LOCUS       NM_172671               5066 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus leucine-rich repeat-containing G protein-coupled
            receptor 4 (Lgr4), mRNA.
ACCESSION   NM_172671 XM_355385 XM_917125
VERSION     NM_172671.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5066)
  AUTHORS   Kubrak,O., Jorgensen,A.F., Koyama,T., Lassen,M., Nagy,S., Hald,J.,
            Mazzoni,G., Madsen,D., Hansen,J.B., Larsen,M.R., Texada,M.J.,
            Hansen,J.L., Halberg,K.V. and Rewitz,K.
  TITLE     LGR signaling mediates muscle-adipose tissue crosstalk and protects
            against diet-induced insulin resistance
  JOURNAL   Nat Commun 15 (1), 6126 (2024)
   PUBMED   39033139
  REMARK    GeneRIF: LGR signaling mediates muscle-adipose tissue crosstalk and
            protects against diet-induced insulin resistance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5066)
  AUTHORS   Zhang,H., Liu,D., Xu,Q.F., Wei,J., Zhao,Y., Xu,D.F., Wang,Y.,
            Liu,Y.J., Zhu,X.Y. and Jiang,L.
  TITLE     Endothelial RSPO3 mediates pulmonary endothelial regeneration by
            LGR4-dependent activation of beta-catenin and ILK signaling
            pathways after inflammatory vascular injury
  JOURNAL   Int J Biol Macromol 269 (Pt 2), 131805 (2024)
   PUBMED   38677673
  REMARK    GeneRIF: Endothelial RSPO3 mediates pulmonary endothelial
            regeneration by LGR4-dependent activation of beta-catenin and ILK
            signaling pathways after inflammatory vascular injury.
REFERENCE   3  (bases 1 to 5066)
  AUTHORS   Liang,Y., Luo,C., Sun,L., Feng,T., Yin,W., Zhang,Y.,
            Mulholland,M.W., Zhang,W. and Yin,Y.
  TITLE     Reduction of specific enterocytes from loss of intestinal LGR4
            improves lipid metabolism in mice
  JOURNAL   Nat Commun 15 (1), 4393 (2024)
   PUBMED   38782937
  REMARK    GeneRIF: Reduction of specific enterocytes from loss of intestinal
            LGR4 improves lipid metabolism in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5066)
  AUTHORS   Gao,Y., Zhai,W., Sun,L., Du,X., Wang,X., Mulholland,M.W., Yin,Y.
            and Zhang,W.
  TITLE     Hepatic LGR4 aggravates cholestasis-induced liver injury in mice
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 326 (4), G460-G472 (2024)
   PUBMED   38440827
  REMARK    GeneRIF: Hepatic LGR4 aggravates cholestasis-induced liver injury
            in mice.
REFERENCE   5  (bases 1 to 5066)
  AUTHORS   Watanabe,K., Horie,M., Hayatsu,M., Mikami,Y. and Sato,N.
  TITLE     Spatiotemporal expression patterns of R-spondins and their
            receptors, Lgrs, in the developing mouse telencephalon
  JOURNAL   Gene Expr Patterns 49, 119333 (2023)
   PUBMED   37651925
REFERENCE   6  (bases 1 to 5066)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   7  (bases 1 to 5066)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 5066)
  AUTHORS   Loh,E.D., Broussard,S.R. and Kolakowski,L.F.
  TITLE     Molecular characterization of a novel glycoprotein hormone
            G-protein-coupled receptor
  JOURNAL   Biochem Biophys Res Commun 282 (3), 757-764 (2001)
   PUBMED   11401528
REFERENCE   9  (bases 1 to 5066)
  AUTHORS   Leighton,P.A., Mitchell,K.J., Goodrich,L.V., Lu,X., Pinson,K.,
            Scherz,P., Skarnes,W.C. and Tessier-Lavigne,M.
  TITLE     Defining brain wiring patterns and mechanisms through gene trapping
            in mice
  JOURNAL   Nature 410 (6825), 174-179 (2001)
   PUBMED   11242070
REFERENCE   10 (bases 1 to 5066)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ093786.1, BE987673.1, CF164628.1, CN667965.1, AK033699.1,
            BU520309.1, CN456468.1, CA527305.1 and BE861913.1.
