LOCUS       NM_020278               4380 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus leucine-rich repeat LGI family, member 1 (Lgi1),
            transcript variant 1, mRNA.
ACCESSION   NM_020278
VERSION     NM_020278.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4380)
  AUTHORS   Miyazaki,Y., Otsuka,T., Yamagata,Y., Endo,T., Sanbo,M., Sano,H.,
            Kobayashi,K., Inahashi,H., Kornau,H.C., Schmitz,D., Pruss,H.,
            Meijer,D., Hirabayashi,M., Fukata,Y. and Fukata,M.
  TITLE     Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize
            juxtaparanodal Kv1 channel clustering for short-term synaptic
            plasticity
  JOURNAL   Cell Rep 43 (1), 113634 (2024)
   PUBMED   38194969
REFERENCE   2  (bases 1 to 4380)
  AUTHORS   Extremet,J., Ramirez-Franco,J., Fronzaroli-Molinieres,L.,
            Boumedine-Guignon,N., Ankri,N., El Far,O., Garrido,J.J., Debanne,D.
            and Russier,M.
  TITLE     Rescue of Normal Excitability in LGI1-Deficient Epileptic Neurons
  JOURNAL   J Neurosci 43 (50), 8596-8606 (2023)
   PUBMED   37863654
  REMARK    GeneRIF: Rescue of Normal Excitability in LGI1-Deficient Epileptic
            Neurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4380)
  AUTHORS   Ramirez-Franco,J., Debreux,K., Extremet,J., Maulet,Y., Belghazi,M.,
            Villard,C., Sangiardi,M., Youssouf,F., El Far,L., Leveque,C.,
            Debarnot,C., Marchot,P., Paneva,S., Debanne,D., Russier,M.,
            Seagar,M., Irani,S.R. and El Far,O.
  TITLE     Patient-derived antibodies reveal the subcellular distribution and
            heterogeneous interactome of LGI1
  JOURNAL   Brain 145 (11), 3843-3858 (2022)
   PUBMED   35727946
  REMARK    GeneRIF: Patient-derived antibodies reveal the subcellular
            distribution and heterogeneous interactome of LGI1.
REFERENCE   4  (bases 1 to 4380)
  AUTHORS   Teng,X.Y., Hu,P., Chen,Y., Zang,Y., Ye,X., Ou,J., Chen,G. and
            Shi,Y.S.
  TITLE     A novel Lgi1 mutation causes white matter abnormalities and impairs
            motor coordination in mice
  JOURNAL   FASEB J 36 (3), e22212 (2022)
   PUBMED   35167164
  REMARK    GeneRIF: A novel Lgi1 mutation causes white matter abnormalities
            and impairs motor coordination in mice.
REFERENCE   5  (bases 1 to 4380)
  AUTHORS   Yokoi,N., Fukata,Y., Okatsu,K., Yamagata,A., Liu,Y., Sanbo,M.,
            Miyazaki,Y., Goto,T., Abe,M., Kassai,H., Sakimura,K., Meijer,D.,
            Hirabayashi,M., Fukai,S. and Fukata,M.
  TITLE     14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure
            thresholds in mice
  JOURNAL   Cell Rep 37 (11), 110107 (2021)
   PUBMED   34910912
REFERENCE   6  (bases 1 to 4380)
  AUTHORS   Ribeiro,P.A., Sbragia,L., Gilioli,R., Langone,F., Conte,F.F. and
            Lopes-Cendes,I.
  TITLE     Expression profile of Lgi1 gene in mouse brain during development
  JOURNAL   J Mol Neurosci 35 (3), 323-329 (2008)
   PUBMED   18563303
  REMARK    GeneRIF: This study was the first to determine a specific profile
            of Lgi1 gene expression during central nervous system development,
            which suggests a possible inhibitory function in latter stages of
            development.
REFERENCE   7  (bases 1 to 4380)
  AUTHORS   Furlan,S., Roncaroli,F., Forner,F., Vitiello,L., Calabria,E.,
            Piquer-Sirerol,S., Valle,G., Perez-Tur,J., Michelucci,R. and
            Nobile,C.
