggacagcgac accggcaatc cgcgccaaac tgttccagcc gctggccttc tatagccgca
      181 gccccaggac attctaaagc tctccaagac gccccctccc ctggcttctc gcgttgacca
      241 aggaaaagaa aaagggaggg aaaaagaaag gaaggagact agaaagaaaa cccagatttg
      301 ccaccgcaca aaaagagagg tgggggggac aaggaaaaaa aaaaaagtcg agcgactgtg
      361 gggccggaac acaggcagcg ggatcgtggg ccgagcgatg caaggctgcg cgcccaagcg
      421 gccgcgagtt gtgactgaag ccaggatgct cgtccaggcg cagtgaagag ccagaccgtg
      481 ttgcctcccc aggagtccaa gcgcagggag ggccgctcgg aggacgcggc agactgcctg
      541 gcaggccacc ggccgaggtg acagggctgg ggcggtgggg agcgagcgag tgcgcccggc
      601 tgcgtccgcc cgaagcggac ggtccctttc catttttgac tggcacaaaa aagaaaactc
      661 tccaaagggg tgggggctac ctaagcaaca actacaatca acaaaatatc ctacccaacc
      721 cgccatctcc cccacacctc ggtctgcccc cgccccctcc ccaggcccag cgcgggcgcc
      781 cagagcgtcc caactcactg caagaaaccg gcaatgtagg atccaaagct ttctactccc
      841 gtgttctttt ctttccgtgt tttttttaaa ggggaaaacc cggtggtggg cagtctgaca
      901 cgcacacaac ctgccttcat actctgacaa aagcagatgc actttgactt ctgacagctc
      961 tacctcaagc tggagagaac ccagctttcc cgaatcctga gctcttggcg tcttcctttt
     1021 cgtctgtttc cattttattt atttacgtcc cgccgcctct cacggtgacc ttcactcctt
     1081 cgcgggcttt gagcagaaga gccgctttct agcccgcttg agactgattt tcctcgcccg
     1141 gtgagctgag gtggcgctgc tccatcccgt tgccccggga ctccggggct gccctctacc
     1201 agcctggtct ctcccccttt tgatttgcta gtacgggttt tttgcttgcc caactagaga
     1261 gggtttcttc tttttggagg agctggttgt cttcagaagt catcccctcg actctaattg
     1321 ccctgtcgct ccgggcctca ccggaccaaa ccaaagacca tggtgcactg tgcgggctgc
     1381 aaaaggccca tcctggaccg tttcctcttg aacgtgttgg acagggcctg gcacgtcaag
     1441 tgcgtccagt gctgtgaatg taaatgcaac ctgaccgaga agtgcttctc ccgggaaggc
     1501 aagctctact gtaaaaacga cttcttccga tgtttcggta ccaaatgcgc cggttgtgcg
     1561 cagggcatct ctccaagcga tctggttcgc agagcgcgaa gcaaagtgtt tcacctcaac
     1621 tgcttcacct gcatgatgtg taacaagcag ctctccaccg gcgaggagct ctacatcata
     1681 gacgagaaca agttcgtttg taaagaggat tacctgagta acagcagtgt cgccaaagag
     1741 aacagcctcc actcggccac cacaggcagt gaccctagtt tatctccgga ttcccaagat
     1801 ccatcgcagg atgatgccaa ggactctgaa agtgccaacg tctcagataa ggaaggtggt
     1861 agtaatgaga atgatgatca gaacctaggt gccaaacgta ggggaccccg gaccacgatc
     1921 aaagccaagc aactggagac gttgaaggca gcctttgcag ctacacccaa gcccacacgc
     1981 catatccgtg agcaactggc ccaggagact ggcctcaaca tgcgtgttat ccaggtctgg
     2041 ttccagaatc gacgctccaa ggagcgaagg atgaaacagc taagcgcgct aggcgcgcgg
     2101 cgccacgcct ttttccgcag tcctcgtcgg atgcggccgc tggtggaccg cctggagccg
