LOCUS       NM_010195               4711 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus leucine rich repeat containing G protein coupled
            receptor 5 (Lgr5), mRNA.
ACCESSION   NM_010195
VERSION     NM_010195.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4711)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 4711)
  AUTHORS   Pashos,A.R.S., Meyer,A.R., Bussey-Sutton,C., O'Connor,E.S.,
            Coradin,M., Coulombe,M., Riemondy,K.A., Potlapelly,S., Strahl,B.D.,
            Hansson,G.C., Dempsey,P.J. and Brumbaugh,J.
  TITLE     H3K36 methylation regulates cell plasticity and regeneration in the
            intestinal epithelium
  JOURNAL   Nat Cell Biol 27 (2), 202-217 (2025)
   PUBMED   39779942
REFERENCE   3  (bases 1 to 4711)
  AUTHORS   Bobzin,L., Nickle,A., Ko,S., Ince,M., Huang,A., Bhojwani,A.,
            Roberts,R. and Merrill,A.E.
  TITLE     FGFR2 directs inhibition of WNT signaling to regulate anterior
            fontanelle closure during skull development
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39775862
REFERENCE   4  (bases 1 to 4711)
  AUTHORS   Wu,M., Jia,G., Liu,Y., Lou,Y., Li,Y., Xia,M., Li,H. and Li,W.
  TITLE     PKM2 controls cochlear development through lactate-dependent
            transcriptional regulation
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2410829122 (2025)
   PUBMED   39773029
REFERENCE   5  (bases 1 to 4711)
  AUTHORS   Lemmetyinen,T.T., Viitala,E.W., Wartiovaara,L., Paivinen,P.,
            Virtanen,H.T., Pentinmikko,N., Katajisto,P., Makela,T.P.,
            Wang,T.C., Andressoo,J.O. and Ollila,S.
  TITLE     Mesenchymal GDNF promotes intestinal enterochromaffin cell
            differentiation
  JOURNAL   iScience 27 (12), 111246 (2024)
   PUBMED   39634560
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4711)
  AUTHORS   Alexandrovich,A., Qureishi,A., Coudert,A.E., Zhang,L.,
            Grigoriadis,A.E., Shah,A.M., Brewer,A.C. and Pizzey,J.A.
  TITLE     A role for GATA-6 in vertebrate chondrogenesis
  JOURNAL   Dev Biol 314 (2), 457-470 (2008)
   PUBMED   18191120
REFERENCE   7  (bases 1 to 4711)
  AUTHORS   Barker,N., van Es,J.H., Kuipers,J., Kujala,P., van den Born,M.,
            Cozijnsen,M., Haegebarth,A., Korving,J., Begthel,H., Peters,P.J.
            and Clevers,H.
  TITLE     Identification of stem cells in small intestine and colon by marker
            gene Lgr5
  JOURNAL   Nature 449 (7165), 1003-1007 (2007)
   PUBMED   17934449
  REMARK    GeneRIF: using two knock-in alleles, exclusive expression of Lgr5
            in cycling columnar cells at the crypt base of the intesine is
            revealed
REFERENCE   8  (bases 1 to 4711)
  AUTHORS   Nef,S., Schaad,O., Stallings,N.R., Cederroth,C.R., Pitetti,J.L.,
            Schaer,G., Malki,S., Dubois-Dauphin,M., Boizet-Bonhoure,B.,
            Descombes,P., Parker,K.L. and Vassalli,J.D.
  TITLE     Gene expression during sex determination reveals a robust female
            genetic program at the onset of ovarian development
  JOURNAL   Dev Biol 287 (2), 361-377 (2005)
   PUBMED   16214126
REFERENCE   9  (bases 1 to 4711)
  AUTHORS   Morita,H., Mazerbourg,S., Bouley,D.M., Luo,C.W., Kawamura,K.,
            Kuwabara,Y., Baribault,H., Tian,H. and Hsueh,A.J.
  TITLE     Neonatal lethality of LGR5 null mice is associated with
            ankyloglossia and gastrointestinal distension
  JOURNAL   Mol Cell Biol 24 (22), 9736-9743 (2004)
   PUBMED   15509778
  REMARK    GeneRIF: physiological role of the LGR5 signaling system during
            embryonic development
REFERENCE   10 (bases 1 to 4711)
  AUTHORS   Hermey,G., Methner,A., Schaller,H.C. and Hermans-Borgmeyer,I.
