LOCUS       NM_025622                607 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus lectin, galactose-binding, soluble 2 (Lgals2), mRNA.
ACCESSION   NM_025622 XM_001000934
VERSION     NM_025622.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 607)
  AUTHORS   Rehman,S.U., Schallschmidt,T., Rasche,A., Knebel,B., Stermann,T.,
            Altenhofen,D., Herwig,R., Schurmann,A., Chadt,A. and Al-Hasani,H.
  TITLE     Alternative exon splicing and differential expression in pancreatic
            islets reveals candidate genes and pathways implicated in early
            diabetes development
  JOURNAL   Mamm Genome 32 (3), 153-172 (2021)
   PUBMED   33880624
  REMARK    GeneRIF: Alternative exon splicing and differential expression in
            pancreatic islets reveals candidate genes and pathways implicated
            in early diabetes development.
REFERENCE   2  (bases 1 to 607)
  AUTHORS   Li,H., Zhao,L., Lau,Y.S., Zhang,C. and Han,R.
  TITLE     Genome-wide CRISPR screen identifies LGALS2 as an oxidative
            stress-responsive gene with an inhibitory function on colon tumor
            growth
  JOURNAL   Oncogene 40 (1), 177-188 (2021)
   PUBMED   33110234
REFERENCE   3  (bases 1 to 607)
  AUTHORS   Sakakura,M., Tamura,M., Fujii,N., Takeuchi,T., Hatanaka,T.,
            Kishimoto,S., Arata,Y. and Takahashi,H.
  TITLE     Structural mechanisms for the S-nitrosylation-derived protection of
            mouse galectin-2 from oxidation-induced inactivation revealed by
            NMR
  JOURNAL   FEBS J 285 (6), 1129-1145 (2018)
   PUBMED   29392834
  REMARK    GeneRIF: Galectin-2 (Gal-2) residues near cysteine residues C57
            experienced significant chemical shift changes following
            S-nitrosylation.
REFERENCE   4  (bases 1 to 607)
  AUTHORS   Tamura,M., Sasai,A., Ozawa,R., Saito,M., Yamamoto,K., Takeuchi,T.,
            Ohtake,K., Tateno,H., Hirabayashi,J., Kobayashi,J. and Arata,Y.
  TITLE     Identification of the cysteine residue responsible for oxidative
            inactivation of mouse galectin-2
  JOURNAL   J Biochem 160 (4), 233-241 (2016)
   PUBMED   27122052
  REMARK    GeneRIF: Therefore, Cys(57) is suggested to be responsible for
            oxidative inactivation of the mGal-2 protein, and protection of the
            sulfhydryl group of the Cys(57) in mGal-2 by S-nitrosylation is
            likely important for maintaining mGal-2 protein function in an
            oxidative environment such as the gastrointestinal tract.
REFERENCE   5  (bases 1 to 607)
  AUTHORS   Akimoto,Y., Ikehara,S., Yamaguchi,T., Kim,J., Kawakami,H.,
            Shimizu,N., Hori,M., Sakakita,H. and Ikehara,Y.
  TITLE     Galectin expression in healing wounded skin treated with
            low-temperature plasma: Comparison with treatment by electronical
            coagulation
  JOURNAL   Arch Biochem Biophys 605, 86-94 (2016)
   PUBMED   26827730
  REMARK    GeneRIF: analysis of the effect of low-temperature plasma on the
            expression of galectin-1, -2, and -3 in the healing skin compared
            with those of electrocoagulation conducted with a high-frequency
            electrical coagulator
REFERENCE   6  (bases 1 to 607)
  AUTHORS   Dvorankova,B., Lacina,L., Smetana,K. Jr., Lensch,M., Manning,J.C.,
            Andre,S. and Gabius,H.J.
  TITLE     Human galectin-2: nuclear presence in vitro and its modulation by
            quiescence/stress factors
  JOURNAL   Histol Histopathol 23 (2), 167-178 (2008)
   PUBMED   17999373
  REMARK    GeneRIF: Galectin-2 was present in nuclei of murine 3T3
            fibroblasts.
REFERENCE   7  (bases 1 to 607)
  AUTHORS   Hou,J., Charters,A.M., Lee,S.C., Zhao,Y., Wu,M.K., Jones,S.J.,
            Marra,M.A. and Hoodless,P.A.
