LOCUS       NM_029990               3072 bp    mRNA    linear   ROD 03-AUG-2024
DEFINITION  Mus musculus lipoma HMGIC fusion partner-like 3 (Lhfpl3),
            transcript variant 1, mRNA.
ACCESSION   NM_029990
VERSION     NM_029990.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3072)
  AUTHORS   Qiu,X., Liang,X., Llongueras,J.P., Cunningham,C. and Muller,U.
  TITLE     The tetraspan LHFPL5 is critical to establish maximal force
            sensitivity of the mechanotransduction channel of cochlear hair
            cells
  JOURNAL   Cell Rep 42 (3), 112245 (2023)
   PUBMED   36917610
REFERENCE   2  (bases 1 to 3072)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   3  (bases 1 to 3072)
  AUTHORS   Zhao,F., Zhou,J., Li,R., Dudley,E.A. and Ye,X.
  TITLE     Novel function of LHFPL2 in female and male distal reproductive
            tract development
  JOURNAL   Sci Rep 6, 23037 (2016)
   PUBMED   26964900
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3072)
  AUTHORS   Georgas,K.M., Chiu,H.S., Lesieur,E., Rumballe,B.A. and Little,M.H.
  TITLE     Expression of metanephric nephron-patterning genes in
            differentiating mesonephric tubules
  JOURNAL   Dev Dyn 240 (6), 1600-1612 (2011)
   PUBMED   21491542
REFERENCE   5  (bases 1 to 3072)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 3072)
  AUTHORS   Longo-Guess,C.M., Gagnon,L.H., Cook,S.A., Wu,J., Zheng,Q.Y. and
            Johnson,K.R.
  TITLE     A missense mutation in the previously undescribed gene Tmhs
            underlies deafness in hurry-scurry (hscy) mice
  JOURNAL   Proc Natl Acad Sci U S A 102 (22), 7894-7899 (2005)
   PUBMED   15905332
  REMARK    GeneRIF: The authors present an overview of the Lhfp gene family in
            mouse and humans.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123661.22, AC138737.10 and AC158942.7.
            
            On Mar 7, 2019 this sequence version replaced NM_029990.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.241239.1,
                                           SRR11927933.2654957.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-572               AC123661.22        37569-38140
            573-809             AC138737.10        63987-64223         c
            810-3072            AC158942.7         157973-160235
FEATURES             Location/Qualifiers
     source          1..3072
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 10.07 cM"
     gene            1..3072
                     /gene="Lhfpl3"
                     /gene_synonym="A930031L14Rik"
                     /note="lipoma HMGIC fusion partner-like 3"
                     /db_xref="GeneID:269629"
                     /db_xref="MGI:MGI:1925076"
     exon            1..572
                     /gene="Lhfpl3"
                     /gene_synonym="A930031L14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..838
                     /gene="Lhfpl3"
                     /gene_synonym="A930031L14Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lipoma HMGIC fusion partner-like 3 protein; LHFPL
                     tetraspan subfamily member 3 protein"
                     /codon_start=1
                     /product="LHFPL tetraspan subfamily member 3 protein
                     isoform 1"
                     /protein_id="NP_084266.1"
                     /db_xref="GeneID:269629"
                     /db_xref="MGI:MGI:1925076"
                     /translation="MPGAAAAAAAMLPAQEAAKLYHTNYVRNSRAIGVLWAIFTICFA
                     IVNVVCFIQPYWIGDGVDTPQAGYFGLFHYCIGNGFSRELTCRGSFTDFSTLPSGAFK
                     AASFFIGLSMMLIIACIVCFTLFFFCNTATVYKICAWMQLTSAACLVLGCMIFPDGWD
                     SDEVKRMCGEKTDKYTLGACSVRWAYILAIIGILDALILSFLAFVLGNRQDSLMAEEL
                     KAENKVLLSQYSLE"
     exon            573..809
                     /gene="Lhfpl3"
                     /gene_synonym="A930031L14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            810..3072
                     /gene="Lhfpl3"
                     /gene_synonym="A930031L14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3046..3051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lhfpl3"
                     /gene_synonym="A930031L14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3052
