LOCUS       NM_146146               3625 bp    mRNA    linear   ROD 19-MAR-2024
DEFINITION  Mus musculus leptin receptor (Lepr), transcript variant 1, mRNA.
ACCESSION   NM_146146
VERSION     NM_146146.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3625)
  AUTHORS   Cardani-Boulton,A., Sung,S.J., Petri,W.A. Jr., Hahn,Y.S. and
            Braciale,T.J.
  TITLE     Leptin Receptor Deficiency Impairs Lymph Node Development and
            Adaptive Immune Response
  JOURNAL   J Immunol 212 (6), 974-981 (2024)
   PUBMED   38251917
  REMARK    GeneRIF: Leptin Receptor Deficiency Impairs Lymph Node Development
            and Adaptive Immune Response.
REFERENCE   2  (bases 1 to 3625)
  AUTHORS   Tang,Q., Cheng,Z., Liu,S., Niu,J., Xu,J., Huang,J., Pan,J., Lu,F.
            and Chen,D.
  TITLE     FGF1DeltaHBS ameliorates retinal inflammation via suppressing TSPO
            signal in a type 2 diabetes mouse model
  JOURNAL   Biochem Pharmacol 221, 116039 (2024)
   PUBMED   38301966
REFERENCE   3  (bases 1 to 3625)
  AUTHORS   Tsuruta,H., Yasuda-Yamahara,M., Yoshibayashi,M., Kuwagata,S.,
            Yamahara,K., Tanaka-Sasaki,Y., Chin-Kanasaki,M., Matsumoto,S.,
            Ema,M. and Kume,S.
  TITLE     Fructose overconsumption accelerates renal dysfunction with
            aberrant glomerular endothelial-mesangial cell interactions in
            db/db mice
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167074 (2024)
   PUBMED   38354758
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 3625)
  AUTHORS   Melo,R.M.F., Barbosa,R.S., Ozorio,V.L., Oliveira,G.M.,
            Horita,S.I.M., Henriques-Pons,A., Araujo-Jorge,T.C. and
            Fragoso,V.M.S.
  TITLE     Influence of leptin and its receptors on individuals under chronic
            social stress behavior
  JOURNAL   Front Endocrinol (Lausanne) 15, 1281135 (2024)
   PUBMED   38362276
  REMARK    GeneRIF: Influence of leptin and its receptors on individuals under
            chronic social stress behavior.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3625)
  AUTHORS   He,H., Wang,H., Chen,X., Zhong,Y., Huang,X.R., Ma,R.C., Wang,C. and
            Lan,H.Y.
  TITLE     Treatment for type 2 diabetes and diabetic nephropathy by targeting
            Smad3 signaling
  JOURNAL   Int J Biol Sci 20 (1), 200-217 (2024)
   PUBMED   38164169
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3625)
  AUTHORS   Tulsiani,D.R. and Touster,O.
  TITLE     Studies on dehydrogenases of the glucuronate-xylulose cycle in the
            livers of diabetic mice and rats
  JOURNAL   Diabetes 28 (9), 793-798 (1979)
   PUBMED   38160
REFERENCE   7  (bases 1 to 3625)
  AUTHORS   Leiter,E.H., Coleman,D.L. and Eppig,J.J.
  TITLE     Endocrine pancreatic cells of postnatal 'diabetes' (db) mice in
            cell culture
  JOURNAL   In Vitro 15 (7), 507-521 (1979)
   PUBMED   393618
REFERENCE   8  (bases 1 to 3625)
  AUTHORS   Johnson,L.M. and Sidman,R.L.
  TITLE     A reproductive endocrine profile in the diabetes (db) mutant mouse
  JOURNAL   Biol Reprod 20 (3), 552-559 (1979)
   PUBMED   378276
REFERENCE   9  (bases 1 to 3625)
  AUTHORS   Mandel,M.A. and Mahmoud,A.A.
