LOCUS       NM_008493               3257 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus leptin (Lep), mRNA.
ACCESSION   NM_008493
VERSION     NM_008493.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3257)
  AUTHORS   Liao,Y., Chen,Q., Liu,L., Huang,H., Sun,J., Bai,X., Jin,C., Li,H.,
            Sun,F., Xiao,X., Zhang,Y., Li,J., Han,W. and Fu,S.
  TITLE     Amino acid is a major carbon source for hepatic lipogenesis
  JOURNAL   Cell Metab 36 (11), 2437-2448 (2024)
   PUBMED   39461344
REFERENCE   2  (bases 1 to 3257)
  AUTHORS   Gusmao,D.O., de Sousa,L.M.M., de Sousa,M.E., Rusew,S.J.R.,
            List,E.O., Kopchick,J.J., Gomes,A.F., Campideli-Santana,A.C.,
            Szawka,R.E. and Donato,J. Jr.
  TITLE     Characterization and Regulation of the Neonatal Growth Hormone
            Surge
  JOURNAL   Endocrinology 165 (12) (2024)
   PUBMED   39446366
REFERENCE   3  (bases 1 to 3257)
  AUTHORS   Yang,S., Li,Y., Tian,M., Deng,W., Liu,D., Chen,C., Zhu,Z.,
            Zheng,H., Yang,G., Li,L. and Yang,M.
  TITLE     Hypothalamic P62 (SQSTM1) regulates energy balance by modulating
            leptin signaling
  JOURNAL   Theranostics 14 (17), 6605-6624 (2024)
   PUBMED   39479445
  REMARK    GeneRIF: Hypothalamic P62 (SQSTM1) regulates energy balance by
            modulating leptin signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3257)
  AUTHORS   Wang,Y., Zhou,J., Yang,Q., Li,X., Qiu,Y., Zhang,Y., Liu,M. and
            Zhu,A.J.
  TITLE     Therapeutic siRNA targeting PLIN2 ameliorates steatosis,
            inflammation, and fibrosis in steatotic liver disease models
  JOURNAL   J Lipid Res 65 (10), 100635 (2024)
   PUBMED   39187042
REFERENCE   5  (bases 1 to 3257)
  AUTHORS   Shannon,C.E., Bakewell,T., Fourcaudot,M.J., Ayala,I., Smelter,A.A.,
            Hinostroza,E.A., Romero,G., Asmis,M., Freitas Lima,L.C., Wallace,M.
            and Norton,L.
  TITLE     The mitochondrial pyruvate carrier regulates adipose glucose
            partitioning in female mice
  JOURNAL   Mol Metab 88, 102005 (2024)
   PUBMED   39137831
REFERENCE   6  (bases 1 to 3257)
  AUTHORS   Thurlby,P.L. and Trayhurn,P.
  TITLE     The role of thermoregulatory thermogenesis in the development of
            obesity in genetically-obese (ob/ob) mice pair-fed with lean
            siblings
  JOURNAL   Br J Nutr 42 (3), 377-385 (1979)
   PUBMED   508700
REFERENCE   7  (bases 1 to 3257)
  AUTHORS   Lin,M.H., Romsos,D.R., Akera,T. and Leveille,G.A.
  TITLE     Na+,K+-ATPase enzyme units in skeletal muscle and liver of
            14-day-old lean and obese (ob/ob) mice
  JOURNAL   Proc Soc Exp Biol Med 161 (3), 235-238 (1979)
   PUBMED   223169
REFERENCE   8  (bases 1 to 3257)
  AUTHORS   Ruddle,N.H., Conta,B.S., Leinwand,L., Kozak,C., Ruddle,F.,
            Besmer,P. and Baltimore,D.
  TITLE     Assignment of the receptor for ecotropic murine leukemia virus to
            mouse chromosome 5
  JOURNAL   J Exp Med 148 (2), 451-465 (1978)
   PUBMED   212501
REFERENCE   9  (bases 1 to 3257)
  AUTHORS   Coleman,D.L.
