LOCUS       NM_008494               2299 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus LFNG O-fucosylpeptide
            3-beta-N-acetylglucosaminyltransferase (Lfng), mRNA.
ACCESSION   NM_008494
VERSION     NM_008494.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2299)
  AUTHORS   Zhai,W., Tian,H., Liang,X., Wu,Y., Wen,J., Liu,Z., Zhao,X., Tao,L.
            and Zou,K.
  TITLE     Androgen blockage impairs proliferation and function of Sertoli
            cells via Wee1 and Lfng
  JOURNAL   Cell Commun Signal 22 (1), 498 (2024)
   PUBMED   39407201
  REMARK    GeneRIF: Androgen blockage impairs proliferation and function of
            Sertoli cells via Wee1 and Lfng.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2299)
  AUTHORS   El Azhar,Y., Schulthess,P., van Oostrom,M.J., Weterings,S.D.C.,
            Meijer,W.H.M., Tsuchida-Straeten,N., Thomas,W.M., Bauer,M. and
            Sonnen,K.F.
  TITLE     Unravelling differential Hes1 dynamics during axis elongation of
            mouse embryos through single-cell tracking
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39315665
REFERENCE   3  (bases 1 to 2299)
  AUTHORS   Wengryn,P., Fenrich,F., Silveira,K.D.C., Oborn,C., Mizumoto,S.,
            Beke,A., Soltys,C.L., Yamada,S. and Kannu,P.
  TITLE     Integrative analysis of Lunatic Fringe variants associated with
            spondylocostal dysostosis type-III
  JOURNAL   FASEB J 38 (13), e23753 (2024)
   PUBMED   38924591
  REMARK    GeneRIF: Integrative analysis of Lunatic Fringe variants associated
            with spondylocostal dysostosis type-III.
REFERENCE   4  (bases 1 to 2299)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2299)
  AUTHORS   Feng,X., Ye,Y., Zhang,J., Zhang,Y., Zhao,S., Mak,J.C.W., Otomo,N.,
            Zhao,Z., Niu,Y., Yonezawa,Y., Li,G., Lin,M., Li,X., Cheung,P.W.H.,
            Xu,K., Takeda,K., Wang,S., Xie,J., Kotani,T., Choi,V.N.T.,
            Song,Y.Q., Yang,Y., Luk,K.D.K., Lee,K.S., Li,Z., Li,P.S.,
            Leung,C.Y.H., Lin,X., Wang,X., Qiu,G., Watanabe,K., Wu,Z.,
            Posey,J.E., Ikegawa,S., Lupski,J.R., Cheung,J.P.Y., Zhang,T.J.,
            Gao,B. and Wu,N.
  CONSRTM   DISCO (Deciphering disorders Involving Scoliosis and COmorbidities)
            study group; Japanese Early Onset Scoliosis Research Group
  TITLE     Core planar cell polarity genes VANGL1 and VANGL2 in predisposition
            to congenital vertebral malformations
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2310283121 (2024)
   PUBMED   38669183
REFERENCE   6  (bases 1 to 2299)
  AUTHORS   Zhang,N. and Gridley,T.
  TITLE     Defects in somite formation in lunatic fringe-deficient mice
  JOURNAL   Nature 394 (6691), 374-377 (1998)
   PUBMED   9690472
REFERENCE   7  (bases 1 to 2299)
  AUTHORS   Kusumi,K., Sun,E.S., Kerrebrock,A.W., Bronson,R.T., Chi,D.C.,
            Bulotsky,M.S., Spencer,J.B., Birren,B.W., Frankel,W.N. and
            Lander,E.S.
  TITLE     The mouse pudgy mutation disrupts Delta homologue Dll3 and
            initiation of early somite boundaries
  JOURNAL   Nat Genet 19 (3), 274-278 (1998)
   PUBMED   9662403
REFERENCE   8  (bases 1 to 2299)
  AUTHORS   Morsli,H., Choo,D., Ryan,A., Johnson,R. and Wu,D.K.
