LOCUS       NM_001039522            2192 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Leo1, Paf1/RNA polymerase II complex component (Leo1),
            mRNA.
ACCESSION   NM_001039522
VERSION     NM_001039522.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2192)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2192)
  AUTHORS   Lantz,B., White,C., Liu,X., Wan,Y., Gabriel,G., Lo,C.W.Y. and
            Szabo-Rogers,H.L.
  TITLE     Finding the Unicorn, a New Mouse Model of Midfacial Clefting
  JOURNAL   Genes (Basel) 11 (1), 83 (2020)
   PUBMED   31940751
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2192)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2192)
  AUTHORS   Soulez,M., Saba-El-Leil,M.K., Turgeon,B., Mathien,S., Coulombe,P.,
            Klinger,S., Rousseau,J., Levesque,K. and Meloche,S.
  TITLE     Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3
            in Perinatal Survival and Postnatal Growth Using New Genetically
            Engineered Mouse Models
  JOURNAL   Mol Cell Biol 39 (6), e00527-18 (2019)
   PUBMED   30642949
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2192)
  AUTHORS   Osipovich,A.B., Gangula,R., Vianna,P.G. and Magnuson,M.A.
  TITLE     Setd5 is essential for mammalian development and the
            co-transcriptional regulation of histone acetylation
  JOURNAL   Development 143 (24), 4595-4607 (2016)
   PUBMED   27864380
REFERENCE   6  (bases 1 to 2192)
  AUTHORS   Vethantham,V., Yang,Y., Bowman,C., Asp,P., Lee,J.H., Skalnik,D.G.
            and Dynlacht,B.D.
  TITLE     Dynamic loss of H2B ubiquitylation without corresponding changes in
            H3K4 trimethylation during myogenic differentiation
  JOURNAL   Mol Cell Biol 32 (6), 1044-1055 (2012)
   PUBMED   22252316
REFERENCE   7  (bases 1 to 2192)
  AUTHORS   Ding,L., Paszkowski-Rogacz,M., Nitzsche,A., Slabicki,M.M.,
            Heninger,A.K., de Vries,I., Kittler,R., Junqueira,M.,
            Shevchenko,A., Schulz,H., Hubner,N., Doss,M.X., Sachinidis,A.,
            Hescheler,J., Iacone,R., Anastassiadis,K., Stewart,A.F.,
            Pisabarro,M.T., Caldarelli,A., Poser,I., Theis,M. and Buchholz,F.
  TITLE     A genome-scale RNAi screen for Oct4 modulators defines a role of
            the Paf1 complex for embryonic stem cell identity
  JOURNAL   Cell Stem Cell 4 (5), 403-415 (2009)
   PUBMED   19345177
REFERENCE   8  (bases 1 to 2192)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   9  (bases 1 to 2192)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2192)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB248994.1, BC083358.1 and BC082540.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083358.1, SRR1660821.16502.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                CB248994.1         1-12
            13-1552             BC083358.1         1-1540
            1553-2192           BC082540.1         3930-4569
FEATURES             Location/Qualifiers
     source          1..2192
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.3 cM"
     gene            1..2192
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /note="Leo1, Paf1/RNA polymerase II complex component"
                     /db_xref="GeneID:235497"
                     /db_xref="MGI:MGI:2685031"
     exon            1..112
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2058
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /note="Leo1, Paf1/RNA polymerase II complex component,
                     homolog"
                     /codon_start=1
                     /product="RNA polymerase-associated protein LEO1"
                     /protein_id="NP_001034611.1"
                     /db_xref="CCDS:CCDS23343.1"
                     /db_xref="GeneID:235497"
                     /db_xref="MGI:MGI:2685031"
                     /translation="MADMEDLFGSEAESEAERKDSESESDSDSDQDNGASGSNASGSE
                     SDQDDRGDSGQPSNKELFGDDSEEEGASHHSGSDNHSERSDNRSEASERSDHEDNEPS
                     DEDQHSGSEAHNDDDDEGHRSDEGSRHSEAEGSEKAQSDDEKWDGEDKSDQSDDEKLQ
                     NSDDEDREQGSDEDKLQNSDDDEEKMQNTDDEDRAQISDDDRQQLSEEEKGNSDDEHP
                     VASDNDEEKQNSDDEDQPQVSDEEKMQNSDDERPQVSDEDGRRSDGEEEQDQKSESAR
                     GSDSEDEVLRLKRKNAIPSDSEADSDTEVPKDNNGTMDLFGGADDISSGSDGEDKPPT
