LOCUS       NM_010704               3407 bp    mRNA    linear   ROD 19-MAR-2024
DEFINITION  Mus musculus leptin receptor (Lepr), transcript variant 2, mRNA.
ACCESSION   NM_010704
VERSION     NM_010704.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3407)
  AUTHORS   Cardani-Boulton,A., Sung,S.J., Petri,W.A. Jr., Hahn,Y.S. and
            Braciale,T.J.
  TITLE     Leptin Receptor Deficiency Impairs Lymph Node Development and
            Adaptive Immune Response
  JOURNAL   J Immunol 212 (6), 974-981 (2024)
   PUBMED   38251917
  REMARK    GeneRIF: Leptin Receptor Deficiency Impairs Lymph Node Development
            and Adaptive Immune Response.
REFERENCE   2  (bases 1 to 3407)
  AUTHORS   Tang,Q., Cheng,Z., Liu,S., Niu,J., Xu,J., Huang,J., Pan,J., Lu,F.
            and Chen,D.
  TITLE     FGF1DeltaHBS ameliorates retinal inflammation via suppressing TSPO
            signal in a type 2 diabetes mouse model
  JOURNAL   Biochem Pharmacol 221, 116039 (2024)
   PUBMED   38301966
REFERENCE   3  (bases 1 to 3407)
  AUTHORS   Tsuruta,H., Yasuda-Yamahara,M., Yoshibayashi,M., Kuwagata,S.,
            Yamahara,K., Tanaka-Sasaki,Y., Chin-Kanasaki,M., Matsumoto,S.,
            Ema,M. and Kume,S.
  TITLE     Fructose overconsumption accelerates renal dysfunction with
            aberrant glomerular endothelial-mesangial cell interactions in
            db/db mice
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167074 (2024)
   PUBMED   38354758
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 3407)
  AUTHORS   Melo,R.M.F., Barbosa,R.S., Ozorio,V.L., Oliveira,G.M.,
            Horita,S.I.M., Henriques-Pons,A., Araujo-Jorge,T.C. and
            Fragoso,V.M.S.
  TITLE     Influence of leptin and its receptors on individuals under chronic
            social stress behavior
  JOURNAL   Front Endocrinol (Lausanne) 15, 1281135 (2024)
   PUBMED   38362276
  REMARK    GeneRIF: Influence of leptin and its receptors on individuals under
            chronic social stress behavior.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3407)
  AUTHORS   He,H., Wang,H., Chen,X., Zhong,Y., Huang,X.R., Ma,R.C., Wang,C. and
            Lan,H.Y.
  TITLE     Treatment for type 2 diabetes and diabetic nephropathy by targeting
            Smad3 signaling
  JOURNAL   Int J Biol Sci 20 (1), 200-217 (2024)
   PUBMED   38164169
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3407)
  AUTHORS   Tulsiani,D.R. and Touster,O.
  TITLE     Studies on dehydrogenases of the glucuronate-xylulose cycle in the
            livers of diabetic mice and rats
  JOURNAL   Diabetes 28 (9), 793-798 (1979)
   PUBMED   38160
REFERENCE   7  (bases 1 to 3407)
  AUTHORS   Leiter,E.H., Coleman,D.L. and Eppig,J.J.
  TITLE     Endocrine pancreatic cells of postnatal 'diabetes' (db) mice in
            cell culture
  JOURNAL   In Vitro 15 (7), 507-521 (1979)
   PUBMED   393618
REFERENCE   8  (bases 1 to 3407)
  AUTHORS   Johnson,L.M. and Sidman,R.L.
  TITLE     A reproductive endocrine profile in the diabetes (db) mutant mouse
  JOURNAL   Biol Reprod 20 (3), 552-559 (1979)
   PUBMED   378276
REFERENCE   9  (bases 1 to 3407)
  AUTHORS   Mandel,M.A. and Mahmoud,A.A.
  TITLE     Impairment of cell-mediated immunity in mutation diabetic mice
            (db/db)
  JOURNAL   J Immunol 120 (4), 1375-1377 (1978)
   PUBMED   347001
REFERENCE   10 (bases 1 to 3407)
  AUTHORS   Coleman,D.L.
  TITLE     Obese and diabetes: two mutant genes causing diabetes-obesity
            syndromes in mice
  JOURNAL   Diabetologia 14 (3), 141-148 (1978)
   PUBMED   350680
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN692760.1 and AK143989.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_010704.3.
            
            On Apr 1, 2008 this sequence version replaced NM_010704.1.
