LOCUS       NM_026571               1275 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus lipoma HMGIC fusion partner-like 5 (Lhfpl5), mRNA.
ACCESSION   NM_026571 XM_283418
VERSION     NM_026571.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1275)
  AUTHORS   Beurg,M., Schwalbach,E.T. and Fettiplace,R.
  TITLE     LHFPL5 is a key element in force transmission from the tip link to
            the hair cell mechanotransducer channel
  JOURNAL   Proc Natl Acad Sci U S A 121 (3), e2318270121 (2024)
   PUBMED   38194445
  REMARK    GeneRIF: LHFPL5 is a key element in force transmission from the tip
            link to the hair cell mechanotransducer channel.
REFERENCE   2  (bases 1 to 1275)
  AUTHORS   Qiu,X., Liang,X., Llongueras,J.P., Cunningham,C. and Muller,U.
  TITLE     The tetraspan LHFPL5 is critical to establish maximal force
            sensitivity of the mechanotransduction channel of cochlear hair
            cells
  JOURNAL   Cell Rep 42 (3), 112245 (2023)
   PUBMED   36917610
REFERENCE   3  (bases 1 to 1275)
  AUTHORS   Fettiplace,R., Furness,D.N. and Beurg,M.
  TITLE     The conductance and organization of the TMC1-containing
            mechanotransducer channel complex in auditory hair cells
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2210849119 (2022)
   PUBMED   36191207
REFERENCE   4  (bases 1 to 1275)
  AUTHORS   Zhou,Z., Yu,X., Jiang,B., Feng,W., Tian,Y., Liu,Z., Wang,J. and
            Huang,P.
  TITLE     Alternative Splicing of Three Genes Encoding
            Mechanotransduction-Complex Proteins in Auditory Hair Cells
  JOURNAL   eNeuro 8 (1) (2021)
   PUBMED   33509951
  REMARK    GeneRIF: Alternative Splicing of Three Genes Encoding
            Mechanotransduction-Complex Proteins in Auditory Hair Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1275)
  AUTHORS   Nakano,Y., Wiechert,S., Fritzsch,B. and Banfi,B.
  TITLE     Inhibition of a transcriptional repressor rescues hearing in a
            splicing factor-deficient mouse
  JOURNAL   Life Sci Alliance 3 (12), e202000841 (2020)
   PUBMED   33087486
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1275)
  AUTHORS   Zhao,F., Zhou,J., Li,R., Dudley,E.A. and Ye,X.
  TITLE     Novel function of LHFPL2 in female and male distal reproductive
            tract development
  JOURNAL   Sci Rep 6, 23037 (2016)
   PUBMED   26964900
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1275)
  AUTHORS   Beurg,M., Xiong,W., Zhao,B., Muller,U. and Fettiplace,R.
  TITLE     Subunit determination of the conductance of hair-cell
            mechanotransducer channels
  JOURNAL   Proc Natl Acad Sci U S A 112 (5), 1589-1594 (2015)
   PUBMED   25550511
REFERENCE   8  (bases 1 to 1275)
  AUTHORS   Xiong,W., Grillet,N., Elledge,H.M., Wagner,T.F., Zhao,B.,
            Johnson,K.R., Kazmierczak,P. and Muller,U.
  TITLE     TMHS is an integral component of the mechanotransduction machinery
            of cochlear hair cells
  JOURNAL   Cell 151 (6), 1283-1295 (2012)
   PUBMED   23217710
  REMARK    GeneRIF: TMHS is an integral component of the hair cell's
            mechanotransduction machinery that functionally couples PCDH15 to
            the transduction channel.
REFERENCE   9  (bases 1 to 1275)
  AUTHORS   Longo-Guess,C.M., Gagnon,L.H., Fritzsch,B. and Johnson,K.R.
  TITLE     Targeted knockout and lacZ reporter expression of the mouse Tmhs
            deafness gene and characterization of the hscy-2J mutation
  JOURNAL   Mamm Genome 18 (9), 646-656 (2007)
   PUBMED   17876667
  REMARK    GeneRIF: Hurry-scurry (hscy)-2J, a mutation of Tmhs, causes
            abnormal splicing from a cryptic splice site within exon 2 that is
            predicted to produce a functionally null protein lacking 51 amino
            acids of the wild-type sequence.
REFERENCE   10 (bases 1 to 1275)
  AUTHORS   Longo-Guess,C.M., Gagnon,L.H., Cook,S.A., Wu,J., Zheng,Q.Y. and
            Johnson,K.R.
  TITLE     A missense mutation in the previously undescribed gene Tmhs
            underlies deafness in hurry-scurry (hscy) mice
  JOURNAL   Proc Natl Acad Sci U S A 102 (22), 7894-7899 (2005)
   PUBMED   15905332
  REMARK    GeneRIF: TMHS localizes to the apical membrane of inner ear hair
            cells during stereocilia formation suggesting a function in hair
            bundle morphogenesis; a missense mutation underlies deafness in
            hurry-scurry mice.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY721459.1 and BC099483.1.
