LOCUS       NM_175036               1891 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus leptin receptor overlapping transcript (Leprot),
            transcript variant 1, mRNA.
ACCESSION   NM_175036
VERSION     NM_175036.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1891)
  AUTHORS   Roca-Rivada,A., Do Cruzeiro,M., Denis,R.G., Zhang,Q., Rouault,C.,
            Rouille,Y., Launay,J.M., Cruciani-Guglielmacci,C., Mattot,V.,
            Clement,K., Jockers,R. and Dam,J.
  TITLE     Whole-body deletion of Endospanin 1 protects from
            obesity-associated deleterious metabolic alterations
  JOURNAL   JCI Insight 9 (9), e168418 (2024)
   PUBMED   38716728
  REMARK    GeneRIF: Whole-body deletion of Endospanin 1 protects from
            obesity-associated deleterious metabolic alterations.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1891)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1891)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   4  (bases 1 to 1891)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1891)
  AUTHORS   Vauthier,V., Roujeau,C., Chen,P., Sarkis,C., Migrenne,S., Hosoi,T.,
            Ozawa,K., Rouille,Y., Foretz,M., Mallet,J., Launay,J.M., Magnan,C.,
            Jockers,R. and Dam,J.
  TITLE     Endospanin1 affects oppositely body weight regulation and glucose
            homeostasis by differentially regulating central leptin signaling
  JOURNAL   Mol Metab 6 (1), 159-172 (2016)
   PUBMED   28123946
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1891)
  AUTHORS   Satoh,T., Yoshino,S., Katano,A., Ishizuka,T., Tomaru,T.,
            Shibusawa,N., Hashimoto,K., Yamada,M. and Mori,M.
  TITLE     Isolation of a novel leptin receptor gene promoter preferentially
            functioning in neuronal cells
  JOURNAL   Biochem Biophys Res Commun 389 (4), 673-677 (2009)
   PUBMED   19766595
REFERENCE   7  (bases 1 to 1891)
  AUTHORS   Couturier,C., Sarkis,C., Seron,K., Belouzard,S., Chen,P.,
            Lenain,A., Corset,L., Dam,J., Vauthier,V., Dubart,A., Mallet,J.,
            Froguel,P., Rouille,Y. and Jockers,R.
  TITLE     Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus
            increases leptin receptor signaling and prevents diet-induced
            obesity
  JOURNAL   Proc Natl Acad Sci U S A 104 (49), 19476-19481 (2007)
   PUBMED   18042720
REFERENCE   8  (bases 1 to 1891)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 1891)
  AUTHORS   Bailleul,B., Akerblom,I. and Strosberg,A.D.
  TITLE     The leptin receptor promoter controls expression of a second
            distinct protein
  JOURNAL   Nucleic Acids Res 25 (14), 2752-2758 (1997)
   PUBMED   9207021
REFERENCE   10 (bases 1 to 1891)
  AUTHORS   Micallef,M.J., Yoshida,K., Kawai,S., Hanaya,T., Kohno,K., Arai,S.,
            Tanimoto,T., Torigoe,K., Fujii,M., Ikeda,M. and Kurimoto,M.
  TITLE     In vivo antitumor effects of murine interferon-gamma-inducing
            factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma
            malignant ascites
  JOURNAL   Cancer Immunol Immunother 43 (6), 361-367 (1997)
   PUBMED   9067408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX323551.8 and AL929373.15.
            
            On Mar 31, 2023 this sequence version replaced NM_175036.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004744.1, AK165821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               BX323551.8         55368-55468
            102-177             AL929373.15        2875-2950
            178-364             AL929373.15        6585-6771
            365-1891            AL929373.15        8314-9840
FEATURES             Location/Qualifiers
     source          1..1891
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 46.94 cM"
     gene            1..1891
                     /gene="Leprot"
                     /gene_synonym="Endo1`; Endospanin1; LEPR; OB-RGRP; Obrgrp;
                     VPS55"
                     /note="leptin receptor overlapping transcript"
                     /db_xref="GeneID:230514"
                     /db_xref="MGI:MGI:2687005"
     exon            1..101
                     /gene="Leprot"
                     /gene_synonym="Endo1`; Endospanin1; LEPR; OB-RGRP; Obrgrp;
                     VPS55"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..481
