LOCUS       NM_008497                509 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus luteinizing hormone beta (Lhb), mRNA.
ACCESSION   NM_008497 XM_001473952 XM_001475125
VERSION     NM_008497.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Lehtonen,H., Jokela,H., Hofmann,J., Tola,L., Mehmood,A.,
            Ginhoux,F., Becher,B., Greter,M., Yegutkin,G.G., Salmi,M., Gerke,H.
            and Rantakari,P.
  TITLE     Early precursor-derived pituitary gland tissue-resident macrophages
            play a pivotal role in modulating hormonal balance
  JOURNAL   Cell Rep 44 (2), 115227 (2025)
   PUBMED   39841599
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 509)
  AUTHORS   Refael,T., Sudman,M., Golan,G., Pnueli,L., Naik,S., Preger-Ben
            Noon,E., Henn,A., Kaplan,A. and Melamed,P.
  TITLE     An i-motif-regulated enhancer, eRNA and adjacent lncRNA affect Lhb
            expression through distinct mechanisms in a sex-specific context
  JOURNAL   Cell Mol Life Sci 81 (1), 361 (2024)
   PUBMED   39158745
  REMARK    GeneRIF: An i-motif-regulated enhancer, eRNA and adjacent lncRNA
            affect Lhb expression through distinct mechanisms in a sex-specific
            context.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 509)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   4  (bases 1 to 509)
  AUTHORS   Lettieri,A., Oleari,R., van den Munkhof,M.H., van Battum,E.Y.,
            Verhagen,M.G., Tacconi,C., Spreafico,M., Paganoni,A.J.J.,
            Azzarelli,R., Andre',V., Amoruso,F., Palazzolo,L., Eberini,I.,
            Dunkel,L., Howard,S.R., Fantin,A., Pasterkamp,R.J. and Cariboni,A.
  TITLE     SEMA6A drives GnRH neuron-dependent puberty onset by tuning median
            eminence vascular permeability
  JOURNAL   Nat Commun 14 (1), 8097 (2023)
   PUBMED   38062045
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 509)
  AUTHORS   Huang,C., Zhao,S., Yang,Y., Guo,T., Ke,H., Mi,X., Qin,Y., Chen,Z.J.
            and Zhao,S.
  TITLE     TP63 gain-of-function mutations cause premature ovarian
            insufficiency by inducing oocyte apoptosis
  JOURNAL   J Clin Invest 133 (5), e162315 (2023)
   PUBMED   36856110
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 509)
  AUTHORS   Voss,J.W. and Rosenfeld,M.G.
  TITLE     Anterior pituitary development: short tales from dwarf mice
  JOURNAL   Cell 70 (4), 527-530 (1992)
   PUBMED   1505020
  REMARK    Review article
REFERENCE   7  (bases 1 to 509)
  AUTHORS   Weiss,J., Axelrod,L., Whitcomb,R.W., Harris,P.E., Crowley,W.F. and
            Jameson,J.L.
  TITLE     Hypogonadism caused by a single amino acid substitution in the beta
            subunit of luteinizing hormone
  JOURNAL   N Engl J Med 326 (3), 179-183 (1992)
   PUBMED   1727547
REFERENCE   8  (bases 1 to 509)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     A molecular genetic linkage map of mouse chromosome 7
  JOURNAL   Genomics 8 (3), 525-535 (1990)
   PUBMED   1981054
REFERENCE   9  (bases 1 to 509)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     The syntenic relationship of proximal mouse chromosome 7 and the
            myotonic dystrophy gene region on human chromosome 19q
  JOURNAL   Genomics 6 (2), 324-332 (1990)
   PUBMED   2307474
REFERENCE   10 (bases 1 to 509)
  AUTHORS   Yang-Feng,T.L., Schneider,J.W., Lindgren,V., Shull,M.M., Benz,E.J.
            Jr., Lingrel,J.B. and Francke,U.
  TITLE     Chromosomal localization of human Na+, K+-ATPase alpha- and
            beta-subunit genes
  JOURNAL   Genomics 2 (2), 128-138 (1988)
   PUBMED   2842249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB618381.1, AV173269.2 and BM224915.2.
            
            On or before Sep 4, 2008 this sequence version replaced
            XM_001475125.1, XM_001473952.1, NM_008497.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB618381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BB618381.1         2-60
            60-141              AV173269.2         72-153
            142-429             BB618381.1         143-430
            430-509             BM224915.2         14-93               c
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.3 cM"
     gene            1..509
                     /gene="Lhb"
                     /gene_synonym="Gm29035; LH; LH-B; LSH-B; LSH-beta"
                     /note="luteinizing hormone beta"
                     /db_xref="GeneID:16866"
                     /db_xref="MGI:MGI:96782"
     exon            1..22
                     /gene="Lhb"
                     /gene_synonym="Gm29035; LH; LH-B; LSH-B; LSH-beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..433
                     /gene="Lhb"
                     /gene_synonym="Gm29035; LH; LH-B; LSH-B; LSH-beta"
                     /note="lutropin subunit beta; lutropin beta chain;
                     luteinizing hormone subunit beta; leutropin"
                     /codon_start=1
                     /product="lutropin subunit beta precursor"
                     /protein_id="NP_032523.2"
                     /db_xref="CCDS:CCDS21242.1"
                     /db_xref="GeneID:16866"
                     /db_xref="MGI:MGI:96782"
                     /translation="MERLQGLLLWLLLSPSVVWASRGPLRPLCRPVNATLAAENEFCP
                     VCITFTTSICAGYCPSMVRVLPAALPPVPQPVCTYRELRFASVRLPGCPPGVDPIVSF
                     PVALSCRCGPCRLSSSDCGGPRTQPMACDLPHLPGLLLL"
     exon            23..190
                     /gene="Lhb"
                     /gene_synonym="Gm29035; LH; LH-B; LSH-B; LSH-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            191..509
                     /gene="Lhb"
                     /gene_synonym="Gm29035; LH; LH-B; LSH-B; LSH-beta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcaagaatg gagaggctcc aggggctgct gctgtggctg ctgctgagcc caagtgtggt
       61 gtgggcctcc aggggccccc ttcggccact gtgccggcct gtcaacgcaa ctctggccgc
      121 agagaatgag ttctgcccag tctgcatcac cttcaccacc agcatctgtg ccggctactg
      181 tcctagcatg gtccgagtac tgccggctgc tttgcctcct gtgcctcagc cagtgtgcac
      241 ctaccgggag ctgcgcttcg catctgtccg cctccctggc tgcccaccgg gtgtagaccc
      301 catagtctcc tttcctgtag ccctcagctg ccgctgtggg ccctgccggc tcagtagctc
      361 tgactgtggg ggtcccagga ctcaaccaat ggcctgtgac ctcccccacc tccccggcct
      421 cctcctcctc tgaggcccac cccttcacca ccagcaggtg ttctaatcat ccctccctcc
      481 ctccttccca ataaaggctt tccaactgc
//