            
            Transcript Variant: This variant (2) lacks the 3' exon but has an
            alternate 3' segment, as compared to variant 1. The resulting
            isoform (2) has a different and shorter C-terminus, as compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U52915.1, AK143989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-313               CN692760.1         1-313
            314-3407            AK143989.1         3-3096
FEATURES             Location/Qualifiers
     source          1..3407
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 46.96 cM"
     gene            1..3407
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /note="leptin receptor"
                     /db_xref="GeneID:16847"
                     /db_xref="MGI:MGI:104993"
     exon            1..532
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            533..592
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     CDS             553..3231
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; OB receptor; B219; LEP-R; leptin receptor
                     gene-related protein"
                     /codon_start=1
                     /product="leptin receptor isoform 2 precursor"
                     /protein_id="NP_034834.1"
                     /db_xref="CCDS:CCDS18397.1"
                     /db_xref="GeneID:16847"
                     /db_xref="MGI:MGI:104993"
                     /translation="MMCQKFYVVLLHWEFLYVIAALNLAYPISPWKFKLFCGPPNTTD
                     DSFLSPAGAPNNASALKGASEAIVEAKFNSSGIYVPELSKTVFHCCFGNEQGQNCSAL
                     TDNTEGKTLASVVKASVFRQLGVNWDIECWMKGDLTLFICHMEPLPKNPFKNYDSKVH
                     LLYDLPEVIDDSPLPPLKDSFQTVQCNCSLRGCECHVPVPRAKLNYALLMYLEITSAG
                     VSFQSPLMSLQPMLVVKPDPPLGLHMEVTDDGNLKISWDSQTMAPFPLQYQVKYLENS
                     TIVREAAEIVSATSLLVDSVLPGSSYEVQVRSKRLDGSGVWSDWSSPQVFTTQDVVYF
                     PPKILTSVGSNASFHCIYKNENQIISSKQIVWWRNLAEKIPEIQYSIVSDRVSKVTFS
                     NLKATRPRGKFTYDAVYCCNEQACHHRYAELYVIDVNINISCETDGYLTKMTCRWSPS
                     TIQSLVGSTVQLRYHRRSLYCPDSPSIHPTSEPKNCVLQRDGFYECVFQPIFLLSGYT
                     MWIRINHSLGSLDSPPTCVLPDSVVKPLPPSNVKAEITVNTGLLKVSWEKPVFPENNL
                     QFQIRYGLSGKEIQWKTHEVFDAKSKSASLLVSDLCAVYVVQVRCRRLDGLGYWSNWS
                     SPAYTLVMDVKVPMRGPEFWRKMDGDVTKKERNVTLLWKPLTKNDSLCSVRRYVVKHR
                     TAHNGTWSEDVGNRTNLTFLWTEPAHTVTVLAVNSLGASLVNFNLTFSWPMSKVSAVE
                     SLSAYPLSSSCVILSWTLSPDDYSLLYLVIEWKILNEDDGMKWLRIPSNVKKFYIHDN
                     FIPIEKYQFSLYPVFMEGVGKPKIINGFTKDAIDKQQNDAGLYVIVPIIISSCVLLLG
                     TLLISHQRMKKLFWDDVPNPKNCSWAQGLNFQKVTV"
     exon            593..922
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1046
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1252
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1395
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1540
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1831
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1949
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2149
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2298
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2458
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2541
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2758
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2941
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3037
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3143
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3407
                     /gene="Lepr"
                     /gene_synonym="db; diabetes; Leprb; LEPROT; Modb1;
                     OB-RGRP; obese-like; obl; Obr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccgcagc gtcgcgcccg cgcacgagtg gtcggcacct tctgagccag cagcatagag
       61 cccaggcatc cctgctttac gccactccgg gacacaggtg ggacactctt ttagtcctca
      121 atccctggcg cgaggccacc caaggcaacg caggacgcag ggcgtttggg gaccaggcag
      181 cagactgggg cggtacctgc ggagagccac gcaacttctc caggcctctg actactttgg
