LOCUS       NP_032524                406 aa            linear   ROD 03-JUN-2025
DEFINITION  LIM/homeobox protein Lhx1 [Mus musculus].
ACCESSION   NP_032524
VERSION     NP_032524.1
DBSOURCE    REFSEQ: accession NM_008498.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 406)
  AUTHORS   Hayashi,S., Suzuki,H., Takada,S. and Takemoto,T.
  TITLE     Wnt3a is an early regulator of the Wolffian duct directionality via
            the regulation of apicobasal cell polarity
  JOURNAL   Dev Biol 522, 136-142 (2025)
   PUBMED   40154784
REFERENCE   2  (residues 1 to 406)
  AUTHORS   Hsu,F.Y., Yen,Y.P., Fan,H.C., Chang,M. and Chen,J.A.
  TITLE     Sertm2 is a conserved micropeptide that promotes GDNF-mediated
            motor neuron subtype specification
  JOURNAL   EMBO Rep 26 (8), 2013-2043 (2025)
   PUBMED   40108406
REFERENCE   3  (residues 1 to 406)
  AUTHORS   Xue,Z., Xuan,H., Lau,K., Su,Y., Wegener,M., Li,K., Turner,L.,
            Adams,M., Shi,X. and Wen,H.
  TITLE     Expression of ENL YEATS domain tumor mutations in nephrogenic or
            stromal lineage impairs kidney development
  JOURNAL   Nat Commun 16 (1), 2531 (2025)
   PUBMED   40087269
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 406)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   5  (residues 1 to 406)
  AUTHORS   Krishnamurthy,A., Lee,A.S., Bayin,N.S., Stephen,D.N., Nasef,O.,
            Lao,Z. and Joyner,A.L.
  TITLE     Engrailed transcription factors direct excitatory cerebellar neuron
            diversity and survival
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38912572
REFERENCE   6  (residues 1 to 406)
  AUTHORS   Shawlot,W. and Behringer,R.R.
  TITLE     Requirement for Lim1 in head-organizer function
  JOURNAL   Nature 374 (6521), 425-430 (1995)
   PUBMED   7700351
REFERENCE   7  (residues 1 to 406)
  AUTHORS   Richman,D.D. and Bozzette,S.A.
  TITLE     The impact of the syncytium-inducing phenotype of human
            immunodeficiency virus on disease progression
  JOURNAL   J Infect Dis 169 (5), 968-974 (1994)
   PUBMED   7909549
REFERENCE   8  (residues 1 to 406)
  AUTHORS   Fujii,T., Pichel,J.G., Taira,M., Toyama,R., Dawid,I.B. and
            Westphal,H.
  TITLE     Expression patterns of the murine LIM class homeobox gene lim1 in
            the developing brain and excretory system
  JOURNAL   Dev Dyn 199 (1), 73-83 (1994)
   PUBMED   7909459
REFERENCE   9  (residues 1 to 406)
  AUTHORS   Barnes,J.D., Crosby,J.L., Jones,C.M., Wright,C.V. and Hogan,B.L.
  TITLE     Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1,
            suggests a role in lateral mesoderm differentiation and
            neurogenesis
  JOURNAL   Dev Biol 161 (1), 168-178 (1994)
   PUBMED   7904966
REFERENCE   10 (residues 1 to 406)
  AUTHORS   Blatt,C., Aberdam,D., Schwartz,R. and Sachs,L.
  TITLE     DNA rearrangement of a homeobox gene in myeloid leukaemic cells
  JOURNAL   EMBO J 7 (13), 4283-4290 (1988)
   PUBMED   2907477
  REMARK    Erratum:[EMBO J 1989 Apr;8(4):1288]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603708.13.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141086.1, Z27410.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..406
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.31 cM"
     Protein         1..406
                     /product="LIM/homeobox protein Lhx1"
                     /note="homeobox protein Lim-1; LIM homeo box protein 1"
                     /calculated_mol_wt=44649
     Region          4..55
                     /region_name="LIM1_Lhx1_Lhx5"
                     /note="The first LIM domain of Lhx1 (also known as Lim1)
                     and Lhx5; cd09367"
                     /db_xref="CDD:188753"
     Site            order(4,7,25,28,31,34,51,54)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188753"
     Region          63..118
                     /region_name="LIM2_Lhx1_Lhx5"
                     /note="The second LIM domain of Lhx1 (also known as Lim1)
                     and Lhx5; cd09375"
                     /db_xref="CDD:188761"
     Site            order(63,66,85,88,91,94,114,117)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188761"
     Region          128..189
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P63006.1)"
     Site            162
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P63007; propagated from
                     UniProtKB/Swiss-Prot (P63006.1)"
     Region          181..237
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          <263..>382
                     /region_name="dnaA"
                     /note="chromosomal replication initiator protein DnaA;
                     cl42516"
                     /db_xref="CDD:455861"
     Region          294..372
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P63006.1)"
     CDS             1..406
                     /gene="Lhx1"
                     /gene_synonym="Lim1"
                     /coded_by="NM_008498.3:1360..2580"
                     /db_xref="CCDS:CCDS25187.1"
                     /db_xref="GeneID:16869"
                     /db_xref="MGI:MGI:99783"
ORIGIN      
        1 mvhcagckrp ildrfllnvl drawhvkcvq cceckcnlte kcfsregkly ckndffrcfg
       61 tkcagcaqgi spsdlvrrar skvfhlncft cmmcnkqlst geelyiiden kfvckedyls
      121 nssvakensl hsattgsdps lspdsqdpsq ddakdsesan vsdkeggsne nddqnlgakr
      181 rgprttikak qletlkaafa atpkptrhir eqlaqetgln mrviqvwfqn rrskerrmkq
      241 lsalgarrha ffrsprrmrp lvdrlepgel ipngpfsfyg dyqseyygpg gnydffpqgp
      301 pssqaqtpvd lpfvpssgps gtplggldhp lpghhpssea qrftdilahp pgdspspeps
      361 lpgplhsmsa evfgpsppfs slsvnggasy gnhlshppem neaavw
//
