LOCUS       NM_029609               1607 bp    mRNA    linear   ROD 20-FEB-2024
DEFINITION  Mus musculus phospholysine phosphohistidine inorganic pyrophosphate
            phosphatase (Lhpp), mRNA.
ACCESSION   NM_029609 XM_486016
VERSION     NM_029609.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1607)
  AUTHORS   Zhuang,L., Gao,W., Chen,Y., Fang,W., Lo,H., Dai,X., Zhang,J.,
            Chen,W., Ye,Q., Chen,X. and Zhang,J.
  TITLE     LHPP in Glutamatergic Neurons of the Ventral Hippocampus Mediates
            Depression-like Behavior by Dephosphorylating CaMKIIalpha and ERK
  JOURNAL   Biol Psychiatry 95 (5), 389-402 (2024)
   PUBMED   37678540
  REMARK    GeneRIF: LHPP in Glutamatergic Neurons of the Ventral Hippocampus
            Mediates Depression-like Behavior by Dephosphorylating CaMKIIalpha
            and ERK.
REFERENCE   2  (bases 1 to 1607)
  AUTHORS   Lin,D., Li,L., Chen,W.B., Chen,J., Ren,D., Zheng,Z.H., Zhao,C.,
            Zhong,Y., Luo,B., Jing,H., Chen,P., Zou,S., Lai,X., Zhou,T.,
            Ding,N., Li,L., Pan,B.X. and Fei,E.
  TITLE     LHPP, a risk factor for major depressive disorder, regulates
            stress-induced depression-like behaviors through its histidine
            phosphatase activity
  JOURNAL   Mol Psychiatry 28 (2), 908-918 (2023)
   PUBMED   36460727
  REMARK    GeneRIF: LHPP, a risk factor for major depressive disorder,
            regulates stress-induced depression-like behaviors through its
            histidine phosphatase activity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY122317.1, AK009207.1, BC065789.1 and BB399046.1.
            
            On Jul 14, 2005 this sequence version replaced XM_486016.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009207.1, BQ964690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BY122317.1         2-3
            3-449               AK009207.1         1-447
            450-779             BC065789.1         426-755
            780-1605            AK009207.1         778-1603
            1606-1607           BB399046.1         271-272
FEATURES             Location/Qualifiers
     source          1..1607
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 76.3 cM"
     gene            1..1607
                     /gene="Lhpp"
                     /gene_synonym="2310007H09Rik"
                     /note="phospholysine phosphohistidine inorganic
                     pyrophosphate phosphatase"
                     /db_xref="GeneID:76429"
                     /db_xref="MGI:MGI:1923679"
     exon            1..188
                     /gene="Lhpp"
                     /gene_synonym="2310007H09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            189..376
                     /gene="Lhpp"
                     /gene_synonym="2310007H09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            377..530
                     /gene="Lhpp"
                     /gene_synonym="2310007H09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            531..594
                     /gene="Lhpp"
                     /gene_synonym="2310007H09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            595..687
                     /gene="Lhpp"
                     /gene_synonym="2310007H09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            688..779
                     /gene="Lhpp"
                     /gene_synonym="2310007H09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            780..1607
                     /gene="Lhpp"
                     /gene_synonym="2310007H09Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaggcgtg gctgcgggat aaaagcagcg gcgacgccga gttcggattt atagctggac
       61 acgatggccg catgggctga gcggctgacg ggcgtgcggg gagtgctgct tgacatctcc
      121 ggggtgctat gtgatagcag cgcaagcggt gcaaccgcta tcgcaggctc tgtggaggca
      181 gtggcgagac tgaaacagtc cccgctgaaa gtgaggttct gtaccaatga gtcccagaaa
      241 tccctgagag agctggtggg ggtgcttcag cagctggggt ttgacatctc agaagaagag
      301 gtgactgccc ctgcaccagc cacctgccag atcctgaagg agcgaggcct gcggccacac
      361 ttgcttatcc atgaaggagt ccgctcagaa tttgatgaca tcgatatgtc caacccaaac
      421 tgtgtggtga ttgcggatgc tggggaggcc ttttcctatc agaacatgaa cagagccttc
      481 caggtgctaa tggagctgga aaaccccgtg ctcatatccc tgggaaaagg acgctattac
      541 aaggagacct ctggcctgat gctggacgtt ggaggttaca tgaaggcgct cgagtatgcc
      601 tgtggtatca aggctgaagt ggtggggaaa ccctcccctg agttcttcaa gtctgctcta
      661 caagccatag gggtggaagc ccaccaggcc atcatgattg gcgatgacat cgtgggtgac
      721 gttggcggtg cccagcagtg tggaatgaga gctctgcagg tgcggaccgg gaagttcagg
      781 cctggtgatg agcatcatcc agaagtacag gcagatgggt acgtggacaa ccttgcggag
      841 gctgtggatc tgctgctgaa gtacacggac aagtgaccag ccttcagaga cagtggacaa
      901 gggcacccct gctcccatac tccatcactg tgccctcttc ccacatactt ccagggcacc
      961 aggccaccca aggctttgcc aggacagatg ctagaagttc tagggtgctt gttcctgggc
     1021 cagagccagc catccccttc acccaccctc tgcggactcc ttgtcaacat tcctccctcc
     1081 ctagcgtctg ggcagaggtt tgttcccctc cctggcccat gccatgtttc ccctaatgac
     1141 atccaagaag gtgaaagaga cctgtcaggc ctccagaaaa tgaaaccctt gggctgaaag
     1201 gtccctctga aactaagtcc ctgaactcct ttagtcacct ttggcacgtg gtcctttaat
     1261 tgaccatcca attggatgag atgcactgcc tcctcgatga actctctgaa tgagaggagc
     1321 ctacagaaac cacagagctg agccagcctg cccaccaccc atagccctat ctggccccag
     1381 tcagaatgac tgatcagcac tctgcctcca acccctgtct taggaaacag gctgggataa
     1441 ctctcaggaa actgaagagt accctcccac agagagaaat gtccacctct acagtcaaga
     1501 ctgaaggcac agaaagctcc ttagagttgg gatggacaga cttaaccatg ttgtctccag
     1561 tgtacagaac aagctaatgg ctcaataaac ttgaccccaa cagcccc
//
