LOCUS       NM_001356574            2474 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus lectin, galactose binding, soluble 12 (Lgals12),
            transcript variant 2, mRNA.
ACCESSION   NM_001356574 XM_006527219
VERSION     NM_001356574.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2474)
  AUTHORS   Lin,F.J., Huang,Y.H., Tsao,C.H., Hsieh,W.C., Lo,Y.H.,
            Zouboulis,C.C., Chen,H.L. and Liu,F.T.
  TITLE     Galectin-12 Regulates Immune Responses in the Skin through
            Sebaceous Glands
  JOURNAL   J Invest Dermatol 143 (11), 2120-2131 (2023)
   PUBMED   37207806
REFERENCE   2  (bases 1 to 2474)
  AUTHORS   Lee,J.L., Wang,Y.C., Hsu,Y.A., Chen,C.S., Weng,R.C., Lu,Y.P.,
            Chuang,C.Y. and Wan,L.
  TITLE     Galectin-12 modulates Kupffer cell polarization to alter the
            progression of nonalcoholic fatty liver disease
  JOURNAL   Glycobiology 33 (8), 673-682 (2023)
   PUBMED   37504513
  REMARK    GeneRIF: Galectin-12 modulates Kupffer cell polarization to alter
            the progression of nonalcoholic fatty liver disease.
REFERENCE   3  (bases 1 to 2474)
  AUTHORS   Tsao,C.H., Hsieh,W.C., Lin,F.J., Yang,R.Y., Chang,M.T., Apaya,M.K.,
            Shyur,L.F., Ke,L.Y., Zouboulis,C.C. and Liu,F.T.
  TITLE     The Critical Role of Galectin-12 in Modulating Lipid Metabolism in
            Sebaceous Glands
  JOURNAL   J Invest Dermatol 143 (6), 913-924 (2023)
   PUBMED   36535362
  REMARK    GeneRIF: The Critical Role of Galectin-12 in Modulating Lipid
            Metabolism in Sebaceous Glands.
REFERENCE   4  (bases 1 to 2474)
  AUTHORS   Lin,E.S., Hsu,Y.A., Chang,C.Y., Lin,H.J., Chen,C.S. and Wan,L.
  TITLE     Ablation of Galectin-12 Inhibits Atherosclerosis through
            Enhancement of M2 Macrophage Polarization
  JOURNAL   Int J Mol Sci 21 (15), 5511 (2020)
   PUBMED   32752134
  REMARK    GeneRIF: Ablation of Galectin-12 Inhibits Atherosclerosis through
            Enhancement of M2 Macrophage Polarization.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2474)
  AUTHORS   Wan,L., Lin,H.J., Huang,C.C., Chen,Y.C., Hsu,Y.A., Lin,C.H.,
            Lin,H.C., Chang,C.Y., Huang,S.H., Lin,J.M. and Liu,F.T.
  TITLE     Galectin-12 enhances inflammation by promoting M1 polarization of
            macrophages and reduces insulin sensitivity in adipocytes
  JOURNAL   Glycobiology 26 (7), 732-744 (2016)
   PUBMED   26873172
  REMARK    GeneRIF: The activation of STAT3 was much higher in Gal12(-/-)
            macrophages activated by lipopolysaccharide, which was correlated
            with higher levels of IL-10. Adipocytes showed higher insulin
            sensitivity when treated with Gal12(-/-) macrophage-conditioned
            media than those treated with Gal12(+/+) macrophages.
REFERENCE   6  (bases 1 to 2474)
  AUTHORS   Yang,R.Y., Yu,L., Graham,J.L., Hsu,D.K., Lloyd,K.C., Havel,P.J. and
            Liu,F.T.
  TITLE     Ablation of a galectin preferentially expressed in adipocytes
            increases lipolysis, reduces adiposity, and improves insulin
            sensitivity in mice
  JOURNAL   Proc Natl Acad Sci U S A 108 (46), 18696-18701 (2011)
   PUBMED   21969596
  REMARK    GeneRIF: galectin 12 has a role in mitochondrial respiration,
            adiposity, and insulin resistance/glucose intolerance
REFERENCE   7  (bases 1 to 2474)
  AUTHORS   Yang,R.Y., Hsu,D.K., Yu,L., Chen,H.Y. and Liu,F.T.
