LOCUS       NM_001310604            6291 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus leucine-rich repeat LGI family, member 2 (Lgi2),
            transcript variant 2, mRNA.
ACCESSION   NM_001310604 XM_006503964
VERSION     NM_001310604.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6291)
  AUTHORS   Kozar-Gillan,N., Velichkova,A., Kanatouris,G., Eshed-Eisenbach,Y.,
            Steel,G., Jaegle,M., Aunin,E., Peles,E., Torsney,C. and Meijer,D.N.
  TITLE     LGI3/2-ADAM23 interactions cluster Kv1 channels in myelinated axons
            to regulate refractory period
  JOURNAL   J Cell Biol 222 (4) (2023)
   PUBMED   36828548
REFERENCE   2  (bases 1 to 6291)
  AUTHORS   Turrero Garcia,M., Stegmann,S.K., Lacey,T.E., Reid,C.M.,
            Hrvatin,S., Weinreb,C., Adam,M.A., Nagy,M.A. and Harwell,C.C.
  TITLE     Transcriptional profiling of sequentially generated septal neuron
            fates
  JOURNAL   Elife 10, e71545 (2021)
   PUBMED   34851821
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6291)
  AUTHORS   Favuzzi,E., Deogracias,R., Marques-Smith,A., Maeso,P., Jezequel,J.,
            Exposito-Alonso,D., Balia,M., Kroon,T., Hinojosa,A.J., F Maraver,E.
            and Rico,B.
  TITLE     Distinct molecular programs regulate synapse specificity in
            cortical inhibitory circuits
  JOURNAL   Science 363 (6425), 413-417 (2019)
   PUBMED   30679375
REFERENCE   4  (bases 1 to 6291)
  AUTHORS   Bibollet-Bahena,O., Okafuji,T., Hokamp,K., Tear,G. and
            Mitchell,K.J.
  TITLE     A dual-strategy expression screen for candidate connectivity labels
            in the developing thalamus
  JOURNAL   PLoS One 12 (5), e0177977 (2017)
   PUBMED   28558017
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6291)
  AUTHORS   Chen,N., Koopmans,F., Gordon,A., Paliukhovich,I., Klaassen,R.V.,
            van der Schors,R.C., Peles,E., Verhage,M., Smit,A.B. and Li,K.W.
  TITLE     Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the
            presence of two Caspr2 isoforms with overlapping interactomes
  JOURNAL   Biochim Biophys Acta 1854 (7), 827-833 (2015)
   PUBMED   25707359
REFERENCE   6  (bases 1 to 6291)
  AUTHORS   Gibson,P., Tong,Y., Robinson,G., Thompson,M.C., Currle,D.S.,
            Eden,C., Kranenburg,T.A., Hogg,T., Poppleton,H., Martin,J.,
            Finkelstein,D., Pounds,S., Weiss,A., Patay,Z., Scoggins,M., Ogg,R.,
            Pei,Y., Yang,Z.J., Brun,S., Lee,Y., Zindy,F., Lindsey,J.C.,
            Taketo,M.M., Boop,F.A., Sanford,R.A., Gajjar,A., Clifford,S.C.,
            Roussel,M.F., McKinnon,P.J., Gutmann,D.H., Ellison,D.W.,
            Wechsler-Reya,R. and Gilbertson,R.J.
  TITLE     Subtypes of medulloblastoma have distinct developmental origins
  JOURNAL   Nature 468 (7327), 1095-1099 (2010)
   PUBMED   21150899
REFERENCE   7  (bases 1 to 6291)
  AUTHORS   Herranz-Perez,V., Olucha-Bordonau,F.E., Morante-Redolat,J.M. and
            Perez-Tur,J.
  TITLE     Regional distribution of the leucine-rich glioma inactivated (LGI)
            gene family transcripts in the adult mouse brain
  JOURNAL   Brain Res 1307, 177-194 (2010)
   PUBMED   19833108
  REMARK    GeneRIF: lGI2 distribution in the vertical limb of the diagonal
            band and in putative hippocampal interneurons suggests that the
            function of these genes might be related to the generation of
            hippocampal theta rhythm.