  TITLE     Obese and diabetes: two mutant genes causing diabetes-obesity
            syndromes in mice
  JOURNAL   Diabetologia 14 (3), 141-148 (1978)
   PUBMED   350680
  REMARK    Review article
REFERENCE   10 (bases 1 to 3257)
  AUTHORS   Trayhurn,P. and James,W.P.
  TITLE     Thermoregulation and non-shivering thermogenesis in the genetically
            obese (ob/ob) mouse
  JOURNAL   Pflugers Arch 373 (2), 189-193 (1978)
   PUBMED   565045
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030984.1.
            
            On Aug 28, 2003 this sequence version replaced NM_008493.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030984.1, HQ166716.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3257
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.3 cM"
     gene            1..3257
                     /gene="Lep"
                     /gene_synonym="ob; obese"
                     /note="leptin"
                     /db_xref="GeneID:16846"
                     /db_xref="MGI:MGI:104663"
     exon            1..28
                     /gene="Lep"
                     /gene_synonym="ob; obese"
                     /inference="alignment:Splign:2.1.0"
     exon            29..203
                     /gene="Lep"
                     /gene_synonym="ob; obese"
                     /inference="alignment:Splign:2.1.0"
     exon            204..3257
                     /gene="Lep"
                     /gene_synonym="ob; obese"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3238..3243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lep"
                     /gene_synonym="ob; obese"
                     /note="putative"
     polyA_site      3257
                     /gene="Lep"
                     /gene_synonym="ob; obese"
                     /note="putative"
ORIGIN      
        1 gagggatccc tgctccagca gctgcaaggt gcaagaagaa gaagatccca gggaggaaaa
       61 tgtgctggag acccctgtgt cggttcctgt ggctttggtc ctatctgtct tatgttcaag
      121 cagtgcctat ccagaaagtc caggatgaca ccaaaaccct catcaagacc attgtcacca
      181 ggatcaatga catttcacac acgcagtcgg tatccgccaa gcagagggtc actggcttgg
      241 acttcattcc tgggcttcac cccattctga gtttgtccaa gatggaccag actctggcag
      301 tctatcaaca ggtcctcacc agcctgcctt cccaaaatgt gctgcagata gccaatgacc
      361 tggagaatct ccgagacctc ctccatctgc tggccttctc caagagctgc tccctgcctc
      421 agaccagtgg cctgcagaag ccagagagcc tggatggcgt cctggaagcc tcactctact
      481 ccacagaggt ggtggctttg agcaggctgc agggctctct gcaggacatt cttcaacagt
      541 tggatgttag ccctgaatgc tgaagtttca aaggccacca ggctcccaag aatcatgtag
      601 agggaagaaa ccttggcttc caggggtctt caggagaaga gagccatgtg cacacatcca
      661 tcattcattt ctctccctcc tgtagaccac ccatccaaag gcatgactcc acaatgcttg
      721 actcaagtta tccacacaac ttcatgagca caaggagggg ccagcctgca gaggggactc
      781 tcacctagtt cttcagcaag tagagataag agccatccca tcccctccat gtcccacctg
      841 ctccgggtac atgttcctcc gtgggtacac gcttcgctgc ggcccaggag aggtgaggta
