LOCUS       NM_001145953            1406 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus lectin, galactose binding, soluble 3 (Lgals3),
            transcript variant 1, mRNA.
ACCESSION   NM_001145953
VERSION     NM_001145953.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1406)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 1406)
  AUTHORS   Ke,X., van Soldt,B., Vlahos,L., Zhou,Y., Qian,J., George,J.,
            Capdevila,C., Glass,I., Yan,K., Califano,A. and Cardoso,W.V.
  TITLE     Morphogenesis and regeneration share a conserved core transition
            cell state program that controls lung epithelial cell fate
  JOURNAL   Dev Cell (2024) In press
   PUBMED   39667932
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 1406)
  AUTHORS   Zhong,X., Wu,H., Zhang,W., Shi,Y., Gwack,Y., Xue,H.H. and Sun,Z.
  TITLE     Distinct RORgammat-dependent Th17 immune responses are required for
            autoimmune pathogenesis and protection against bacterial infection
  JOURNAL   Cell Rep 43 (11), 114951 (2024)
   PUBMED   39504243
REFERENCE   4  (bases 1 to 1406)
  AUTHORS   Amore,E., Cenni,V., Piazzi,M., Signore,M., Orlandi,G., Neri,S.,
            Biressi,S., Barone,R., Di Felice,V., Follo,M.Y., Bertacchini,J. and
            Palumbo,C.
  TITLE     Myoblast-Derived Galectin 3 Impairs the Early Phases of
            Osteogenesis Affecting Notch and Akt Activity
  JOURNAL   Biomolecules 14 (10), 1243 (2024)
   PUBMED   39456175
  REMARK    GeneRIF: Myoblast-Derived Galectin 3 Impairs the Early Phases of
            Osteogenesis Affecting Notch and Akt Activity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1406)
  AUTHORS   Kim,K.S., Lee,C., Kim,H.S., Gu,S.J., Yoon,H.J., Won,S.B., Lee,H.,
            Lee,Y.S., Kim,S.S., Kane,L.P. and Park,E.J.
  TITLE     TIM-3 on myeloid cells promotes pulmonary inflammation through
            increased production of galectin-3
  JOURNAL   Commun Biol 7 (1), 1090 (2024)
   PUBMED   39237613
  REMARK    GeneRIF: TIM-3 on myeloid cells promotes pulmonary inflammation
            through increased production of galectin-3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1406)
  AUTHORS   Gritzmacher,C.A., Mehl,V.S. and Liu,F.T.
  TITLE     Genomic cloning of the gene for an IgE-binding lectin reveals
            unusual utilization of 5' untranslated regions
  JOURNAL   Biochemistry 31 (40), 9533-9538 (1992)
   PUBMED   1390736
REFERENCE   7  (bases 1 to 1406)
  AUTHORS   Kanno,H., Nose,M., Itoh,J., Taniguchi,Y. and Kyogoku,M.
  TITLE     Spontaneous development of pancreatitis in the MRL/Mp strain of
            mice in autoimmune mechanism
  JOURNAL   Clin Exp Immunol 89 (1), 68-73 (1992)
   PUBMED   1352748
REFERENCE   8  (bases 1 to 1406)
  AUTHORS   Woo,H.J., Lotz,M.M., Jung,J.U. and Mercurio,A.M.
  TITLE     Carbohydrate-binding protein 35 (Mac-2), a laminin-binding lectin,
            forms functional dimers using cysteine 186
  JOURNAL   J Biol Chem 266 (28), 18419-18422 (1991)
   PUBMED   1917966
REFERENCE   9  (bases 1 to 1406)
  AUTHORS   Woo,H.J., Shaw,L.M., Messier,J.M. and Mercurio,A.M.
  TITLE     The major non-integrin laminin binding protein of macrophages is
            identical to carbohydrate binding protein 35 (Mac-2)
  JOURNAL   J Biol Chem 265 (13), 7097-7099 (1990)
   PUBMED   2332426
REFERENCE   10 (bases 1 to 1406)
  AUTHORS   Raz,A., Pazerini,G. and Carmi,P.
