LOCUS       NM_001418305            6853 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus leucine-rich repeat-containing G protein-coupled
            receptor 6 (Lgr6), transcript variant 2, mRNA.
ACCESSION   NM_001418305
VERSION     NM_001418305.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6853)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 6853)
  AUTHORS   Zhu,X., Xu,M., Portal,C., Lin,Y., Ferdinand,A., Peng,T.,
            Morrisey,E.E., Dlugosz,A.A., Castellano,J.M., Lee,V., Seykora,J.T.,
            Wong,S.Y., Iomini,C. and Millar,S.E.
  TITLE     Identification of Meibomian gland stem cell populations and
            mechanisms of aging
  JOURNAL   Nat Commun 16 (1), 1663 (2025)
   PUBMED   39955307
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6853)
  AUTHORS   Bobzin,L., Nickle,A., Ko,S., Ince,M., Huang,A., Bhojwani,A.,
            Roberts,R. and Merrill,A.E.
  TITLE     FGFR2 directs inhibition of WNT signaling to regulate anterior
            fontanelle closure during skull development
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39775862
REFERENCE   4  (bases 1 to 6853)
  AUTHORS   Zhao,M., Shen,Z., Zheng,Z., Xu,Y., Zhang,J., Liu,J., Peng,S.,
            Wan,J., Qin,J.J. and Wang,M.
  TITLE     Cardiomyocyte LGR6 alleviates ferroptosis in diabetic
            cardiomyopathy via regulating mitochondrial biogenesis
  JOURNAL   Metabolism 159, 155979 (2024)
   PUBMED   39038735
  REMARK    GeneRIF: Cardiomyocyte LGR6 alleviates ferroptosis in diabetic
            cardiomyopathy via regulating mitochondrial biogenesis.
REFERENCE   5  (bases 1 to 6853)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 6853)
  AUTHORS   Page,M.E., Lombard,P., Ng,F., Gottgens,B. and Jensen,K.B.
  TITLE     The epidermis comprises autonomous compartments maintained by
            distinct stem cell populations
  JOURNAL   Cell Stem Cell 13 (4), 471-482 (2013)
   PUBMED   23954751
REFERENCE   7  (bases 1 to 6853)
  AUTHORS   Leushacke,M. and Barker,N.
  TITLE     Lgr5 and Lgr6 as markers to study adult stem cell roles in
            self-renewal and cancer
  JOURNAL   Oncogene 31 (25), 3009-3022 (2012)
   PUBMED   22002312
  REMARK    GeneRIF: Lgr5 has been identified as a marker of Wnt-regulated
            adult stem cell populations in the hair-follicle, intestine and
            stomach. A closely-related protein, Lgr6 marks adult stem cells
            responsible for fueling the renewal of the sebaceous gland and
            skin.[Review]
            Review article
REFERENCE   8  (bases 1 to 6853)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   9  (bases 1 to 6853)
  AUTHORS   Snippert,H.J., Haegebarth,A., Kasper,M., Jaks,V., van Es,J.H.,
            Barker,N., van de Wetering,M., van den Born,M., Begthel,H.,
            Vries,R.G., Stange,D.E., Toftgard,R. and Clevers,H.
