LOCUS       NM_177763               4782 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus lipoma HMGIC fusion partner-like protein 4 (Lhfpl4),
            mRNA.
ACCESSION   NM_177763
VERSION     NM_177763.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4782)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4782)
  AUTHORS   Wu,M., Tian,H.L., Liu,X., Lai,J.H.C., Du,S. and Xia,J.
  TITLE     Impairment of Inhibitory Synapse Formation and Motor Behavior in
            Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4
  JOURNAL   Cell Rep 23 (6), 1691-1705 (2018)
   PUBMED   29742426
  REMARK    GeneRIF: the essential role of LHFPL4/GARLH4 in brain functions by
            regulating inhibitory synapse formation as a major NL2 binding
            partner, is reported.
REFERENCE   3  (bases 1 to 4782)
  AUTHORS   Davenport,E.C., Pendolino,V., Kontou,G., McGee,T.P., Sheehan,D.F.,
            Lopez-Domenech,G., Farrant,M. and Kittler,J.T.
  TITLE     An Essential Role for the Tetraspanin LHFPL4 in the
            Cell-Type-Specific Targeting and Clustering of Synaptic GABAA
            Receptors
  JOURNAL   Cell Rep 21 (1), 70-83 (2017)
   PUBMED   28978485
  REMARK    GeneRIF: The results establish LHFPL4 as a synapse-specific
            tetraspanin essential for inhibitory synapse function and provide
            fresh insights into the molecular make-up of inhibitory synapses.
REFERENCE   4  (bases 1 to 4782)
  AUTHORS   Yamasaki,T., Hoyos-Ramirez,E., Martenson,J.S., Morimoto-Tomita,M.
            and Tomita,S.
  TITLE     GARLH Family Proteins Stabilize GABAA Receptors at Synapses
  JOURNAL   Neuron 93 (5), 1138-1152 (2017)
   PUBMED   28279354
REFERENCE   5  (bases 1 to 4782)
  AUTHORS   Zhao,F., Zhou,J., Li,R., Dudley,E.A. and Ye,X.
  TITLE     Novel function of LHFPL2 in female and male distal reproductive
            tract development
  JOURNAL   Sci Rep 6, 23037 (2016)
   PUBMED   26964900
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB645074.1, AK220449.1, BC085130.1 and AI847853.1.
            
            On Apr 11, 2007 this sequence version replaced NM_177763.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046437.1, SRR1660815.66455.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BB645074.1         1-56
            57-2116             AK220449.1         1-2060
            2117-2208           BC085130.1         2064-2155
            2209-4762           AK220449.1         2061-4614
            4763-4782           AI847853.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..4782
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.74 cM"
     gene            1..4782
                     /gene="Lhfpl4"
                     /gene_synonym="1190004M23Rik; B230384L07; mKIAA4027"
                     /note="lipoma HMGIC fusion partner-like protein 4"
                     /db_xref="GeneID:269788"
                     /db_xref="MGI:MGI:3057108"
     exon            1..170
                     /gene="Lhfpl4"
                     /gene_synonym="1190004M23Rik; B230384L07; mKIAA4027"
                     /inference="alignment:Splign:2.1.0"
     exon            171..656
                     /gene="Lhfpl4"
                     /gene_synonym="1190004M23Rik; B230384L07; mKIAA4027"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..994
                     /gene="Lhfpl4"
                     /gene_synonym="1190004M23Rik; B230384L07; mKIAA4027"
                     /note="lipoma HMGIC fusion partner-like 4 protein; GABAA
                     receptor regulatory Lhfpl4"
                     /codon_start=1
                     /product="LHFPL tetraspan subfamily member 4 protein"
                     /protein_id="NP_808431.2"
                     /db_xref="CCDS:CCDS39591.1"