  TITLE     Identification of the metastasis-associated, galactoside-binding
            lectin as a chimeric gene product with homology to an IgE-binding
            protein
  JOURNAL   Cancer Res 49 (13), 3489-3493 (1989)
   PUBMED   2525069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123665.9, AK149783.1 and BY440035.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138790.1, AK159536.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC123665.9         37724-37777
            55-1037             AK149783.1         2-984
            1038-1406           BY440035.1         38-406
FEATURES             Location/Qualifiers
     source          1..1406
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 24.6 cM"
     gene            1..1406
                     /gene="Lgals3"
                     /gene_synonym="gal3; GBP; L-34; Mac-2"
                     /note="lectin, galactose binding, soluble 3"
                     /db_xref="GeneID:16854"
                     /db_xref="MGI:MGI:96778"
     exon            1..120
                     /gene="Lgals3"
                     /gene_synonym="gal3; GBP; L-34; Mac-2"
                     /inference="alignment:Splign:2.1.0"
     exon            121..142
                     /gene="Lgals3"
                     /gene_synonym="gal3; GBP; L-34; Mac-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..919
                     /gene="Lgals3"
                     /gene_synonym="gal3; GBP; L-34; Mac-2"
                     /note="gal-3; CBP 35; lectin L-29; 35 kDa lectin; mac-2
                     antigen; igE-binding protein; laminin-binding protein;
                     galactose-specific lectin 3; L-34 galactoside-binding
                     lectin; carbohydrate-binding protein 35"
                     /codon_start=1
                     /product="galectin-3"
                     /protein_id="NP_001139425.1"
                     /db_xref="CCDS:CCDS26986.1"
                     /db_xref="GeneID:16854"
                     /db_xref="MGI:MGI:96778"
                     /translation="MADSFSLNDALAGSGNPNPQGYPGAWGNQPGAGGYPGAAYPGAY
                     PGQAPPGAYPGQAPPGAYPGQAPPSAYPGPTAPGAYPGPTAPGAYPGSTAPGAFPGQP
                     GAPGAYPSAPGGYPAAGPYGVPAGPLTVPYDLPLPGGVMPRMLITIMGTVKPNANRIV
                     LDFRRGNDVAFHFNPRFNENNRRVIVCNTKQDNNWGKEERQSAFPFESGKPFKIQVLV
                     EADHFKVAVNDAHLLQYNHRMKNLREISQLGISGDITLTSANHAMI"
     exon            143..508
                     /gene="Lgals3"
                     /gene_synonym="gal3; GBP; L-34; Mac-2"
                     /inference="alignment:Splign:2.1.0"
     exon            509..597
                     /gene="Lgals3"
                     /gene_synonym="gal3; GBP; L-34; Mac-2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..763
                     /gene="Lgals3"
                     /gene_synonym="gal3; GBP; L-34; Mac-2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..1406
                     /gene="Lgals3"
                     /gene_synonym="gal3; GBP; L-34; Mac-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1015..1020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lgals3"
                     /gene_synonym="gal3; GBP; L-34; Mac-2"
                     /note="hexamer: AATAAA"
     polyA_site      1036
                     /gene="Lgals3"
                     /gene_synonym="gal3; GBP; L-34; Mac-2"
                     /note="major polyA site"
ORIGIN      
        1 gggagggcgg gcccggggaa aagagtacta gaagcggccg agccaccgcc cagctctgac
       61 agctagcgga gcggcgggtg gagcactaat caggtgagcg gcacagagag cactacccag
      121 gaaaatggca gacagctttt cgcttaacga tgccttagct ggctctggaa acccaaaccc
      181 tcaaggatat ccgggtgcat gggggaacca gcctggggca gggggctacc caggggctgc
      241 ttatcctggg gcctacccag gacaagctcc tccaggggcc tacccaggac aggctcctcc
      301 aggggcctac ccaggacagg ctcctcctag tgcctacccc ggcccaactg cccctggagc
      361 ttatcctggc ccaactgccc ctggagctta tcctggctca actgcccctg gagccttccc
      421 agggcaacct ggggcacctg gggcctaccc cagtgctcct ggaggctatc ctgctgctgg
      481 cccttatggt gtccccgctg gaccactgac ggtgccctat gacctgccct tgcctggagg
      541 agtcatgccc cgcatgctga tcacaatcat gggcacagtg aaacccaacg caaacaggat
      601 tgttctagat ttcaggagag ggaatgatgt tgccttccac tttaaccccc gcttcaatga
      661 gaacaacagg agagtcattg tgtgtaacac gaagcaggac aataactggg gaaaggaaga
      721 aagacagtca gccttcccct ttgagagtgg caaaccattc aaaatacaag tcctggttga
      781 agctgaccac ttcaaggttg cggtcaacga tgctcaccta ctgcagtaca accatcggat
      841 gaagaacctc cgggaaatca gccaactggg gatcagtggt gacataaccc tcaccagcgc
      901 taaccacgcc atgatctaag ccagaagggg cggcaccgaa accggccctg tgtgccttag
      961 gagtgggaaa ctttgcattt ctctctcctt atccttcttg taagacatcc atttaataaa
     1021 gtctcatgct gagagatacc catcgctttg ggggttttta tgatactgga tgtcaaatct
     1081 taggactgct cgtgactgct aggcaagtgt tctctcactg agctacacat ccctagcctt
     1141 ttaaactttg tgtgttgtgt gtctgtgcac atgggtacag gtgcctgctc acttgagagg
     1201 caccaggcct cctggagctg gagttacagg tggttgtaag taagctgtgt gaccaggttg
     1261 ctgggaacca gtctcagatc ctcctgagac aggtcaggtc cactgatgcc tccagctgcc
     1321 tgtctttata tgccctttga tttggtgcag ttttatataa agggaactat gtaattatca
     1381 ataaaccatc ctgattttta caaagg
//