REFERENCE   8  (bases 1 to 6291)
  AUTHORS   Bermingham,J.R. Jr., Shearin,H., Pennington,J., O'Moore,J.,
            Jaegle,M., Driegen,S., van Zon,A., Darbas,A., Ozkaynak,E.,
            Ryu,E.J., Milbrandt,J. and Meijer,D.
  TITLE     The claw paw mutation reveals a role for Lgi4 in peripheral nerve
            development
  JOURNAL   Nat Neurosci 9 (1), 76-84 (2006)
   PUBMED   16341215
REFERENCE   9  (bases 1 to 6291)
  AUTHORS   Senechal,K.R., Thaller,C. and Noebels,J.L.
  TITLE     ADPEAF mutations reduce levels of secreted LGI1, a putative tumor
            suppressor protein linked to epilepsy
  JOURNAL   Hum Mol Genet 14 (12), 1613-1620 (2005)
   PUBMED   15857855
REFERENCE   10 (bases 1 to 6291)
  AUTHORS   Staub,E., Perez-Tur,J., Siebert,R., Nobile,C., Moschonas,N.K.,
            Deloukas,P. and Hinzmann,B.
  TITLE     The novel EPTP repeat defines a superfamily of proteins implicated
            in epileptic disorders
  JOURNAL   Trends Biochem Sci 27 (9), 441-444 (2002)
   PUBMED   12217514
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120128.17, CJ124394.1, AJ487515.1 and AI843865.1.
            
            On Jul 16, 2015 this sequence version replaced XM_006503964.1.
            
            Transcript Variant: This variant (2) contains an alternate in-frame
            exon and uses an alternate in-frame splice site compared to variant
            1. The encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122570.1, AY841361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               AC120128.17        126528-126887
            361-991             CJ124394.1         2-632
            992-1929            AJ487515.1         1013-1950
            1930-5929           AC120128.17        154971-158970
            5930-6291           AI843865.1         1-362               c
FEATURES             Location/Qualifiers
     source          1..6291
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 28.25 cM"
     gene            1..6291
                     /gene="Lgi2"
                     /gene_synonym="mKIAA1916"
                     /note="leucine-rich repeat LGI family, member 2"
                     /db_xref="GeneID:246316"
                     /db_xref="MGI:MGI:2180196"
     exon            1..389
                     /gene="Lgi2"
                     /gene_synonym="mKIAA1916"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1830
                     /gene="Lgi2"
                     /gene_synonym="mKIAA1916"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; leucine-rich glioma-inactivated protein 2"
                     /codon_start=1
                     /product="leucine-rich repeat LGI family member 2 isoform
                     2 precursor"
                     /protein_id="NP_001297533.1"
                     /db_xref="CCDS:CCDS80281.1"
                     /db_xref="GeneID:246316"
                     /db_xref="MGI:MGI:2180196"
                     /translation="MALWRGGGALGLLLLSAACLIPPSAQVRRLARCPATCSCTKESI
                     ICVGSSWVPRIVPGDISSLSLVNGTFLEIKDRMFSHLPSLQLLLLNSNSFTVIRDDAF
                     AGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELD
                     LRGNKFECDCKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNEVTSFDYECTTTDFV
                     VHQTLPYQSVSVDTFNSKNDVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVG
                     CKAILIDDQVFVVVAQLFGGSHIYKYDESWTKFVKFQDIEVSRISKPNDIELFEIDDE
                     TFFIIADSSKAGLSTVYKWNSKGFYSYQSLHEWFRDTDAEFVDIDGKSHLILSSRSQV
                     PIILQWNKSSKKFVPHGDIPNMEDVLAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQF
                     VEVQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQWDKEKQQFKKFKEIYVQAPR
                     SFTAVSTDRRDFFFASSFKGKTKIFEHIIVDLSL"
     exon            390..461
                     /gene="Lgi2"
                     /gene_synonym="mKIAA1916"
                     /inference="alignment:Splign:2.1.0"
     exon            462..533
                     /gene="Lgi2"
                     /gene_synonym="mKIAA1916"
                     /inference="alignment:Splign:2.1.0"
     exon            534..605
                     /gene="Lgi2"
                     /gene_synonym="mKIAA1916"
                     /inference="alignment:Splign:2.1.0"
     exon            606..677
                     /gene="Lgi2"
                     /gene_synonym="mKIAA1916"
                     /inference="alignment:Splign:2.1.0"
     exon            678..847
                     /gene="Lgi2"
                     /gene_synonym="mKIAA1916"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1012
                     /gene="Lgi2"
                     /gene_synonym="mKIAA1916"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..6276
                     /gene="Lgi2"
                     /gene_synonym="mKIAA1916"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6254..6259
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lgi2"
                     /gene_synonym="mKIAA1916"
                     /note="hexamer: AATAAA"
     polyA_site      6276
                     /gene="Lgi2"
                     /gene_synonym="mKIAA1916"
                     /note="major polyA site"
ORIGIN      
        1 gccgagtggg ggtggcggcc agcatgctgc tcggctgcgg ctcggcctcc cacacccgcg
       61 gcgcccgcgt cctcgccagc agcgctggcg gccgatcggc aagcggcacc cgcgtctgct
      121 gcggcgctgg gtccgagcgc acggcgcggg gcggcggcgg cggcgggggt ccgagcccgg
      181 gcggggaccc ggggacccgg catggcgcta tggagaggcg gcggggcgct ggggttgctg
      241 ctgctgagcg ccgcgtgcct catcccgccg agcgcgcagg tgaggcggtt ggcgcgctgc
      301 cccgccactt gcagctgtac caaggagtcc atcatctgcg tgggctcctc ttgggtgcct
      361 aggatcgtgc ctggcgacat cagctccctg agcctagtaa atggaacatt tctggaaatc
      421 aaggaccgaa tgttttccca cctgccctct ctgcagctgc tattgctgaa ttctaactca
      481 ttcacggtga tccgggacga tgcctttgct ggcctttttc atcttgaata cctgttcatt
      541 gaagggaaca aaatagaaac catttcaaga aatgcctttc ggggcctccg tgacctgact
      601 cacctttcct tggccaacaa ccacataaaa gcacttccaa gggacgtgtt cagtgatctg
      661 gactccctca ttgaactaga cttaaggggt aataaatttg aatgtgactg caaagccaaa
      721 tggctgtatc tatggctgaa gatgacaaac tccaccgtct ctgatgtgct gtgtatcggt
      781 ccaccagaat accaggagaa gaaactcaac gaagtgacca gctttgacta tgagtgtacc
      841 accacagatt ttgtcgttca tcagactctg ccgtaccagt cggtgtcagt agacacgttc
      901 aactccaaga acgatgtgta cgtggccatc gctcagccca gcatggagaa ctgcatggtg
      961 ttggagtggg accacataga aatgaatttc cggagttatg acaatatcac aggccagtcc
     1021 atcgtgggct gcaaggccat cctcattgac gaccaggtct ttgtggtggt ggcccagctc