                     /db_xref="GeneID:269788"
                     /db_xref="MGI:MGI:3057108"
                     /translation="MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQP
                     YWVGDSVSTPKPGYFGLFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLS
                     MVLILGCITCFALFFFCNTATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCG
                     AKTGKYSLGDCSVRWAYILAIIGILNALILSFLAFVLGNRQTDLLQEELKQENKDFVG
                     TTVSSVLRPGGDVSGWGVLPCPVAHTQGP"
     exon            657..893
                     /gene="Lhfpl4"
                     /gene_synonym="1190004M23Rik; B230384L07; mKIAA4027"
                     /inference="alignment:Splign:2.1.0"
     exon            894..4765
                     /gene="Lhfpl4"
                     /gene_synonym="1190004M23Rik; B230384L07; mKIAA4027"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3406
                     /gene="Lhfpl4"
                     /gene_synonym="1190004M23Rik; B230384L07; mKIAA4027"
     regulatory      4742..4747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lhfpl4"
                     /gene_synonym="1190004M23Rik; B230384L07; mKIAA4027"
                     /note="hexamer: AATAAA"
     polyA_site      4765
                     /gene="Lhfpl4"
                     /gene_synonym="1190004M23Rik; B230384L07; mKIAA4027"
                     /note="major polyA site"
ORIGIN      
        1 agtgcccggg agcgcgcgcc tcggcgcggg agcgcgcccc ggggagagcc ggagcaagat
       61 ggaggccgcg cagaggacgc cgcctgggcc aaggcaaccg ctgttaggag catcgagcac
      121 cggagcttga gccctgccgg tcccggatca gccgtcccga ctcggcccag ctcccgcccc
      181 gcggccggtg gtcagtcctg ggccggcggc cccctgtcag ccgctgccgc cggccccgcc
      241 cccgggcacc atgctgccct cgcaggaagc ctccaagctc taccatgagc actacatgcg
      301 gaactcgcgg gccatcggcg tgctatgggc catcttcacc atctgcttcg ccatcatcaa
      361 cgtggtggtc ttcatccagc cctactgggt aggcgacagc gtgagcactc ccaagcctgg
      421 ctacttcggc ctcttccact actgcgtggg cagcgggcta gcgggccgcg agctcacctg
      481 ccggggctct ttcaccgact tcagcaccat cccgtccagc gccttcaagg cggccgcctt
      541 cttcgtgttg ctttccatgg tgctgattct cggctgcatc acctgcttcg ctcttttctt
      601 cttctgcaac actgctactg tctacaagat ctgcgcctgg atgcagctcc tggcagccct
      661 gtgcctcgtc ttgggctgta tgatctttcc tgatggctgg gatgctgaga ccatccggga
      721 catgtgcggg gccaagacag ggaagtactc cctgggggac tgttcagtgc gctgggcgta
      781 cattctggcc atcatcggca tcctcaacgc gctcatcctg tccttccttg ccttcgtgct
      841 gggcaaccgg cagacggacc tgctgcagga ggagctcaaa caggagaaca aagatttcgt
      901 gggcactaca gtaagttccg tgctgcggcc aggaggtgat gtgtctggct ggggagtcct
      961 accatgccct gttgctcaca cacagggacc ctgaaagccg ggattttata gcccaggagt
     1021 tggcctgacc tcagcatatc ccgtctgctg ccctctcatt cctgcgttca agctccagac
     1081 ccaaatcttg aactggctgc acacggacct cctccgggct ctgaagagag gcaggggcta
     1141 ggtggcagcc tggcaagaag gcagagccct tgagatcctg agtctggccc cgcctccatt
     1201 ggacctagtg gagcctgggc ctccctcttt ggtccctcgg tttccttctc tcctgtgtag
     1261 actagctgga ggtccctggg gatccccagg gaaaggacgc tctgccgcgc aatctccttg
     1321 gaccccttca gtgtgcaggg ctgcctgctg cgtccttgcc tgccggtcct gatcgcctaa
     1381 agagacttac tcaacacact gccccaggag ggccagactc tttcctactt tatttttatt
     1441 cgctgatgat ggtcccacca catctgccac aaagctccag gtgccaccag ccccccaacg
     1501 gggcctcctc tgcctccctc attcaagcct gcacccagct ctcaaaagaa tctgagccgt
     1561 gctgaggggg aaaggatagg gtcttccttc ctgctgctgg tagtccttca tcacctcaga
     1621 gtctgagggg gagacacggg ctctggaggc tgtgggagga ggaagctagt tccagcctga
     1681 ggctggcctg gcctcttccc tactgggata tctcactggt gactggcccc tcgagcctgg
     1741 cctgttttgt acagcataga cttctcaggc ccattgtcag ggttggtggc tgtggagagg