  TITLE     Lgr6 marks stem cells in the hair follicle that generate all cell
            lineages of the skin
  JOURNAL   Science 327 (5971), 1385-1389 (2010)
   PUBMED   20223988
  REMARK    GeneRIF: study concludes that Lgr6 marks the most primitive
            epidermal stem cell
REFERENCE   10 (bases 1 to 6853)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133097.3 and AC117827.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.3026280.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-415               AC133097.3         83311-83725         c
            416-487             AC133097.3         53609-53680         c
            488-559             AC133097.3         51267-51338         c
            560-631             AC133097.3         42003-42074         c
            632-847             AC117827.6         22259-22474
            848-919             AC117827.6         27680-27751
            920-1030            AC117827.6         30064-30174
            1031-1099           AC117827.6         43767-43835
            1100-1171           AC117827.6         45997-46068
            1172-1243           AC117827.6         46255-46326
            1244-1312           AC117827.6         47758-47826
            1313-1384           AC117827.6         48977-49048
            1385-1450           AC117827.6         50147-50212
            1451-1522           AC117827.6         51270-51341
            1523-1594           AC117827.6         51802-51873
            1595-1720           AC117827.6         53417-53542
            1721-1881           AC117827.6         55497-55657
            1882-1962           AC117827.6         58841-58921
            1963-6853           AC117827.6         61335-66225
FEATURES             Location/Qualifiers
     source          1..6853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.24 cM"
     gene            1..6853
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /note="leucine-rich repeat-containing G protein-coupled
                     receptor 6"
                     /db_xref="GeneID:329252"
                     /db_xref="MGI:MGI:2441805"
     exon            1..415
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..3218
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /note="isoform b precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="leucine-rich repeat-containing G-protein coupled
                     receptor 6 isoform b precursor"
                     /protein_id="NP_001405234.1"
                     /db_xref="GeneID:329252"
                     /db_xref="MGI:MGI:2441805"
                     /translation="MHSPPGLLALWLCAVLCASARAGSDPQPGPGRPACPAPCHCQED
                     GIMLSADCSELGLSVVPADLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHL
                     SHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDANLISLVPERSFEG
                     LSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNHIRHIPDYAFQNLTSLVVLHLH
                     NNRIQHVGTHSFEGLHNLETLVFFLFCSPERFLGEPAGEGRCGGGGAAARMKGGRNDR
                     DLNYNELQEFPLAIRTLGRLQELGFHNNNIKAIPEKAFMGSPLLQTIHFYDNPIQFVG
                     RSAFQYLSKLHTLSLNGATDIQEFPDLKGTTSLEILTLTRAGIRLLPPGVCQQLPRLR
                     ILELSHNQIEELPSLHRCQKLEEIGLRHNRIKEIGADTFSQLGSLQALDLSWNAIRAI
                     HPEAFSTLRSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRIL
                     EVPYAYQCCAYGICASFFKTSGQWQAEDFHPEEEEAPKRPLGLLAGQAENHYDLDLDE
                     LQMGTEDSKPHPSVQCSPVPGPFKPCEHLFESWGIRLAVWAIVLLSVLCNGLVLLTVF
                     ASGPSPLSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLGCQAT
                     GFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAAL
                     PLASVGEYGASPLCLPYAPPEGRPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRG
                     DFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLP
                     ACLNPLLYLLFNPHFRDDLRRLWPSPRSPGPLAYAAAGELEKSSCDSTQALVAFSDVD
                     LILEASEAGQPPGLETYGFPSVTLISRHQPGATRLEGNHFVESDGTKFGNPQPPMKGE
                     LLLKAEGATLAGCGSSVGGALWPSGSLFASHL"
     exon            416..487
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            488..559
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            560..631
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            632..847
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            848..919
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1030
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1099
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1171
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1243
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1312
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1384
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1450
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1522
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1594
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1720
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1881
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1962
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..6853
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3668..3673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /note="hexamer: AATACA"
     polyA_site      3690
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /note="major polyA site"
     regulatory      3779..3784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /note="hexamer: ATTAAA"
     polyA_site      3802
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /note="major polyA site"
     regulatory      6834..6839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /note="hexamer: AGTAAA"
     polyA_site      6853
                     /gene="Lgr6"
                     /gene_synonym="A530037C04Rik; D830026M09"
                     /note="major polyA site"
ORIGIN      
        1 actcaacaat gcctgcccct ctctgactgc accgtcccgc cgccgctgcc gccgccgcgc
       61 ccaagccaag tcgagcgggg gcgttgccca ccgacggcgc agccctcggg cccgcccggg
      121 accaggaggt gagccgcgcg cgcacaactc cgtgcgctcg cccgtctgag cgcccgccag
      181 gtgccccgca gcccgccgcc gagatgcaca gcccgcctgg gctcctggcg ctgtggcttt
      241 gcgctgtgct gtgcgcatcg gcgcgcgcgg gcagcgaccc ccagcctggc ccggggcgtc
      301 ccgcctgccc ggctccctgc cactgccagg aggacggcat catgctgtcc gctgactgct
      361 ccgagctcgg gctctcagtg gtgcctgcgg acctggaccc cctgacggct tacctagacc
      421 tcagtatgaa caacctcacg gagcttcagc cgggtctctt ccaccacctg cgcttcctgg
      481 aggagctgcg gctctcaggg aaccacctct cacacatccc gggacaggca ttctctggcc
      541 tccacagcct caaaattcta atgctgcaga gcaaccagct ccgtgggatc ccagcagagg
      601 cactatggga gctgcccagc ctgcagtcgc tgcgcctaga tgctaatctc atctccctgg
      661 tccctgagag aagctttgag gggctctcct ccctccgcca cctctggctg gatgacaatg
      721 cactcaccga gatccccgtc agagctctca acaaccttcc tgccctacaa gccatgacct
      781 tggctctcaa ccatatccgc cacatccctg actatgcctt ccagaacctc accagtcttg
      841 tggtgctgca tctacataac aaccgcatcc agcatgtggg gacccacagc ttcgaggggc
      901 tgcacaatct ggagacactt gtgttctttc tcttctgttc cccagagcgt tttcttgggg
      961 agcctgcagg ggaaggcaga tgtggaggag gaggagcggc tgcgagaatg aaagggggaa
     1021 gaaatgatag agacctgaac tataatgagc tgcaggagtt ccccttggct atccggaccc