  TITLE     Development of the mouse inner ear and origin of its sensory organs
  JOURNAL   J Neurosci 18 (9), 3327-3335 (1998)
   PUBMED   9547240
REFERENCE   9  (bases 1 to 2299)
  AUTHORS   Cohen,B., Bashirullah,A., Dagnino,L., Campbell,C., Fisher,W.W.,
            Leow,C.C., Whiting,E., Ryan,D., Zinyk,D., Boulianne,G., Hui,C.C.,
            Gallie,B., Phillips,R.A., Lipshitz,H.D. and Egan,S.E.
  TITLE     Fringe boundaries coincide with Notch-dependent patterning centres
            in mammals and alter Notch-dependent development in Drosophila
  JOURNAL   Nat Genet 16 (3), 283-288 (1997)
   PUBMED   9207795
REFERENCE   10 (bases 1 to 2299)
  AUTHORS   Johnston,S.H., Rauskolb,C., Wilson,R., Prabhakaran,B., Irvine,K.D.
            and Vogt,T.F.
  TITLE     A family of mammalian Fringe genes implicated in boundary
            determination and the Notch pathway
  JOURNAL   Development 124 (11), 2245-2254 (1997)
   PUBMED   9187150
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153283.1, AK004642.1 and AW061165.1.
            
            On Mar 20, 2007 this sequence version replaced NM_008494.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004642.1, AK153283.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1320              AK153283.1         2-1321
            1321-2282           AK004642.1         1322-2283
            2283-2299           AW061165.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..2299
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 79.15 cM"
     gene            1..2299
                     /gene="Lfng"
                     /note="LFNG O-fucosylpeptide
                     3-beta-N-acetylglucosaminyltransferase"
                     /db_xref="GeneID:16848"
                     /db_xref="MGI:MGI:1095413"
     exon            1..504
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1212
                     /gene="Lfng"
                     /EC_number="2.4.1.222"
                     /note="lunatic fringe; O-fucosylpeptide
                     3-beta-N-acetylglucosaminyltransferase"
                     /codon_start=1
                     /product="beta-1,3-N-acetylglucosaminyltransferase lunatic
                     fringe"
                     /protein_id="NP_032520.1"
                     /db_xref="CCDS:CCDS19821.1"
                     /db_xref="GeneID:16848"
                     /db_xref="MGI:MGI:1095413"
                     /translation="MLQRCGRRLLLALVGALLACLLVLTADPPPTPMPAERGRRALRS
                     LAGSSGGAPASGSRAAVDPGVLTREVHSLSEYFSLLTRARRDADPPPGVASRQGDGHP
                     RPPAEVLSPRDVFIAVKTTRKFHRARLDLLFETWISRHKEMTFIFTDGEDEALAKLTG
                     NVVLTNCSSAHSRQALSCKMAVEYDRFIESGKKWFCHVDDDNYVNLRALLRLLASYPH
                     TQDVYIGKPSLDRPIQATERISEHKVRPVHFWFATGGAGFCISRGLALKMGPWASGGH
                     FMSTAERIRLPDDCTIGYIVEALLGVPLIRSGLFHSHLENLQQVPTTELHEQVTLSYG
                     MFENKRNAVHIKGPFSVEADPSRFRSVHCHLYPDTPWCPRSAIF"
     exon            505..553
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
     exon            554..653
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
     exon            654..807
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
     exon            808..893
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1059
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1145