            
            On or before Feb 4, 2007 this sequence version replaced
            XM_917125.2, XM_355385.4, NM_172671.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-584               CJ093786.1         2-585
            585-988             BE987673.1         122-525
            989-1543            CF164628.1         11-565
            1544-1926           CN667965.1         116-498
            1927-3630           AK033699.1         47-1750
            3631-4268           BU520309.1         13-650
            4269-4283           CN456468.1         509-523
            4284-4883           CA527305.1         1-600
            4884-5066           BE861913.1         1-183               c
FEATURES             Location/Qualifiers
     source          1..5066
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 56.65 cM"
     gene            1..5066
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /note="leucine-rich repeat-containing G protein-coupled
                     receptor 4"
                     /db_xref="GeneID:107515"
                     /db_xref="MGI:MGI:1891468"
     exon            1..659
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     CDS             475..3330
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /note="G protein-coupled receptor GPR48; G-protein coupled
                     receptor 48"
                     /codon_start=1
                     /product="leucine-rich repeat-containing G-protein coupled
                     receptor 4 precursor"
                     /protein_id="NP_766259.2"
                     /db_xref="CCDS:CCDS38195.1"
                     /db_xref="GeneID:107515"
                     /db_xref="MGI:MGI:1891468"
                     /translation="MPGPLRLLCFFALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCS
                     GKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALS
                     GLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWL
                     DDNILTEVPVRPLSNLPTLQALTLALNNISSIPDFAFTNLSSLVVLHLHNNKIKSLSQ
                     HCFDGLDNLETLDLNYNNLDEFPQAIKALPSLKELGFHSNSISVIPDGAFAGNPLLRT
                     IHLYDNPLSFVGNSAFHNLSDLHSLVIRGASLVQWFPNLAGTVHLESLTLTGTKISSI
                     PDDLCQNQKMLRTLDLSYNDIRDLPSFNGCRALEEISLQRNQISLIKETTFQGLTSLR
                     ILDLSRNLIREIHSGAFAKLGTITNLDVSFNELTSFPTEGLNGLNQLKLVGNFQLKDA
                     LAARDFANLRSLSVPYAYQCCAFWGCDSYANLNTEDNSPQDHSVTKEKGATDAANATS
                     TAESEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALLFNLLVILTVFAS
                     CSSLPASKLFIGLISVSNLLMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGSL
                     AVFSSESAVFLLTLAAVERSVFAKDVMKNGKSSHLRQFQVAALVALLGAAIAGCFPLF
                     HGGQYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDPSEN
                     SQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNP
                     VLYVFFNPKFKDDWKLLKRRVTRKHGSVSVSISSQGGCGEQDFYYDCGMYSHLQGNLT
                     VCDCCESFLLTKPVSCKHLIKSHSCPVLTVASCQRPEAYWSDCGTQSAHSDYADEEDS
                     FVSDSSDQVQACGRACFYQSRGFPLVRYAYNLPRVRD"
     exon            660..731
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            732..803
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            804..875
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1091
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1163
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1232
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1304
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1376
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1445