            
            On Nov 15, 2007 this sequence version replaced NM_026571.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099483.1, AK020389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               BY721459.1         3-104
            103-1275            BC099483.1         1-1173
FEATURES             Location/Qualifiers
     source          1..1275
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.77 cM"
     gene            1..1275
                     /gene="Lhfpl5"
                     /gene_synonym="9330179O15Rik; hscy; Tmhs"
                     /note="lipoma HMGIC fusion partner-like 5"
                     /db_xref="GeneID:328789"
                     /db_xref="MGI:MGI:1915382"
     exon            1..694
                     /gene="Lhfpl5"
                     /gene_synonym="9330179O15Rik; hscy; Tmhs"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..942
                     /gene="Lhfpl5"
                     /gene_synonym="9330179O15Rik; hscy; Tmhs"
                     /note="tetraspan membrane protein of hair cell
                     stereocilia; lipoma HMGIC fusion partner-like 5 protein;
                     tetraspan transmembrane protein, hair cell stereocilia"
                     /codon_start=1
                     /product="LHFPL tetraspan subfamily member 5 protein"
                     /protein_id="NP_080847.2"
                     /db_xref="CCDS:CCDS37530.1"
                     /db_xref="GeneID:328789"
                     /db_xref="MGI:MGI:1915382"
                     /translation="MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALF
                     IQPYWIGDSVSTPQAGYFGLFSYCVGNVLSSELICKGGPLDFSSIPSRAFKTAMFFVA
                     LAMFLIIGSIICFSLFFVCNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRM
                     CGEQTGKYTLGHCTIRWAFMLAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGNEE
                     V"
     exon            695..931
                     /gene="Lhfpl5"
                     /gene_synonym="9330179O15Rik; hscy; Tmhs"
                     /inference="alignment:Splign:2.1.0"
     exon            932..977
                     /gene="Lhfpl5"
                     /gene_synonym="9330179O15Rik; hscy; Tmhs"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1247
                     /gene="Lhfpl5"
                     /gene_synonym="9330179O15Rik; hscy; Tmhs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1140..1145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lhfpl5"
                     /gene_synonym="9330179O15Rik; hscy; Tmhs"
                     /note="hexamer: ATTAAA"
     polyA_site      1165
                     /gene="Lhfpl5"
                     /gene_synonym="9330179O15Rik; hscy; Tmhs"
                     /note="major polyA site"
ORIGIN      
        1 aaagcggagg cgcaggccca gaccctggcc gacctagagg aggcggcaga ctcgagccca
       61 tcctggtcag aacgggcaca ttcatctggg aagcatctct tgcgaagaca aggttgacct
      121 tggcctgctg cactcccaac ctactggggg gaatgtttgc atggctccct gacctcaggc
      181 tgctcctcac accaggctga ggactgaccc acgacttctg ctccctagag ctgtagacct
      241 gcacccagcc agtgtccccg tcctagtcca gcggccttcg ccatggtgaa gttgctgcca
      301 gcccaggagg ccgccaagat ctaccacacc aactatgtgc gaaactcgcg cgctgtggga
      361 gtgatgtggg gcacgctcac tatctgtttc tcggtgctgg tcatggccct ctttatccag
      421 ccctactgga taggcgacag tgttagcaca ccacaggctg gttactttgg cttgttctcc
      481 tactgcgtgg gcaacgtgct gtcgtcggaa ctcatctgca aggggggccc tctggacttc
      541 tcctccatcc cctccagagc cttcaagact gccatgttct ttgtggcctt ggccatgttc
      601 cttatcatcg gctccatcat ctgcttcagc ctgttcttcg tctgtaatac agccacggtc
      661 tacaagattt gcgcctggat gcagctggct gctgccacgg gcctaatgat cggatgtcta
      721 gtctacccag atggttggga ctccagtgag gtgcggcgta tgtgtggcga gcagacgggc
      781 aagtacacac tgggccactg caccatccgc tgggccttca tgctggccat cctcagcatt
      841 ggagatgcac tcatcctctc cttcctggct tttgtgttgg gctatcggca ggacaagctc
      901 ctcccggatg actacaaggc agatgggaat gaggaagtct gaagcaaccg aggtgctggc
      961 agcaacaatt ctaacagctg aagaaaaaga atgatctact ggtttcaacg tgattccaaa
     1021 agaaacatga tgtgctcatt cccgcttgct tctgctttgg agacagcatc tctctaggta
     1081 gtgttgacca gccttgaact ctcagagatc cacctgcttc tgcctccctg agatctagga
     1141 ttaaaggtgt ggctactaca cctaaccttg tataatttct ttatcgtctt ttagcttcca
     1201 aaatgatttt gaaattaaga gaaaaacaaa accagaaatc cctttttaaa aaaaaaaaaa
     1261 aaaaaaaaaa aaaaa
//
