LOCUS       NM_011150               2219 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus lectin, galactoside-binding, soluble, 3 binding
            protein (Lgals3bp), mRNA.
ACCESSION   NM_011150
VERSION     NM_011150.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2219)
  AUTHORS   Arutyunov,A., Duran-Laforet,V., Ai,S., Ferrari,L., Murphy,R.,
            Schafer,D.P. and Klein,R.S.
  TITLE     West Nile Virus-Induced Expression of Senescent Gene Lgals3bp
            Regulates Microglial Phenotype within Cerebral Cortex
  JOURNAL   Biomolecules 14 (7), 808 (2024)
   PUBMED   39062523
  REMARK    GeneRIF: West Nile Virus-Induced Expression of Senescent Gene
            Lgals3bp Regulates Microglial Phenotype within Cerebral Cortex.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2219)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2219)
  AUTHORS   Keinanen,O., Sarrett,S.M., Delaney,S., Rodriguez,C., Dayts,E.J.,
            Capone,E., Sauniere,F., Ippoliti,R., Sala,G., Iacobelli,S. and
            Zeglis,B.M.
  TITLE     Visualizing Galectin-3 Binding Protein Expression with ImmunoPET
  JOURNAL   Mol Pharm 20 (6), 3241-3248 (2023)
   PUBMED   37191353
  REMARK    GeneRIF: Visualizing Galectin-3 Binding Protein Expression with
            ImmunoPET.
REFERENCE   4  (bases 1 to 2219)
  AUTHORS   Sakurai,T., Fukutomi,T., Yamamoto,S., Nozaki,E. and Kizaki,T.
  TITLE     Physical Activity Attenuates the Obesity-Induced Dysregulated
            Expression of Brown Adipokines in Murine Interscapular Brown
            Adipose Tissue
  JOURNAL   Int J Mol Sci 22 (19), 10391 (2021)
   PUBMED   34638731
  REMARK    GeneRIF: Physical Activity Attenuates the Obesity-Induced
            Dysregulated Expression of Brown Adipokines in Murine Interscapular
            Brown Adipose Tissue.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2219)
  AUTHORS   DeRoo,E.P., Wrobleski,S.K., Shea,E.M., Al-Khalil,R.K., Hawley,A.E.,
            Henke,P.K., Myers,D.D. Jr., Wakefield,T.W. and Diaz,J.A.
  TITLE     The role of galectin-3 and galectin-3-binding protein in venous
            thrombosis
  JOURNAL   Blood 125 (11), 1813-1821 (2015)
   PUBMED   25428218
  REMARK    GeneRIF: Using a mouse stasis model of venous thrombosis, we found
            that gal3bp and gal3 were localized on vein wall, red blood cells,
            platelets, and microparticles, whereas leukocytes expressed gal3
            only.
REFERENCE   6  (bases 1 to 2219)
  AUTHORS   Kong,W., Longaker,M.T. and Lorenz,H.P.
  TITLE     Cyclophilin C-associated protein is a mediator for fibronectin
            fragment-induced matrix metalloproteinase-13 expression
  JOURNAL   J Biol Chem 279 (53), 55334-55340 (2004)
   PUBMED   15507443
  REMARK    GeneRIF: CyC-AP is an important factor for the regulation of MMP-13
            expression
REFERENCE   7  (bases 1 to 2219)
  AUTHORS   Trahey,M. and Weissman,I.L.
  TITLE     Cyclophilin C-associated protein: a normal secreted glycoprotein
            that down-modulates endotoxin and proinflammatory responses in vivo
  JOURNAL   Proc Natl Acad Sci U S A 96 (6), 3006-3011 (1999)
   PUBMED   10077627
REFERENCE   8  (bases 1 to 2219)
  AUTHORS   Brakebusch,C., Jallal,B., Fusco,O., Iacobelli,S. and Ullrich,A.
  TITLE     Expression of the 90K immunostimulator gene is controlled by a
            promoter with unique features
  JOURNAL   J Biol Chem 272 (6), 3674-3682 (1997)
   PUBMED   9013622
REFERENCE   9  (bases 1 to 2219)
  AUTHORS   Chicheportiche,Y. and Vassalli,P.
  TITLE     Cloning and expression of a mouse macrophage cDNA coding for a
            membrane glycoprotein of the scavenger receptor cysteine-rich
            domain family
  JOURNAL   J Biol Chem 269 (8), 5512-5517 (1994)
   PUBMED   8119883
REFERENCE   10 (bases 1 to 2219)
  AUTHORS   Friedman,J., Trahey,M. and Weissman,I.