  TITLE     A systematic screen for genes expressed in definitive endoderm by
            Serial Analysis of Gene Expression (SAGE)
  JOURNAL   BMC Dev Biol 7, 92 (2007)
   PUBMED   17683524
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 607)
  AUTHORS   Lohr,M., Lensch,M., Andre,S., Kaltner,H., Siebert,H.C., Smetana,K.
            Jr., Sinowatz,F. and Gabius,H.J.
  TITLE     Murine homodimeric adhesion/growth-regulatory galectins-1, -2 and
            -7: comparative profiling of gene/ promoter sequences by database
            mining, of expression by RT-PCR/immunohistochemistry and of contact
            sites for carbohydrate ligands by computational chemistry
  JOURNAL   Folia Biol (Praha) 53 (4), 109-128 (2007)
   PUBMED   17706016
  REMARK    GeneRIF: A comparative profiling has been started in the mouse as a
            model organism, combining sequence analysis, expression patterns
            and structural features in the cases of the homodimeric
            galectins-1, -2 and -7.
REFERENCE   9  (bases 1 to 607)
  AUTHORS   MacLaren,E.J., Bennett,B., Johnson,T.E. and Sikela,J.M.
  TITLE     Expression profiling identifies novel candidate genes for ethanol
            sensitivity QTLs
  JOURNAL   Mamm Genome 17 (2), 147-156 (2006)
   PUBMED   16465594
REFERENCE   10 (bases 1 to 607)
  AUTHORS   Puche,A.C., Poirier,F., Hair,M., Bartlett,P.F. and Key,B.
  TITLE     Role of galectin-1 in the developing mouse olfactory system
  JOURNAL   Dev Biol 179 (1), 274-287 (1996)
   PUBMED   8873770
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008636.1 and AW456488.1.
            
            On Nov 25, 2009 this sequence version replaced NM_025622.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008423.1, AK008636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-590               AK008636.1         2-591
            591-607             AW456488.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..607
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.7 cM"
     gene            1..607
                     /gene="Lgals2"
                     /gene_synonym="2200008F12Rik"
                     /note="lectin, galactose-binding, soluble 2"
                     /db_xref="GeneID:107753"
                     /db_xref="MGI:MGI:895068"
     exon            1..58
                     /gene="Lgals2"
                     /gene_synonym="2200008F12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..445
                     /gene="Lgals2"
                     /gene_synonym="2200008F12Rik"
                     /note="gal-2"
                     /codon_start=1
                     /product="galectin-2"
                     /protein_id="NP_079898.2"
                     /db_xref="CCDS:CCDS37135.1"
                     /db_xref="GeneID:107753"
                     /db_xref="MGI:MGI:895068"
                     /translation="MSEKFEVKDLNMKPGMSLKIKGKIHNDVDRFLINLGQGKETLNL
                     HFNPRFDESTIVCNTSEGGRWGQEQRENHMCFSPGSEVKITITFQDKDFKVTLPDGHQ
                     LTFPNRLGHNQLHYLSMGGLQISSFKLE"
     exon            59..141
                     /gene="Lgals2"
                     /gene_synonym="2200008F12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            142..301
                     /gene="Lgals2"
                     /gene_synonym="2200008F12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            302..592
                     /gene="Lgals2"
                     /gene_synonym="2200008F12Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      558..563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lgals2"
                     /gene_synonym="2200008F12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      592
                     /gene="Lgals2"
                     /gene_synonym="2200008F12Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagcacaaac ctctaggagc aactgggaga gctgtggcca ggagctgtca ccatgtcgga
       61 gaaatttgag gtcaaagacc tgaacatgaa accagggatg tccctgaaga ttaaaggcaa
      121 gatccacaat gatgtggacc gcttcctcat taacctgggc caggggaaag aaaccctcaa
      181 cctgcatttt aaccctcgct tcgatgaatc caccattgtc tgtaacacca gtgaaggtgg
      241 ccgctgggga caagagcaac gagaaaatca catgtgcttc agtccagggt cagaggtcaa
      301 gatcaccatc accttccaag ataaagactt caaggtgacg ttgcctgacg gacaccagct
      361 gaccttcccc aacaggctgg gccacaacca actgcactac ttgagcatgg gtgggctcca
      421 gatctcctcc ttcaaactgg agtgagcggc acctcagaag accttagccc ccagaaccag
      481 cttcagccag ccctccagca agcccccacc agaaccacag cctttagggt ctgtgctttt
      541 ccccaaggtc aaggtcaaat aaaagaatcc acatttatta tttccacagc aaaaaaaaaa
      601 aaaaaaa
//
