LOCUS       NP_598854                360 aa            linear   ROD 28-APR-2025
DEFINITION  LETM1 domain-containing protein 1 isoform 1 [Mus musculus].
ACCESSION   NP_598854
VERSION     NP_598854.1
DBSOURCE    REFSEQ: accession NM_134093.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 360)
  AUTHORS   Levi,J., Guglielmetti,C., Henrich,T.J., Yoon,J.C., Gokhale,P.C.,
            Reardon,D.A., Packiasamy,J., Huynh,L., Cabrera,H., Ruzevich,M.,
            Blecha,J., Peluso,M.J., Huynh,T.L., An,S.M., Dornan,M.,
            Belanger,A.P., Nguyen,Q.D., Seo,Y., Song,H., Chaumeil,M.M.,
            VanBrocklin,H.F. and Chae,H.D.
  TITLE     [18F]F-AraG imaging reveals association between neuroinflammation
            and brown- and bone marrow adipose tissue
  JOURNAL   Commun Biol 7 (1), 793 (2024)
   PUBMED   38951146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 360)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 360)
  AUTHORS   Xing,Z., Du,M., Zhen,Y., Chen,J., Li,D., Liu,R. and Zheng,J.
  TITLE     LETMD1, a target of KLF4, hinders endothelial inflammation and
            pyroptosis: A protective mechanism in the pathogenesis of
            atherosclerosis
  JOURNAL   Cell Signal 112, 110907 (2023)
   PUBMED   37769890
  REMARK    GeneRIF: LETMD1, a target of KLF4, hinders endothelial inflammation
            and pyroptosis: A protective mechanism in the pathogenesis of
            atherosclerosis.
REFERENCE   4  (residues 1 to 360)
  AUTHORS   Park,A., Kim,K.E., Park,I., Lee,S.H., Park,K.Y., Jung,M., Li,X.,
            Sleiman,M.B., Lee,S.J., Kim,D.S., Kim,J., Lim,D.S., Woo,E.J.,
            Lee,E.W., Han,B.S., Oh,K.J., Lee,S.C., Auwerx,J., Mun,J.Y.,
            Rhee,H.W., Kim,W.K., Bae,K.H. and Suh,J.M.
  TITLE     Mitochondrial matrix protein LETMD1 maintains thermogenic capacity
            of brown adipose tissue in male mice
  JOURNAL   Nat Commun 14 (1), 3746 (2023)
   PUBMED   37353518
  REMARK    GeneRIF: Mitochondrial matrix protein LETMD1 maintains thermogenic
            capacity of brown adipose tissue in male mice.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 360)
  AUTHORS   Xiao,H., Bozi,L.H.M., Sun,Y., Riley,C.L., Philip,V.M., Chen,M.,
            Li,J., Zhang,T., Mills,E.L., Emont,M.P., Sun,W., Reddy,A.,
            Garrity,R., Long,J., Becher,T., Vitas,L.P., Laznik-Bogoslavski,D.,
            Ordonez,M., Liu,X., Chen,X., Wang,Y., Liu,W., Tran,N., Liu,Y.,
            Zhang,Y., Cypess,A.M., White,A.P., He,Y., Deng,R., Schoder,H.,
            Paulo,J.A., Jedrychowski,M.P., Banks,A.S., Tseng,Y.H., Cohen,P.,
            Tsai,L.T., Rosen,E.D., Klein,S., Chondronikola,M., McAllister,F.E.,
            Van Bruggen,N., Huttlin,E.L., Spiegelman,B.M., Churchill,G.A.,
            Gygi,S.P. and Chouchani,E.T.
  TITLE     Architecture of the outbred brown fat proteome defines regulators
            of metabolic physiology
  JOURNAL   Cell 185 (24), 4654-4673 (2022)
   PUBMED   36334589
REFERENCE   6  (residues 1 to 360)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (residues 1 to 360)
  AUTHORS   Ha,S.A., Shin,S.M., Kim,H.K., Kim,S., Namkoong,H., Lee,Y.S.,
            Kim,H.J., Jung,S.M., Lee,Y.S., Chung,Y.J., Park,Y.G., Jung,S.S. and
            Kim,J.W.
  TITLE     Dual action of apolipoprotein E-interacting HCCR-1 oncoprotein and
            its implication for breast cancer and obesity
  JOURNAL   J Cell Mol Med 13 (9B), 3868-3875 (2009)
   PUBMED   20196787
  REMARK    GeneRIF: HCCR-1 might play a role in the breast tumourigenesis
            while the overexpression of HCCR-1 induces the obesity probably by
            inhibiting the cholesterol-lowering effect of ApoE
REFERENCE   8  (residues 1 to 360)
  AUTHORS   Cho,G.W., Shin,S.M., Namkoong,H., Kim,H.K., Ha,S.A., Hur,S.Y.,
            Kim,T.E., Chai,Y.G. and Kim,J.W.
  TITLE     The phosphatidylinositol 3-kinase/Akt pathway regulates the HCCR-1
            oncogene expression
  JOURNAL   Gene 384, 18-26 (2006)
   PUBMED   16949218
  REMARK    GeneRIF: The level of HCCR-1 expression was increased during the
            mouse embryogenesis and expression of phosphatidylinositol 3-kinase
            (PI3K) in NIH/3T3 cells activated the HCCR-1 promoter.
REFERENCE   9  (residues 1 to 360)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (residues 1 to 360)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139571.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF287293.1, AK080221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.31 cM"
     Protein         1..360
                     /product="LETM1 domain-containing protein 1 isoform 1"
                     /note="cervical cancer receptor; LETM1 domain-containing
                     protein 1"
                     /calculated_mol_wt=41570
     Region          1..110
                     /region_name="Required and sufficient for mitochondrial
                     import. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924L1.1)"
     Region          120..350
                     /region_name="LETM1_RBD"
                     /note="LETM1-like, RBD; pfam07766"
                     /db_xref="CDD:462258"
     Site            138..158
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q924L1.1)"
     Site            192
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q924L1.1)"
     CDS             1..360
                     /gene="Letmd1"
                     /gene_synonym="1110019O13Rik; HCCR-2; HCCR1; MCC-32; Mccr"
                     /coded_by="NM_134093.3:114..1196"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS27838.1"
                     /db_xref="GeneID:68614"
                     /db_xref="MGI:MGI:1915864"
ORIGIN      
        1 malsrvcwar aalwgstvap gpfvtrrlql grsgpawrap rssklhlspk advknlisyv
       61 vtktraings yhrflgrhfp rfyalyttfm kgiqmlwadg kkarrikadm wkqnlkfhql
      121 syremehlrq frrditkclf vglisippfa nylvfllmyl fprqllvkhf wtpkqqidfl
      181 dvyhglrrrs hsevithlrr astfvshekl rrqltdlctk vqsgthpaaq dvlalrdcfs
      241 typlgfsqlq asqmralsqa mlltpylppp llrqrlksht tvihqldral aklgigqlta
      301 qevksacylr glnsthiadd rcrawlgewl hiscslkepe lslllhnvvl lstnyletrr
//
