LOCUS       NM_001159301            1493 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus lectin, galactose binding, soluble 9 (Lgals9),
            transcript variant 2, mRNA.
ACCESSION   NM_001159301
VERSION     NM_001159301.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1493)
  AUTHORS   Tsukamoto,T.
  TITLE     The expression of Galectin-9 correlates with mTOR and AMPK in
            murine colony-forming erythroid progenitors
  JOURNAL   Eur J Haematol 113 (4), 416-425 (2024)
   PUBMED   38853593
  REMARK    GeneRIF: The expression of Galectin-9 correlates with mTOR and AMPK
            in murine colony-forming erythroid progenitors.
REFERENCE   2  (bases 1 to 1493)
  AUTHORS   Wang,X., Wang,S., Xu,X., Jiang,Y., Ren,L., Zhang,H., Li,Z., Liu,X.,
            Hu,X. and Ren,Y.
  TITLE     The effect of Toxoplasma gondii infection on galectin-9 expression
            in decidual macrophages contributing to dysfunction of decidual NK
            cells during pregnancy
  JOURNAL   Parasit Vectors 17 (1), 299 (2024)
   PUBMED   38987795
  REMARK    GeneRIF: The effect of Toxoplasma gondii infection on galectin-9
            expression in decidual macrophages contributing to dysfunction of
            decidual NK cells during pregnancy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1493)
  AUTHORS   Luo,Y., Zhang,Z., Ren,J., Dou,C., Wen,J., Yang,Y., Li,X., Yan,Z.
            and Han,Y.
  TITLE     SARS-Cov-2 spike induces intestinal barrier dysfunction through the
            interaction between CEACAM5 and Galectin-9
  JOURNAL   Front Immunol 15, 1303356 (2024)
   PUBMED   38686388
  REMARK    GeneRIF: SARS-Cov-2 spike induces intestinal barrier dysfunction
            through the interaction between CEACAM5 and Galectin-9.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1493)
  AUTHORS   Fu,H., Vuononvirta,J., Fanti,S., Bonacina,F., D'Amati,A., Wang,G.,
            Poobalasingam,T., Fankhaenel,M., Lucchesi,D., Coleby,R.,
            Tarussio,D., Thorens,B., Hearnden,R.J., Longhi,M.P., Grevitt,P.,
            Sheikh,M.H., Solito,E., Godinho,S.A., Bombardieri,M., Smith,D.M.,
            Cooper,D., Iqbal,A.J., Rathmell,J.C., Schaefer,S., Morales,V.,
            Bianchi,K., Norata,G.D. and Marelli-Berg,F.M.
  TITLE     The glucose transporter 2 regulates CD8+ T cell function via
            environment sensing
  JOURNAL   Nat Metab 5 (11), 1969-1985 (2023)
   PUBMED   37884694
REFERENCE   5  (bases 1 to 1493)
  AUTHORS   Morrison,H.M., Craft,J., Rivera-Lugo,R., Johnson,J.R.,
            Golovkine,G.R., Bell,S.L., Dodd,C.E., Van Dis,E., Beatty,W.L.,
            Margolis,S.R., Repasy,T., Shaker,I., Lee,A.Y., Vance,R.E.,
            Stanley,S.A., Watson,R.O., Krogan,N.J., Portnoy,D.A., Penn,B.H. and
            Cox,J.S.
  TITLE     Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic
            Mycobacterium tuberculosis infection but not acute infection with
            multiple intracellular pathogens
  JOURNAL   PLoS Pathog 19 (6), e1011088 (2023)
   PUBMED   37352334
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1493)
  AUTHORS   Wada,J. and Kanwar,Y.S.
  TITLE     Identification and characterization of galectin-9, a novel
            beta-galactoside-binding mammalian lectin
  JOURNAL   J Biol Chem 272 (9), 6078-6086 (1997)
   PUBMED   9038233
REFERENCE   7  (bases 1 to 1493)
  AUTHORS   Puche,A.C., Poirier,F., Hair,M., Bartlett,P.F. and Key,B.
  TITLE     Role of galectin-1 in the developing mouse olfactory system
  JOURNAL   Dev Biol 179 (1), 274-287 (1996)
   PUBMED   8873770
REFERENCE   8  (bases 1 to 1493)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   9  (bases 1 to 1493)
  AUTHORS   Colnot,C., Ripoche,M.A., Scaerou,F., Foulis,D. and Poirier,F.
  TITLE     Galectins in mouse embryogenesis
  JOURNAL   Biochem Soc Trans 24 (1), 141-146 (1996)
   PUBMED   8674632
  REMARK    Review article
REFERENCE   10 (bases 1 to 1493)
  AUTHORS   Gitt,M.A., Wiser,M.F., Leffler,H., Herrmann,J., Xia,Y.R.,
            Massa,S.M., Cooper,D.N., Lusis,A.J. and Barondes,S.H.