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..2284
                     /gene="Lfng"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2262..2267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lfng"
                     /note="hexamer: AATAAA"
     polyA_site      2284
                     /gene="Lfng"
                     /note="major polyA site"
ORIGIN      
        1 gcagctggac cgggagcctc gggcagccgg accagttggc actgggatag atattacgtg
       61 cggccgccgg ccaccatgct ccagcggtgc ggccggcgcc tgctgctggc gctggtgggc
      121 gcgctgttgg cttgtctcct ggtgctcacg gccgacccgc caccgactcc gatgcccgct
      181 gagcgcggac ggcgcgcgct gcgtagcctg gcgggctcct ctggaggagc tccggcttca
      241 gggtccaggg cggctgtgga tcccggagtc ctcacccgcg aggtgcatag cctctccgag
      301 tacttcagtc tactcacccg cgcgcgcaga gacgcggatc caccgcccgg ggtcgcttct
      361 cgccagggcg acggccatcc gcgtcccccc gccgaagttc tgtcccctcg cgacgtcttc
      421 atcgccgtca agaccaccag aaagtttcac cgcgcgcggc tcgatctgct gttcgagacc
      481 tggatctcgc gccacaagga gatgacgttc atcttcactg atggggagga cgaagctctg
      541 gccaagctca caggcaatgt ggtgctcacc aactgctcct cggcccacag ccgccaggct
      601 ctgtcctgca agatggctgt ggagtatgac cgattcattg agtctgggaa gaagtggttc
      661 tgccacgtgg atgatgacaa ctacgtcaac ctccgggcgc tgctgcggct cctggccagc
      721 tatccccaca cccaagacgt gtacatcggc aagcccagcc tggacaggcc catccaggcc
      781 acagaacgga tcagcgagca caaagtgaga cctgtccact tttggtttgc caccggagga
      841 gctggcttct gcatcagccg agggctggcc ctaaagatgg gcccatgggc cagtggagga
      901 cacttcatga gcacggcaga gcgcatccgg ctccccgatg actgcaccat tggctacatt
      961 gtagaggctc tgctgggtgt acccctcatc cggagcggcc tcttccactc ccacctagag
     1021 aacctgcagc aggtgcccac caccgagctt catgagcagg tgaccctgag ctatggcatg
     1081 tttgagaaca agcggaacgc agtgcacatc aagggaccat tctctgtgga agctgaccca
     1141 tccaggttcc gctctgtcca ttgccacctg tacccagaca caccctggtg tcctcgctcc
     1201 gccatcttct agcagtcgtg gttgaaactc tgtccctggg cgcccctggt atccaaaggg
     1261 cccagggacc tttattgtat gccctggcct tggtgtccga ggctcttcag ggctatgtgt
     1321 atgtgtgtgt atgtctatat ttgtgtgttt gtgtggcgtg cccacccgtg ttgcagactg
     1381 ctgggcagtc gtgttcttca gggagtggca ggtctgtccc taactacact ctgagcacca
     1441 ctccgagggc agttgtgtgg gatctgtgtt tggatctctg cagtgggggt gggtgaggcc
     1501 ttggggctcc actcaggggt ccgtgggtgc tgattgtagc agtctcttat gttggggtgc
     1561 tagcacctat ctggagcctt ccctgtcagc tgagctgtgc ccagtcctag ggaagctgat
     1621 ttgggtagta aaggcctgga ccccttgtga gctctggccc gggcgctgcc tggtgccatt
     1681 ctggtgaaca atgctccccc accccctgcc ctccagggtg gaggcgaagt cttcagcccc
     1741 accctctgat gccctatctt tgtctcccac accaagtggg gttcagagct atgaatttta
     1801 tctcctctcc aaagtagaga gaaagtcgcc catagtgggt gtgcctgtac atattgtgac
     1861 agtatttttt tactgtgctc tttcttgaaa ggggaggggt gggtgtgaaa ggaggtgggg
     1921 ggtggttgtt ttctggggtg ggctggagag ggtcttattt tatcttttct gtggatcaga
     1981 aaaaagtgga agccagacag gcttggtctt tggaaagctg gacaatgagt gccttagtac
     2041 tgtatttatg ccttccagta tctggaatcc tgctcccccc caaccctccc cagcacccca
     2101 agacttacct cacccccacc acccccaact cctcactccc ctacccctgg gctgtattct
     2161 gtgttctttt tgcaaagacc ttaactaggc aagctaatga tgataaggga aaagctctca
     2221 gggaattgat gtgttgttgc tatggtgacg tccttcctct gaataaaggt gctctttgca
     2281 gcaaaaaaaa aaaaaaaaa
//