      241 aaactgcccg gggctgcgac atcaacccct taagtcccgg aggcggaaag agggtgggtt
      301 ggtttgaaag acacaaggaa gaaaaatgtg ctgtggggcg ggttaagttt cccaccctct
      361 tcccccttcc cgagcaaatt agaaacaaaa caaatagaaa agccagccct ccggccaacc
      421 aaagccccaa gcggagcccc aagcggagcc ccagccggag cactccttta aaaggatttg
      481 cagcggtgag gaaaaaacca gacccgaccg aggaatcgtt ctgcaaatcc aggtgtacac
      541 ctctgaagaa agatgatgtg tcagaaattc tatgtggttt tgttacactg ggaatttctt
      601 tatgtgatag ctgcacttaa cctggcatat ccaatctctc cctggaaatt taagttgttt
      661 tgtggaccac cgaacacaac cgatgactcc tttctctcac ctgctggagc cccaaacaat
      721 gcctcggctt tgaagggggc ttctgaagca attgttgaag ctaaatttaa ttcaagtggt
      781 atctacgttc ctgagttatc caaaacagtc ttccactgtt gctttgggaa tgagcaaggt
      841 caaaactgct ctgcactcac agacaacact gaagggaaga cactggcttc agtagtgaag
      901 gcttcagttt ttcgccagct aggtgtaaac tgggacatag agtgctggat gaaaggggac
      961 ttgacattat tcatctgtca tatggagcca ttacctaaga accccttcaa gaattatgac
     1021 tctaaggtcc atcttttata tgatctgcct gaagtcatag atgattcgcc tctgccccca
     1081 ctgaaagaca gctttcagac tgtccaatgc aactgcagtc ttcggggatg tgaatgtcat
     1141 gtgccggtac ccagagccaa actcaactac gctcttctga tgtatttgga aatcacatct
     1201 gccggtgtga gttttcagtc acctctgatg tcactgcagc ccatgcttgt tgtgaaaccc
     1261 gatccaccct taggtttgca tatggaagtc acagatgatg gtaatttaaa gatttcttgg
     1321 gacagccaaa caatggcacc atttccgctt caatatcagg tgaaatattt agagaattct
     1381 acaattgtaa gagaggctgc tgaaattgtc tcagctacat ctctgctggt agacagtgtg
     1441 cttcctggat cttcatatga ggtccaggtg aggagcaaga gactggatgg ttcaggagtc
     1501 tggagtgact ggagttcacc tcaagtcttt accacacaag atgttgtgta ttttccaccc
     1561 aaaattctga ctagtgttgg atcgaatgct tcttttcatt gcatctacaa aaacgaaaac
     1621 cagattatct cctcaaaaca gatagtttgg tggaggaatc tagctgagaa aatccctgag
     1681 atacagtaca gcattgtgag tgaccgagtt agcaaagtta ccttctccaa cctgaaagcc
     1741 accagacctc gagggaagtt tacctatgac gcagtgtact gctgcaatga gcaggcgtgc
     1801 catcaccgct atgctgaatt atacgtgatc gatgtcaata tcaatatatc atgtgaaact
     1861 gacgggtact taactaaaat gacttgcaga tggtcaccca gcacaatcca atcactagtg
     1921 ggaagcactg tgcagctgag gtatcacagg cgcagcctgt attgtcctga tagtccatct
     1981 attcatccta cgtctgagcc caaaaactgc gtcttacaga gagacggctt ttatgaatgt
     2041 gttttccagc caatctttct attatctggc tatacaatgt ggatcaggat caaccattct
     2101 ttaggttcac ttgactcgcc accaacgtgt gtccttcctg actccgtagt aaaaccacta
     2161 cctccatcta acgtaaaagc agagattact gtaaacactg gattattgaa agtatcttgg
     2221 gaaaagccag tctttccgga gaataacctt caattccaga ttcgatatgg cttaagtgga
     2281 aaagaaatac aatggaagac acatgaggta ttcgatgcaa agtcaaagtc tgccagcctg
     2341 ctggtgtcag acctctgtgc agtctatgtg gtccaggttc gctgccggcg gttggatgga
     2401 ctaggatatt ggagtaattg gagcagtcca gcctatacgc ttgtcatgga tgtaaaagtt
     2461 cctatgagag ggcctgaatt ttggagaaaa atggatgggg acgttactaa aaaggagaga
     2521 aatgtcacct tgctttggaa gcccctgacg aaaaatgact cactgtgtag tgtgaggagg
     2581 tacgtggtga agcatcgtac tgcccacaat gggacgtggt cagaagatgt gggaaatcgg
     2641 accaatctca ctttcctgtg gacagaacca gcgcacactg ttacagttct ggctgtcaat
     2701 tccctcggcg cttcccttgt gaattttaac cttaccttct catggcccat gagtaaagtg
     2761 agtgctgtgg agtcactcag tgcttatccc ctgagcagca gctgtgtcat cctttcctgg
     2821 acactgtcac ctgatgatta tagtctgtta tatctggtta ttgaatggaa gatccttaat
     2881 gaagatgatg gaatgaagtg gcttagaatt ccctcgaatg ttaaaaagtt ttatatccac
     2941 gataatttta ttcccatcga gaaatatcag tttagtcttt acccagtatt tatggaagga
     3001 gttggaaaac caaagataat taatggtttc accaaagatg ctatcgacaa gcagcagaat
     3061 gacgcagggc tgtatgtcat tgtacccata attatttcct cttgtgtcct actgctcgga
     3121 acactgttaa tttcacacca gagaatgaaa aagttgtttt gggacgatgt tccaaacccc
     3181 aagaattgtt cctgggcaca aggactgaat ttccaaaagg tcactgttta agtattttaa
     3241 cccagatatc taaggttgca gtttagatgc cacagtactt acagatcttt aaacaacttt
     3301 aaagggcttt atgttgttgt gttcatgttc tcaagcctgt tcatcctttc tctttctcaa
     3361 aagctgggtt tgggatttga tcagagaaaa caaagttcgc tccctta
//