  TITLE     The LGI1/epitempin gene encodes two protein isoforms differentially
            expressed in human brain
  JOURNAL   J Neurochem 98 (3), 985-991 (2006)
   PUBMED   16787412
  REMARK    GeneRIF: Two protein isoforms encoded by LGI1/epitempin are
            differentially expressed in mouse brain: the 60-kDa form is
            detected in the microsomal fraction, while the 65-kDa product is
            found in the cytosolic fraction.
REFERENCE   8  (bases 1 to 4380)
  AUTHORS   Bermingham,J.R. Jr., Shearin,H., Pennington,J., O'Moore,J.,
            Jaegle,M., Driegen,S., van Zon,A., Darbas,A., Ozkaynak,E.,
            Ryu,E.J., Milbrandt,J. and Meijer,D.
  TITLE     The claw paw mutation reveals a role for Lgi4 in peripheral nerve
            development
  JOURNAL   Nat Neurosci 9 (1), 76-84 (2006)
   PUBMED   16341215
REFERENCE   9  (bases 1 to 4380)
  AUTHORS   Senechal,K.R., Thaller,C. and Noebels,J.L.
  TITLE     ADPEAF mutations reduce levels of secreted LGI1, a putative tumor
            suppressor protein linked to epilepsy
  JOURNAL   Hum Mol Genet 14 (12), 1613-1620 (2005)
   PUBMED   15857855
  REMARK    GeneRIF: Reduce levels of secreted LGI1 is associated with
            autosomal dominant partial epilepsy with auditory features
REFERENCE   10 (bases 1 to 4380)
  AUTHORS   Somerville,R.P., Chernova,O., Liu,S., Shoshan,Y. and Cowell,J.K.
  TITLE     Identification of the promoter, genomic structure, and mouse
            ortholog of LGI1
  JOURNAL   Mamm Genome 11 (8), 622-627 (2000)
   PUBMED   10920229
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ133398.1 and BC066090.1.
            
            On Jul 24, 2018 this sequence version replaced NM_020278.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066090.1, SRR1660811.121443.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                CJ133398.1         23-117
            96-4380             BC066090.1         1-4285
FEATURES             Location/Qualifiers
     source          1..4380
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 32.9 cM"
     gene            1..4380
                     /gene="Lgi1"
                     /note="leucine-rich repeat LGI family, member 1"
                     /db_xref="GeneID:56839"
                     /db_xref="MGI:MGI:1861691"
     exon            1..411
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1870
                     /gene="Lgi1"
                     /note="leucine-rich glioma-inactivated protein 1"
                     /codon_start=1
                     /product="leucine-rich glioma-inactivated protein 1
                     precursor"
                     /protein_id="NP_064674.1"
                     /db_xref="CCDS:CCDS29786.1"
                     /db_xref="GeneID:56839"
                     /db_xref="MGI:MGI:1861691"
                     /translation="MESESSRRMGNACIPLKRIAYFLCLFSVVLLTEGKKPAKPKCPA
                     VCTCSKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNS
                     FDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFK
                     GLDSLTNVDLRGNAFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSPKD
                     FDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYD
                     NITGTSTVVCKPIVIDTQLYVIVAQLFGGSHIYKRDGFANKFIKIQDIEVLKIRKPND