  TITLE     Sequence and mapping of galectin-5, a beta-galactoside-binding
            lectin, found in rat erythrocytes
  JOURNAL   J Biol Chem 270 (10), 5032-5038 (1995)
   PUBMED   7890611
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA546274.1 and AK146044.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon, compared to variant 1. This difference results in a shorter
            isoform (2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146044.1, BC003754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                CA546274.1         1-48
            49-1493             AK146044.1         5-1449
FEATURES             Location/Qualifiers
     source          1..1493
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6NCrl"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..1493
                     /gene="Lgals9"
                     /gene_synonym="gal-9; galectin-9; LGALS35; Lgals5"
                     /note="lectin, galactose binding, soluble 9"
                     /db_xref="GeneID:16859"
                     /db_xref="MGI:MGI:109496"
     exon            1..147
                     /gene="Lgals9"
                     /gene_synonym="gal-9; galectin-9; LGALS35; Lgals5"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1077
                     /gene="Lgals9"
                     /gene_synonym="gal-9; galectin-9; LGALS35; Lgals5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     lectin, galactose binding, soluble 5"
                     /codon_start=1
                     /product="galectin-9 isoform 2"
                     /protein_id="NP_001152773.1"
                     /db_xref="CCDS:CCDS48858.1"
                     /db_xref="GeneID:16859"
                     /db_xref="MGI:MGI:109496"
                     /translation="MALFSAQSPYINPIIPFTGPIQGGLQEGLQVTLQGTTKSFAQRF
                     VVNFQNSFNGNDIAFHFNPRFEEGGYVVCNTKQNGQWGPEERKMQMPFQKGMPFELCF
                     LVQRSEFKVMVNKKFFVQYQHRVPYHLVDTIAVSGCLKLSFITFQTQNFRPAHQAPMA
                     QTTIHMVHSTPGQMFSTPGIPPVVYPTPAYTIPFYTPIPNGLYPSKSIMISGNVLPDA
                     TRFHINLRCGGDIAFHLNPRFNENAVVRNTQINNSWGQEERSLLGRMPFSRGQSFSVW
                     IICEGHCFKVAVNGQHMCEYYHRLKNLQDINTLEVAGDIQLTHVQT"
     exon            148..236
                     /gene="Lgals9"
                     /gene_synonym="gal-9; galectin-9; LGALS35; Lgals5"
                     /inference="alignment:Splign:2.1.0"
     exon            237..438
                     /gene="Lgals9"
                     /gene_synonym="gal-9; galectin-9; LGALS35; Lgals5"
                     /inference="alignment:Splign:2.1.0"
     exon            439..549
                     /gene="Lgals9"
                     /gene_synonym="gal-9; galectin-9; LGALS35; Lgals5"
                     /inference="alignment:Splign:2.1.0"
     exon            550..585
                     /gene="Lgals9"
                     /gene_synonym="gal-9; galectin-9; LGALS35; Lgals5"
                     /inference="alignment:Splign:2.1.0"
     exon            586..636
                     /gene="Lgals9"
                     /gene_synonym="gal-9; galectin-9; LGALS35; Lgals5"
                     /inference="alignment:Splign:2.1.0"
     exon            637..678
                     /gene="Lgals9"
                     /gene_synonym="gal-9; galectin-9; LGALS35; Lgals5"
                     /inference="alignment:Splign:2.1.0"
     exon            679..767
                     /gene="Lgals9"
                     /gene_synonym="gal-9; galectin-9; LGALS35; Lgals5"
                     /inference="alignment:Splign:2.1.0"
     exon            768..930
                     /gene="Lgals9"
                     /gene_synonym="gal-9; galectin-9; LGALS35; Lgals5"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1493
                     /gene="Lgals9"
                     /gene_synonym="gal-9; galectin-9; LGALS35; Lgals5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaaatagc tgtggtttct gtttcctagc tcagccctgc cctgcgcaga gttctgtcgt
       61 ccaccatcga gtgaggaaga gagcattggt tcccctgaga tagaagagat ggctctcttc
      121 agtgcccagt ctccatacat taacccgatc atccccttta ctggaccaat ccaaggaggg
      181 ctgcaggagg gacttcaggt gaccctccag gggactacca agagttttgc acaaaggttt
      241 gtggtgaact ttcagaacag cttcaatgga aatgacattg ccttccactt caacccccgg
      301 tttgaggaag gagggtatgt ggtttgcaac acgaagcaga acggacagtg gggtcctgag
      361 gagagaaaga tgcagatgcc cttccagaag gggatgccct ttgagctttg cttcctggtg
      421 cagaggtcag agttcaaggt gatggtgaac aagaaattct ttgtgcagta ccaacaccgc
      481 gtaccctacc acctcgtgga caccatcgct gtctccggct gcttgaagct gtcctttatc
      541 accttccaga ctcagaactt tcgtcctgcc caccaggcac ccatggctca aactaccatc
      601 catatggttc acagcacccc tggacagatg ttctctactc ctggaatccc tcctgtggtg
      661 taccccaccc cagcctatac catacctttc tacaccccca ttccaaatgg gctttacccg
      721 tccaagtcca tcatgatatc aggcaatgtc ttgccagatg ctacgaggtt ccatatcaac
      781 cttcgctgtg gaggtgacat tgctttccac ctgaaccccc gtttcaatga gaatgctgtt
      841 gtccgaaaca ctcagatcaa caactcctgg gggcaggaag agcgaagtct gcttgggagg
      901 atgcccttca gtcgaggcca gagcttctcg gtgtggatca tatgtgaagg tcactgcttc
      961 aaggtagctg tgaatggtca acacatgtgt gaatattacc accgcctgaa gaacttgcag
     1021 gatatcaaca ctctagaagt ggcgggtgat atccagctga cccacgtgca gacataggca
     1081 aggtctctgg cctagggata agggctggag cactctgcct gtgtcttatc tttcccctgt
     1141 ctcagccctg gcaccatcag aagagatcat cacttatagg aattccagga aggtgaaatt
     1201 cccaattgac tccctccaca aagggggttt tctaggctgt gtggcacatg gctgtcagcc
     1261 catagtctga gccattgccc ccaagctagc tatatactga gggaagtgac cctcctgggt
     1321 ttgctcagat ctctgatcgt tcccccctct gtggcccttt tctttcaccc ctccaggaga
     1381 gccaccctga tatcatccca ctggcctcca actgacccac aatgtccaca gtaactttcc
     1441 cccattctca cccagtatcc ataaaataaa gaaataatat tgcttgtcta cac
//