                     /gene="Leprot"
                     /gene_synonym="Endo1`; Endospanin1; LEPR; OB-RGRP; Obrgrp;
                     VPS55"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leptin receptor gene-related protein; OB-R gene-related
                     protein; endospanin-1"
                     /codon_start=1
                     /product="leptin receptor gene-related protein isoform 1"
                     /protein_id="NP_778201.1"
                     /db_xref="CCDS:CCDS18396.1"
                     /db_xref="GeneID:230514"
                     /db_xref="MGI:MGI:2687005"
                     /translation="MAGVKALVALSFSGAIGLTFLMLGCALEDYGVYWPLFVLIFYVI
                     SPIPYFIAKRVTYDSDATSSACRELAYFFTTGIVVSAFGLPVVLARVDVIKWGACGLV
                     LAGNAVIFLTIQGFFLVFGRGDDFSWEQW"
     exon            102..177
                     /gene="Leprot"
                     /gene_synonym="Endo1`; Endospanin1; LEPR; OB-RGRP; Obrgrp;
                     VPS55"
                     /inference="alignment:Splign:2.1.0"
     exon            178..364
                     /gene="Leprot"
                     /gene_synonym="Endo1`; Endospanin1; LEPR; OB-RGRP; Obrgrp;
                     VPS55"
                     /inference="alignment:Splign:2.1.0"
     exon            365..1891
                     /gene="Leprot"
                     /gene_synonym="Endo1`; Endospanin1; LEPR; OB-RGRP; Obrgrp;
                     VPS55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1867..1872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Leprot"
                     /gene_synonym="Endo1`; Endospanin1; LEPR; OB-RGRP; Obrgrp;
                     VPS55"
                     /note="hexamer: AATAAA"
     polyA_site      1891
                     /gene="Leprot"
                     /gene_synonym="Endo1`; Endospanin1; LEPR; OB-RGRP; Obrgrp;
                     VPS55"
                     /note="major polyA site"
ORIGIN      
        1 ggattcgcgc gccggccctg gctagtctgg gtgtgggcgg cttttggaga aagccggaag
       61 cagcgacagc cccagctcca gagacatggc gggcgttaaa gctctcgtgg cgctctcctt
      121 cagtggggca attgggctga cttttcttat gctgggatgt gcgttggagg actatggcgt
      181 ttactggccc ctgttcgtct tgattttcta cgtcatctcc cccatcccct acttcattgc
      241 caaaagggtc acatatgact ccgacgcgac cagcagtgcc tgtcgggaac tggcgtattt
      301 cttcaccact gggattgttg tttctgcctt tggacttcct gttgttcttg ctcgtgtgga
      361 tgtgatcaag tggggagcct gtggtcttgt gctggccggc aacgctgtca ttttcctcac
      421 aattcaaggc ttcttcctcg tctttggaag aggagatgat ttcagttggg aacagtggta
      481 gcccctcctc cccatggaaa gcattgagtc ttagaatttg tactgtacgt atatgtgtgc
      541 acatgtgttt cagatttgaa tatgctgagt ttttttatac ctttatatca tgatcatctt
      601 agggaagatg ttgtaaacaa aagatgagtt ttactcctgg cacacaggtc actccattga
      661 ctcaaagtga attattttta tcttctagct tccagaaagc ctgttactat ggccttgtag
      721 acagctgctc acttatccag ggggtctaaa ccttttgcct tgggttaggc ttgggagaca
      781 ctggggcaga tctcctacag cccaaacata ggtggcgctc tccctgtaca cttagactca
      841 tctcatccac acagagcatc agcatctgct aggagcccat tggggatgca gggtcagact
      901 gggtaacttt gatgcgattg cacacttggc gcacgcacat tgacgggtga ggaggtttgt
      961 tgtagaggaa taagcatcat agctcccctg ccctctctgg gtgttgcatg ctcatttgca
     1021 ggaaaaaaaa aaaaatcacc tgccccctgc tgtgaatgag ttcagacttc aggtgtttct
     1081 aacatgttca atacttgtgt tgttcctcaa atttggggga cctgttctta ggcaggaaca
     1141 gataagtcat ccaaaaggca gtggctgatt gctcagaata agatacaaaa taaccaaaaa
     1201 acccctctgg ggtgcaagga gggaaacttg gctggaatgg tccctacttt aagtggaggg
     1261 caggatagac aattcttgga aatgtccctc tacggtgcct cccatccccc atgcagcatt
     1321 tggtttgctc ttggtggtgg gtctcctgaa gggtatgagg caagagtgag cagaggggag
     1381 ggagtcactg aagttacacg ctggtgcact tttcatcctt gatattgaac ttgatgtcac
     1441 ctccacagga cacacaggga tccacatcat tttggttctt ataaacagtt tttctagctc
     1501 atctttttta tctggagcct actgggagaa ggaagtgaga actacaagca cccagtcagg
     1561 atgccatcag cggtgtttaa gcattgatgc tgctcgctaa tgagtgtcca gagcactctc
     1621 ccttgaggct tgcggtccaa ggagtcagca tccaggccag ggctggtgtg acgctgggac
     1681 cagcaggtga atggacagag gacagtgtgc aatgttatat tttggccttg tgcatgacat
     1741 tatgttttga atattttgtg tacaaataga attgttagcg ttgtcatttc tagtatttac
     1801 attagaaaaa ttatttagat acttgatcat ttaactggca tttttaatca tgacacttgc
     1861 tattgtaata aatttgactt ttaacactga a
//