     1081 ttcggtggct ctcacattta caaatacgac gagagctgga ccaagtttgt caagttccaa
     1141 gacatagagg tgtctcggat ttccaagccc aacgacattg agctgttcga gatcgacgac
     1201 gagaccttct tcatcatcgc cgacagctcc aaagcggggc tgtccacagt ttacaagtgg
     1261 aacagcaaag ggttttactc ctaccagtca ctacatgagt ggttcaggga cacagatgcg
     1321 gagtttgttg acatcgacgg gaagtctcac ctcatcctgt ctagccgctc ccaggtcccc
     1381 atcatcctgc agtggaataa aagttccaag aagtttgtcc cccatggtga catccccaat
     1441 atggaggatg tgctggctgt gaagagcttc cggatgcaga acaccctcta cctttccctc
     1501 acccgtttca ttggggactc gcgggtcatg cgttggaaca gtaagcagtt tgtggaggtc
     1561 caggctcttc cttcccgggg ggctatgacc ttgcaaccct tctccttcaa agataaccac
     1621 tacctggccc tggggagtga ctacacgttc tcacagatct accagtggga taaagagaaa
     1681 cagcagttta aaaagtttaa agaaatctat gtgcaggcgc ctcggtcctt cacagccgtc
     1741 tccaccgaca ggagagattt cttttttgca tccagtttca aagggaagac aaagattttt
     1801 gaacatatca ttgttgattt aagtttgtga aggtgtgact agaagcattt caaagatgtg
     1861 tagtgttagc tctcacaaga gagacaggac caagaagaaa taataataat aataaaaaaa
     1921 tcataaaata agccaggctc agagctctga aactaaaatt cacaatgcac tgggggaaat
     1981 agttagacat tttcaaactt ttaggattca cattttaacc agggattgca tttttctttt
     2041 ggctgattgc atgagaggcc tatgctgctg tttacaagcg acatcttaaa gcctgtaata
     2101 tctgagacag gagcgcagca tctttaccat ctagaaggca gtgtgcttct actttaattt
     2161 caataaaaaa ggataaaaca gacaagatgg gccagccctt ctagtgaaat taagacaaga
     2221 gacccccacc catctaactc cactgacctt tccattccta ttaagatagg aattaagaaa
     2281 ttaagaaaaa ctgataaggc agtctttcaa ttaagaactg gtaaagccaa agtgagctga
     2341 aaagatttgc tgattgtttg tttgaaaatc ttagaacact ccacagtgct attttgagcc
     2401 atcctagttt cctgaaagtc atggccaggc cagtcttcca gaatcttcct tagagtagaa
     2461 ccttggctct gccctcatca gggtcgatct ctgtcatgag tatgctcata ggttaatgtt
     2521 taacatcgtt tcctctgcca cagagaaaat attctggtga cacgtgtcta ggccagcctg
     2581 gaatgtgccc aagatgaagg gatttccctg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2641 tgtgtgtgtg tggtttaaag gtaaccctcg aggtggctgg agcaatcatg tgtgtttgat
     2701 gttatccgtt gagcgctcaa atctctgagc cgttcctttt agtttgtggg taactggcag
     2761 gcaggccaaa ggctgactgg tgcttttcat ctgtccctta gagggatgga acaggtgttc
     2821 ccatctcctg ggcattgggt agggtttttg aagtgagatt ttacggagtc agagggcact
     2881 taactcagat ctccatgtgc tttgagaccc agagggggtc ctttgattgt tgcatgtctt
     2941 tgccctctgg acaacttaat atttcaagta attgattcaa tagcagtctg cctacctgcc
     3001 cacctgcctc ccttcctcct ggaacagtcc tttgttaagt tgtaggtgtg cacagtggct
     3061 ggctcgtgcg gccctgcaga agtttctgaa catacaaaag tcaaaatcac gggaacacac
     3121 ctccctcctc cagcacgcta gcaataggag gcaggtcgtg cgctagtgct ggggtatctg
     3181 atagagcttc aggcgagacc agctggaacc agatgagcgt aatctcatag gccaggtctg
     3241 tgtgtgggac caggtggctt atttcaaaat aggcctcctg tggggacagc agggaaatgc
     3301 ttggggtctg gttgtgtaga tggttgcaca gtggatattc tgtctaagca gctgctttag
     3361 gggagtgttt tgcagagtcc cactgcagca cgatgtcgtt ttaatggtca tcctcgctgt
     3421 agctaggtag agggtacccc acaaatgcga atgagtctgt tgtctcctga ctgtaagcag
     3481 caggggatga ttggtacgcc atactggaga gctatgcatt gatggtaatc agcactcctg
     3541 gctgatgctt ccagcctagg gggaatcaag gactttaatg aactctggct ctatagtgtg
     3601 gttgcttaga ctgctggtgc taaatgccaa gcaaatagaa agagcggtct gttttaatgc