     1081 tgggcaggct gcaggaattg ggtttccata acaacaacat caaggctatc ccagagaaag
     1141 ccttcatggg cagccctctc ctgcagacaa tacattttta tgacaaccca atccagtttg
     1201 tgggaaggtc agcattccag tacctgtcta aactgcatac gctatctttg aatggtgcca
     1261 ctgatatcca agagttccca gacctcaaag gcaccactag cctggagatc ctgaccctga
     1321 cccgtgcggg catcagactg ctcccaccgg gagtgtgcca acagctgcct aggctccgaa
     1381 tcctggagct gtctcataat cagatcgagg agttacccag cctgcacagg tgtcagaagc
     1441 tggaggaaat tggcctccga cataaccgga tcaaggaaat tggtgcagat accttcagcc
     1501 agctgggctc cttgcaagct ttagacctga gttggaatgc catccgtgcc atccaccctg
     1561 aggctttctc aacccttcga tccttggtta agctggacct gactgacaac cagctgacca
     1621 cactgcccct ggctgggctg ggaggcctga tgcacctgaa gctcaaaggg aacttggccc
     1681 tgtctcaggc cttctccaag gacagtttcc caaaactgag gatcctggag gtgccctacg
     1741 cctaccagtg ctgtgcctac ggcatctgtg ccagcttctt caagacctct gggcagtggc
     1801 aggccgagga ctttcatcca gaggaagagg aggcaccaaa gaggcccctg ggtctccttg
     1861 ctggacaagc tgagaaccac tatgacctag acctggatga gctccagatg gggacagagg
     1921 actcaaagcc acaccccagt gtccagtgca gccctgttcc aggccccttc aagccctgcg
     1981 agcacctctt tgagagctgg ggcatccgcc ttgctgtgtg ggccatcgtg ttactctccg
     2041 tactctgtaa cgggctggtg ctgctgacag tctttgccag cggacccagc ccgctgtccc
     2101 ccgtcaagct tgtggtgggt gcgatggcag gcgccaacgc cctgtcgggc atttcctgtg
     2161 gtctcctggc ctcggtggac gccttgacct atggtcagtt cgctgagtat ggagcccgct
     2221 gggagagcgg tctgggctgc caggctacgg gcttcctggc tgtcctgggt tcagaggcgt
     2281 cggtgctgct gctcacactg gcggccgtgc agtgcagcat ctccgtgacc tgcgtccgag
     2341 cctacgggaa ggcgccgtcg cctggcagcg tccgcgcagg cgcactggga tgcctggcgc
     2401 tggccgggct ggccgcagca ctgccgctgg cctcggtggg agagtatggc gcctccccac
     2461 tctgcctgcc ctacgcccca cccgagggcc ggccggctgc cctgggcttc gctgtagccc
     2521 tggtgatgat gaactcgctc tgcttcctgg tggtggccgg cgcctacatc aagctctact
     2581 gtgacctgcc acggggtgac tttgaggccg tgtgggactg cgccatggtg cgccacgtgg
     2641 cctggctcat ctttgcagat ggcctcctct actgccccgt ggccttcctc agctttgcct
     2701 ctatgctggg cctcttccct gtcacccccg aggctgtcaa gtcagtcctt ctggtggtgc
     2761 tgcctctgcc tgcctgcctc aacccactgc tctacctgct cttcaaccct cacttccggg
     2821 atgaccttcg gcggctctgg ccaagccctc ggtccccagg gcccctagcc tacgctgcag
     2881 ccggtgagct ggagaagagc tcctgcgact ccacccaagc gctggtggct ttctcagatg
     2941 tggatcttat tctggaagct tctgaggctg ggcagcctcc tgggctagag acctatggct
     3001 tcccttcagt gaccctcatc tcccgacatc agccgggggc taccaggctg gagggaaacc
     3061 attttgtaga gtctgatgga accaagtttg ggaacccaca acctcccatg aagggagaac
     3121 tgctgctgaa ggcagaggga gccactttgg caggctgtgg ctcttccgtg ggtggagccc
     3181 tctggccctc tggctctctc tttgcctctc acttgtaaat atccctctct gtttgtcctc
     3241 ttcccgtcca atgatggctg cttataaaag aaagacaact ccaactccat agcaagatgg
     3301 ccaacacctc tgactccatt gttctctctc cacgacccct aaccaatgag tgcttccaag
     3361 tcttgctttg tcttggcctt cagcttcact ttcaccctgg gccttctctg tccaatccaa
     3421 tacttctgac agaggcctgg gaaatttgca taggagaaag gagaaaagca aaagacagtg
     3481 aaggttatgg ggccctgaca gagccatgat cagtaagtgc agagtgatgg ggaggtctca
     3541 cagagcatga cactggaaga caactaccaa agacattgga gagtctcccc tgtgacatat
     3601 agaatataaa atgtgttttg tgttccatta atcttgacct atgctgtgcc aaagtgcttc
     3661 ctgttaaaat acactttgga agacattgca tattatgtcc ctttcttaga gtcatggggt
     3721 catgttagtg tctaaaaggt cctgagaatt aggacttttt ggcttaatta ctacagcaat
     3781 taaacttaat tatttgatga tacctatata tttgcttttc atgaaacact tacaaatctc
     3841 tcatagaact ttatggtttt tctcccgggg aatcatcttc ataccatgga gtactaccct
     3901 atgacatcat aagatgccac cctctttcaa agcccctatg aagccaacct ggggtgaagt