  TITLE     Identification of a novel seven-transmembrane receptor with
            homology to glycoprotein receptors and its expression in the adult
            and developing mouse
  JOURNAL   Biochem Biophys Res Commun 254 (1), 273-279 (1999)
   PUBMED   9920770
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK132387.1 and BM935530.1.
            
            On Jul 22, 2006 this sequence version replaced NM_010195.1.
            
            Summary: The protein encoded by this gene is a leucine-rich
            repeat-containing receptor (LGR) and member of the G
            protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The
            encoded protein is a receptor for R-spondins and is involved in the
            canonical Wnt signaling pathway. This protein plays a role in the
            formation and maintenance of adult intestinal stem cells during
            postembryonic development. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132387.1, AF110818.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4534              AK132387.1         1-4534
            4535-4613           BM935530.1         1-79                c
            4614-4711           AK132387.1         4614-4711
FEATURES             Location/Qualifiers
     source          1..4711
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 63.51 cM"
     gene            1..4711
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /note="leucine rich repeat containing G protein coupled
                     receptor 5"
                     /db_xref="GeneID:14160"
                     /db_xref="MGI:MGI:1341817"
     exon            1..499
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..3011
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /note="G protein-coupled receptor 49; follicle expressed
                     hormone; orphan G-protein coupled receptor FEX"
                     /codon_start=1
                     /product="leucine-rich repeat-containing G-protein coupled
                     receptor 5 precursor"
                     /protein_id="NP_034325.2"
                     /db_xref="CCDS:CCDS24180.1"
                     /db_xref="GeneID:14160"
                     /db_xref="MGI:MGI:1341817"
                     /translation="MDTSCVHMLLSLLALLQLVAAGSSPGPDAIPRGCPSHCHCELDG
                     RMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLPASLLHRLCFLEELRLAGNAL
                     THIPKGAFTGLHSLKVLMLQNNQLRQVPEEALQNLRSLQSLRLDANHISYVPPSCFSG
                     LHSLRHLWLDDNALTDVPVQAFRSLSALQAMTLALNKIHHIADYAFGNLSSLVVLHLH
                     NNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIKTLSNLKELGFHSNNIRSIPERA
                     FVGNPSLITIHFYDNPIQFVGVSAFQHLPELRTLTLNGASHITEFPHLTGTATLESLT
                     LTGAKISSLPQAVCDQLPNLQVLDLSYNLLEDLPSLSGCQKLQKIDLRHNEIYEIKGS
                     TFQQLFNLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPVTGLHGLTHLKL
                     TGNRALQSLIPSANFPELKIIEMPSAYQCCAFGGCENVYKISNQWNKDDGNSVDDLHK
                     KDAGLFQVQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLFGSWLIRIGVWT
                     TAVLALSCNALVALTVFRTPLYISSIKLLIGVIAVVDILMGVSSAVLAAVDAFTFGRF
                     AQHGAWWEDGIGCQIVGFLSIFASESSIFLLTLAALERGFSVKCSSKFEVKAPLFSLR
                     AIVLLCVLLALTIATIPLLGGSKYNASPLCLPLPFGEPSTTGYMVALVLLNSLCFLIM
                     TIAYTKLYCSLEKGELENLWDCSMVKHIALLLFANCILYCPVAFLSFSSLLNLTFISP
                     DVIKFILLVIVPLPSCLNPLLYIVFNPHFKEDMGSLGKHTRFWMRSKHASLLSINSDD
                     VEKRSCESTQALVSFTHASIAYDLPSTSGASPAYPMTESCHLSSVAFVPCL"
     exon            500..571
