LOCUS       NM_134093               2602 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus LETM1 domain containing 1 (Letmd1), transcript variant
            1, mRNA.
ACCESSION   NM_134093
VERSION     NM_134093.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2602)
  AUTHORS   Levi,J., Guglielmetti,C., Henrich,T.J., Yoon,J.C., Gokhale,P.C.,
            Reardon,D.A., Packiasamy,J., Huynh,L., Cabrera,H., Ruzevich,M.,
            Blecha,J., Peluso,M.J., Huynh,T.L., An,S.M., Dornan,M.,
            Belanger,A.P., Nguyen,Q.D., Seo,Y., Song,H., Chaumeil,M.M.,
            VanBrocklin,H.F. and Chae,H.D.
  TITLE     [18F]F-AraG imaging reveals association between neuroinflammation
            and brown- and bone marrow adipose tissue
  JOURNAL   Commun Biol 7 (1), 793 (2024)
   PUBMED   38951146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2602)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2602)
  AUTHORS   Xing,Z., Du,M., Zhen,Y., Chen,J., Li,D., Liu,R. and Zheng,J.
  TITLE     LETMD1, a target of KLF4, hinders endothelial inflammation and
            pyroptosis: A protective mechanism in the pathogenesis of
            atherosclerosis
  JOURNAL   Cell Signal 112, 110907 (2023)
   PUBMED   37769890
  REMARK    GeneRIF: LETMD1, a target of KLF4, hinders endothelial inflammation
            and pyroptosis: A protective mechanism in the pathogenesis of
            atherosclerosis.
REFERENCE   4  (bases 1 to 2602)
  AUTHORS   Park,A., Kim,K.E., Park,I., Lee,S.H., Park,K.Y., Jung,M., Li,X.,
            Sleiman,M.B., Lee,S.J., Kim,D.S., Kim,J., Lim,D.S., Woo,E.J.,
            Lee,E.W., Han,B.S., Oh,K.J., Lee,S.C., Auwerx,J., Mun,J.Y.,
            Rhee,H.W., Kim,W.K., Bae,K.H. and Suh,J.M.
  TITLE     Mitochondrial matrix protein LETMD1 maintains thermogenic capacity
            of brown adipose tissue in male mice
  JOURNAL   Nat Commun 14 (1), 3746 (2023)
   PUBMED   37353518
  REMARK    GeneRIF: Mitochondrial matrix protein LETMD1 maintains thermogenic
            capacity of brown adipose tissue in male mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2602)
  AUTHORS   Xiao,H., Bozi,L.H.M., Sun,Y., Riley,C.L., Philip,V.M., Chen,M.,
            Li,J., Zhang,T., Mills,E.L., Emont,M.P., Sun,W., Reddy,A.,
            Garrity,R., Long,J., Becher,T., Vitas,L.P., Laznik-Bogoslavski,D.,
            Ordonez,M., Liu,X., Chen,X., Wang,Y., Liu,W., Tran,N., Liu,Y.,
            Zhang,Y., Cypess,A.M., White,A.P., He,Y., Deng,R., Schoder,H.,
            Paulo,J.A., Jedrychowski,M.P., Banks,A.S., Tseng,Y.H., Cohen,P.,
            Tsai,L.T., Rosen,E.D., Klein,S., Chondronikola,M., McAllister,F.E.,
            Van Bruggen,N., Huttlin,E.L., Spiegelman,B.M., Churchill,G.A.,
            Gygi,S.P. and Chouchani,E.T.
  TITLE     Architecture of the outbred brown fat proteome defines regulators
            of metabolic physiology
  JOURNAL   Cell 185 (24), 4654-4673 (2022)
   PUBMED   36334589
REFERENCE   6  (bases 1 to 2602)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (bases 1 to 2602)
  AUTHORS   Ha,S.A., Shin,S.M., Kim,H.K., Kim,S., Namkoong,H., Lee,Y.S.,
            Kim,H.J., Jung,S.M., Lee,Y.S., Chung,Y.J., Park,Y.G., Jung,S.S. and
            Kim,J.W.
  TITLE     Dual action of apolipoprotein E-interacting HCCR-1 oncoprotein and
            its implication for breast cancer and obesity
  JOURNAL   J Cell Mol Med 13 (9B), 3868-3875 (2009)
   PUBMED   20196787
  REMARK    GeneRIF: HCCR-1 might play a role in the breast tumourigenesis
            while the overexpression of HCCR-1 induces the obesity probably by
            inhibiting the cholesterol-lowering effect of ApoE
REFERENCE   8  (bases 1 to 2602)
  AUTHORS   Cho,G.W., Shin,S.M., Namkoong,H., Kim,H.K., Ha,S.A., Hur,S.Y.,
            Kim,T.E., Chai,Y.G. and Kim,J.W.