  TITLE     Cloning and characterization of cyclophilin C-associated protein: a
            candidate natural cellular ligand for cyclophilin C
  JOURNAL   Proc Natl Acad Sci U S A 90 (14), 6815-6819 (1993)
   PUBMED   8341703
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK079915.1 and BP765555.1.
            
            On Feb 22, 2018 this sequence version replaced NM_011150.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079915.1, AK150021.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2173              AK079915.1         2-2174
            2174-2219           BP765555.1         1-46                c
FEATURES             Location/Qualifiers
     source          1..2219
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.14 cM"
     gene            1..2219
                     /gene="Lgals3bp"
                     /gene_synonym="90K; CyCAP; MAC-2BP; Ppicap; Tango10b"
                     /note="lectin, galactoside-binding, soluble, 3 binding
                     protein"
                     /db_xref="GeneID:19039"
                     /db_xref="MGI:MGI:99554"
     exon            1..174
                     /gene="Lgals3bp"
                     /gene_synonym="90K; CyCAP; MAC-2BP; Ppicap; Tango10b"
                     /inference="alignment:Splign:2.1.0"
     exon            175..248
                     /gene="Lgals3bp"
                     /gene_synonym="90K; CyCAP; MAC-2BP; Ppicap; Tango10b"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1930
                     /gene="Lgals3bp"
                     /gene_synonym="90K; CyCAP; MAC-2BP; Ppicap; Tango10b"
                     /EC_number="3.6.1.6"
                     /note="peptidylprolyl isomerase C-associated protein;
                     mama; galectin-3-binding protein; cyp-C-associated
                     protein"
                     /codon_start=1
                     /product="galectin-3-binding protein precursor"
                     /protein_id="NP_035280.1"
                     /db_xref="CCDS:CCDS25701.1"
                     /db_xref="GeneID:19039"
                     /db_xref="MGI:MGI:99554"
                     /translation="MALLWLLSVFLLVPGTQGTEDGDMRLVNGASANEGRVEIFYRGR
                     WGTVCDNLWNLLDAHVVCRALGYENATQALGRAAFGPGKGPIMLDEVECTGTESSLAS
                     CRSLGWMVSRCGHEKDAGVVCSNDTTGLHILDLSGELSDALGQIFDSQQGCDLFIQVT
                     GQGYEDLSLCAHTLILRTNPEAQALWQVVGSSVIMRVDAECMPVVRDFLRYFYSRRIE
                     VSMSSVKCLHKLASAYGATELQDYCGRLFATLLPQDPTFHTPLDLYAYARATGDSMLE
                     DLCVQFLAWNFEPLTQSESWSAVPTTLIQALLPKSELAVSSELDLLKAVDQWSTETIA
                     SHEDIERLVEQVRFPMMLPQELFELQFNLSLYQDHQALFQRKTMQALEFHTVPVEVLA
                     KYKGLNLTEDTYKPRLYTSSTWSSLVMASTWRAQRYEYNRYNQLYTYGYGSVARYNSY
                     QSFQTPQHPSFLFKDKQISWSATYLPTMQSCWNYGFSCTSNELPVLGLTTSSYSNPTI
                     GYENRVLILCGGYSVVDVTSFEGSKAPIPTALDTNSSKTPSLFPCASGAFSSFRVVIR
                     PFYLTNSTDMV"
     exon            249..440
                     /gene="Lgals3bp"
                     /gene_synonym="90K; CyCAP; MAC-2BP; Ppicap; Tango10b"
                     /inference="alignment:Splign:2.1.0"
     exon            441..572
                     /gene="Lgals3bp"
                     /gene_synonym="90K; CyCAP; MAC-2BP; Ppicap; Tango10b"
                     /inference="alignment:Splign:2.1.0"
     exon            573..825
                     /gene="Lgals3bp"
                     /gene_synonym="90K; CyCAP; MAC-2BP; Ppicap; Tango10b"