  TITLE     Impairment of cell-mediated immunity in mutation diabetic mice
            (db/db)
  JOURNAL   J Immunol 120 (4), 1375-1377 (1978)
   PUBMED   347001
REFERENCE   10 (bases 1 to 3625)
  AUTHORS   Coleman,D.L.
  TITLE     Obese and diabetes: two mutant genes causing diabetes-obesity
            syndromes in mice
  JOURNAL   Diabetologia 14 (3), 141-148 (1978)
   PUBMED   350680
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929373.15.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_146146.4.
            
            On May 13, 2019 this sequence version replaced NM_146146.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U58861.1, U46135.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AL929373.15        68382-68414
            34-93               AL929373.15        78486-78545
            94-423              AL929373.15        83743-84072
            424-547             AL929373.15        86036-86159
            548-753             AL929373.15        95987-96192
            754-896             AL929373.15        100763-100905
            897-1041            AL929373.15        102537-102681
            1042-1332           AL929373.15        115337-115627
            1333-1450           AL929373.15        115780-115897
            1451-1650           AL929373.15        118523-118722
            1651-1799           AL929373.15        121773-121921
            1800-1959           AL929373.15        123312-123471
            1960-2042           AL929373.15        124677-124759
            2043-2259           AL929373.15        130381-130597
            2260-2442           AL929373.15        133021-133203
            2443-2538           AL929373.15        139739-139834
            2539-2644           AL929373.15        141277-141382
            2645-2720           AL929373.15        142471-142546
            2721-3625           AL929373.15        164924-165828
FEATURES             Location/Qualifiers
     source          1..3625
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 46.96 cM"
     gene            1..3625
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /note="leptin receptor"
                     /db_xref="GeneID:16847"
                     /db_xref="MGI:MGI:104993"
     exon            1..33
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            34..93
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..3542
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; OB receptor; B219; LEP-R; leptin receptor
                     gene-related protein"
                     /codon_start=1
                     /product="leptin receptor isoform 1 precursor"
                     /protein_id="NP_666258.2"
                     /db_xref="CCDS:CCDS51240.1"
                     /db_xref="GeneID:16847"
                     /db_xref="MGI:MGI:104993"
                     /translation="MMCQKFYVVLLHWEFLYVIAALNLAYPISPWKFKLFCGPPNTTD
                     DSFLSPAGAPNNASALKGASEAIVEAKFNSSGIYVPELSKTVFHCCFGNEQGQNCSAL
                     TDNTEGKTLASVVKASVFRQLGVNWDIECWMKGDLTLFICHMEPLPKNPFKNYDSKVH
                     LLYDLPEVIDDSPLPPLKDSFQTVQCNCSLRGCECHVPVPRAKLNYALLMYLEITSAG
                     VSFQSPLMSLQPMLVVKPDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQYQVKYLENS
                     TIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLDGSGVWSDWSSPQVFTTQDVVYF
