LOCUS       NM_145219               3197 bp    mRNA    linear   ROD 11-NOV-2023
DEFINITION  Mus musculus leucine-rich repeat LGI family, member 3 (Lgi3), mRNA.
ACCESSION   NM_145219
VERSION     NM_145219.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3197)
  AUTHORS   Kozar-Gillan N, Velichkova A, Kanatouris G, Eshed-Eisenbach Y,
            Steel G, Jaegle M, Aunin E, Peles E, Torsney C and Meijer DN.
  TITLE     LGI3/2-ADAM23 interactions cluster Kv1 channels in myelinated axons
            to regulate refractory period
  JOURNAL   J Cell Biol 222 (4) (2023)
   PUBMED   36828548
REFERENCE   2  (bases 1 to 3197)
  AUTHORS   Marafi D, Kozar N, Duan R, Bradley S, Yokochi K, Al Mutairi F,
            Saadi NW, Whalen S, Brunet T, Kotzaeridou U, Choukair D, Keren B,
            Nava C, Kato M, Arai H, Froukh T, Faqeih EA, AlAsmari AM, Saleh MM,
            Pinto E Vairo F, Pichurin PN, Klee EW, Schmitz CT, Grochowski CM,
            Mitani T, Herman I, Calame DG, Fatih JM, Du H, Coban-Akdemir Z,
            Pehlivan D, Jhangiani SN, Gibbs RA, Miyatake S, Matsumoto N,
            Wagstaff LJ, Posey JE, Lupski JR, Meijer D and Wagner M.
  TITLE     A reverse genetics and genomics approach to gene paralog function
            and disease: Myokymia and the juxtaparanode
  JOURNAL   Am J Hum Genet 109 (9), 1713-1723 (2022)
   PUBMED   35948005
REFERENCE   3  (bases 1 to 3197)
  AUTHORS   Jones MR, Dilai S, Lingampally A, Chao CM, Danopoulos S, Carraro G,
            Mukhametshina R, Wilhelm J, Baumgart-Vogt E, Al Alam D, Chen C,
            Minoo P, Zhang JS and Bellusci S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3197)
  AUTHORS   Gerhardt B, Leesman L, Burra K, Snowball J, Rosenzweig R, Guzman N,
            Ambalavanan M and Sinner D.
  TITLE     Notum attenuates Wnt/beta-catenin signaling to promote tracheal
            cartilage patterning
  JOURNAL   Dev Biol 436 (1), 14-27 (2018)
   PUBMED   29428562
REFERENCE   5  (bases 1 to 3197)
  AUTHORS   Kim HA, Kwon NS, Baek KJ, Kim DS and Yun HY.
  TITLE     Leucine-rich glioma inactivated 3: Integrative analyses support its
            role in the cytokine network
  JOURNAL   Int J Mol Med 40 (1), 251-259 (2017)
   PUBMED   28534931
  REMARK    GeneRIF: Taken together, these results support the critical
            involvement of LGI3 in the cytokine network by interplaying with
            multiple adipokines, cytokines and signaling proteins.
REFERENCE   6  (bases 1 to 3197)
  AUTHORS   Okabayashi S and Kimura N.
  TITLE     Leucine-rich glioma inactivated 3 is involved in amyloid beta
            peptide uptake by astrocytes and endocytosis itself
  JOURNAL   Neuroreport 19 (12), 1175-1179 (2008)
   PUBMED   18628660
  REMARK    GeneRIF: Data show that LGI3 localizes to the endocytic pathway and
            its accumulation is caused by endocytic perturbation.
REFERENCE   7  (bases 1 to 3197)
  AUTHORS   Lee SE, Lee AY, Park WJ, Jun DH, Kwon NS, Baek KJ, Kim YG and Yun
            HY.
  TITLE     Mouse LGI3 gene: expression in brain and promoter analysis
  JOURNAL   Gene 372, 8-17 (2006)
   PUBMED   16545924
  REMARK    GeneRIF: The expression of mouse LGI3 (mLGI3) in adult and
            developing brain and analyzed the 5'-upstream transcriptional
            regulatory regions of mLGI3 gene.
REFERENCE   8  (bases 1 to 3197)
  AUTHORS   Bermingham JR Jr, Shearin H, Pennington J, O'Moore J, Jaegle M,
            Driegen S, van Zon A, Darbas A, Ozkaynak E, Ryu EJ, Milbrandt J and
            Meijer D.
  TITLE     The claw paw mutation reveals a role for Lgi4 in peripheral nerve
            development
  JOURNAL   Nat Neurosci 9 (1), 76-84 (2006)
   PUBMED   16341215
REFERENCE   9  (bases 1 to 3197)
  AUTHORS   Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber
            G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong
            WH and Cepko CL.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 3197)
  AUTHORS   Gu W, Wevers A, Schroder H, Grzeschik KH, Derst C, Brodtkorb E, de
            Vos R and Steinlein OK.