                     IETFKIEDNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIARPPL
                     ALRTPHLILSSSSQRPVIYQWSKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTR
                     FIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEK
                     AKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA"
     exon            412..483
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..555
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..627
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..699
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..869
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1034
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..4354
                     /gene="Lgi1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4331..4336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lgi1"
                     /note="hexamer: AATAAA"
     polyA_site      4354
                     /gene="Lgi1"
                     /note="major polyA site"
ORIGIN      
        1 agcagtgcgc tgcctgagcg aggaacagct cacgaatcag ctggaggtcc ctgttttgaa
       61 aaaaaaaaaa aaaaaaaaaa aagcagatag agaagcagag aagggtggac tcctatgtga
      121 cctgttctta gagcaagaca atcagcagct gaattccaga agccctgttc atgtgtgggg
      181 atattctctc gactgcatgg aatcagaaag cagcagaagg atgggaaatg cctgcattcc
      241 cctgaaaaga attgcctatt tcctatgcct cttttctgtg gttttgctga ctgaggggaa
      301 gaaaccagcg aagccaaaat gccctgccgt gtgtacttgt agcaaagata acgctttatg
      361 tgagaatgcg agatccattc cacgcaccgt tcctcctgat gttatctcac tatcctttgt
      421 gagatctggt tttactgaaa tctcagaagg gagtttctta ttcacaccat cgctgcagct
      481 cttgttattt acgtcgaact cctttgatgt gatcagtgat gatgctttta ttggtcttcc
      541 acatctagaa tatttattca tagaaaacaa caatatcaag tccatttcaa gacatacttt
      601 ccggggactc aagtctttga ttcacttgag tcttgcaaac aacaatctcc agacactccc
      661 aaaagacatt ttcaaaggcc tggattcctt aacaaatgtg gacctaagag ggaacgcatt
      721 taattgtgac tgtaagttga agtggctggt ggaatggctc ggccatacca atgcaactgt
      781 ggaagacatc tactgtgaag gcccaccgga atataagaaa cggaaaatca atagcctctc
      841 ccccaaggat tttgactgta tcattacaga atttgcaaag tcccaagacc taccttatca
      901 gtcgctgtcc atagacactt tttcttattt gaatgatgaa tatgtagtca ttgctcagcc
      961 ttttactgga aaatgcattt tcctggaatg ggaccacgta gagaagacct tccggaatta
     1021 tgacaacatt acaggcacgt ccactgtggt gtgcaagccc atagttattg acactcagct
     1081 ctatgtcatt gtggcccagc tgtttggtgg ctctcatatc tataagcgag atggttttgc
     1141 aaacaaattc ataaaaatcc aagatattga agttctcaaa attcgaaaac ccaatgacat
     1201 cgaaacattc aagattgaag acaactggta cttcgttgtc gctgacagtt ccaaagctgg
     1261 gtttactacc atttacaagt ggaatggaaa cggattctac tcccaccaat ccttacatgc
     1321 ctggtacagg gatactgatg tggaatacct tgaaatagcc agaccaccat tggccctcag
     1381 aacacctcat ttaatcctgt ccagtagttc tcagcgccct gttatttacc agtggagcaa
     1441 agcaacacag ctattcacta accaaaccga cattcctaac atggaggacg tatacgcggt
     1501 gaagcacttc tctgtgaaag gtgatgtgta catctgcttg accagattca ttggcgactc
     1561 taaagtcatg aagtggggcg gctcctcctt ccaggacatc cagaggatgc catctcgagg
     1621 atccatggtg ttccaacctc ttcagataaa taattaccaa tatgcaattc tcggaagcga
     1681 ttactccttt actcaagtgt ataactggga tgcagagaaa gccaaatttg tgaagtttca
     1741 ggagttaaac gttcaggcac ccagatcatt cacacacgta tccattaata agcgtaattt