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            572..643
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            644..715
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            716..931
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1003
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1072
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1144
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1216
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1285
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1357
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1423
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1495
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1567
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1693
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1839
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1923
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..4711
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4677..4682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
     regulatory      4688..4693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
     polyA_site      4711
                     /gene="Lgr5"
                     /gene_synonym="FEX; Gpr49"
ORIGIN      
        1 gagcgtgcga gcggagatgc tgctgcacac agctcagacc gcctgcagca gcaacaacgc
       61 tcacagccac tgcggcgact tcagagagag ggctcccgag gccggtggga ccacgattct
      121 ctgcgcggtc cccacggggc tacgacccgg cagacgccca ttggggttgc agacgtctgg
      181 tgagctgcag aagccggtgg agaagagccc ggagcgcctc ggttctgcat cagccccggc
      241 gctgccctct acaggctccc tgctctctgc tcccagtctc gggcaccatg gacacctcct
      301 gcgtccacat gctcctgtcc ttgctggcgc tgctgcagtt ggtggccgcc ggcagctcac
      361 cgggaccaga tgcgataccg cggggctgcc catcacactg tcactgtgag ctggatggca
      421 ggatgctgct cagggtggac tgctcggacc tggggctctc ggagctgccc tccaacctca
      481 gcgtcttcac ctcctacctg gacctcagta tgaacaacat cagtcagcta cccgccagtc
      541 tcctacatcg cctctgcttc ctagaagagt tacgtcttgc tggaaatgct ttgacacaca
      601 ttcccaaggg agcgttcacg ggccttcaca gcctcaaagt gcttatgctg cagaacaacc
      661 agctgagaca ggttccggag gaagcgctac agaatttgag aagccttcaa tccctgcgcc
      721 tagatgccaa ccacatcagc tacgtgccac ccagctgttt cagcggcctg cactccctga
      781 ggcacctgtg gctagatgac aatgctctca cagacgtccc tgtccaggct ttcagaagtt
      841 tatcagccct gcaagccatg accttggccc tgaacaaaat acaccacata gcagactacg
      901 cctttggaaa cctctccagc ctcgtggttc tgcatctcca taataataga atccactccc
      961 tgggaaagaa atgctttgat ggactccaca gcctggagac tttagattta aattataata
     1021 accttgatga attccccact gcaatcaaga cactctccaa ccttaaggaa ctaggattcc
     1081 acagcaacaa catcaggtca ataccggagc gagcgttcgt aggcaaccct tctcttatca
     1141 caatacactt ctatgacaac cccatccaat ttgttggagt atctgctttt cagcatttgc
     1201 ctgaactaag aacactgact ttgaatggtg cctcgcacat tactgaattt cctcacttga
     1261 caggaactgc caccctggag agtctgactt taactggagc aaagatctca tctcttcccc
     1321 aggccgtctg tgatcagtta cctaatctcc aagtgctaga tttgtcttac aacctactcg
     1381 aagacttacc cagtttgtca ggctgccaaa aacttcagaa aattgacctg aggcataacg
     1441 agatctatga aattaagggc agcacttttc agcagttgtt taacctccga tctctgaact
     1501 tagcatggaa taaaattgct atcattcacc ccaatgcgtt ttctacgttg ccgtctctaa
     1561 taaagttgga cctatcatcc aatctcctgt cgtccttccc tgtgactggg ttacatggtt
     1621 taactcactt aaaattaaca gggaaccgag ccttacagag cctgatacca tctgcaaact
     1681 tcccagagct caagattata gaaatgccat ctgcttacca gtgttgtgca tttggggggt
     1741 gtgagaatgt ctataaaatt tctaaccaat ggaataaaga cgacggcaac agtgtggacg
     1801 accttcataa gaaagacgct gggttatttc aagttcaaga tgagcgggac cttgaagatt