     1801 gggcacagag gtggggactt aggggttacc cctctccttc tcatgcttcc tacaccctgg
     1861 acatctgcca agggcagaga ctgtcttgcg tctttgatac ttttctgcct aacttgaact
     1921 tgcaggtcac ctctgaacag ggtacccttg tccccacccc aggccctgtt accctgtccc
     1981 tgcctctttc tcctctttgc ccacttctcg ccttgcgata agcccagggt ctgcaacctc
     2041 atgggcagtg cttggagctg aggtaggtgt gtgtgcatga gtgtgtgcgt gtatgtgtgt
     2101 gtatgtgtgt gtatgcgtgt gtatgcgtga gtatgtgtgt gcgtgtatgt gtgtatgtgt
     2161 gtgtttgtgt gtgtgtgcgt gtgtgtatgt gtgtatgtgt gtgtgtgtgt gtgtgtgcgt
     2221 gtgtatgtgt gtgcatgtat gtatgtatgt gtgtgtttgt gtgtgcgtgt gtgtgtgtgt
     2281 gtgtgtgtgt gtgtgtgtgc gtgtgttagg aaagggcaga tgagaagatc tctcttctcc
     2341 tgcagtgggg ggcccctccc tcccccttag cagagagaaa aacgagggag attccaggtg
     2401 gttttttgtt gttgttgttg ttgttgtttt gttttttatt ttgttgtagt ttttgaccat
     2461 ctttggctac cttatggatc tggtggcaga gccatctaat catagaaaag cctccagttt
     2521 ccagtggagg ggtggcagac gaacgtcatc aaacataatg tctccgagga cacggcctgc
     2581 tgcctggtcc ttgtgtcgag gaatgtgtgc ctcctatagg ctgtccagga ggcgtctcac
     2641 ttccctgtgt tacattggcc tcagccagag aggaagaacg gctagtctat gagtttgctg
     2701 tccttgtgtt cattttcaga ggacttggag ctgagttagg attcctgagc caggcccatg
     2761 acccaaggct gccccagcag gaccctacct ggaatctgat gctggttcct ggcagaattc
     2821 ctgacacttg gaacgttcca gatcccatct ccacattttc tcctctctcc tccagggtag
     2881 acacctcctc ctgagctttg gccactgccc ttgtcttccc cagctcttgt cccaacctgg
     2941 tccctccctg gagccagagt gctggagtca tcttcagcag gtagccagga gactgggaat
     3001 ggacagggag ggtgggggag ccttgtcaga aggagaaggg agcaggaagt cagatcctca
     3061 gcttcaaacc agaggggagg gtccaggtag tggcgagagg ggcaggagtg ggtgactgac
     3121 tgagaagcgg gcaggagcaa agccggcgaa gtaaagatga ggcaggagac aggcgacagg
     3181 catggaaagg gaggaatgga gagaatggag agagagagag agagagagag agagagagag
     3241 agagagagag agagagagag agagagagag atctggagag gcacacacaa cgatggagaa
     3301 gtgaagaact agaatgggtt ttccatggat gggcagcaga tgaagaaacc tgggaggtgg
     3361 gaaatggagg ggtaattcac agggagcaag aacaaaatgt agagaagaaa gaagatagtg
     3421 ggtatgtgtg tgaagaggaa acgctaggga ttgaggaggg cagccatgtg tgtgcttgga
     3481 gagcctgttt tcctaagaac acttgctgcc cagggggtcc cttgtgcttt ggcagacagg
     3541 atagaattga cttcttggtg tctgcggtag ctctgatcct ttggagagaa ctgtgtgtgt
     3601 acaagggacc gagcaggcca ggctgtgtta gatagaggtg ggctaatgac agagaggaag
     3661 ggcatgagtt ccctctgagg agtcgtctac cagtgttctt gccactctcc agccaaccag
     3721 ctgctgccca gcggtgcagt gtggagtttc aggctggcag gctgaggtct gcagtctgca
     3781 ggagccccag ggtatcgcgg ggaaagaaga gagggagcaa tgggaaccaa aatgtggtct
     3841 tgaaggctta gaagagttag ggacaaagaa aatggatgtt tcggccaaga actcaggtga
     3901 ggctctaact gacctcctgg cagttgacgt aggacagtta gggcggggag ctggtgttag
     3961 cctttgggga aggataggat atggacatca acatctctgt ttctgatcac taaccaagag
     4021 cttcccgttg ttgggtccct gaaaatcctc agctatttgt gactggatgg agaggctggt
     4081 gtttggtgtt agcggatttc tttgctcttg acagagaggg gagaggagaa agcagttata
     4141 gcttcaatgg ggtccagcct ctgctccaga gcactgttta gactagtcct tggggttgag
     4201 ggaagtagaa cactgccctc taaggaccag agctatggag gaaagctgtt ccaagggcct
     4261 gaggatgtgg ggaatattaa catccttctg gggcctgcaa gagccaagat ggcagcttgc
     4321 agatggcgct tgggaggacg gggaagcttc tacaagttga gtccctcttg agcacagagg
     4381 gactagtcct tctccagcct ctggtatgaa ccaaaaaagg gaaaccctct tggaagggct
     4441 ggattccttc tagcatgaga ggcttctggg ggcccttgtc tggctcagag ctagcttttg
     4501 ggtgggacag gaggtattcc tgagaagaga gcaggagcca ccagccatcc caggactctg
     4561 actggcagtc ctccaaggac ctgtgctgtg tgttagggta gcttggtgtt gtctgtgccc
     4621 cactagtaag ttctgtctga atgtgtctta gatgttcact gtccaatttg gtaacatttc
     4681 ttttggtccc gcccccttct gctgctggat ttatgcttca gtgcaggtgg aatggtgttc
     4741 aaataaagac acaatttata tcaccaaaaa aaaaaaaaaa aa
//
