LOCUS       NM_001364069            1954 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus leucine zipper-EF-hand containing transmembrane
            protein 2 (Letm2), transcript variant 2, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001364069 XM_017312842
VERSION     NM_001364069.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1954)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV647889.1, BC055685.1, BE648035.1 and AW048776.1.
            
            On Jun 6, 2018 this sequence version replaced XM_017312842.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3646350.1,
                                           ERR3363658.4932478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-757               DV647889.1         3-759
            758-1639            BC055685.1         904-1785
            1640-1691           BE648035.1         573-624
            1692-1954           AW048776.1         16-278              c
FEATURES             Location/Qualifiers
     source          1..1954
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 14.17 cM"
     gene            1..1954
                     /gene="Letm2"
                     /gene_synonym="6030453H13; D030041N04Rik"
                     /note="leucine zipper-EF-hand containing transmembrane
                     protein 2"
                     /db_xref="GeneID:270035"
                     /db_xref="MGI:MGI:2444979"
     exon            1..222
                     /gene="Letm2"
                     /gene_synonym="6030453H13; D030041N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            223..306
                     /gene="Letm2"
                     /gene_synonym="6030453H13; D030041N04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1702
                     /gene="Letm2"
                     /gene_synonym="6030453H13; D030041N04Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; LETM1 domain-containing protein LETM2,
                     mitochondrial; LETM1 and EF-hand domain-containing protein
                     2"
                     /codon_start=1
                     /product="LETM1 domain-containing protein LETM2,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_001350998.1"
                     /db_xref="CCDS:CCDS52527.1"
                     /db_xref="GeneID:270035"
                     /db_xref="MGI:MGI:2444979"
                     /translation="MAFYSYNSFLAIFWTRLPGHSVYPSCSHFPSLAFLHLPDSHLRT
                     AYIKNCGSRKYSYPSLTGNNKVHPLRTRLPQKLHTTCWLQHVPGKPQLEQTGKPKAAS
                     PQPTKEAKTETTEEKRSLRQKIVNELKYYYKGFSLLWIDTKVAARIVWRLLHGNALTR
                     RERRRLLRTCADVFRLVPFMVFIIVPFMEFLIPVFLKLFPDMLPSTFESESKKEEKQK
                     KTMAAKLEIAKFLQETMTEMARRNRAKLGDASSQLSSYVKQVQTGHKPSTKEIVRFSK
                     LFKDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMTLKSIKADDEIIAKEGVK
                     ALSVSELQSACRARGMRSLGLTEEQLCQQLTGWLDLHLKENVPPSLLLLSRTFYLIDV
                     KPKPIELPPNIETPKPNLGIPTPPPPESKENLTDSAPQLKGTKDEEFIQLPPVPSSLI
                     APAATISKEAILQAKSQETSQNSKADSKGA"
     exon            307..754
                     /gene="Letm2"
                     /gene_synonym="6030453H13; D030041N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            755..898
                     /gene="Letm2"
                     /gene_synonym="6030453H13; D030041N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1036
                     /gene="Letm2"
                     /gene_synonym="6030453H13; D030041N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1237
                     /gene="Letm2"
                     /gene_synonym="6030453H13; D030041N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1357
                     /gene="Letm2"
                     /gene_synonym="6030453H13; D030041N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1471
                     /gene="Letm2"
                     /gene_synonym="6030453H13; D030041N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1564
                     /gene="Letm2"
                     /gene_synonym="6030453H13; D030041N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1639
                     /gene="Letm2"
                     /gene_synonym="6030453H13; D030041N04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1954
                     /gene="Letm2"
                     /gene_synonym="6030453H13; D030041N04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1935..1940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Letm2"
                     /gene_synonym="6030453H13; D030041N04Rik"
                     /note="hexamer: CATAAA"
     polyA_site      1954
                     /gene="Letm2"
                     /gene_synonym="6030453H13; D030041N04Rik"
                     /note="major polyA site"
ORIGIN      
        1 agggttgggg ccttagtcac ctcgcagcgg acaagggctc cctcggcgtc tcccgtcaac
       61 cccgatctct cccctaaact ttggacattc tcccctacgg tgtacctgac cccactccaa
      121 caatccccag acccaccgca gtcctcccca ctttccgcgg agactaccgg ccgagagccg
      181 agggcgcctt ttgcaccggt gcggcgagcg cggggtgcag aggtctctgt gttggttagt
      241 tgaaacaaaa aaaataaaca tggccttcta cagttataat tcattcttag ctattttctg
      301 gacaagactg cctggccatt ctgtgtaccc ttcctgctct catttcccat cacttgcatt
      361 tctccacttg ccagattctc acttgcgtac agcctacatt aaaaactgcg gaagcaggaa
      421 gtactcctat cccagtctaa caggcaataa taaagtccat cccttacgga ccaggctccc
      481 acaaaaactg cacacaacct gctggctaca acatgtccct ggcaaacctc agctggagca
      541 aacagggaag ccaaaggcag caagccctca gcctaccaaa gaagccaaga cagagactac
      601 agaagaaaag cggtcgttga gacaaaaaat tgtgaatgaa cttaaatact attacaaagg
      661 attcagcttg ctttggattg acaccaaagt cgctgccaga atagtgtgga ggctactgca
      721 tggtaatgcg ctaaccagac gagagaggcg aaggctgttg agaacgtgtg ccgatgtctt
      781 ccgcttggtt ccatttatgg tgttcataat tgtacctttt atggagttct tgataccagt
      841 gtttctgaag ctcttcccag acatgttgcc atcaactttt gaaagtgaat ccaaaaagga
      901 agaaaaacag aaaaaaacga tggctgccaa actggaaata gcaaaattcc ttcaagaaac
      961 aatgacagag atggcgagga gaaaccgagc gaagctggga gatgcatctt cccagctttc
     1021 ctcctatgtg aaacaggtcc aaacaggtca caagccctcc acgaaggaga tagttaggtt
     1081 ctccaaactc ttcaaggatc agttagccct ggaacactta gaccggcccc agctggttgc
     1141 cctgtgcaag ctgctggaac tgcagacctt cggaacaaac aatctgctcc gcttccagct
     1201 cctgatgaca ctgaagtcta taaaagcaga tgatgaaata attgccaaag aaggggtgaa
     1261 ggctttgagt gtgtcagaac tgcagtctgc gtgccgggcc cgggggatga ggtcgctggg
     1321 cctcactgag gagcaactgt gccagcagct cacagggtgg ctggacctcc acttgaagga
     1381 gaacgtccct ccttctcttt tgctcctgtc gcgcaccttc tacctgatag atgtgaagcc
     1441 aaagcctatt gaacttccac cgaatataga gactccaaag ccaaaccttg gaataccgac
     1501 acctccaccc cccgagtcaa aggagaacct cacagactct gcacctcagc tgaagggaac
     1561 gaaggatgaa gaatttatac aactgccccc agtaccgtca tcactcatag caccagcagc
     1621 aactatttcc aaagaagcaa tcctccaggc caagtcccag gagacctcac agaacagcaa
     1681 ggctgattcc aaaggagcct aaggatccct tgaaggtggc gctccctctc ttcagtcact
     1741 ccgctcagca gtggcgtcca caaaggaatt ccagctaaga ctgtctggct tgagataaag
     1801 gatcagccat taagtcgttg gaggccttgt gaccatccca gagatgcaag cagtgacacc
     1861 aagttcaggc catttagaga agcttaatta cagtccatct ctactgtata attttgtcat
     1921 cttactaaac gttgcataaa gacactccca ccaa
//