  TITLE     The phosphatidylinositol 3-kinase/Akt pathway regulates the HCCR-1
            oncogene expression
  JOURNAL   Gene 384, 18-26 (2006)
   PUBMED   16949218
  REMARK    GeneRIF: The level of HCCR-1 expression was increased during the
            mouse embryogenesis and expression of phosphatidylinositol 3-kinase
            (PI3K) in NIH/3T3 cells activated the HCCR-1 promoter.
REFERENCE   9  (bases 1 to 2602)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 2602)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139571.2.
            
            On Nov 14, 2017 this sequence version replaced NM_134093.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF287293.1, AK080221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               AC139571.2         76590-76824         c
            236-387             AC139571.2         75999-76150         c
            388-503             AC139571.2         74060-74175         c
            504-586             AC139571.2         73204-73286         c
            587-773             AC139571.2         70626-70812         c
            774-875             AC139571.2         70428-70529         c
            876-1028            AC139571.2         70181-70333         c
            1029-1125           AC139571.2         68949-69045         c
            1126-2602           AC139571.2         66583-68059         c
FEATURES             Location/Qualifiers
     source          1..2602
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.31 cM"
     gene            1..2602
                     /gene="Letmd1"
                     /gene_synonym="1110019O13Rik; HCCR-2; HCCR1; MCC-32; Mccr"
                     /note="LETM1 domain containing 1"
                     /db_xref="GeneID:68614"
                     /db_xref="MGI:MGI:1915864"
     exon            1..235
                     /gene="Letmd1"
                     /gene_synonym="1110019O13Rik; HCCR-2; HCCR1; MCC-32; Mccr"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1196
                     /gene="Letmd1"
                     /gene_synonym="1110019O13Rik; HCCR-2; HCCR1; MCC-32; Mccr"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cervical cancer receptor; LETM1 domain-containing protein
                     1"
                     /codon_start=1
                     /product="LETM1 domain-containing protein 1 isoform 1"
                     /protein_id="NP_598854.1"
                     /db_xref="CCDS:CCDS27838.1"
                     /db_xref="GeneID:68614"
                     /db_xref="MGI:MGI:1915864"
                     /translation="MALSRVCWARAALWGSTVAPGPFVTRRLQLGRSGPAWRAPRSSK
                     LHLSPKADVKNLISYVVTKTRAINGSYHRFLGRHFPRFYALYTTFMKGIQMLWADGKK
                     ARRIKADMWKQNLKFHQLSYREMEHLRQFRRDITKCLFVGLISIPPFANYLVFLLMYL
                     FPRQLLVKHFWTPKQQIDFLDVYHGLRRRSHSEVITHLRRASTFVSHEKLRRQLTDLC
                     TKVQSGTHPAAQDVLALRDCFSTYPLGFSQLQASQMRALSQAMLLTPYLPPPLLRQRL
                     KSHTTVIHQLDRALAKLGIGQLTAQEVKSACYLRGLNSTHIADDRCRAWLGEWLHISC
                     SLKEPELSLLLHNVVLLSTNYLETRR"
     exon            236..387
                     /gene="Letmd1"
                     /gene_synonym="1110019O13Rik; HCCR-2; HCCR1; MCC-32; Mccr"
                     /inference="alignment:Splign:2.1.0"
     exon            388..503
                     /gene="Letmd1"
                     /gene_synonym="1110019O13Rik; HCCR-2; HCCR1; MCC-32; Mccr"
                     /inference="alignment:Splign:2.1.0"
     exon            504..586
                     /gene="Letmd1"
                     /gene_synonym="1110019O13Rik; HCCR-2; HCCR1; MCC-32; Mccr"
                     /inference="alignment:Splign:2.1.0"
     exon            587..773
                     /gene="Letmd1"
                     /gene_synonym="1110019O13Rik; HCCR-2; HCCR1; MCC-32; Mccr"
                     /inference="alignment:Splign:2.1.0"
     exon            774..875
                     /gene="Letmd1"
                     /gene_synonym="1110019O13Rik; HCCR-2; HCCR1; MCC-32; Mccr"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1028
                     /gene="Letmd1"