  TITLE     Galectin-12 is required for adipogenic signaling and adipocyte
            differentiation
  JOURNAL   J Biol Chem 279 (28), 29761-29766 (2004)
   PUBMED   15131127
  REMARK    GeneRIF: Results suggest that galectin-12 is required for signal
            transduction that conveys hormone stimulation to the induction of
            adipogenic factors essential for adipocyte differentiation.
REFERENCE   8  (bases 1 to 2474)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (bases 1 to 2474)
  AUTHORS   Hotta,K., Funahashi,T., Matsukawa,Y., Takahashi,M., Nishizawa,H.,
            Kishida,K., Matsuda,M., Kuriyama,H., Kihara,S., Nakamura,T.,
            Tochino,Y., Bodkin,N.L., Hansen,B.C. and Matsuzawa,Y.
  TITLE     Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing
            Apoptosis-inducing Activity
  JOURNAL   J Biol Chem 276 (36), 34089-34097 (2001)
   PUBMED   11435439
REFERENCE   10 (bases 1 to 2474)
  AUTHORS   Yang,R.Y., Hsu,D.K., Yu,L., Ni,J. and Liu,F.T.
  TITLE     Cell cycle regulation by galectin-12, a new member of the galectin
            superfamily
  JOURNAL   J Biol Chem 276 (23), 20252-20260 (2001)
   PUBMED   11283015
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109225.14.
            
            On May 23, 2019 this sequence version replaced NM_001356574.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030890.2, AF223223.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC109225.14        88960-89026
            68-229              AC109225.14        89330-89491
            230-318             AC109225.14        91761-91849
            319-532             AC109225.14        91971-92184
            533-652             AC109225.14        93025-93144
            653-691             AC109225.14        94072-94110
            692-718             AC109225.14        94881-94907
            719-807             AC109225.14        95417-95505
            808-958             AC109225.14        97243-97393
            959-2474            AC109225.14        97982-99497
FEATURES             Location/Qualifiers
     source          1..2474
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.33 cM"
     gene            1..2474
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
                     /note="lectin, galactose binding, soluble 12"
                     /db_xref="GeneID:56072"
                     /db_xref="MGI:MGI:1929094"
     exon            1..67
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            68..229
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1105
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     galectin-related inhibitor of proliferation 1;
                     galectin-12"
                     /codon_start=1
                     /product="galectin-12 isoform 1"
                     /protein_id="NP_001343503.1"
                     /db_xref="CCDS:CCDS29529.1"
                     /db_xref="GeneID:56072"
                     /db_xref="MGI:MGI:1929094"
                     /translation="MSTDEHLDPIPDSFILQPPVFHPVIPYGTTIFGGLYAGKMVTLQ
                     GVVPLHARRFQVDFQCGCCLHPQPDVAFRFSPRFYTVKPHVICNTHQGGLWQKEIRWP
                     GVALQRGDSFLILFLFENEEVKVSVNGQHFLHYRYRLPLSRVDTLDISGDILVKAVGF
                     LNINPFVEGSREYPVGYPFLLYSPRLEVPCSRALPRGLWPGQVIVVRGLVLKEPKDFT
                     LSLKDGTTHVPVTLRASFTDRTLAWVSSWGRKKLISAPFLFHPQRFFEVLLLCQEGGL
                     KLALNGQGLGATSLDQKALEQLRELRISGNVHLYCVHC"
     exon            230..318
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..532
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..652
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..691
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..718
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..807