                     /gene="Lhfpl3"
                     /gene_synonym="A930031L14Rik"
                     /note="major polyA site"
     polyA_site      3072
                     /gene="Lhfpl3"
                     /gene_synonym="A930031L14Rik"
ORIGIN      
        1 agactctaga actggtgctg ctgggctgag gcggaggcag gggaattgca acgcacgccg
       61 ctcgctcggc gagtgtgtct cctgcgcgcc gagaggcggg gggaggcgga ggaccgggag
      121 gaggaggagg agggggagaa tgcccggagc cgccgccgcc gccgccgcga tgctcccggc
      181 tcaggaggct gccaagctgt accacaccaa ctatgtgcgg aactcgcggg ccatcggcgt
      241 gctgtgggcc atcttcacca tctgctttgc catcgtcaat gtggtgtgct tcatccagcc
      301 ctactggatc ggcgacggcg tggacacccc gcaagccggc tatttcgggc tcttccacta
      361 ctgcatcggc aacggcttct cccgggagct gacctgcagg ggtagcttca cggacttctc
      421 cacgctgccc tcgggcgcct tcaaagccgc ctccttcttc atcggcctct ccatgatgct
      481 catcatcgcc tgcatcgttt gctttaccct cttcttcttc tgcaacacag ccaccgtgta
      541 caagatctgt gcttggatgc agctcacctc cgctgcctgc cttgtccttg gctgtatgat
      601 tttccctgat ggctgggatt cagacgaagt aaaacggatg tgcggagaga agacagacaa
      661 gtacactctt ggggcctgct cggtccgctg ggcgtacatc ctggctatca tcggaatctt
      721 agacgccctg atcctctcgt ttctagcgtt tgtgcttggg aaccgacaag acagcttgat
      781 ggcagaggaa ctgaaagcag aaaacaaagt tctgttaagc caatattctc tagaatgagc
      841 acaaaacaag tcaaataaca gctaaacaaa cagctttgta catcagcacc aagaaggaag
      901 acgcttggga gagatcagag tccagagatg actacacaca aaagtgaaac atctactctt
      961 caaagcacct tctgattcta gatctgcaga gactcgagta atttttctga gaggagctat
     1021 gattacagat taaacaccag ctcattggaa actgtcatta gataagatca gataacactc
     1081 atgaaaatca tattcaggaa atagtttaag aaagaagaat acaaatgtgc tagaattgtg
     1141 taaaatacat atgtatcgag gtttataagc tgtccttttt aaatcaaact gaaaacaaaa
     1201 taaaacaaaa aaagctttaa tctttcaatg ctattaaatg aagtaaaagg gcagttagtt
     1261 ctagactatt cccatcccag tagccaagag gcccatggag tgtcatgttt tgaggaatgc
     1321 ctctgatcct tgatccctca ttgctactgt ccactcatgt cactgtgcaa ttagttacaa
     1381 ccacgtggtt attaagagac ttagcccttc aaacttctta cccaatgtgt gttcagttta
     1441 atctgtttgt acgacttatc acgaaggaaa tgtttctgcc atgtgctatg actccatcaa
     1501 actgtgaatc acaggaagta catccagaca tcgtaggttc ccaagcaaca tagattcccc
     1561 tgtcattgac aaaacagcat caaggagctc tgaacaatat agaaagttta ttttcacttg
     1621 gatgctctct catgtaatat ataggctact atcaaataaa cgctttttct aattctccct
     1681 agtatatgca taggaattta atatacttta taaatagatg tctaaaatat gagttttcta
     1741 tttcttcatt ctatatgtca ctagaaatcc acattcttta tttcctttac tgacatatac
     1801 tcatttttgt tttgttaaaa gaaactattc cattaaatct acttctaaat gatagtaagt
     1861 ggtactaaca aaataagtaa aaacttaata gccttagaag taaataacta tatacttata
     1921 tgtcaaagga acttggtagg aataagttac cttttgttta ttaatgttga ttttgaaatt
     1981 tctcatattt tttccctttt ggttagctgg tacttgaaag tagttacaac taactagctg
     2041 tcttcaagaa tcttttcctt ccagggtccc ccagccgttg cccttataac atgtcctgcc
     2101 tcagtccaac aacagagaaa tacttgatat taaagtaatt cttcattgtc tgagtataaa
     2161 cgcaagttga agtacatata aagggggctc aatgcaagcc agcccatgtt ctatacttga
     2221 gcaggaaaaa aaaaaaacac aaatagaatg cctgcactcc caggcttggg attgggttaa
     2281 atcagcatcc cactcgagca tcagctggag gacaacacaa gaatcaggtt gccctctctt
     2341 atgctcccat aagaccgtgc tcatattttt agccatgttg tcacgaagca aatgtttcca
     2401 atggctaaaa atacattaca aatacactca agtgctcatg taactaaaac ccagttcaca
     2461 gaaagaaaac tcaggctttc ccaaagcact aaattaaggg aatgttagcc tctgtaattg
     2521 tagtcctggt catcctgggg gctggtcatt gctttaggta cttgtcccga ggcattcaga
     2581 ataccctact tactaaattt aattacacac aacttttaaa aaattcacct tttatttaag
     2641 gggaggcatc tctatatcta tactaaaatc agaaggtatt aggttcctct aatccatgta
     2701 aattatgatt ctgtctgggt cctacatcat tagcagtaat gtttcaaaac aataaaaggt
     2761 acttcctctc cacatgcaaa tgcttttatg tttttgccat aaaccctaag tgtaatttag
     2821 cacaccgcag tgctatgaag atggatcatt gatgataaac catctgtaca tacgtaacac
     2881 acatgtaaac cactaaatgt taagtataag aaatatgttt ttacctttaa aaaagactcc
     2941 ttttctcatt ctgttctatt atgtccaaaa gttgtgtgta attttttaag gtccaggaaa
     3001 tgtaaagaaa tttgttggaa tatctgaatt tctgtaaaaa ataaaaataa aattttgtta
     3061 cataaaaata ta
//