     1801 tctctttgct tccagtttta agggaaacac gcagatttac aaacatgtca tagttgactt
     1861 aagcgcatga gacaccaaac tccacggctg ccatcggaaa ctttctacag tgcgtgacct
     1921 ggatgaactc aatgcatgat gactcttctt atcacacttg cagatgaata cctttcaaca
     1981 ctgagactgc taaagccaat actaccagta tcaccatcct taactgtccg gtccagtggt
     2041 gtgggaagtt accttttata agacaaaagt ttccttatgt aactgttctt tgcagtgaag
     2101 atgtgtaaat aagcgtttaa tggcatctgt tactccgaaa agaaatattc atatgtactt
     2161 ttccatttat ttattcacgt gttcagaaac aactgccaaa taaaatgttt acattttctt
     2221 tcatatccca aaggtaatta tttacaagag ctgtttgatt cctgttgatt gtatgttgag
     2281 gaaatagttt tatacactag gattatattt ggatcaagga tttattgtat gaatattgag
     2341 taaagataac aaatgaaaat aatttcccat aatttataag cacctttatc cgggttctat
     2401 ccgtgggttt tgaatactca gaagtcacga cgtttaggga cacttaaagg tgaaagggta
     2461 acacccttca atgagaggga gtttgcctat tatgataagg ctaacctgta atgagaagga
     2521 agaccaccct gttctatctg atagcctggg ttaaatacca ctcagccatt ttatagaaga
     2581 aatttcagat ttaggattga aaagctcctg atctgggacc ttctgaatat ctaactctag
     2641 agtctcctga cagctggtag attgtaaatt atggagagca cttgcctccc aacatgctgg
     2701 ccctggaggc ctctctatct ggcagaggac attttgcttc tagacactgg atttgctgtg
     2761 actgacctgc cacacagtgc ctgtgaggct catgtttgat tttctagatt cctgcttctg
     2821 gatcacttga gtcattagta gctagcacaa tgcctgttat gtacatgtag gctctcaaac
     2881 attgcttttc aaaggctgag gatatagttt cacggaaaag tactcaatgt ggcctgtgta
     2941 aaacctggag ttcaattccc agcataaaac aaaagagttt gcgggggtgg agggggaacg
     3001 agtgactcct tctcttataa taaactccac gggtccctct gacctatcga gtacttactg
     3061 gctacttgtt cagaatatgg tgtggttgtg ggtaactaat acaggaggag ggtgcaatgc
     3121 tcaccctctg tagtcttgaa aaagattggc agcgggctaa atatacaaaa acatctatag
     3181 attaagcaat gtgtacaaag aatgacctga aaattctaga ttttgagtat catgggaaca
     3241 accagagcaa ctttggggaa gctatgctct tcgtctgact taaagggaag aggcaaaaga
     3301 aagtgtgtag ggaagacatt gcgggcacaa actggttatg tgtgctgcct ctatggagag
     3361 cttttgagct tgctatgttc ccactggatg gaggtaggca gacagcagta ccctctgccc
     3421 aggataagtc tggttgcctg gagcatcagg ggtctccaca ataatcacac agtctccaaa
     3481 gaagcaacac cctgggtcac cacgcacaaa gacagaattt cattactcat ctagaaaaga
     3541 tagtagattt ggcttcagag tgataaggaa gaggaaagct taactcctga tcattcgctg
     3601 gccttggaat gccttttcct ttgttctaat aagcaacatc atcatatgct gctggaggac
     3661 gcctgcactg tacagtcgga gttgaaatct agctctgcca tgcacaggct ttgtaacagg
     3721 aaagatctta accaacctga gcccacttct tcattcgtaa agatggataa caaaacctac
     3781 ttctgagaag agggataaat gagaaaaccc gtgaacagca gatggtattt tttccaaata
     3841 catcccctac cgcaccttga acccccacgc ctgtgagacc ttgtccaaaa ttcactaaga
     3901 ggtagcatcg aactcacctg aatggttggt gacttgctgt taatacgttg aatttggtga
     3961 aagtgatagt ttggcttcca cgctaagtca taaaaaccat gaactccttc ttgccttgca
     4021 aattggaaca cttgcctgca gagcccagaa catctgcata agaagtcttt ctaaccagag
     4081 gccattcttc tttgttgaaa accaatcccc tcgggagcaa ccacctcctg gtgctctggt
     4141 caacaggccc agctggtgtt gcagccaaca gccatcatca accaccagtc ctgtaaagcc
     4201 tacagctcca gaccgtgtgg tcaagttcct accagacatc agaccttccc acctaagggg
     4261 cagccattaa agagcagcaa gccatccaca atatccctgc ccaaatttgt gacccggact
     4321 ctatgagaat aataaagtgg ttgttttaaa tggaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