  TITLE     The LGI1 gene involved in lateral temporal lobe epilepsy belongs to
            a new subfamily of leucine-rich repeat proteins
  JOURNAL   FEBS Lett 519 (1-3), 71-76 (2002)
   PUBMED   12023020
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY273969.1, AK132296.1, AK087125.1 and AW049851.1.
            
            [WARNING] On Nov 22, 2023 this sequence was replaced by
            NM_145219.5.
            
            On Dec 10, 2009 this sequence version replaced NM_145219.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055315.1, AK132296.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BY273969.1         3-9
            8-1073              AK132296.1         2-1067
            1074-2878           AK087125.1         1213-3017
            2879-3197           AW049851.1         1-319               c
FEATURES             Location/Qualifiers
     source          1..3197
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.32 cM"
     gene            1..3197
                     /gene="Lgi3"
                     /note="leucine-rich repeat LGI family, member 3"
                     /db_xref="GeneID:213469"
                     /db_xref="MGI:MGI:2182619"
     exon            1..450
                     /gene="Lgi3"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1891
                     /gene="Lgi3"
                     /note="leubrin; leucine-rich glioma-inactivated protein 3"
                     /codon_start=1
                     /product="leucine-rich repeat LGI family member 3
                     precursor"
                     /protein_id="NP_660254.1"
                     /db_xref="CCDS:CCDS27255.1"
                     /db_xref="GeneID:213469"
                     /db_xref="MGI:MGI:2182619"
                     /translation="MAGLRARRGPGRRLLVLSTLGFCLMLQVSAKRPPKTPPCPPSCS
                     CTRDTAFCVDSKSVPKNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTL
                     IGDNAFIGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLD
                     ILSDLDLRGNALNCDCKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDC
                     ITTDFVLYQTLSFPAVSAEPFLYSSDLYLALAQPGASACTILKWDYVERQLRDYDRIP
                     APSAVHCKPMVVDGQLYVVVAQLFGGSYIYHWDPNTTRFTKLQDIDPQRVRKPNDLEA
                     FRIDGDWFFAVADSSKAGATSLYRWHQNGFYSHQALHAWHRDTDLEFVDGEGKPRLIV
                     SSSSQAPVIYQWSRSQKQFVAQGEVTQVPDAQAVKHFRAGRDSYLCLSRYIGDSKILR
                     WEGTRFSEVQALPSRGSLALQPFLVGGHRYLALGSDFSFTQIYQWDEGRQKFVRFQEL
                     AVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYRHVVVDLSA"
     exon            451..522
                     /gene="Lgi3"
                     /inference="alignment:Splign:2.1.0"
     exon            523..594
                     /gene="Lgi3"
                     /inference="alignment:Splign:2.1.0"
     exon            595..666
                     /gene="Lgi3"
                     /inference="alignment:Splign:2.1.0"
     exon            667..738
                     /gene="Lgi3"
                     /inference="alignment:Splign:2.1.0"
     exon            739..908
                     /gene="Lgi3"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1073
                     /gene="Lgi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..3181
                     /gene="Lgi3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgccgcagt ccgcgtccac cagccccggc agccagtagt tgcggtccca gttccgcgca
       61 gcgctccgga gctgaaagga ctgcaatcag cgcccgaggt caggaggaat aggtggcgcc
      121 tagagagcgg gtggcaccag agttgcggca gcccggaggt ggaagctctc gagaggggca
      181 gaacagcctg cagggagcag cggggcgccg gcaggctggt gtggggggag accctgcagg
      241 agtcatggcc gggctacgag ccaggcgggg ccctgggcgc aggctactgg tgttgtccac