                     /inference="alignment:Splign:2.1.0"
     exon            826..2201
                     /gene="Lgals3bp"
                     /gene_synonym="90K; CyCAP; MAC-2BP; Ppicap; Tango10b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2175..2180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lgals3bp"
                     /gene_synonym="90K; CyCAP; MAC-2BP; Ppicap; Tango10b"
                     /note="hexamer: ATTAAA"
     polyA_site      2197
                     /gene="Lgals3bp"
                     /gene_synonym="90K; CyCAP; MAC-2BP; Ppicap; Tango10b"
                     /note="major polyA site"
ORIGIN      
        1 gaggtttaca aagcatttcc tgggacgagg ctgaggaaag ccacatggtg gagcttttct
       61 ctgctgaaca gtctacagaa ggcttccagt tgcagccagg aaggaggctc caggactgcc
      121 ttcagccact gcctcgctgc ctgagggaca gttgagtccc tctcttgctc ccagggttgg
      181 gcttctaggc caggcaatgg ctctcctgtg gctcctctct gtgttcttgc tggttccagg
      241 gactcaaggt acagaagatg gagacatgcg cttggttaac ggggcctcag ccaatgaggg
      301 ccgcgtggag atcttctaca gaggccggtg ggggacagtg tgtgacaacc tctggaacct
      361 tttggatgcc cacgtcgtct gccgggccct gggctatgag aacgccaccc aagcactggg
      421 cagagctgcc ttcgggccag gaaagggacc gatcatgctg gatgaggtgg aatgtacagg
      481 gaccgagtcc tcactggcca gttgcagatc cctgggttgg atggtgagcc gctgtgggca
      541 cgagaaggac gcaggcgtgg tctgctccaa cgataccacg gggcttcaca tcctggacct
      601 ctctggagag ctctcagatg cactgggcca gatctttgac agccagcagg gctgcgacct
      661 attcatccag gtgacagggc aggggtatga ggacctgagc ctctgtgccc acacgctgat
      721 cctgcgcacc aaccccgagg cccaggccct gtggcaagtg gtgggcagca gcgtcatcat
      781 gagagtggat gctgagtgca tgcctgtcgt cagagacttc ctcaggtact tttactcccg
      841 aagaatcgag gtcagcatgt cttctgttaa gtgcttgcac aagctagcct ctgcctatgg
      901 ggccacagag cttcaggact actgtggacg gctttttgcc accctcctcc cccaagaccc
      961 cactttccat actcccttgg acctttatgc gtacgcacgg gccaccgggg actctatgct
     1021 ggaagatctg tgtgtacagt ttctggcctg gaacttcgag cctctgacac agtctgagtc
     1081 ctggtcggct gttcccacca ccttgatcca ggctctcctc cccaagagtg agctggctgt
     1141 gtctagtgag ctggatctgc tgaaggcagt ggaccagtgg agcacagaaa ccattgcctc
     1201 acacgaggat atagagcgcc tggtggaaca ggtccgcttc cccatgatgc tgccccagga
     1261 gctgttcgag ctgcagttca acctgtcctt gtaccaagat caccaggcac tgttccagag
     1321 gaagaccatg caggccttgg agttccacac agtgcctgtc gaagtgctgg ccaagtacaa
     1381 aggcctgaac ctcacggagg acacctacaa gccccgcctt tacacctctt ccacctggag
     1441 tagcttggtg atggcctcca cctggagggc acaaagatat gaatacaatc gatacaatca
     1501 gctctataca tatggctatg gctcagtagc ccggtacaat agctaccagt ccttccaaac
     1561 cccacaacac cccagcttcc tcttcaagga caagcagatc tcctggtcag ccacctacct
     1621 ccccaccatg cagagctgct ggaactatgg cttctcgtgt acctctaacg agctccctgt
     1681 actgggcctc accacatcca gctactccaa tccgacaatt ggctatgaga acagagtact
     1741 gatcctctgc ggaggctaca gtgtggtgga tgtcaccagc tttgaaggct ccaaggcccc
     1801 tattcccact gccctggaca ccaatagttc caagactccc tccctctttc cctgtgcctc
     1861 aggggccttt agcagcttcc gtgtggtcat acgccccttc tacctcacta actccactga
     1921 catggtgtaa atggtacatc tcagtggtgg ggacgcagac attcctgtgt cccctccttc
     1981 gcctccagct gctttgtaag cataaactga ttgtattcaa atgaaaattt actagaaggt
     2041 ttcagccagc actcactcca ggactgagag tcccagggcc ctcactgcag gtacaagcag
     2101 gttccatgag gtcctgtggg atttcctgtg cctactgcag tagccccatc tgtcacagtc
     2161 actcatcaaa aatcattaaa gtctcacgtg cttctcacga aaaaaaaaaa aaaaaaaaa
//