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..958
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..2474
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2394..2399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
                     /note="hexamer: AATAAA"
     polyA_site      2417
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
     regulatory      2449..2454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
                     /note="hexamer: ATTAAA"
     polyA_site      2474
                     /gene="Lgals12"
                     /gene_synonym="gal-12; Grip1"
                     /note="major polyA site"
ORIGIN      
        1 aaggaacctg cacacgtgta ccaccagcag cagcagcttc ccttcctact atccgctgaa
       61 ggcccagctg ttgcagaggc tgggaaaagt gagtccattc cgtggggaat cgcgttgctg
      121 gaatcaggat cagaggctga gttgaagttg cccctccccc atgtcaactg acgaacacct
      181 ggacccgatt cctgacagct tcatcctgca gccgccagtc ttccacccgg tgattcctta
      241 tggcacaaca atttttggtg gcctgtatgc aggcaagatg gtcacgctgc agggtgtggt
      301 ccctctgcat gcaaggaggt ttcaggtgga cttccagtgt gggtgctgcc tgcatcctca
      361 gccagatgtt gccttccgct tcagccctcg attctacact gtcaagcccc atgtcatctg
      421 caacacccac caaggtggac tctggcaaaa agagatccgg tggccagggg tcgccctgca
      481 gagaggggat agcttcctca ttctctttct ctttgagaac gaagaggtga aggtgagtgt
      541 aaatggccag cactttcttc actaccgcta ccggctccca ctgtcacggg tagataccct
      601 tgacatatct ggtgacatct tggtaaaggc tgttggattc ctgaacatca atccatttgt
      661 ggagggtagc agagagtatc cagttggata tcccttcctg ctgtatagcc ccaggctgga
      721 ggtgccctgc tcacgtgctc ttcctcgggg tctctggcct gggcaagtca ttgtagttcg
      781 aggactggtc ttgaaagagc cgaaagattt taccctgagc ctgaaggatg ggaccaccca
      841 tgttcctgtg acactcaggg cttccttcac agacagaaca ctggcctggg tctcctcctg
      901 gggacgaaag aagctgatct ccgccccctt cctctttcac ccccagcgat tcttcgaggt
      961 actgcttctg tgccaagagg gagggctgaa gttggcactc aatgggcagg ggctgggggc
     1021 caccagcctg gaccagaaag ccctggagca gctgcgggag ctcaggatca gtggaaatgt
     1081 ccacctctac tgtgtccact gctaagaagg gctccaaggg cacccccgcc agagaagagg
     1141 aggggcggct gcaaccaggg ctccacagtt acagcccatt ctcctattct caagggagaa
     1201 actgacctgg catcactttg tcaggccgag ctcacatctc aaagggcgcg cgcacacaca
     1261 cacacacaca cacacacaca cacacacaca cacacacaca cattgcattt taatctatca
     1321 attctgaaaa taagggccca ggtcaatgtg tctctgcatc tatcttccac attcaaattc
     1381 tgtcttggtc ttcattccaa tccaggccca gccactgaga aggcaaatag agtgtgaaca
     1441 agatgagccc caaatctgtg atcaacacac accatctaca ctcacctttt catctacact
     1501 tgttttatct acagtcactc actagtttgt gaagcctttg cccaaagtga acaaaatatc
     1561 acagctgctt tcatggtttt ggccaaaggg aaccagccac atcctaggaa aacacactga
     1621 ttatgggacc ttttggtcac ccaaccatgt aaacaacaat aatctctcat aaaattaatc
     1681 tataatatag tctgggtggg ccagggatta ttcagtctat gtttctacag cataccctgc
     1741 aatatctata caatggccaa atggtcaaac aatgcatttc ccagaatttg tccttgtcat
     1801 gaaatgatac atgactgtat ctagcagagc aggtagacca ggaaaaagga agctgtagag
     1861 tgtttgattt gaactattcc tggaaatgaa gtctgggctc actttaaatc taaagtgact
     1921 taagactctg tctcctggga atgtttctgt aatcccatct acctgcccag agctgtgccc
     1981 gggtacacac tgtagaagat actgatgaag gatttgctgt gttctaacat tatactctaa
     2041 gcaaagagcc gttttcttcc cttgtccatt taccaagatt gatcatgtac ctttcataaa
     2101 ggaaaaaaaa accctcaaat ttccaagggg aaagttttta ctgcaaatat atgtctttat
     2161 tgtaatccag ggaaactaga ggtcagaaaa agaggtggct gagaggcatc ccctagacac
     2221 caaagcccgg aactctagga agaatctatg tcaaagaaga gatggcaggt tggtggttga
     2281 ggttacttag ttaaccttct aatgaaataa actatattga gaatctctaa tatatatctt
     2341 agtatactat actaaattta gggaataaaa tttatttggt gttgattaat cttaataaaa
     2401 atacagtgta cattttatcc actgatatta tgtatcttat gttcataaat taaattggct
     2461 tgtcattcta ctta
//