      301 gctgggtttt tgcctaatgc tgcaagtcag tgccaagaga cctcctaaga cgcccccctg
      361 cccacccagc tgctcctgca ccagggacac cgccttctgc gtggactcta agtcggtgcc
      421 caagaacctg ccttcagagg tcatctccct gacgctggtg aatgctgcct tctcagagat
      481 ccaggatgga gccttctccc atctgccgtt gttgcagttc ttgttactca actctaacaa
      541 gttcacactg attggagaca atgccttcat aggactgtcg cacctgcagt acctcttcat
      601 agagaacaat gacatctggg ctctctccaa gtttaccttc agaggactga agtccttgac
      661 acacctttct ctggccaaca ataacctgca gacactgccc agagacatct tccgtcccct
      721 ggacatcctg agtgacttag acctccgggg caacgcactt aactgtgact gcaaggtaaa
      781 gtggctggtg gagtggctgg cacacaccaa caccacggtg gctcccatct actgcgccag
      841 cccgccccgc ttccaggaac acaaggtgca ggacttgcct cttcgagaat tcgactgcat
      901 caccactgat tttgtcctct accagaccct gtccttccca gcagtgtctg cggaaccttt
      961 cctttactct agtgacctct acttggctct ggcccagcca ggtgccagcg cctgcaccat
     1021 cctcaagtgg gactatgtgg aacgacagct tcgagactat gacagaattc cagccccttc
     1081 agctgtgcac tgcaagccga tggtggtgga tggccagctc tatgtcgttg tggcccagct
     1141 gtttggtggc tcatacattt accactggga ccccaacacc acacgtttca ccaagttgca
     1201 ggacatcgac ccacagcgcg tgcgcaaacc caatgacctg gaagccttcc gcatcgacgg
     1261 tgactggttt ttcgcagtgg ctgacagctc caaggcaggt gccaccagcc tctaccgttg
     1321 gcaccagaat ggcttctatt cccaccaggc cctgcacgcc tggcaccgcg acaccgacct
     1381 ggagtttgtg gacggtgagg gcaaaccacg gttaattgtg tctagcagct cgcaagcacc
     1441 tgtcatctat caatggagtc gttctcagaa acagtttgtg gctcagggag aggtgactca
     1501 ggtacctgat gcccaggccg tgaaacactt tcgtgctggc cgagacagct acctgtgcct
     1561 tagccgctac attggcgact ccaagatcct gcgctgggaa ggtacccgtt tctctgaggt
     1621 gcaagccctt ccctcccgag gctcgctggc cctacagccc ttcctggtgg gtggtcaccg
     1681 ctacctggcc ctgggcagtg acttctcctt cacccagatc taccagtggg atgaggggcg
     1741 acagaaattt gtacggttcc aagagctggc agtacaggca ccccgggcct tctgctacat
     1801 gcctgctgga gatgcccagc tgctcctggc ccccagtttc aagggacaaa cactggtgta
     1861 ccgacatgtt gtggtggacc ttagtgccta gaggggggct aagtcctttg ggttcctcag
     1921 ggtggcactg tacgatgggt ggggacctct gtgagcaact tgtggcccca agtgaagtca
     1981 caggtggcca gcctgtctat gtagctacac acacatacac aaagaagtgg gcctgggcac
     2041 acaccaggga ctagcccagg ggagccattc ccattactgt aataagcacc tacgtatgca
     2101 ccaggcaccc agtgtccagg ctctctatgt gcgcaccaac agcccctgat cttcagtgtt
     2161 ccctgctctg ctccgttgct agcgtgtctg agtaacaaag cgagtgcagg aaggggtgag
     2221 ccacagcctt ctcttctcag cttagctttc tgctctctgg cctctggatg cccgaggtgc
     2281 ttgtgtacct gtttggcatc cacagttgca gcccccctgc aggtgtgccc acacttccaa
     2341 gtgtgcctgc ccacgccatg ctccttctgc atgcacctgt ggacactgat ggacaaactc
     2401 agctgcatac ttgtgcatac cccaccacac ttctgattct gtatctgcac acgtctgggg
     2461 gtgtgtacgt gagcggacta ggtgctgggc aaaccggcgt ccttgatacc ccgtagctgc
     2521 tcttcttgga gggtgcctac agcacccaca ctttctctgc tctccccagt gtgccccctg
     2581 tgtggctcat aaggatagca acagaaaacg tgaccatggc ctcgtgggga caaagccact
     2641 tcatccagaa gcaataataa caagaggcag cagcaactgg gttcttcaca gtgcagtata
     2701 gctctcctca ctagagtttt cttccacgac tcagtcccag ctcaaaggga cacgggtggg
     2761 aaggctttct ctggatagct attgcttttt caagctcggg ccatctcctc tctcacccta
     2821 tctttgagat gcggatccca aagtgtgatt gctccttgac tggatatata aaaaaaaatc
     2881 agccaaggca agaatcctga gacagcctga gctacttgtg tgggcgccag gaacatgttg
     2941 gtcgccctgg cacccctcca tgccatggag atgccccccg gaggcacagc tcggtggagg
     3001 ctggatgagg atggcaggga gggacacctg ggaaccaggc ctctgctgcc ctctgctgtc
     3061 ctctgggagc agcagccctg aagtaggaaa tgatcaggct gagaggattt cttgcggcct
     3121 gatgcacctg gggataatgc taagattcct ttgcttcgaa taaagttcca ccccactgct
     3181 aaaaaaaaaa aaaaaaa
//