                     PPKILTSVGSNASFHCIYKNENQIISSKQIVWWRNLAEKIPEIQYSIVSDRVSKVTFS
                     NLKATRPRGKFTYDAVYCCNEQACHHRYAELYVIDVNINISCETDGYLTKMTCRWSPS
                     TIQSLVGSTVQLRYHRRSLYCPDSPSIHPTSEPKNCVLQRDGFYECVFQPIFLLSGYT
                     MWIRINHSLGSLDSPPTCVLPDSVVKPLPPSNVKAEITVNTGLLKVSWEKPVFPENNL
                     QFQIRYGLSGKEIQWKTHEVFDAKSKSASLLVSDLCAVYVVQVRCRRLDGLGYWSNWS
                     SPAYTLVMDVKVPMRGPEFWRKMDGDVTKKERNVTLLWKPLTKNDSLCSVRRYVVKHR
                     TAHNGTWSEDVGNRTNLTFLWTEPAHTVTVLAVNSLGASLVNFNLTFSWPMSKVSAVE
                     SLSAYPLSSSCVILSWTLSPDDYSLLYLVIEWKILNEDDGMKWLRIPSNVKKFYIHDN
                     FIPIEKYQFSLYPVFMEGVGKPKIINGFTKDAIDKQQNDAGLYVIVPIIISSCVLLLG
                     TLLISHQRMKKLFWDDVPNPKNCSWAQGLNFQKPETFEHLFTKHAESVIFGPLLLEPE
                     PISEEISVDTAWKNKDEMVPAAMVSLLLTTPDPESSSICISDQCNSANFSGSQSTQVT
                     CEDECQRQPSVKYATLVSNDKLVETDEEQGFIHSPVSNCISSNHSPLRQSFSSSSWET
                     EAQTFFLLSDQQPTMISPQLSFSGLDELLELEGSFPEENHREKSVCYLGVTSVNRRES
                     GVLLTGEAGILCTFPAQCLFSDIRILQERCSHFVENNLSLGTSGENFVPYMPQFQTCS
                     THSHKIMENKMCDLTV"
     exon            94..423
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            424..547
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            548..753
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            754..896
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1041
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1332
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1450
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1650
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1799
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1959
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2042
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2259
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2442
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2538
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2644
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2720
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..3625
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacccgacc gaggaatcgt tctgcaaatc caggtgtaca cctctgaaga aagatgatgt
       61 gtcagaaatt ctatgtggtt ttgttacact gggaatttct ttatgtgata gctgcactta
      121 acctggcata tccaatctct ccctggaaat ttaagttgtt ttgtggacca ccgaacacaa
      181 ccgatgactc ctttctctca cctgctggag ccccaaacaa tgcctcggct ttgaaggggg
      241 cttctgaagc aattgttgaa gctaaattta attcaagtgg tatctacgtt cctgagttat
      301 ccaaaacagt cttccactgt tgctttggga atgagcaagg tcaaaactgc tctgcactca
      361 cagacaacac tgaagggaag acactggctt cagtagtgaa ggcttcagtt tttcgccagc
      421 taggtgtaaa ctgggacata gagtgctgga tgaaagggga cttgacatta ttcatctgtc
      481 atatggagcc attacctaag aaccccttca agaattatga ctctaaggtc catcttttat
      541 atgatctgcc tgaagtcata gatgattcgc ctctgccccc actgaaagac agctttcaga
      601 ctgtccaatg caactgcagt cttcggggat gtgaatgtca tgtgccggta cccagagcca
      661 aactcaacta cgctcttctg atgtatttgg aaatcacatc tgccggtgtg agttttcagt
      721 cacctctgat gtcactgcag cccatgcttg ttgtgaaacc cgatccaccc ttaggtttgc
      781 atatggaagt cacagatgat ggtaatttaa agatttcttg ggacagccaa acaatggcac
      841 catttccgct tcaatatcag gtgaaatatt tagagaattc tacaattgta agagaggctg
      901 ctgaaattgt ctcagctaca tctctgctgg tagacagtgt gcttcctgga tcttcatatg
