LOCUS       NM_026609               2609 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus leptin receptor overlapping transcript-like 1
            (Leprotl1), mRNA.
ACCESSION   NM_026609
VERSION     NM_026609.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2609)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2609)
  AUTHORS   Lancel,S., Hesselink,M.K., Woldt,E., Rouille,Y., Dorchies,E.,
            Delhaye,S., Duhem,C., Thorel,Q., Mayeuf-Louchart,A., Pourcet,B.,
            Montel,V., Schaart,G., Beton,N., Picquet,F., Briand,O.,
            Salles,J.P., Duez,H., Schrauwen,P., Bastide,B., Bailleul,B.,
            Staels,B. and Sebti,Y.
  TITLE     Endospanin-2 enhances skeletal muscle energy metabolism and running
            endurance capacity
  JOURNAL   JCI Insight 3 (9), 98081 (2018)
   PUBMED   29720572
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2609)
  AUTHORS   Abu-Toamih Atamni,H.J., Ziner,Y., Mott,R., Wolf,L. and Iraqi,F.A.
  TITLE     Glucose tolerance female-specific QTL mapped in collaborative cross
            mice
  JOURNAL   Mamm Genome 28 (1-2), 20-30 (2017)
   PUBMED   27807798
  REMARK    GeneRIF: Gene browse revealed QTL for body weight/size, genes
            involved in immune system, and two main protein-coding genes
            involved in the Glucose homeostasis, Mboat4 and Leprotl1.
            Heritability and coefficient of genetic variance (CVg) were 0.49
            and 0.31 for females, while for males, these values 0.34 and 0.22,
            respectively.
REFERENCE   4  (bases 1 to 2609)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2609)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2609)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   7  (bases 1 to 2609)
  AUTHORS   Touvier,T., Conte-Auriol,F., Briand,O., Cudejko,C., Paumelle,R.,
            Caron,S., Bauge,E., Rouille,Y., Salles,J.P., Staels,B. and
            Bailleul,B.
  TITLE     LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone
            action in mice
  JOURNAL   J Clin Invest 119 (12), 3830-3838 (2009)
   PUBMED   19907080
  REMARK    GeneRIF: both LEPROT and LEPROTL1 expression were regulated in
            liver by physiologic and pathologic changes in glucose homeostasis
REFERENCE   8  (bases 1 to 2609)
  AUTHORS   Liu,Y. and Hogan,B.L.
  TITLE     Differential gene expression in the distal tip endoderm of the
            embryonic mouse lung
  JOURNAL   Gene Expr Patterns 2 (3-4), 229-233 (2002)
   PUBMED   12617806
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC004677.1.
            
            On Jun 9, 2003 this sequence version replaced NM_026609.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004677.1, AK154712.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849385,
                                           SAMN00849386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2609
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 20.9 cM"
     gene            1..2609
                     /gene="Leprotl1"
                     /gene_synonym="1110067H13Rik; 1520402O14Rik"
                     /note="leptin receptor overlapping transcript-like 1"
                     /db_xref="GeneID:68192"
                     /db_xref="MGI:MGI:1915442"
     exon            1..55
                     /gene="Leprotl1"
                     /gene_synonym="1110067H13Rik; 1520402O14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..435
                     /gene="Leprotl1"
                     /gene_synonym="1110067H13Rik; 1520402O14Rik"
                     /note="endospanin-2"
                     /codon_start=1
                     /product="leptin receptor overlapping transcript-like 1"
                     /protein_id="NP_080885.1"
                     /db_xref="CCDS:CCDS22239.1"
                     /db_xref="GeneID:68192"
                     /db_xref="MGI:MGI:1915442"
                     /translation="MAGIKALISLSFGGAIGLMFLMLGCALPIYNQYWPLFVLFFYIL
                     SPIPYCIARRLVDDTDAMSNACKELAIFLTTGIVVSAFGLPVVFARAHLIEWGACALV
                     LTGNTVIFATILGFFLVFGSNDDFSWQQW"
     exon            56..131
                     /gene="Leprotl1"
                     /gene_synonym="1110067H13Rik; 1520402O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            132..318
                     /gene="Leprotl1"
                     /gene_synonym="1110067H13Rik; 1520402O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            319..2585