     3961 gccagaggtg actgatgatc cgtcatccag gacagatttt gcattctgct cccctcccca
     4021 cctcacttat cctactggaa cagacacctg gaggagcctg ccccatctcc aaggtggggc
     4081 ggggggaaag agaccttgat gtgttcccac accacaccga ccccaagcag taatgaaatt
     4141 tctgccctca gcaagacagg attctcaggt cctggtaaga tatacactga gaagtctgtg
     4201 gttctctggg cttccccgaa ctctatgcta actttgtatg gttttacatt gtatgcatct
     4261 cactatggcc tggacctctc ttctcatccc aatcctgtta ctggtaggga tggaaaaccc
     4321 aagagaaggg atatttgtat tgtgaatatt gcattttagg gagtgctgtg gctatctggg
     4381 actcctggat gcccccaaca ggcctttgat tcttctgcct ctctcctctt gatctttctt
     4441 accctctgct tccccaagtg cagttgaggt tctatgcagt gcctccgcct cactccaaac
     4501 acgggaattc aatctcagag agaggaggta acaagtgggg agaagccaag actcagcaat
     4561 agacgataat tgctcctggg attgccccca acaccattta cctagaaagg accaagtttg
     4621 gatcctgaag cccagtggag caccattctc tgcctgaatc ctgttgtgat ccctagccaa
     4681 gtcctctttc caaaaactcc acctttaaaa caagctgaga aggcccttct ctaagtttaa
     4741 tagttaactt tccatagctt agcttctctg cggtctcctg agtgcccagt gaaaattctg
     4801 ccataggtca acaagtgagg tggagagatg agtcagaggc catgcatgga gctcagaaca
     4861 tttccaaacc tcctgtgatt cactgagtag cccctagact ctagaaggct cagaagcaga
     4921 aaaggatgac tttattattc cttagggtct tctcatgggg ccagtttcag gaagggcatt
     4981 caccaaatga tggcagattt atttatcaat tgtttctggg tgcctgattt ctttatttcc
     5041 cccgggctat gagagccctt ggtgggaggt ccccccacct tgagaattgg tgggttttgg
     5101 tttttttgtt tttttgtttt ttttttttta tttcctaggg ttggctattt tagttagggt
     5161 tttactgctg tgaagagata ccatgaccaa ggcaactctc ataaggacaa catttaattg
     5221 gggctggttt gcaggtttag aggttcagtc cattatcatc aaggtgagaa catggcagaa
     5281 tccaggcaag cacagtgcag gaggagctga gagttctaca tcttcatctg aaggttgcta
     5341 gcagaatact cacttccagg cagctaagga ctaaggtatt aaagcccaca cccacagtga
     5401 cccatctact ccaacaaggc cacacctcct aatagtccca ctccctgatc caagcatata
     5461 caaactatca caatggcaaa attggcattc ttttggggag gcttgactta cagcaagtta
     5521 cctagatttt taccctgctc tctccaccta catcactatg agatcattct cccctttgga
     5581 gtcaaggaac tagccttgga gtgaagtggc catgtgttgg tggtctaaga atgtaggcat
     5641 tgttccttaa agaggtcttc tatgagagtg agccagcccc tttgggctgc aagctttagc
     5701 atggcacagt tgtcacctta ctgtctgctt ctaaatctgg acatcagcca aagttcaaca
     5761 ttctaattag agaagaggca agggaggaga gagttgaagt tccataaact tttatttaaa
     5821 cgtctagcta ggagtggtgg tgccagtgtg gaggtggcaa gatcgagtgt tagggtcatc
     5881 ctcagctaca taatgagttt gaggctatcc taggctacat gagactctgt ctcaaaaaac
     5941 aaaagcaagc aagcaagcaa acaaaacctc caactactag ttcatataca tttaccccaa
     6001 ataagattga gtagttaagt ttccttgtgt tttactttgg gccaaatttc tagcaagcca
     6061 gaatgttagt actttggtta tctcctttgt ggtcagttga agaccatggg tcttcttcta
     6121 agcaaatttc tgagtctctg ttctacatat ttggatctga caagaaggac catgagtctt
     6181 tgactggtca taggatgaaa aactgaactg ttaggagcac ctaagtcctc tactgttatc
     6241 attaacaaaa tcttcccaaa gccatggaaa agaatccact ccaaggctga gatggtggtg
     6301 gtagaaacgc aagggattgg tatgtactac catgggctct gtgtgctgtg ccattagtta
     6361 gtgccaacca caatcttctc ttacacagag gagaactcat ggtaggatca cagcttgtta
     6421 agcatctcat caaaaggaaa aaacccaaaa acaaatgtag agctaaagtc aatcagaaga
     6481 ctatgagtgg gcggggcttc ttactgggcc ctacctttcc tcttcacctc ttctcctgct
     6541 cctttgggct catttttcca ggaagagtaa aggcttaaag agtaagggag gagaagaagg
     6601 aagagctggc aataggcagt aggctcttgg gacaagggtg gaagaggtag taggaaccgc
     6661 catcttccta gctccagtcc ctctgactac ctctgctctg ggttaccaag ttctcccacc
     6721 taagacctac cacctccacc tcctttctgg gttccagtcc catgcctcat caccaacccc
     6781 agccatgtga actataacaa ttgtcaagat gtaaatatcc ggtttttctg tatagtaaag
     6841 cacctatgaa gta
//