      961 aggtccaggt gaggagcaag agactggatg gttcaggagt ctggagtgac tggagttcac
     1021 ctcaagtctt taccacacaa gatgttgtgt attttccacc caaaattctg actagtgttg
     1081 gatcgaatgc ttcttttcat tgcatctaca aaaacgaaaa ccagattatc tcctcaaaac
     1141 agatagtttg gtggaggaat ctagctgaga aaatccctga gatacagtac agcattgtga
     1201 gtgaccgagt tagcaaagtt accttctcca acctgaaagc caccagacct cgagggaagt
     1261 ttacctatga cgcagtgtac tgctgcaatg agcaggcgtg ccatcaccgc tatgctgaat
     1321 tatacgtgat cgatgtcaat atcaatatat catgtgaaac tgacgggtac ttaactaaaa
     1381 tgacttgcag atggtcaccc agcacaatcc aatcactagt gggaagcact gtgcagctga
     1441 ggtatcacag gcgcagcctg tattgtcctg atagtccatc tattcatcct acgtctgagc
     1501 ccaaaaactg cgtcttacag agagacggct tttatgaatg tgttttccag ccaatctttc
     1561 tattatctgg ctatacaatg tggatcagga tcaaccattc tttaggttca cttgactcgc
     1621 caccaacgtg tgtccttcct gactccgtag taaaaccact acctccatct aacgtaaaag
     1681 cagagattac tgtaaacact ggattattga aagtatcttg ggaaaagcca gtctttccgg
     1741 agaataacct tcaattccag attcgatatg gcttaagtgg aaaagaaata caatggaaga
     1801 cacatgaggt attcgatgca aagtcaaagt ctgccagcct gctggtgtca gacctctgtg
     1861 cagtctatgt ggtccaggtt cgctgccggc ggttggatgg actaggatat tggagtaatt
     1921 ggagcagtcc agcctatacg cttgtcatgg atgtaaaagt tcctatgaga gggcctgaat
     1981 tttggagaaa aatggatggg gacgttacta aaaaggagag aaatgtcacc ttgctttgga
     2041 agcccctgac gaaaaatgac tcactgtgta gtgtgaggag gtacgtggtg aagcatcgta
     2101 ctgcccacaa tgggacgtgg tcagaagatg tgggaaatcg gaccaatctc actttcctgt
     2161 ggacagaacc agcgcacact gttacagttc tggctgtcaa ttccctcggc gcttcccttg
     2221 tgaattttaa ccttaccttc tcatggccca tgagtaaagt gagtgctgtg gagtcactca
     2281 gtgcttatcc cctgagcagc agctgtgtca tcctttcctg gacactgtca cctgatgatt
     2341 atagtctgtt atatctggtt attgaatgga agatccttaa tgaagatgat ggaatgaagt
     2401 ggcttagaat tccctcgaat gttaaaaagt tttatatcca cgataatttt attcccatcg
     2461 agaaatatca gtttagtctt tacccagtat ttatggaagg agttggaaaa ccaaagataa
     2521 ttaatggttt caccaaagat gctatcgaca agcagcagaa tgacgcaggg ctgtatgtca
     2581 ttgtacccat aattatttcc tcttgtgtcc tactgctcgg aacactgtta atttcacacc
     2641 agagaatgaa aaagttgttt tgggacgatg ttccaaaccc caagaattgt tcctgggcac
     2701 aaggactgaa tttccaaaag cctgaaacat ttgagcatct ttttaccaag catgcagaat
     2761 cagtgatatt tggtcctctt cttctggagc ctgaacccat ttcagaagaa atcagtgtcg
     2821 atacagcttg gaaaaataaa gatgagatgg tcccagcagc tatggtctcc cttcttttga
     2881 ccacaccaga ccctgaaagc agttctattt gtattagtga ccagtgtaac agtgctaact
     2941 tctctgggtc tcagagcacc caggtaacct gtgaggatga gtgtcagaga caaccctcag
     3001 ttaaatatgc aactctggtc agcaacgata aactagtgga aactgatgaa gagcaagggt
     3061 ttatccatag tcctgtcagc aactgcatct ccagtaatca ttccccactg aggcagtctt
     3121 tctctagcag ctcctgggag acagaggccc agacattttt ccttttatca gaccagcaac
     3181 ccaccatgat ttcaccacaa ctttcattct cggggttgga tgagcttttg gaactggagg
     3241 gaagttttcc tgaagaaaat cacagggaga agtctgtctg ttatctagga gtcacctccg
     3301 tcaacagaag agagagtggt gtgcttttga ctggtgaggc aggaatcctg tgcacattcc
     3361 cagcccagtg tctgttcagt gacatcagga tcctccagga gagatgctca cactttgtag
     3421 aaaataattt gagtttaggg acctctggtg agaactttgt accttacatg ccccaatttc
     3481 aaacctgttc cacgcacagt cacaagataa tggagaataa gatgtgtgac ttaactgtgt
     3541 aatctcatcc aagaagcctc aaggttccat tccagtagag cctgtcatgt ataatgtgtt
     3601 cttttattgt tgtggatgtg ggaga
//