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1517
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1583
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1655
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1727
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1853
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1969
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2053
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..5060
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5034..5039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /note="hexamer: ATTAAA"
     polyA_site      5055
                     /gene="Lgr4"
                     /gene_synonym="9130225G07; A330106J01Rik; A930009A08Rik;
                     Gpr48"
                     /note="major polyA site"
ORIGIN      
        1 agaagggaaa aggacgcgcg gagcgggagc cgcctcgggg agagcgcgga caaccagggt
       61 gtttgtgaga gctggggcgg gggttgggac gcctggccgg catggctgga ggctgcgctc
      121 cgcaaccttg aggagctgtg cggctggagg aggcccggga caggaggcgg cggcgatggc
      181 agcgcgcggc ccgggcagcc gctctgggcc gggtcggctg gcctgagccg cggggctgcc
      241 ggtgcgcgtc catggagcag cgggaaggga gaaactgcgg agcgccgcgt cctaacgctc
      301 cggcggcaga ctgctgaagg aagcgagcgc acgcggaccg ccgagggacg gcgcccgggc
      361 cccgagcccc gcaggccggc tgcccctggt gcggcgcggt gcggcggagg gcagcggagg
      421 cgagtcgagc gagaggagcc gcgggagagg cgggcgcggg cggcggccgc agcaatgccg
      481 ggcccgctgc ggctgctctg cttcttcgcc ctggggctgc tcggctcggc cgggcccagc
      541 ggcgcggcgc cacctctctg cgctgcgccc tgcagctgcg acggcgaccg tcgggtggac
      601 tgctccggga aggggttgac ggcggtaccg gaggggctca gcgccttcac ccaagcactg
      661 gatatcagta tgaacaatat cactcagtta ccagaagatg catttaagaa ttttcctttt
      721 ctagaggagc tacaactggc tggtaacgac ctttctttta tccacccaaa agccttgtct
      781 gggttgaaag aactcaaagt cctaaccctc cagaacaatc agttgaaaac agtacccagt
      841 gaagccattc gtggactgag tgctttgcag tctctacgct tagatgccaa ccatattacc
      901 tcagtcccgg aggacagttt tgaagggctc gttcagttgc ggcatctgtg gctggatgac
      961 aacatcttga cggaagtgcc tgtgcgtccg ctcagcaacc tgccaaccct gcaggcgctg
     1021 accttggctc tcaacaacat ctcaagcatc cccgacttcg cattcaccaa cctttcaagc
     1081 ttggtagtgc tgcatcttca taacaataaa attaaaagcc tcagtcaaca ctgttttgat
     1141 ggactagata acctggaaac cctggacttg aattataata acttggatga atttcctcag
     1201 gctattaaag cccttcccag ccttaaagag ctgggatttc acagtaattc tatttctgtt
     1261 atcccggatg gagcatttgc tggtaatcca ctgctaagaa ctatccattt gtatgataat
     1321 cctctgtctt ttgtggggaa ctcagcattt cacaacctgt ctgatctgca ttccttagtc
     1381 attcgtggtg caagcctggt gcagtggttc cccaatctgg ccggaactgt ccatctggag
     1441 agtctaacct tgacagggac aaaaataagc agcatacctg atgatctgtg ccaaaaccaa
     1501 aagatgctgc ggactctgga cttatcttat aacgatataa gagaccttcc aagttttaat
     1561 ggttgtcgtg cattggaaga aatttcattg cagcgtaatc aaatctccct gataaaggaa
     1621 actacttttc aaggcctaac atccctaagg attctagatc tgagtagaaa cctgattcgt
     1681 gaaattcaca gtggagcttt tgcgaagctt gggacaatta ctaacctgga tgtgagtttc
     1741 aatgaattaa cctcatttcc tacggaaggc ctgaatgggc tcaatcaact taaacttgtg
     1801 ggtaacttcc agctgaaaga tgccttggca gccagagact ttgccaatct caggtctcta
     1861 tcagtaccat atgcttatca gtgttgtgca ttttgggggt gtgactctta tgcaaattta
     1921 aacacagaag ataacagccc ccaagaccac agtgtgacaa aagagaaagg tgctacagat
     1981 gcagcaaatg ccaccagcac tgctgaaagt gaagaacata gccaaataat catccattgt
     2041 acaccttcaa caggtgcttt taagccctgt gaatatttac tgggaagctg gatgattcgc
     2101 cttacagtgt ggttcatttt cctggtcgcc ttgcttttca acctgcttgt cattttaaca
     2161 gtgtttgcgt cttgttcatc actgcctgcc tccaagctct tcataggctt gatttctgtg