     1861 tcctacttga ctttgaggaa gacctgaagg cccttcactc ggtgcagtgc tcgccttccc
     1921 caggtccctt caagccctgt gagcacctat ttggtagctg gctgatccga atcggggtgt
     1981 ggaccacggc agtactggcg ctttcctgca atgccttggt ggctttgacc gtgttcagaa
     2041 ctcctctgta catctcttcc ataaagctgc taattggggt aatcgcggta gtggacattc
     2101 tcatgggggt ctccagtgct gtgctggctg ccgtggatgc attcactttt ggccgttttg
     2161 ctcagcacgg tgcgtggtgg gaagacggaa tcggctgcca aatcgttggc ttcctgtcca
     2221 tttttgcttc cgaatcgtcg atcttcctgc tcactctggc agcgctggaa cgaggttttt
     2281 ctgtcaagtg ctcttcgaag tttgaagtga aagctcccct ttttagcctg agagcgatcg
     2341 ttttgctatg tgtcctgttg gccctgacca ttgccacaat ccccttgcta ggaggcagta
     2401 agtacaatgc ctctcccctc tgcctgccct tgccctttgg ggagcccagc accacgggct
     2461 acatggtggc tctcgtgttg ctcaactctc tctgtttcct cataatgacc attgcctaca
     2521 caaagctcta ctgcagtttg gagaaaggag agctggagaa tctttgggat tgttcgatgg
     2581 tgaagcacat tgctctgttg ctcttcgcca actgcatcct ttactgcccc gtggctttct
     2641 tatccttctc ctctttgcta aacctcacct ttatcagtcc tgacgtcatt aaatttatac
     2701 ttctcgtgat cgtcccactt ccttcctgtc tcaacccact tctctacatt gtcttcaatc
     2761 cccattttaa ggaggatatg ggcagcctgg gaaagcatac ccgtttctgg atgagatcaa
     2821 aacacgcgag tctgctgtcc attaactcgg acgatgttga gaaacggtcc tgtgagtcaa
     2881 cccaagcctt agtatccttt acccacgcca gcatagccta tgacttgcct tccacttccg
     2941 gggcatcacc agcttacccc atgactgaaa gctgtcatct ctcttcagtt gcatttgtcc
     3001 catgtctcta gtgactatga gagaggaacg tttttaagag ttggaaacct gaaaagtgat
     3061 ttctatcaga gcagtagcta agaaaagctg agctaaaaac ctaccttaaa acccaagcaa
     3121 acatctctaa attggtgtgg aaacagtggt gccttagagc aggagagcat cattaaacac
     3181 cgcttgtatc atttgttcag ctaagaagga aagccatcaa gtcacttagg tgaacccaga
     3241 tgagaaaagc agcctgaaat gctcttcgca ttgtagtctc ttctgactca ccagcatagt
     3301 ctcccatagt gagaagactc gttggatgac tcaatgggtg tatttaaatc cacaaattcc
     3361 ttgtttaaaa ggttagagtt ttaagaaaaa aaaaaaaaag gatctttaat gggctatgtt
     3421 gcccacagag tttagtttta atggctacac agagatggtt gtgtgtcttt ttgccttttg
     3481 acggacaggc tccttccaag acaccagttt cttggactga catttttaat ccatatataa
     3541 atttaagata ctggcttcta agccgggcgt ggcggcgcgc gcctttaatc ccagcacttg
     3601 ggaggcagag gcaggtggat ttctgagttc gaggccagcc tggtctacaa agtgagttcc
     3661 aggacagcca ggactataca gagaaacccc tgtctcaaaa aacaacaaca acaacaacaa
     3721 caaaaagaca ctgggttata tagataagta tccagtgcat tctcccttgc tgagataaaa
     3781 ctggtttcaa ggttttttgg aacattaact taaatggttc ctcgagcaat tatatatagg
     3841 taagatttgg ttatcttcct cgagcaatta tatataggta agatttggtt atcctgattc
     3901 gtcttttaaa atcctggagt ctgaagctca gaaagttcgt tgtcagccgt ggtcatagct
     3961 acgaaagaca gtatgaaatt gtcggatctg tatttatttc tgagtaggag catgcttctg
     4021 gcaagatgtt catcactctc tcaaatggct gtgcattttc agtgctcaaa cgcagggcgt
     4081 taagtccact gtgtaacttc acacacccat ctctggtagc tcgagcaaca atgcctctcc
     4141 acacttcgga ctcaacagaa actgggcaaa gtaggattcg gtgcatttag cttggtttta
     4201 gctgtgtctt gtttccggat caaccacttg atatgaagtt cattacttct ctgcttagtc
     4261 catattcacg caggtgttcg atgtttcaag acaaattgtt aaatctggag agcgaaaggt
     4321 ttattcttaa cttctgtgat cttacattag ctttgctgca cccgaaccaa aaggccatta
     4381 ggtagattta tttttatata agcatgtttt attttgacca gatgttttaa tgtggaattt
     4441 aaaaaaaaat acatttatga gatgttttat aagatgtgta catatagact tgtatttatt
     4501 gctacaggaa aaatgcagtg acattaaaga acatgataat aaaccatgta cagtagccta
     4561 ttctcccaga catattgttt ctctgccaat ttccccaatg cattaactgt acataacaca
     4621 tgtaaatacg tagtgcttgt aaatagatcc agaatttgct tttctactgg gctcaaaata
     4681 aatttgtaat aaaatgtgtg acttgcaaaa c
//