     2161 ggcgaactca tccccaacgg ccccttctcc ttttacggag attaccagag tgagtactac
     2221 ggtcccggag gcaactacga cttcttcccg caaggaccgc catcctctca ggctcagacg
     2281 ccagtggacc taccctttgt gccatcatct ggcccttcgg ggacgcccct tggaggtctg
     2341 gaccacccgc tgcctggtca ccacccttcc agtgaggcgc agcgatttac tgacatcctg
     2401 gcacatcccc caggggactc gcctagtcct gagcccagct tgcccgggcc tctccactcc
     2461 atgtcagcgg aggtcttcgg gcccagtcca cctttctcat ctctgtcggt caatggtgga
     2521 gccagctacg ggaaccattt gtctcaccct cctgaaatga acgaggcagc cgtgtggtag
     2581 cggggtctcg catgggccac gggagctcgt ggttgtacag agacgagctt ttatttcaga
     2641 aaaatagatt aaaaagacaa aaaaaaaaaa acccccaaaa caaaaaagca agcctcctgc
     2701 tccacttcct tcagcctcgg ggaccagtct gtttggggag actggatagc aaagggggtc
     2761 caaaatagga tccaaatccg cctcacagta gagctggtat atccacacac tggctggcaa
     2821 agcgcaaaac tggggctccg gaaggggaat tccgagctat ccccaccttc atgacctgga
     2881 tccatggaca gactccacca gcggttcctc tgactaatgg gaagacgtct tggacagctg
     2941 aagcctcgcc tcgatcagtc ctgggcaatg ccaggaggct gggaccgaga ccttcctaga
     3001 ggcgctctgc cagatgagga aggaaaagat gtcaggggcg ctccagtcca gagggttcta
     3061 gttctagttt tgggagatcc cttcttagtg ttgtctcaga gttcagcgat gacaacaaac
     3121 tcttaatagc ttcagaaaca ccgacctgct gtgcatcagg tgggactata tatatatata
     3181 catatttttt ttgtctctct gggtttttga tttgtttttg ccaaaattgc aaaattctaa
     3241 atgtaaagcc ctcagtatca actcttctac cttaacatct ctctctccct ctctctctcc
     3301 ttctctctcc ctgtctctcc ctctctctct atctctctct ccctacacac atacatacac
     3361 tcacacacac acactcacac tcacgttctc tccacaggat ggtctccagc cagacctctc
     3421 agtaaaatga cttgaacatc acctcttcaa aaaaagtatt ctaccttcac atgaaagttt
     3481 aaaaaaagaa aagactatcg aactaaaaac agtcaactgt ttacgtacaa tgataaattc
     3541 aggagttcag tgttttacta atatatcctg ttttgaaacc tcttgttcaa aaacaaactt
     3601 ttgagcaatc aaccaaaatt gttccttttc ttttcctgta gacgttctga cagatttgca
     3661 gggcttgcgg ctcactgtgc tagtatgtaa aaaggtgttg tttacacgag gcaaaggaaa
     3721 aaccatgata ttcagacagt tgccaaatag aataaattat agcacaaata ctgtaatggt
     3781 gcctggcacc agcaacctga gaaagtgttt taaaaaaaag tgttacaagg tttaaaaaaa
     3841 aaaaaacatc tttgctaact tttagtcctg ttaaacattc atgaaattgt taatatgact
     3901 tatatagacc cacacaggtt ttatttttgt gtctttaaaa taaaagtcca aaatatttaa
     3961 attttatggt caaatatgca gtcaacagct gctacttttt tctttatata ttaaatttct
     4021 catatgtctt ttattgttct aataaaccta agcttgtgtg acctccagtg catattagac
     4081 cattcactgt atgaaagaaa acatgttgaa taaatttgtg agtttttaat aaaaatagaa
     4141 aacctgatgt ttag
//