                     /gene_synonym="1110019O13Rik; HCCR-2; HCCR1; MCC-32; Mccr"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1125
                     /gene="Letmd1"
                     /gene_synonym="1110019O13Rik; HCCR-2; HCCR1; MCC-32; Mccr"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..2602
                     /gene="Letmd1"
                     /gene_synonym="1110019O13Rik; HCCR-2; HCCR1; MCC-32; Mccr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2494..2499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Letmd1"
                     /gene_synonym="1110019O13Rik; HCCR-2; HCCR1; MCC-32; Mccr"
                     /note="hexamer: AGTAAA"
     polyA_site      2514
                     /gene="Letmd1"
                     /gene_synonym="1110019O13Rik; HCCR-2; HCCR1; MCC-32; Mccr"
                     /note="major polyA site"
ORIGIN      
        1 gcgcggggcg gctcgcagcc gcctgtcggc gtggaggggc ggcgcgtgcg tgctgcgggg
       61 cgcactctga cccggagacg acctctctcc gcgctccctc ccctgctgtg aagatggcgc
      121 tgtccagggt gtgctgggct cgggctgctc tgtggggttc gactgtcgcc cctggaccct
      181 ttgtcacccg gaggctgcag ctgggccgct ctggccctgc gtggcgagcc cctcggtctt
      241 caaagcttca cctttctccg aaggcggacg tgaagaactt gatttcttac gtggtgacca
      301 agacaagagc gattaacgga tcgtaccatc gtttcttggg gcgtcatttc ccccgcttct
      361 atgccttata cacaaccttc atgaaaggaa tacagatgtt atgggctgat ggcaaaaagg
      421 ctagaagaat aaaggcagac atgtggaaac aaaacctaaa gtttcatcaa ctctcttacc
      481 gggagatgga gcatttgaga cagttccgac gagatatcac caagtgtctc ttcgttggcc
      541 tcatctccat tccacccttt gccaactacc tggtcttttt gctaatgtac ctgtttccta
      601 ggcaactgct agtcaagcat ttctggaccc ccaaacaaca aattgatttc ttggacgttt
      661 atcatggtct ccggaggcgg tcccactcgg aagtcatcac acatctaaga agggccagca
      721 cttttgtttc tcatgagaaa ctccggaggc agctgacaga cctgtgcacc aaggtgcaga
      781 gtggcaccca cccagcagca caggacgtcc tggctctcag agattgcttc tctacctacc
      841 ccttgggctt cagccagctc caagcctcgc agatgagagc cttgagccag gccatgctcc
      901 tcacacctta cctgcccccg cccttgctga ggcagcggct aaagagtcac accaccgtga
      961 tccaccagct ggacagggct ctggcaaagc tggggattgg ccagctgact gcacaggaag
     1021 tgaaatcggc ttgctatctt cgtggcttga actctaccca cattgctgac gacaggtgtc
     1081 gagcctggct gggggaatgg ttgcacatct cctgtagcct gaaagaaccc gagctgtccc
     1141 tcttgctgca caacgtggtc ctgctctcca ccaactacct tgagacaagg cgctgagtga
     1201 accccacgga aaggacggca ttgtcctgca gtcacctagt gtagtggtgt gggaccaaga
     1261 agcacctgtc agctgtctgt gcgcaccact agtgtgggag gcagcggagt gggttccacg
     1321 ggcttcagag cacgctaccc ccctgggagc tatagacatt ccttcacagc ttgagcctaa
     1381 caaacccatg tgtgctaacc tggaactggc aagcatctct ggtactgaac ttttattgtg
     1441 atgtaatact taggtcctat aaagtcagcc tttgcccagg tgggaatcat gtggcctaaa
     1501 attgagcact gccatggttt tgtttttaag gtgttttttg tgtgttcctt tttgagatga
     1561 gtctctgttg cccaggctgg cctccaatcc ctgtgctcaa gggatcctct ctctccagac
     1621 tcgggtgctg cggctgcact ggcctcactg ccacgttctc tacagccgag ccttgttttc
     1681 ctgagacccc gtgtctcatg tagccgaaga ggaccttgag atctggtctt cctaccccca
     1741 gctcccaggc gctggaacac cggcaaggag cccacgaagc tctggggtgt tgtcttggct
     1801 gagtgctttt taccgagtct ttgtgcacta gcggatctct ggtaccaaga acagtgcagc
     1861 ttactctggg gtgagggcac ccatgcctgg ccctgcgcca acaccccggc agtggttttt
     1921 cttatgcccc ctcccttttc cttttatggc ctttttgaga gtcttactgt ataacctggc
     1981 aatcctgaca gacaattctg ccacagcctc ctggagcgag aatataagca tgagccacac
     2041 ccatcctttc tggtgagacc aaaagtaggg ctgtttctcc tcgtcactat catgggctaa
     2101 cttccacccc tcctctcagt attctatgga cacttttttt tttttaatag taatttatgg
     2161 gaacattcta aaggaggcgg tgagaaagaa tggctgcctg gcccctccct gcgtttgtcc
     2221 ccagtgtctt actttccagg ctgtcacaca gcccctaggg accttacatg tttgctacct
     2281 ccactgtgtt gcactaagcc atctgtaacc agcagtggct gccttctcta ggctgtgggt
     2341 caaaaacgca caaggtacta attactgccc agccctggga gaccaggaga tttgcaatag
     2401 atagtgagtt gggcttaact gtcgtgtgta catctatgcc ctgtcgtttt gtaataactt
     2461 actgtaaatg catgaagcac tggtttaagc ctaagtaaag actgcctgaa accagtttct
     2521 gggaattact tatgcacact ctactcactt ccctaaggct tctttctaag agtgacgtaa
     2581 cctaactaat gggtacttaa ct
//