     2221 tctaacttac tcatgggcat ctatactggc atccttactt ttcttgatgc tgtgtcctgg
     2281 ggccgatttg ctgaatttgg catttggtgg gaaactggca gcggctgcaa ggtagctggg
     2341 tctctggcag tcttctcctc agagagcgcc gtattcctgt taaccctggc agccgtggaa
     2401 agaagcgttt ttgcaaagga tgtaatgaaa aatgggaaaa gcagtcacct ccgacagttc
     2461 caggtggctg ccctcgtagc tttgctgggt gctgcaatag caggctgctt cccccttttt
     2521 cacggagggc aatattctgc atcacccttg tgcttgccat ttcctacagg agagacacca
     2581 tcattaggat tcactgtgac cctagtgcta ttaaactcac tagcattttt attgatggcc
     2641 attatctaca ctaaactcta ctgcaactta gagaaagaag acccgtcaga aaactcccag
     2701 tctagcatga ttaagcacgt tgcttggctc atcttcacaa actgcatctt cttctgccct
     2761 gttgcatttt tctcattcgc accattgatc acggcaatct ccatcagccc cgagataatg
     2821 aagtctgtta cgctgatatt cttcccgctg cctgcttgcc tgaatccagt cctgtacgtt
     2881 ttcttcaacc caaagtttaa agacgactgg aagctcctga agcggcgtgt caccaggaaa
     2941 cacggatcag tctcagtctc catcagcagc caaggcggtt gtggggaaca ggatttctac
     3001 tacgactgtg gcatgtattc ccacttgcag ggtaacctga ctgtctgtga ctgctgtgag
     3061 tcatttcttc tgacaaaacc agtatcgtgc aaacacttaa taaaatcgca cagttgtcct
     3121 gtattgacag tggcctcttg ccagaggcca gaggcctact ggtctgattg tggcacacag
     3181 tcggcccatt ctgactatgc agatgaagag gattcctttg tctcggacag ctctgaccag
     3241 gtgcaggcct gtggacgagc ctgcttctac cagagtcgcg gattccctct ggtgcgctat
     3301 gcttataatc taccgagagt cagagactga actcctgtcc gcgactgttt tcctccatca
     3361 accaatcaca gctcatacct tgagctgtct gtcttttgac ctttcatctg ggaaggactt
     3421 gtgtaatcac ttcctggtgt cacgcagaag aggaggaagg tggcagttta tttttcaagt
     3481 cagaagtctg tgaagaatgg gagcctaaag tataaattgt tgaaaaacat tgtgatgccc
     3541 cagcagtgta tgctctattg gaaataaatg cgacttaaaa atgatttgat gtatggcata
     3601 gcaatataaa attagttgtt tttttttttt cttttctgat ccatcaggtg caaagttcaa
     3661 attatttctg aattaagcac aaaataaagg acagctgtta atatatttta agtgaaaatg
     3721 tgaatttata aaactaagaa aatgtcttgc taattttacc taatgattca tcattaatct
     3781 caggatgact tacttcaggg ccaaaaaagg gactatctcc cagcaagagc taggaagagt
     3841 tcaaacaggc attaccttca catgttttct gtgtccataa attgaaaggt tttgttcaaa
     3901 tgatttataa atctaaaacc tgaagatggt tttgagaagg atgttaacag ctgttagatt
     3961 ttttttttta atagcagaac atttgttttt gttcattgca cattgctctg atgaaatccc
     4021 agtgattccc ctctcagtgt ttgacaatcg cagcacagag cacagggaca cagcaaaagg
     4081 ctgattgcca cgtgggttta agtagaggtg actgagtagt aagtaccact gagcttttca
     4141 tagtatccaa gggatttgat ggctctaagt aatgtcctca tctggactgg caatgtccta
     4201 atgtcactgg ctgctctgac atttccaaat ttgttgaagt tatctatcat tctgattata
     4261 caggaagcac acttgagtct tttttttttt tttttttttt tgcaattgta agataataat
     4321 gactcaaagc acttaaattg attttttagt gagctgttgt atgagaactt ccatacattg
     4381 tttgcatgct gtaatttaaa aaaacaacaa aaccattcag tagctcagct gcggtgtgct
     4441 gtggttcaac gagacacata ctaggagtgg gggagtcaaa ccttgtccta tgtctttaca
     4501 ttttctaaat ttacttgact cttacctata ggcttctgat gtggaagact taacactgtg
     4561 ctaagtcagt agcaaaccca ctgccatctt agttatactg gttgaacaaa aacttaagct
     4621 agattgcagt ttgattaaac tgtacatact gtgcatatga tgaagtttat cttgtgtaaa
     4681 ttatttttag aacacgagtt gggcaatgag gcttctgttc actgtttaat taaagctacc
     4741 tcctaaactc tagtggctgc cagtagcaca atggttaatt gtggtttaga tacatgttct
     4801 tggttttgat ttttttttta tccttgcctt gtaaatagtc ttggttgtac attgtcagtg
     4861 gaataaaaac agaatctttg tatatcaaaa tcacgtagtt tgtataaaat gtgggaggga
     4921 tttatttact gtgcttgtaa ttttgtaagg tcatctattt acaacataaa tataatgttt
     4981 gtatatttac acatctgata aatattaaat cataacttgg taagaaaatc ccaattaaag
     5041 gctttcttcc taaaattcaa aaaaaa
//