                     PGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDP
                     QYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMS
                     LHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLS
                     LADRCSKTQKIRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGL
                     SASYLEPDRYDEEEEGEESVSLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLL
                     KAKKLNSDEEGESSGKRKAEDDDKANKKHKKYVISDEEEEEDD"
     exon            113..871
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /inference="alignment:Splign:2.1.0"
     exon            872..976
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1071
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1217
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1302
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1397
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1532
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1668
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1855
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1953
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2192
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2174..2179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /note="hexamer: AATAAA"
     polyA_site      2192
                     /gene="Leo1"
                     /gene_synonym="Gm185"
                     /note="major polyA site"
ORIGIN      
        1 ctggccgtaa agcaggctcg agccgagcaa gccaaggccg cggaccaagc tgctatggcg
       61 gacatggagg acctcttcgg gagcgaagct gagagcgagg ccgagcgcaa agattccgag
      121 tctgagtccg actcggactc tgaccaggac aacggcgctt ctggcagcaa cgcctctggc
      181 agcgaaagtg atcaggatga cagaggtgac tccggacagc ccagtaacaa ggaactgttc
      241 ggggacgaca gtgaggagga gggggcctct catcacagtg gcagtgacaa tcactctgaa
      301 cggtcagaca ataggtcgga ggcttccgag cgctctgacc acgaggataa tgagccctct
      361 gacgaggacc agcacagtgg ctctgaagcc cacaacgatg acgacgatga gggccacagg
      421 tcggacgaag ggagccgtca ctcagaggca gaagggtctg aaaaagccca gtcagatgat
      481 gagaaatggg atggagagga taaaagtgac cagtcagatg acgagaagct gcagaactct
      541 gacgacgagg atcgggagca agggtccgat gaggataagc tgcagaactc tgacgacgac
      601 gaggagaaaa tgcagaacac agatgacgag gaccgggccc agatttctga tgatgacaga
      661 cagcagctgt ctgaggagga gaaggggaat tctgacgatg agcatccagt agcttctgat
      721 aatgacgagg agaagcagaa ttcggacgat gaggaccagc cgcaggtgtc cgatgaggag
      781 aaaatgcaga actcagacga tgaaaggcca caagtctcag atgaagatgg aaggcgttca
      841 gacggtgagg aggagcaaga ccagaagtca gaatctgcaa gaggcagtga cagtgaagat
      901 gaagttttac gactgaagcg caagaacgcg attccatcgg attccgaagc agacagcgac
      961 accgaggtgc ccaaagataa taatggaacc atggatctgt tcggaggtgc agatgacata
     1021 tcttcaggga gtgatggaga agataagccc ccaactccag gacagcctgt ggatgaaaat
     1081 ggcttgcccc aggatcagca ggaggaagag cccatacctg agaccagaat agaagtggag
     1141 atccccaaag taaacacgga cttgggcaat gacttatatt ttgttaaact gcccaacttc
     1201 ctcagtgtag agcccaggcc ttttgatcct cagtattatg aagatgaatt tgaagatgag
     1261 gagatgctgg atgaagaggg gagaaccagg ttaaaattga aggtagaaaa cactataaga
     1321 tggaggatac gcagagatga agaaggaaat gaaattaaag aaagcaatgc gcggatcgtc
     1381 aagtggtcag atggaagcat gtccctgcat ttagggaatg aagtgtttga tgtgtacaaa
     1441 gccccactgc agggcgacca caaccatctt ttcataagac aaggtactgg gctgcagggg
     1501 caggccgtct ttaaaacgaa gctcaccttc aggcctcact ctacagacag tgccacacac
     1561 aggaagatga ccctgtcact tgcagataga tgctcaaaga cacagaagat tcgaatctta
     1621 ccaatggctg gccgtgaccc tgagtgccag cgcacagaga tgattaagaa agaagaagaa
     1681 cgcctgaggg cctccatcag gagggagtct cagcagcgcc ggatgcgaga gaaacagcac
     1741 cagcgggggc tgagcgccag ctacctggag cctgatcgct acgacgagga ggaggaaggc
     1801 gaggagtccg tcagcctggc tgccattaaa aaccgctaca aagggggcat ccgcgaggaa
     1861 cgagccagaa tctactcctc ggacagtgat gagggctccg aagaagacaa agctcaaagg
     1921 ttactcaaag caaagaagct caacagtgat gaggaaggtg aatcttctgg aaagaggaaa
     1981 gcggaagacg atgacaaagc gaataaaaag cataagaagt atgtgatcag tgatgaagaa
     2041 gaagaagaag atgactgagc tacaaactgt gaatgcgttt tatatattta ttgtacagct
     2101 tgtctataaa tacaatgtaa acatgagtta ttttgattga gattaattga tctgtttgtg
     2161 aaattttgat tgtaataaaa catttaaggc aa
//
