LOCUS       NM_153601               1911 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus lengsin, lens protein with glutamine synthetase domain
            (Lgsn), mRNA.
ACCESSION   NM_153601
VERSION     NM_153601.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1911)
  AUTHORS   Saitoh,F. and Araki,T.
  TITLE     Proteasomal degradation of glutamine synthetase regulates schwann
            cell differentiation
  JOURNAL   J Neurosci 30 (4), 1204-1212 (2010)
   PUBMED   20107048
  REMARK    GeneRIF: These results indicate that the ZNRF1-GS system may play
            an important role in correlating Schwann cell metabolism with its
            differentiation.
REFERENCE   2  (bases 1 to 1911)
  AUTHORS   Wyatt,K., Gao,C., Tsai,J.Y., Fariss,R.N., Ray,S. and Wistow,G.
  TITLE     A role for lengsin, a recruited enzyme, in terminal differentiation
            in the vertebrate lens
  JOURNAL   J Biol Chem 283 (10), 6607-6615 (2008)
   PUBMED   18178558
  REMARK    GeneRIF: lengsin may act as a component of the cytoskeleton itself
            or as a chaperone for the reorganization of intermediate filament
            proteins during terminal differentiation in the lens.
            GeneRIF: Lengsin interacts with intermediate filament proteins of
            the eye lens and is associated with terminal differentiation of
            fiber cells
REFERENCE   3  (bases 1 to 1911)
  AUTHORS   Wyatt,K., White,H.E., Wang,L., Bateman,O.A., Slingsby,C.,
            Orlova,E.V. and Wistow,G.
  TITLE     Lengsin is a survivor of an ancient family of class I glutamine
            synthetases re-engineered by evolution for a role in the vertebrate
            lens
  JOURNAL   Structure 14 (12), 1823-1834 (2006)
   PUBMED   17161372
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF545851.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF545851.1, BC117746.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849384,
                                           SAMN01164135 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1911
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 11.53 cM"
     gene            1..1911
                     /gene="Lgsn"
                     /gene_synonym="Gluld1; lengsin; Lgs"
                     /note="lengsin, lens protein with glutamine synthetase
                     domain"
                     /db_xref="GeneID:266744"
                     /db_xref="MGI:MGI:2672844"
     exon            1..46
                     /gene="Lgsn"
                     /gene_synonym="Gluld1; lengsin; Lgs"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1708
                     /gene="Lgsn"
                     /gene_synonym="Gluld1; lengsin; Lgs"
                     /note="glutamate-ammonia ligase (glutamine synthase)
                     domain containing 1; glutamate-ammonia ligase
                     domain-containing protein 1; glutamate-ammonia ligase
                     (glutamine synthetase) domain containing 1"
                     /codon_start=1
                     /product="lengsin"
                     /protein_id="NP_705829.1"
                     /db_xref="CCDS:CCDS14859.1"
                     /db_xref="GeneID:266744"
                     /db_xref="MGI:MGI:2672844"
                     /translation="MTDEGDLAQEDTAKDEGNVTEGSRMSKLRRARRKVTKPHLCSMD
                     GEEIAKANSSEMSRNQIADLSKPGSAESWSSHSAKDAYHPTPVVKPSLPSALAGAPDA
                     EFSPNTDPTRYNAQSFNPPQLSARMKHIKQEMAKNHLQFVRFEATDLHGVSRSKSIPA
                     QFFQEKVIHGVFMPRGYLELMPNPKDNEVNHIRATCFNSDIVLMPELSTFRVLPWAER
                     TARVICDTFTVTGEPLLTSPRYIAKRQLRQLQDAGFCLLSAFIYDFCIFGVPEVINSK
                     TISFPASTLLSNHDQPFMQELVEGLYQTGANVESFSSSTRPGQMEICFLPEFGISSAD
