LOCUS       NM_001403038             679 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus lectin, galactose binding, soluble 7 (Lgals7),
            transcript variant 2, mRNA.
ACCESSION   NM_001403038 XM_006539569
VERSION     NM_001403038.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 679)
  AUTHORS   Wu,G., Deng,W., Chen,H.Y., Cho,H.J. and Kim,J.
  TITLE     Galectin 7 leads to a relative reduction in CD4+ T cells, mediated
            by PD-1
  JOURNAL   Sci Rep 14 (1), 6625 (2024)
   PUBMED   38503797
  REMARK    GeneRIF: Galectin 7 leads to a relative reduction in CD4+ T cells,
            mediated by PD-1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 679)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 679)
  AUTHORS   Pinto,N.A., Abba,M.C., Laporte,L., Perez Saez,J.M., Blidner,A.G.,
            Torres,N.I., Morales,R.M., Gatto,S.G., Bach,C.A., Veigas,F., Garcia
            Rivello,H.J., Song,P., Frederiksen,J.H., Rasmussen,L.J.,
            Poirier,F., Croci,D.O., Sundblad,V., Rabinovich,G.A. and
            Cerliani,J.P.
  TITLE     Galectin-7 reprograms skin carcinogenesis by fostering innate
            immune evasive programs
  JOURNAL   Cell Death Differ 30 (4), 906-921 (2023)
   PUBMED   36693903
  REMARK    GeneRIF: Galectin-7 reprograms skin carcinogenesis by fostering
            innate immune evasive programs.
REFERENCE   4  (bases 1 to 679)
  AUTHORS   An,J., Nagaki,Y., Motoyama,S., Kuze,Y., Hoshizaki,M.,
            Kemuriyama,K., Yamaguchi,T., Ebihara,T., Minamiya,Y., Suzuki,Y.,
            Imai,Y. and Kuba,K.
  TITLE     Identification of Galectin-7 as a crucial metastatic enhancer of
            squamous cell carcinoma associated with immunosuppression
  JOURNAL   Oncogene 41 (50), 5319-5330 (2022)
   PUBMED   36335283
  REMARK    GeneRIF: Identification of Galectin-7 as a crucial metastatic
            enhancer of squamous cell carcinoma associated with
            immunosuppression.
REFERENCE   5  (bases 1 to 679)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   6  (bases 1 to 679)
  AUTHORS   Yang,Q.S., Ying,K., Yuan,H.L., Chen,J.Z., Meng,X.F., Wang,Z.,
            Xie,Y. and Mao,Y.M.
  TITLE     Cloning and expression of a novel human galectin cDNA,
            predominantly expressed in placenta(1)
  JOURNAL   Biochim Biophys Acta 1574 (3), 407-411 (2002)
   PUBMED   11997112
REFERENCE   7  (bases 1 to 679)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   8  (bases 1 to 679)
  AUTHORS   Timmons,P.M., Colnot,C., Cail,I., Poirier,F. and Magnaldo,T.
  TITLE     Expression of galectin-7 during epithelial development coincides
            with the onset of stratification
  JOURNAL   Int J Dev Biol 43 (3), 229-235 (1999)
   PUBMED   10410902
REFERENCE   9  (bases 1 to 679)
  AUTHORS   Magnaldo,T., Fowlis,D. and Darmon,M.
  TITLE     Galectin-7, a marker of all types of stratified epithelia
  JOURNAL   Differentiation 63 (3), 159-168 (1998)
   PUBMED   9697310
REFERENCE   10 (bases 1 to 679)
  AUTHORS   Magnaldo,T., Bernerd,F. and Darmon,M.
  TITLE     Galectin-7, a human 14-kDa S-lectin, specifically expressed in
            keratinocytes and sensitive to retinoic acid
  JOURNAL   Dev Biol 168 (2), 259-271 (1995)
   PUBMED   7729568
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171210.1.
            
            On Mar 25, 2022 this sequence version replaced XM_006539569.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3890528.1,
                                           SRR7652917.388572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AC171210.1         26597-26720         c
            125-181             AC171210.1         26067-26123         c
            182-270             AC171210.1         25634-25722         c
            271-472             AC171210.1         24818-25019         c
            473-679             AC171210.1         24267-24473         c
FEATURES             Location/Qualifiers
     source          1..679
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.94 cM"
     gene            1..679
                     /gene="Lgals7"
                     /gene_synonym="Galectin-7; Pig1"
                     /note="lectin, galactose binding, soluble 7"
                     /db_xref="GeneID:16858"
                     /db_xref="MGI:MGI:1316742"
     exon            1..124
                     /gene="Lgals7"
                     /gene_synonym="Galectin-7; Pig1"
                     /inference="alignment:Splign:2.1.0"
     exon            125..181
                     /gene="Lgals7"
                     /gene_synonym="Galectin-7; Pig1"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..586
                     /gene="Lgals7"
                     /gene_synonym="Galectin-7; Pig1"
                     /note="gal-7"
                     /codon_start=1
                     /product="galectin-7"
                     /protein_id="NP_001389967.1"
                     /db_xref="GeneID:16858"
                     /db_xref="MGI:MGI:1316742"
                     /translation="MSATQHKTSLPQGVRVGTVMRIRGMVPDQAGRFHVNLLCGEEQG
                     ADAALHFNPRLDTSEVVFNTKEQGKWGREERGTGIPFERGQPFEVLLIATEEGFKAVV
                     GDDEYLHFHHRMPPARVRLVEVGGDVQLHSVKIF"
     exon            182..270
                     /gene="Lgals7"
                     /gene_synonym="Galectin-7; Pig1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..472
                     /gene="Lgals7"
                     /gene_synonym="Galectin-7; Pig1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..679
                     /gene="Lgals7"
                     /gene_synonym="Galectin-7; Pig1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      655..660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lgals7"
                     /gene_synonym="Galectin-7; Pig1"
                     /note="hexamer: AATAAA"
     polyA_site      679
                     /gene="Lgals7"
                     /gene_synonym="Galectin-7; Pig1"
                     /note="major polyA site"
ORIGIN      
        1 agacacacat ctggacaccc agaggtctca gcagcctggc cactgttagt gaaacttcat
       61 tatttgaccc tccgttactg gccactccat tactgaccac ttcaaacgtg ccaacacact
      121 cttggtcccc tcccacagcg actggccaca ttgttgctgt attgctgtgc ccgccatgtc
      181 tgctacccag cacaagacct ccctgcctca gggcgtccgc gtgggcactg tcatgagaat
      241 tcgaggcatg gtccctgacc aggctggcag gttccatgta aacctgctat gcggtgagga
      301 gcaaggagca gatgccgcct tgcactttaa cccgaggctg gacacttccg aggttgtctt
      361 caacaccaaa gaacaaggca aatggggccg tgaggagcga ggcaccggca tccccttcga
      421 gcgtgggcag ccctttgaag tgctcctcat cgccacagag gaaggcttca aggctgtggt
      481 cggggatgac gaatatctcc acttccacca ccggatgccg cccgcgcgcg tgcgcttggt
      541 ggaggtgggc ggagacgtgc agctgcattc agtgaagatc ttctaagcaa ggacccaagg
      601 gcgtggcggg taggggtggg ggtgtaggat cgcagaggag ggttttggat ggcgaataaa
      661 gtgtagctgt agttctgac
//