     3661 tctaagcgta aatgacacgt atgcgttctt cgccttcttt tgtcttcttg gttcatttgg
     3721 cttgcccatg agttcctggc tctccctatt ggaggctgga agtgtgatgg ttgcttttcc
     3781 tttctctgaa gaactggtga gccatgttcc tccatacatg ggtcctgcag acaggcacgt
     3841 agcactaatg tcaggcagag agaacacctt tgcttctcac cgcttgtaga ggaacccaca
     3901 ggggcatctc tcagagtgcc acctctacag agcctggtac cagcttctct gtgcttcctc
     3961 acagggtgaa gccatggcca ttgcttagag ttcaaaaagc caagatatgt ggggtttgac
     4021 ttgggggtgg ggcaggctgt cagacccgga tgaagcattt ggggagtgaa aaagaccctg
     4081 gtgggtggtg cagcaggggt atgagaggac cagcaatcga gttttctttt taagacaagt
     4141 ttataccaga ctggagtctg cagccttctg agtcctgcgc tatgggagga gatatttgtt
     4201 ctggccaact taacgaagga acatagatgt tcttggcata aggtgggaag ctctgcttca
     4261 ttaatcttac tgctctctcc caagaatccc tgaagtttta agcagtttct gcaaaatgct
     4321 ttcttccagt aaaataacaa aacccaccca cacagctata acaagagccc aaggcagaga
     4381 aatgcatagg actgtccagc tgagggggac tggtctctcc ttccccctcc ttcctgctct
     4441 cccccttcct ccctccctcc cccctccctc tcttccttcc tccctcctca tttcttcttt
     4501 ctttccttcc caacacccat gcactgacat ctgctcagcc cgccctttgt ccgtctctgc
     4561 agctggcttc agaagatgat ccctccaatc agtcctgcgg ctttaaggcc ataacctaaa
     4621 gcaagggtta gtcctcagac tctgtaggat ccgcagtaga tttctataaa gactaaaaat
     4681 aaaccttagg gctgacaagc actttgttcc tgggctgtgg ataagatcag ctcgcatccc
     4741 ggaagcttcc tgtcattccc gcctgtgcat ctgtgttctg ctcacgtgtc acatgtagct
     4801 ctttggttta cggagggcag gtgttattct aatttcatag agaaggaaat agacacagaa
     4861 ccgaagtaga tggcctgcct gagattatcc ggttttaagc agcaaagcta gaactttccc
     4921 gtggacgaca ggtgctgcat tttctctttc taatgctctg ctgtgcccac ccaaagtcag
     4981 actctgttac catgacagtg aagacagcag cagttcttgt agattacgta caagcagaat
     5041 gaagagccag gggtgaaagt catgcctgac acacaccgtt caatcgtcaa tgccatcgaa
     5101 caactagcaa gcacctcaga actgtggggc atgcctagcc aggcttgaga aagccttcca
     5161 gaagtggtgg atggcttcag ttgtctagcg aggatttcta gccggcatga ctgtgtcttc
     5221 tcacatatag ccatggaggg aatactgagg ctagacacat ctggttcttg tcatggtgtc
     5281 taccagatac gatgagttct aggagagaga aattaaaaac cccaactcag gagcaatggt
     5341 gaattgctcc gggccagtgt tgtgttcttc tcgtggaatg aggctgcatg tttttagggg
     5401 aaaaaaaatc aatatgaggt tctacaagct gagcctctgg gagtgctcac gatggagatt
     5461 tctctggctt aggggactcc aggcaaacca gaggaaggtc tgcaggaagg gctctggttt
     5521 gcatgccccc taaaggaagc cttgagccag cttcccgagt cttctgcagg agactcgctc
     5581 cttgtgtgac ttcactcctt gcttccttag gcagggccaa gggttgtgtt cgacagcgtg
     5641 ccagagcaga gtcagcaacc tagcagcggg tgcaaagaat agggtggttt agacctgggg
     5701 cgccatggga aaagtggggg aggcgtgcag ggcagatggt ttgggagtgg atgctttgtg
     5761 ggggaaggag gaatgagctt gaaagagcaa tgataacttc cgttgcctta gcagagggta
     5821 ggatggccag gcacatccgt agcatgccaa tcactgaaca gcatccactg taatgctgat
     5881 tcagacaaca gtgacatcac tgggccactg ggctctcagc cgagcactct gctctttacc
     5941 ctgtctcatt gcttgcgcca gcagccacct ctttctagcg gggaaactat gcgttcccta
     6001 tccaaccccc tgactatcag gaatgtatga gaactgtgat aaactagtcc aatatgccgt
     6061 ttggtactgt ttttatgtct tttaaatgca caacttaggt gaaataatac tttatacgtg
     6121 tatggacgtg gattttacag tggacggaca atgctggatg tgttttaaag ctgtatctac
     6181 ttagctcttt ttggaaaata gattggacac atgatatgcc tcttgattct tctatatatt
     6241 ctgtaatcct gtgaataaaa agtagtaaat gcctaaaaaa aaaaaaaaaa a
//