                     NAFTLRTGLQEVARRYNYIASLVIETGFCNSGILSHSIWDVGGKTNMFCSGSGVERLT
                     LTGKKWLAGLLKHSAALSCLMAPAVNCRKRYCKDSRDLKDSVPTTWGYNDNSCALNIK
                     CHGEKGTQIENKLGSATANPYLVLAATVAAGLDGLQSSDGAAAGSDESQDLYQPEPSE
                     IPLKMEDALAALEQDECLKQALGETFIRYFVAMKKYELENEETDAEGNKFLEYFI"
     exon            47..179
                     /gene="Lgsn"
                     /gene_synonym="Gluld1; lengsin; Lgs"
                     /inference="alignment:Splign:2.1.0"
     exon            180..341
                     /gene="Lgsn"
                     /gene_synonym="Gluld1; lengsin; Lgs"
                     /inference="alignment:Splign:2.1.0"
     exon            342..508
                     /gene="Lgsn"
                     /gene_synonym="Gluld1; lengsin; Lgs"
                     /inference="alignment:Splign:2.1.0"
     exon            509..1903
                     /gene="Lgsn"
                     /gene_synonym="Gluld1; lengsin; Lgs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1869..1874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lgsn"
                     /gene_synonym="Gluld1; lengsin; Lgs"
                     /note="hexamer: AATAAA"
     polyA_site      1903
                     /gene="Lgsn"
                     /gene_synonym="Gluld1; lengsin; Lgs"
                     /note="major polyA site"
ORIGIN      
        1 gtaagaaaca gttgacatga ccgacgaagg ggacctcgca caggaggaca cagcaaaaga
       61 tgaaggcaat gtgactgaag gcagcaggat gagcaaactg agaagggcaa ggagaaaagt
      121 caccaaacca catctttgct caatggatgg ggaagaaatc gccaaggcca attccagtga
      181 gatgtccaga aaccaaatag cagatctgag caaacctggc tctgctgagt cttggtcctc
      241 gcacagtgcc aaagatgcct accacccgac accagtggta aaaccctcgc ttcccagtgc
      301 cttagccggt gctcctgatg ctgaattcag cccgaatact gatcccaccc ggtacaatgc
      361 tcagagtttt aacccgcctc aactttctgc tagaatgaaa cacattaaac aagaaatggc
      421 caaaaaccac ctccagtttg tacgatttga agcaacagat ttgcacggtg tctccagatc
      481 taagagcatc cccgcacagt tttttcaaga aaaagtgatc cacggagttt tcatgccccg
      541 tgggtatctg gaattgatgc cgaaccctaa ggacaatgag gtgaatcaca taagagccac
      601 atgcttcaat agtgatatag tcctcatgcc agagctgtcg accttcagag tcttgccttg
      661 ggcagagagg actgcgaggg tgatttgtga caccttcaca gtgacgggcg agcctctcct
      721 gacatcccct aggtacatcg ccaagaggca gctgcgccag ctgcaggacg ccggcttctg
      781 cctgctgtcc gctttcatct atgatttctg catttttggt gtgcccgaag tgatcaattc
      841 aaagaccata tcttttcctg cctccacatt actaagtaac catgatcagc ccttcatgca
      901 ggaactggtt gagggcctgt atcagacagg ggcgaatgtg gagagcttct cctcgtctac
      961 caggcctggg cagatggaga tctgttttct cccagagttt ggcattagct cagctgataa
     1021 tgcctttacc ctcagaacag gtctccaaga agtggccagg agatataatt acatagctag
     1081 ccttgtaatt gagactggat tctgcaattc aggaattttg tctcatagca tctgggatgt
     1141 gggcgggaag acaaatatgt tctgcagtgg ttctggggtg gagaggctca cgctcaccgg
     1201 gaagaagtgg ttggcaggcc tgctgaagca ctctgcggct ctcagctgcc tgatggcccc
     1261 tgcggtcaac tgtcgcaagc gctactgcaa ggacagcaga gacctgaagg acagcgtgcc
     1321 caccacgtgg ggatacaatg acaacagctg tgccttgaac atcaagtgtc atggtgaaaa
     1381 aggcacccag atagaaaata aactagggtc tgcaaccgcg aacccttacc tggtgttggc
     1441 ggccactgtg gcagcaggct tggatggtct tcagagcagt gatggtgctg cggctggttc
     1501 cgatgagagt caggatctct atcaaccaga accttccgag atccctttga agatggaaga
     1561 tgcccttgcc gccctggagc aagatgagtg tctgaagcag gctctgggag agactttcat
     1621 ccgctacttt gttgccatga agaagtatga actggaaaac gaagaaacag atgcagaggg
     1681 aaataaattc ctggagtatt ttatatagga tgggactctg ccctgtagag atatgatgag
     1741 tagctagttt atcagaaaga aaagattgag tctttgtaat gaacaatact agacagcttc
     1801 tgcccctctc ccatggatta ctgggcagct gaaacgggat tgctcggatc ctgatctcag
     1861 ctataaacaa taaatttgtg gtgaaacagc atatgcaaac ttaaaaaaaa a
//