                     /gene="Leprotl1"
                     /gene_synonym="1110067H13Rik; 1520402O14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      598..603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Leprotl1"
                     /gene_synonym="1110067H13Rik; 1520402O14Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      624
                     /gene="Leprotl1"
                     /gene_synonym="1110067H13Rik; 1520402O14Rik"
                     /note="major polyA site"
     regulatory      2084..2089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Leprotl1"
                     /gene_synonym="1110067H13Rik; 1520402O14Rik"
                     /note="hexamer: ACTAAA"
     polyA_site      2102
                     /gene="Leprotl1"
                     /gene_synonym="1110067H13Rik; 1520402O14Rik"
     regulatory      2565..2570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Leprotl1"
                     /gene_synonym="1110067H13Rik; 1520402O14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2585
                     /gene="Leprotl1"
                     /gene_synonym="1110067H13Rik; 1520402O14Rik"
ORIGIN      
        1 caccgcccgg gtcgtggagc caggagcgac gtcaccgcca tggcgggcat caaagcttta
       61 attagtttgt cctttggagg agcgatcggg ctgatgttcc tgatgcttgg atgtgccctt
      121 ccgatataca accaatactg gcccctcttc gttctcttct tttacatcct ctcgcccatc
      181 ccgtactgca tagccagaag attagtggat gacacggacg ccatgagcaa cgcgtgtaag
      241 gagcttgcca tattcctcac cacaggcatc gtcgtctcgg cttttggact ccctgttgtg
      301 tttgccagag cacatctgat cgagtgggga gcttgcgcac ttgttctcac gggaaacaca
      361 gtcatcttcg cgactattct aggcttcttc ctggtctttg gaagcaacga cgacttcagc
      421 tggcagcagt ggtgaggagc tgctgaactg tagtcacgtt ggacttctgt cgtctgccgg
      481 ccacccgtgc acaggagaag gggccgtgat gctgagctgt tggcgagcct ctggggtgtc
      541 ctagttgctt ccttctcact gttgttcgcc tcctgtttcc atggggactt gctgaagatt
      601 aaaaggattt tctcatttgg aaaagcttgg ctggtttccc acttctctag actgctttcc
      661 atggtgtcct gctgaatcta aaatccttac atgttttccc tgttcagttg ttttaaaatc
      721 agtatgcaat gttacccatt tttaagatgt aatagccatt tgcattggtt taggaattca
      781 gaacttctgg ctgtattatg ggctaaagta tatattttct ctaaaaatca gttaatctcc
      841 attattaaaa aaaaaagtat acatgagtaa gttttcattc agtcaggatg acatcactcc
      901 aggtgaatgc aaaccttcag agcgttgaca taccttatct actatttact cagtgaaaga
      961 tagctgcatt tatacctcag gggggccgac tgatactgcc catgccctcc agaagggttg
     1021 ctggttttac tagtggacag gtgttttgtg aattgaaaac tattttgtgg aattgctata
     1081 aaagagtgct tttctcctca actgttagaa gaatttatgt tagactttaa ggtacaagtg
     1141 taaaaacaag ttccgggatc cagtttctat ccgtgtgtgt tatggtcaaa gcaagcgagt
     1201 agctgtgtgg gaaaaagcaa cattggcttc ccactgtctg cgtgccgttt ccatccttag
     1261 tgacaggtct gagctctgtc acctctcatg gtttggaggg tgaaagggac atgcatggga
     1321 cagttgtgtg tttgcagtgt agatattcaa aagcttccct ctgcttcctc cttttaactt
     1381 atttgtacat tgtatatatt aagtaaaaga acttttcaaa tatagtttaa taacgtttag
     1441 aaatgtttga ctactaggaa accaattgct atgccataca tgcagagtgc ccctccccca
     1501 caaggccttg acatgattca caagtgactt gttagtcttg caggtaatcc aggaacgtgc
     1561 agttgtagga cttagaccac cgtaagagta gtctcccaac cttacagcgt atgtacttga
     1621 aaagcactta aggcaggttt gctgtaaacc tctcagttgt cgcggtttgg tttcatcgtg
     1681 atggatccgc tgtcgtgagt aaggtattta ttgtatgaat tcatacagag tagccaaatc
     1741 cagctgtgtc acctcttcaa acacagccct gaccaaaatc ttctcagtga ccaggcatga
     1801 ccaaatcgta gcggtcattg gcatcttcag ttctcagtcc tttccttacc caagagctga
     1861 ttttgaaaat gttctcattg atccagcagt attttttgtg aggacacttg tatgtctctc
     1921 cagtgtgctt atataaaaag aagtgttctg cctttagctg aaaaaatgag taaccatgac
     1981 aactgtcttt tgttgttgtt ttttttccta cagtttattt ctcaaaaaaa caaaacaaaa
     2041 caaaaaaaaa acctggaaca tgcaccaagt ttgttcagct tttactaaag atgtctacag
     2101 ccgcggtttt tattttgttt ctgtttgccc tgacccatgt tttattacta tggtggtgag
     2161 gtgggaagcg ttatgaaatg tccaaatgcg gccatgccat ttgtgggtta gaccagcagt
     2221 ggcttgttga gtaatgatga cagagactcg ccggcggtgt gcgcatggtc agaaccctct
     2281 ctgggatcaa gaatggagca ggaggttttg tctctggtcc tccctgccct ctgctccttc
     2341 acaagcgaag tgctgagcgc ttggccatag actcctttct aacagctgca tattctttct
     2401 gggtactaac taatcttagc agcagcattg cgtgtctgac atgacactgg cttgccaatc
     2461 ccatctctgg tttctaggct agctacttaa gagtattttc atgagtatgc gccaacacat
     2521 tgtcgtccta ccgtggagag agagaaaact tttgatgaca aaacaataaa gattttaaat
     2581 atccaaaaaa aaaaaaaaaa aaaaaaaaa
//