      901 gggatgggta gagcctttgg gctgtctcag agtctttggg agcaccgtga aggctgcatc
      961 cacacacagc tggaaactcc caagcagcac acgatggaag cacttattta tttattctgc
     1021 attctatttt ggatggatct gaagcaagcc atcagctttt tcaggctttg ggggtcagcc
     1081 aggatgagga aggctcctgg ggtgctgctt tcaatcctat tgatgggtct gcccaaggca
     1141 aacctaattt ttgagtgact ggaaggaagg ttgggatctt ccaaacaaga gtctatgcag
     1201 gtagcgctca agcttgacct ctggtgactg gttttgtttc tattgtgact gactctatgc
     1261 aaacacgttt gcagcggcat tgccgggagc ataggctagg ttattatcaa aagcagatga
     1321 attttgtcaa gtgtaatatg tatctatgtg cacctgaggg tagaggatgt gttagaggga
     1381 gggtgaagga tccggaagtg ttctctgaat tacatatgtg tggtaggctt ttctgaaagg
     1441 gtgaggcatt ttcttacctc tgtggccaca tagtgtggct ttgtgaaaag gacaaaggag
     1501 ttgactcttt ccggaacatt tggagtgtac caggcaccct tggaggggct aaagctacag
     1561 gccttttgtt ggcatattgc tgagctcagg gagtgagggc cccacatttg agacagtgag
     1621 ccccaagaaa agggtccctg gtgtagatct ccaaggttgt ccagggttga tctcacaatg
     1681 cgtttcttaa gcaggtagac gtttgcatgc caatatgtgg ttctcatctg attggttcat
     1741 ccaaagtaga accctgtctc ccacccattc tgtggggagt tttgttccag tgggaatgag
     1801 aaatcactta gcagatggtc ctgagccctg ggccagcact gctgaggaag tgccagggcc
     1861 ccaggccagg ctgccagaat tgcccttcgg gctggaggat gaacaaaggg gcttgggttt
     1921 ttccatcacc cctgcaccct atgtcaccat caaactgggg ggcagatcag tgagaggaca
     1981 cttgatggaa agcaatacac tttaagactg agcacagttt cgtgctcagc tctgtctggt
     2041 gctgtgagct agagaagctc accaaataca tataaaaatc agaggctcat gtccctgtgg
     2101 ttagacccta ctcacggcgg tgtactccac cacagcagcc ccgcaccgct ggaagtacag
     2161 tgctgtcttc aacaggtgtg aaagaacctg agctgagggt gacagtgccc aggggaaccc
     2221 tgcttgcagt ctattgcatt tacataccgc atttcagggc acattagcat ccactgctat
     2281 ggtagcacac tgttgacacg ggatacctgg ggtcgtaaaa ataagaaaat acaggttgac
     2341 tatcccttat ccaaaatgct tgggactaga agagttttgg attttagagt cttttcaggc
     2401 ataggtatat ttgagtatat ataaaatgag atatcttggg gatggggccc aagtataaac
     2461 atgaagttca tttatatttc ataataccgt atagacactg cttgaagtgt agttttatac
     2521 agtgttttaa ataacgttgt atgcatgaaa gacgttttta cagcatgaac ctgtctactc
     2581 atgccagcac tcaaaaacct tggggttttg gagcagtttg gatcttgggt tttctgttaa
     2641 gagatggtta gcttatacct aaaaccataa tggcaaacag gctgcaggac cagactggat
     2701 cctcagccct gaagtgtgcc cttccagcca ggtcataccc tgtggaggtg agcgggatca
     2761 ggttttgtgg tgctaagaga ggagttggag gtagattttg gaggatctga ggggtgatgt
     2821 gatgttttat tggacacttg gtatgttgaa gggatgaaag tccaaacagg aagtgacagg
     2881 gaagactgaa gagaccggga aagagtgaca ggaagtgctg agaggacttt atgggccaca
     2941 aaagtggctt ctgaaagatc ccacgtgcca cagtctggag cgaaggctcg tggtggctgg
     3001 tgtcagattg ctctggggct gtgctatgcc accttggtca cctcatcaag ctggaatgtc
     3061 ctgagccttt cgctcagaga accttgcact atggcttgtt cccagattgt gaaacttccc
     3121 atatgcaaaa atgcttggtt tggttttttt ggtttttgtt tttgttttct tttttaaata
     3181 catatatata tgtaacaaca gcaacaacaa aattttgttt tattttgtgt caattcaaat
     3241 aaattaatga tgcctcc
//
